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Q6ZWR6

- SYNE1_MOUSE

UniProt

Q6ZWR6 - SYNE1_MOUSE

Protein

Nesprin-1

Gene

Syne1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. May be involved in the maintenance of nuclear organization and structural integrity. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm By similarity. Required for centrosome migration to the apical cell surface during early ciliogenesis.By similarity1 Publication

    GO - Molecular functioni

    1. actin filament binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. protein homodimerization activity Source: UniProtKB

    GO - Biological processi

    1. establishment of nucleus localization Source: MGI

    Keywords - Ligandi

    Actin-binding

    Enzyme and pathway databases

    ReactomeiREACT_198626. Meiotic synapsis.
    REACT_75800. Meiotic Synapsis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nesprin-1
    Alternative name(s):
    Enaptin
    Myocyte nuclear envelope protein 1
    Short name:
    Myne-1
    Nuclear envelope spectrin repeat protein 1
    Synaptic nuclear envelope protein 1
    Short name:
    Syne-1
    Gene namesi
    Name:Syne1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1927152. Syne1.

    Subcellular locationi

    Nucleus outer membrane Curated; Single-pass type IV membrane protein Curated; Cytoplasmic side Curated. Nucleus. Nucleus envelope. Cytoplasmcytoskeleton. Cytoplasmmyofibrilsarcomere By similarity
    Note: The largest part of the protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. In skeletal and smooth muscles, a significant amount is found in the sarcomeres By similarity.By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. nuclear envelope Source: UniProtKB
    4. nuclear outer membrane Source: UniProtKB-SubCell
    5. sarcomere Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 87998799Nesprin-1PRO_0000392209Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei8227 – 82271PhosphoserineBy similarity
    Modified residuei8278 – 82781PhosphothreonineBy similarity
    Modified residuei8281 – 82811PhosphoserineBy similarity
    Modified residuei8284 – 82841PhosphoserineBy similarity
    Modified residuei8308 – 83081Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6ZWR6.
    PaxDbiQ6ZWR6.
    PRIDEiQ6ZWR6.

    PTM databases

    PhosphoSiteiQ6ZWR6.

    Expressioni

    Tissue specificityi

    Expressed in C2F3 and CH310T1/2 cells, brain and skeletal muscle (at protein level).2 Publications

    Gene expression databases

    ArrayExpressiQ6ZWR6.
    BgeeiQ6ZWR6.
    GenevestigatoriQ6ZWR6.

