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Q6ZWU9

- RS27_MOUSE

UniProt

Q6ZWU9 - RS27_MOUSE

Protein

40S ribosomal protein S27

Gene

Rps27

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cofactori

    Binds 1 zinc ion per subunit.Curated

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri38 – 6023C4-typeSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S27
    Gene namesi
    Name:Rps27Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3, UP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1888676. Rps27.

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 848340S ribosomal protein S27PRO_0000149052Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei11 – 111Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6ZWU9.
    PaxDbiQ6ZWU9.
    PRIDEiQ6ZWU9.

    PTM databases

    PhosphoSiteiQ6ZWU9.

    Expressioni

    Gene expression databases

    BgeeiQ6ZWU9.
    CleanExiMM_RPS27.
    GenevestigatoriQ6ZWU9.

    Interactioni

    Protein-protein interaction databases

    BioGridi208248. 6 interactions.
    786971. 4 interactions.
    IntActiQ6ZWU9. 2 interactions.
    MINTiMINT-1212966.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZWU9.
    SMRiQ6ZWU9. Positions 1-84.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S27e family.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri38 – 6023C4-typeSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG2051.
    GeneTreeiENSGT00390000013514.
    HOVERGENiHBG000252.
    InParanoidiQ6ZWU9.
    KOiK02978.
    OMAiCASVLCQ.
    OrthoDBiEOG78SQM9.
    PhylomeDBiQ6ZWU9.
    TreeFamiTF300265.

    Family and domain databases

    Gene3Di2.20.25.100. 1 hit.
    HAMAPiMF_00371. Ribosomal_S27e.
    InterProiIPR000592. Ribosomal_S27e.
    IPR023407. Ribosomal_S27e_Zn-bd_dom.
    IPR011332. Ribosomal_zn-bd.
    [Graphical view]
    PANTHERiPTHR11594. PTHR11594. 1 hit.
    PfamiPF01667. Ribosomal_S27e. 1 hit.
    [Graphical view]
    ProDomiPD004466. Ribosomal_S27e. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF57829. SSF57829. 1 hit.
    PROSITEiPS01168. RIBOSOMAL_S27E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6ZWU9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLAKDLLHP SPEEEKRKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA   50
    QTVVLCVGCS TVLCQPTGGK ARLTEGCSFR RKQH 84
    Length:84
    Mass (Da):9,461
    Last modified:January 23, 2007 - v3
    Checksum:i242C4466AC8A8900
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014294 mRNA. Translation: BAB29250.1.
    AK088320 mRNA. Translation: BAC40279.1.
    AK166551 mRNA. Translation: BAE38849.1.
    BC048352 mRNA. Translation: AAH48352.1.
    BC055693 mRNA. Translation: AAH55693.1.
    CCDSiCCDS50970.1.
    RefSeqiNP_001177187.1. NM_001190258.1.
    NP_081291.1. NM_027015.4.
    UniGeneiMm.270283.
    Mm.371611.

    Genome annotation databases

    EnsembliENSMUST00000053150; ENSMUSP00000060523; ENSMUSG00000050621.
    ENSMUST00000170122; ENSMUSP00000132102; ENSMUSG00000090733.
    GeneIDi100043813.
    57294.
    KEGGimmu:100043813.
    mmu:57294.
    UCSCiuc008qbl.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014294 mRNA. Translation: BAB29250.1 .
    AK088320 mRNA. Translation: BAC40279.1 .
    AK166551 mRNA. Translation: BAE38849.1 .
    BC048352 mRNA. Translation: AAH48352.1 .
    BC055693 mRNA. Translation: AAH55693.1 .
    CCDSi CCDS50970.1.
    RefSeqi NP_001177187.1. NM_001190258.1.
    NP_081291.1. NM_027015.4.
    UniGenei Mm.270283.
    Mm.371611.

    3D structure databases

    ProteinModelPortali Q6ZWU9.
    SMRi Q6ZWU9. Positions 1-84.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208248. 6 interactions.
    786971. 4 interactions.
    IntActi Q6ZWU9. 2 interactions.
    MINTi MINT-1212966.

    Chemistry

    BindingDBi Q6ZWU9.

    PTM databases

    PhosphoSitei Q6ZWU9.

    Proteomic databases

    MaxQBi Q6ZWU9.
    PaxDbi Q6ZWU9.
    PRIDEi Q6ZWU9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053150 ; ENSMUSP00000060523 ; ENSMUSG00000050621 .
    ENSMUST00000170122 ; ENSMUSP00000132102 ; ENSMUSG00000090733 .
    GeneIDi 100043813.
    57294.
    KEGGi mmu:100043813.
    mmu:57294.
    UCSCi uc008qbl.2. mouse.

    Organism-specific databases

    CTDi 100043813.
    6232.
    MGIi MGI:1888676. Rps27.

    Phylogenomic databases

    eggNOGi COG2051.
    GeneTreei ENSGT00390000013514.
    HOVERGENi HBG000252.
    InParanoidi Q6ZWU9.
    KOi K02978.
    OMAi CASVLCQ.
    OrthoDBi EOG78SQM9.
    PhylomeDBi Q6ZWU9.
    TreeFami TF300265.

    Enzyme and pathway databases

    Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Miscellaneous databases

    NextBioi 313647.
    PROi Q6ZWU9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6ZWU9.
    CleanExi MM_RPS27.
    Genevestigatori Q6ZWU9.

    Family and domain databases

    Gene3Di 2.20.25.100. 1 hit.
    HAMAPi MF_00371. Ribosomal_S27e.
    InterProi IPR000592. Ribosomal_S27e.
    IPR023407. Ribosomal_S27e_Zn-bd_dom.
    IPR011332. Ribosomal_zn-bd.
    [Graphical view ]
    PANTHERi PTHR11594. PTHR11594. 1 hit.
    Pfami PF01667. Ribosomal_S27e. 1 hit.
    [Graphical view ]
    ProDomi PD004466. Ribosomal_S27e. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF57829. SSF57829. 1 hit.
    PROSITEi PS01168. RIBOSOMAL_S27E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Head and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported and FVB/N-3.
      Tissue: BrainImported and Mammary gland.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiRS27_MOUSE
    AccessioniPrimary (citable) accession number: Q6ZWU9
    Secondary accession number(s): Q3TLE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 97 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3