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Q6ZWU9

- RS27_MOUSE

UniProt

Q6ZWU9 - RS27_MOUSE

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Protein

40S ribosomal protein S27

Gene

Rps27

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri38 – 6023C4-typeSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.
REACT_231519. Eukaryotic Translation Termination.
REACT_236458. Ribosomal scanning and start codon recognition.
REACT_249044. Formation of a pool of free 40S subunits.
REACT_249316. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_253640. Peptide chain elongation.
REACT_256488. Translation initiation complex formation.
REACT_256756. Mitotic Prometaphase.
REACT_259469. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_262078. GTP hydrolysis and joining of the 60S ribosomal subunit.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S27
Gene namesi
Name:Rps27Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3, UP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1888676. Rps27.

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 848340S ribosomal protein S27PRO_0000149052Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6ZWU9.
PaxDbiQ6ZWU9.
PRIDEiQ6ZWU9.

PTM databases

PhosphoSiteiQ6ZWU9.

Expressioni

Gene expression databases

BgeeiQ6ZWU9.
CleanExiMM_RPS27.
GenevestigatoriQ6ZWU9.

Interactioni

Protein-protein interaction databases

BioGridi208248. 6 interactions.
786971. 4 interactions.
IntActiQ6ZWU9. 2 interactions.
MINTiMINT-1212966.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWU9.
SMRiQ6ZWU9. Positions 2-84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S27e family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri38 – 6023C4-typeSequence AnalysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG2051.
GeneTreeiENSGT00390000013514.
HOVERGENiHBG000252.
InParanoidiQ6ZWU9.
KOiK02978.
OMAiCASVLCQ.
OrthoDBiEOG78SQM9.
PhylomeDBiQ6ZWU9.
TreeFamiTF300265.

Family and domain databases

Gene3Di2.20.25.100. 1 hit.
HAMAPiMF_00371. Ribosomal_S27e.
InterProiIPR000592. Ribosomal_S27e.
IPR023407. Ribosomal_S27e_Zn-bd_dom.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PANTHERiPTHR11594. PTHR11594. 1 hit.
PfamiPF01667. Ribosomal_S27e. 1 hit.
[Graphical view]
ProDomiPD004466. Ribosomal_S27e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF57829. SSF57829. 1 hit.
PROSITEiPS01168. RIBOSOMAL_S27E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZWU9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLAKDLLHP SPEEEKRKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA
60 70 80
QTVVLCVGCS TVLCQPTGGK ARLTEGCSFR RKQH
Length:84
Mass (Da):9,461
Last modified:January 23, 2007 - v3
Checksum:i242C4466AC8A8900
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014294 mRNA. Translation: BAB29250.1.
AK088320 mRNA. Translation: BAC40279.1.
AK166551 mRNA. Translation: BAE38849.1.
BC048352 mRNA. Translation: AAH48352.1.
BC055693 mRNA. Translation: AAH55693.1.
CCDSiCCDS50970.1.
RefSeqiNP_001177187.1. NM_001190258.1.
NP_081291.1. NM_027015.4.
UniGeneiMm.270283.
Mm.371611.

Genome annotation databases

EnsembliENSMUST00000053150; ENSMUSP00000060523; ENSMUSG00000050621.
ENSMUST00000170122; ENSMUSP00000132102; ENSMUSG00000090733.
GeneIDi100043813.
57294.
KEGGimmu:100043813.
mmu:57294.
UCSCiuc008qbl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014294 mRNA. Translation: BAB29250.1 .
AK088320 mRNA. Translation: BAC40279.1 .
AK166551 mRNA. Translation: BAE38849.1 .
BC048352 mRNA. Translation: AAH48352.1 .
BC055693 mRNA. Translation: AAH55693.1 .
CCDSi CCDS50970.1.
RefSeqi NP_001177187.1. NM_001190258.1.
NP_081291.1. NM_027015.4.
UniGenei Mm.270283.
Mm.371611.

3D structure databases

ProteinModelPortali Q6ZWU9.
SMRi Q6ZWU9. Positions 2-84.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 208248. 6 interactions.
786971. 4 interactions.
IntActi Q6ZWU9. 2 interactions.
MINTi MINT-1212966.

Chemistry

BindingDBi Q6ZWU9.

PTM databases

PhosphoSitei Q6ZWU9.

Proteomic databases

MaxQBi Q6ZWU9.
PaxDbi Q6ZWU9.
PRIDEi Q6ZWU9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053150 ; ENSMUSP00000060523 ; ENSMUSG00000050621 .
ENSMUST00000170122 ; ENSMUSP00000132102 ; ENSMUSG00000090733 .
GeneIDi 100043813.
57294.
KEGGi mmu:100043813.
mmu:57294.
UCSCi uc008qbl.2. mouse.

Organism-specific databases

CTDi 100043813.
6232.
MGIi MGI:1888676. Rps27.

Phylogenomic databases

eggNOGi COG2051.
GeneTreei ENSGT00390000013514.
HOVERGENi HBG000252.
InParanoidi Q6ZWU9.
KOi K02978.
OMAi CASVLCQ.
OrthoDBi EOG78SQM9.
PhylomeDBi Q6ZWU9.
TreeFami TF300265.

Enzyme and pathway databases

Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.
REACT_231519. Eukaryotic Translation Termination.
REACT_236458. Ribosomal scanning and start codon recognition.
REACT_249044. Formation of a pool of free 40S subunits.
REACT_249316. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_253640. Peptide chain elongation.
REACT_256488. Translation initiation complex formation.
REACT_256756. Mitotic Prometaphase.
REACT_259469. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_262078. GTP hydrolysis and joining of the 60S ribosomal subunit.

Miscellaneous databases

NextBioi 313647.
PROi Q6ZWU9.
SOURCEi Search...

Gene expression databases

Bgeei Q6ZWU9.
CleanExi MM_RPS27.
Genevestigatori Q6ZWU9.

Family and domain databases

Gene3Di 2.20.25.100. 1 hit.
HAMAPi MF_00371. Ribosomal_S27e.
InterProi IPR000592. Ribosomal_S27e.
IPR023407. Ribosomal_S27e_Zn-bd_dom.
IPR011332. Ribosomal_zn-bd.
[Graphical view ]
PANTHERi PTHR11594. PTHR11594. 1 hit.
Pfami PF01667. Ribosomal_S27e. 1 hit.
[Graphical view ]
ProDomi PD004466. Ribosomal_S27e. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF57829. SSF57829. 1 hit.
PROSITEi PS01168. RIBOSOMAL_S27E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Head and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported and FVB/N-3.
    Tissue: BrainImported and Mammary gland.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiRS27_MOUSE
AccessioniPrimary (citable) accession number: Q6ZWU9
Secondary accession number(s): Q3TLE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3