    Interactioni

    Subunit structurei

    Dimer. Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN domain-containing proteins interact with A-type lamins of the nuclear lamina, while at the other end of the complex, nesprins interact with unique cytoskeletal components. Interacts with SYNE3. May interact with MUSK. Interacts with EMD and LMNA in vitro By similarity. Interacts with F-actin via its N-terminal domain.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi211015. 1 interaction.
    DIPiDIP-60966N.
    STRINGi10090.ENSMUSP00000051825.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZWR6.
    SMRiQ6ZWR6. Positions 23-283, 997-1042.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 87488748CytoplasmicPROSITE-ProRule annotationAdd
    BLAST
    Topological domaini8770 – 879930Perinuclear spacePROSITE-ProRule annotationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8749 – 876921Helical; Anchor for type IV membrane proteinPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 289289Actin-bindingAdd
    BLAST
    Domaini27 – 134108CH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini178 – 283106CH 2PROSITE-ProRule annotationAdd
    BLAST
    Repeati592 – 62433HAT 1Add
    BLAST
    Repeati915 – 94935TPR 1Add
    BLAST
    Repeati1015 – 104834TPR 2Add
    BLAST
    Repeati1103 – 113533HAT 2Add
    BLAST
    Repeati1127 – 1229103Spectrin 1Add
    BLAST
    Repeati1423 – 145533HAT 3Add
    BLAST
    Repeati1447 – 1546100Spectrin 2Add
    BLAST
    Repeati1538 – 157235TPR 3Add
    BLAST
    Repeati1553 – 164997Spectrin 3Add
    BLAST
    Repeati1656 – 1759104Spectrin 4Add
    BLAST
    Repeati2087 – 2191105Spectrin 5Add
    BLAST
    Repeati2305 – 240298Spectrin 6Add
    BLAST
    Repeati2407 – 2509103Spectrin 7Add
    BLAST
    Repeati2516 – 2618103Spectrin 8Add
    BLAST
    Repeati2703 – 274240HAT 4Add
    BLAST
    Repeati2841 – 2982142Spectrin 9Add
    BLAST
    Repeati2947 – 298034TPR 4Add
    BLAST
    Repeati3065 – 3167103Spectrin 10Add
    BLAST
    Repeati3174 – 3274101Spectrin 11Add
    BLAST
    Repeati3281 – 3383103Spectrin 12Add
    BLAST
    Repeati3390 – 348697Spectrin 13Add
    BLAST
    Repeati3479 – 351234TPR 5Add
    BLAST
    Repeati3490 – 3593104Spectrin 14Add
    BLAST
    Repeati3817 – 3916100Spectrin 15Add
    BLAST
    Repeati3923 – 4030108Spectrin 16Add
    BLAST
    Repeati4138 – 423699Spectrin 17Add
    BLAST
    Repeati4345 – 4447103Spectrin 18Add
    BLAST
    Repeati4454 – 4556103Spectrin 19Add
    BLAST
    Repeati4563 – 4665103Spectrin 20Add
    BLAST
    Repeati4580 – 461334TPR 6Add
    BLAST
    Repeati4672 – 4772101Spectrin 21Add
    BLAST
    Repeati4885 – 4987103Spectrin 22Add
    BLAST
    Repeati4994 – 5095102Spectrin 23Add
    BLAST
    Repeati5078 – 511033HAT 5Add
    BLAST
    Repeati5102 – 5205104Spectrin 24Add
    BLAST
    Repeati5212 – 5317106Spectrin 25Add
    BLAST
    Repeati5426 – 552196Spectrin 26Add
    BLAST
    Repeati5514 – 554734TPR 7Add
    BLAST
    Repeati5528 – 562699Spectrin 27Add
    BLAST
    Repeati5736 – 576934TPR 8Add
    BLAST
    Repeati5747 – 5867121Spectrin 28Add
    BLAST
    Repeati5961 – 599434TPR 9Add
    BLAST
    Repeati5975 – 6078104Spectrin 29Add
    BLAST
    Repeati6702 – 679493Spectrin 30Add
    BLAST
    Repeati6777 – 680933HAT 6Add
    BLAST
    Repeati6801 – 6906106Spectrin 31Add
    BLAST
    Repeati6917 – 7021105Spectrin 32Add
    BLAST
    Repeati7004 – 703633HAT 7Add
    BLAST
    Repeati7028 – 7129102Spectrin 33Add
    BLAST
    Repeati7136 – 7238103Spectrin 34Add
    BLAST
    Repeati7214 – 725340HAT 8Add
    BLAST
    Repeati7358 – 745598Spectrin 35Add
    BLAST
    Repeati7462 – 7562101Spectrin 36Add
    BLAST
    Repeati7569 – 7672104Spectrin 37Add
    BLAST
    Repeati7679 – 7779101Spectrin 38Add
    BLAST
    Repeati7786 – 788499Spectrin 39Add
    BLAST
    Repeati7891 – 7998108Spectrin 40Add
    BLAST
    Repeati7978 – 801033HAT 9Add
    BLAST
    Repeati8005 – 8107103Spectrin 41Add
    BLAST
    Repeati8025 – 805834TPR 10Add
    BLAST
    Repeati8114 – 8214101Spectrin 42Add
    BLAST
    Repeati8131 – 816535TPR 11Add
    BLAST
    Repeati8445 – 8548104Spectrin 43Add
    BLAST
    Repeati8555 – 8659105Spectrin 44Add
    BLAST
    Domaini8740 – 879960KASHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi8665 – 873167Ser-richAdd
    BLAST

    Domaini

    The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains.By similarity

    Sequence similaritiesi

    Belongs to the nesprin family.Curated
    Contains 1 actin-binding domain.Curated
    Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation
    Contains 9 HAT repeats.Curated
    Contains 1 KASH domain.PROSITE-ProRule annotation
    Contains 44 spectrin repeats.Curated
    Contains 11 TPR repeats.Curated

    Keywords - Domaini

    Repeat, TPR repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5069.
    GeneTreeiENSGT00750000117361.
    HOGENOMiHOG000120125.
    HOVERGENiHBG106534.
    InParanoidiQ9ERT7.
    OMAiCATESEC.
    OrthoDBiEOG72JWF7.
    PhylomeDBiQ6ZWR6.
    TreeFamiTF317709.
    TF337116.

