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Protein

Multifunctional fusion protein

Gene

Fgf1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinUniRule annotation, Growth factorUniRule annotationSAAS annotation, Heparin-bindingUniRule annotation, MitogenUniRule annotation
Biological processAngiogenesisUniRule annotation, DifferentiationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional fusion proteinUniRule annotation
Including the following 2 domains:
Fibroblast growth factorUniRule annotation
Short name:
FGFUniRule annotation
Fibroblast growth factor 1UniRule annotation
Alternative name(s):
Acidic fibroblast growth factorUniRule annotation
Heparin-binding growth factor 1UniRule annotation
Gene namesi
Name:Fgf1Imported
ORF Names:mCG_18337Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95515 Fgf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation, SecretedUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000036585

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the heparin-binding growth factors family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
HOVERGENiHBG007580
KOiK18496
OMAiLGPRTHY
OrthoDBiEOG091G0NAY

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028210 FGF1
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF86 PTHR11486:SF86, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZWS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGEITTFA ALTERFNLPL GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR
60 70 80 90 100
DRSDQHIQLQ LSAESAGEVY IKGTETGQYL AMDTEGLLYG SQTPNEECLF
110 120 130 140 150
LERLEENHYN TYTSKKHAEK NWFVGLKKNG SCKRGPRTHY GQKAILFLPL

PVSSD
Length:155
Mass (Da):17,418
Last modified:May 10, 2005 - v1
Checksum:i8880E4FF0FBA4161
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035330 mRNA Translation: BAC29035.1
CH466528 Genomic DNA Translation: EDL10065.1
CH466528 Genomic DNA Translation: EDL10066.1
CH466528 Genomic DNA Translation: EDL10067.1
CH466528 Genomic DNA Translation: EDL10068.1
RefSeqiNP_034327.1, NM_010197.3
XP_006525707.1, XM_006525644.3
XP_006525708.1, XM_006525645.3
XP_006525710.1, XM_006525647.3
XP_006525711.1, XM_006525648.3
XP_006525712.1, XM_006525649.1
XP_011245144.1, XM_011246842.2
XP_011245145.1, XM_011246843.2
XP_017173319.1, XM_017317830.1
UniGeneiMm.241282

Genome annotation databases

GeneIDi14164
KEGGimmu:14164

Similar proteinsi

Entry informationi

Entry nameiQ6ZWS1_MOUSE
AccessioniPrimary (citable) accession number: Q6ZWS1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health