    Family and domain databases

    Gene3Di1.10.418.10. 2 hits.
    InterProiIPR001589. Actinin_actin-bd_CS.
    IPR001715. CH-domain.
    IPR012315. KASH.
    IPR018159. Spectrin/alpha-actinin.
    IPR002017. Spectrin_repeat.
    [Graphical view]
    PfamiPF00307. CH. 2 hits.
    PF10541. KASH. 1 hit.
    PF00435. Spectrin. 10 hits.
    [Graphical view]
    SMARTiSM00033. CH. 2 hits.
    SM00150. SPEC. 42 hits.
    [Graphical view]
    SUPFAMiSSF47576. SSF47576. 2 hits.
    PROSITEiPS00019. ACTININ_1. 1 hit.
    PS00020. ACTININ_2. 1 hit.
    PS50021. CH. 2 hits.
    PS51049. KASH. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZWR6-1) [UniParc]FASTAAdd to Basket

    Also known as: Nesprin-1 Giant, Enaptin

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MATSRASSRS HRDITNVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV     50
    DDLFEDMKDG IKLLALLEVL SGQKLPCEQG HRVKRIHAVA NIGTALKFLE 100
    GRKIKLVNIN ATDIADGRPS IVLGLMWTII LYFQIEELTS NLPQLQSLSS 150
    SASSVDSMVS TETASPPSKR KVAAKIQGNA KKTLLKWVQH TAGKQMGIEV 200
    KDFGKSWRTG LAFHSVIHAI QPELVDLEKV KTRSNRENLE DAFTIAETQL 250
    GIPRLLDPED VDVDKPDEKS IMTYVAQFLT QYPDIHGAGC DGQEDDVVFV 300
    GFTNNIALLL GFQRDDRLIL KETKVWIEQF ERDFTRAQMT ESSLQDKYQA 350
    FKHFRVQYEM KRKQVEHIIQ PLQRDGKLTL DQALVKQCWE RVSSRLFDWH 400
    IQLDKSLPAP LGTIGAWLYR AEVALREEIT IQQVHEETAN TIQRKLEQHK 450
    DLLQNTDAHK RAFHEIYQTR SVNGIPMPPD QLEDMAERFH FVSSTSELHL 500
    MKMEFLELKY RLLSLLVLAE SKLKSWIIKY GRRESVELLL QSYISFIENS 550
    KFFEQYEVTY QILKQTADIY VKAEGSVEEA ENVMKFMSEA TAQWRNLSVE 600
    VRSVRSMLEE VISNWDRYGD TVASLQAWLE DAEKMLSQSE HAKKDFFRNL 650
    PHWIQQHTAM NDAGNFLIET CDEIVSRDLK QQLLLLNGRW RELFMEVKQY 700
    ARADEMDRMK KEYIDVTTTL FGFATEAHRK LSEPLEVSFI NVKLLIQDLE 750
    DLEKRVPVMD AQYKMIAKKA HLFAKESPQE EANEMLTTMS KLKEQLSKVK 800
    ECCSPLLYEA QQLTVPLEEL ETQITSFYDS LGKINEILSV LEQEAQSSTL 850
    FKQKHQELLA SQENCKKSLT LIEKGSQSVQ KLVTSSQARK PWDHTKLQKQ 900
    IADVHHAFQS MIKKTGDWKK HVEANSRLMK KFEESRAELE KVLRVAQEGL 950
    EEKGDPEELL RRHTEFFSQL DQRVLNAFLK ACDELTDILP EQEQQGLQEA 1000
    VRKLHKQWKD LQGEAPYHLL HLKIAVEKDR FSAAVEECRA ELEQETKLAP 1050
    QEGSEKIIKE HRVFFSDKGP HHLCEKRLQL IEELCGKLPV QDPVRDTCGA 1100
    CHTALKELKA SIDNTYTMLV DDPDKWKDYT SRFSEFSSWV SAKKACLKKI 1150
    KDEPIDTGNH DEVKHMVDEI RNDITKKGES LSWLKSRLKY LIDISSENEA 1200
    QKRGDELAEL SSSFKALVAL LSEVEKLLSN FGECVQYKEI VKSSLEGLIS 1250
    GPQESKEEAE MILDSKNLLE AQQLLLHHQQ KTKMISAKKR DLQEQMEQAQ 1300
    QGGQAGPGQE ELRKLESTLT GLEQSRERQE RRIQVSLRKW ERFETNKETV 1350
    VRYLFQTGSS HERFLSFSSL ESLSSELEQT KEFSKRTESI ATQAENLVKE 1400
    AAELPLGPRN KRVLQRQAKS IKEQVTTLED TLEEDIKTME MVKSKWDHFG 1450
    SNFETLSIWI LEKENELSSL EASASAADVQ ISQIKVTIQE IESKIDSIVG 1500
    LEEEAQSFAQ FVTTGESARI KAKLTQIRRY WEELQEHARG LEGTILGHLS 1550
    QQQKFEENLR KIRQSVSEFA ERLADPIKIC SSAAETYKVL QEHMDLCQAV 1600
    ESLSSTVTMF SASAQKAVNR ESCTQEAAAL QQQYEEILHK AKEMQTALED 1650
    LLARWQRLEK GLSPFLTWLE RCEAIASSPE KDISADRGKV ESELQLIQAL 1700
    QNEVVSQASL YSNLLQLKEA LFSVASKEDV AVMKLQLEQL DERWGDLPQI 1750
    ISKRMHFLQS VLAEHKQFDE LLFSFSVWIK QFLGELQRTS EINLRDHQVA 1800
    LTRHKDHAAE IEKKRGEITH LQGHLSQLRS LGRAQDLHPL QSKVDDCFQL 1850
    FEEASQVVER RKLALAQLAE FLQSHACMST LLYQLRQTVE ATKSMSKKQS 1900
    DSLKTDLHSA IQDVKTLESS AISLDGTLTK AQCHLKSASP EERTSCRATT 1950
    DQLSLEVERI QNLLGTKQSE ADALVALKEA FREQKEELLR SIEDIEERMD 2000
    RERLKVPTRQ ALQHRLRVFN QLEDELNSHE HELCWLKDKA KQIAQKDVAF 2050
    APEVDREING LEATWDDTRR QIHENQGQCC GLIDLVREYQ SLKSTVCNVL 2100
    EDASNVVVMR ATIKDQGDLK WAFSKHETSR NEMNSKQKEL DSFTSKGKHL 2150
    LSELKKIHSG DFSLVKTDME STLDKWLDVS ERIEENMDML RVSLSIWDDV 2200
    LSRKDEIEGW SNSSLPKLAE NISNLNNSLR AEELLKELES EVKIKALKLE 2250
    DLHSKINNLK ELTKNPETPT ELQFIEADLR QKLEHAKEIT EEARGTLKDF 2300
    TAQRTQVERF VKDITAWLIN VEESLTRCAQ TETCEGLKKA KDIRKELQSQ 2350
    QNSITSTQEE LNSLCRKHHS VELESLGRAM TGLIKKHEAT SQLCSQTQAR 2400
    IQDSLEKHFS GSMKEFQEWF LGAKAAARES SNLTGDSQIL EARLHNLQGV 2450
    LDSLSDGQSK LDVVTQEGQT LYAHLPKQIV SSIQEQITKA NEEFQAFLKQ 2500
    CLKEKQALQD CVSELGSFED QHRKLNLWIH EMEERLKTEN LGESKHHISE 2550
    KKNEVRKVEM FLGELLAARE SLDKLSQRGQ LLSEESHSAG KGGCRSTQLL 2600
    TSYQSLLRVT KEKLRSCQLA LKEHEALEEA TQSMWARVKD VQDRLACAES 2650
    TLGNKETLEG RLSQIQDILL MKGEGEVKLN LAIGKGDQAL RSSNKEGQQA 2700
    IQDQLEMLKK AWAEAMNSAV HAQSTLESVI DQWNDYLEKK SQLEQWMESV 2750
    DQRLEHPLQL QPGLKEKFSL LDHFQSIVSE AEDHTGALQQ LAAKSRELYQ 2800
    KTQDESFKEA GQEELRTQFQ DIMTVAKEKM RTVEDLVKDH LMYLDAVQEF 2850
    ADWLHSAKEE LHRWSDTSGD PSATQKKLLK IKELIDSREI GAGRLSRVES 2900
    LAPAVKQNTA ASGCELLNSE MQALRADWRQ WEDCLFQTQS SLESLVSEMA 2950
    LSEQEFFGQV TQLEQALEQF CTLLKTWAQQ LTLLEGKNSD EEILECWHKG 3000
    REILDALQKA EPMTEDLKSQ LNELCRFSRD LSPYSEKVSG LIKEYNCLCL 3050
    QASKGCQNKE QILQERFQKA SRGFQQWLVN AKITTAKCFD LPQNLSEVSS 3100
    SLQKIQEFLS ESENGQHKLN TMLFKGELLS SLLTEEKAQA VQAKVLTAKE 3150
    EWKSFHANLH QKESALENLK IQMKDFEVSA ELVQNWLSKT ERLVQESSNR 3200
    LYDLPAKRRE QQKLQSVLEE IQCYEPQLHR LKEKARQLWE GQAASKSFVH 3250
    RVSQLSSQYL ALSNVTKEKV SRLDRIIAEH NRFSQGVKEL QDWMSDAVHM 3300
    LDSYCLPTSD KSVLDSRMLK LEALLSVRQE KEIQMKMVVT RGEYVLQSTS 3350
    LEGSAAVQQQ LQAVKDMWES LLSAAIRCKS QLEGALSKWT SYQDDVRQFS 3400
    SWMDSVEVSL TESEKQHTEL REKITALGKA KLLNEEVLSH SSLLETIEVK 3450
    RAAMTEHYVT QLELQDLQER HQALKEKAKE AVTKLEKLVR LHQEYQRDLK 3500
    AFESWLEQEQ EKLDRCSVHE GDTNAHETML RDLQELQVRC AEGQALLNSV 3550
    LHTREDVIPS GLPQAEDRVL ESLRQDWQVY QHRLAEARMQ LNNVVNKLRL 3600
    MEQKFQQADE WLKRMEEKIN FRSECQSSRS DKEIQLLQLK KWHEDLSAHR 3650
    DEVEEVGTRA QGILDETHIS SRMGCQATQL TSRYQALLLQ VLEQIKFFEE 3700
    ELQCLEETES SLSSYSDWYG STHKNFKNVA TKIDKVDESM MGKKLKTLEV 3750
    LLKDMEKGHS LLKSAREKGE RAMKFLAEHE AEALRKEIHT YMEQLKNLTS 3800
    TVRKECMSLE KGLHLAKEFS DKYKVLAQWM AEYQEILCTP EEPKMELYEK 3850
    KAQLSKYKSL QQMVLSHEPS VTSVQEKSEA LLELVQDQSL KDKIQKLQSD 3900
    FQDLCSRAKE RVFSLEAKVK DHEDYNTELQ EVEKWLLQMS GRLVAPDLLE 3950
    MSSLETITQQ LAHHKAMMEE IAGFEDRLDN LKAKGDTLIG QCPEHLQAKQ 4000
    KQTVQAHLQG TKDSYSAICS TAQRVYRSLE YELQKHVSSQ DTLQQCQAWI 4050
    SAVQPDLKPS PQPPLSRAEA VKQVKHFRAL QEQARTYLDL LCSMCDLSNS 4100
    SVKNTAKDIQ QTEQLIEQRL VQAQNLTQGW EEIKSLKAEL WIYLQDADQQ 4150
    LQNMKRRHTE LEINIAQNMV MQVKDFIKQL QCKQVSVSTI VEKVDKLTKN 4200
    QESPEHKEIT HLNDQWQDLC LQSDKLCAQR EQDLQRTSSY HDHMRVVEAF 4250
    LEKFTTEWDS LARSNAESTA IHLEALKKLA LALQEEMYAI DDLKDCKQKL 4300
    IEQLGLDDRE LVREQTSHLE QRWFQLQDLV KRKIQVSVTN LEELNVIQSR 4350
    FQELMEWAEE QQPNIVEALK QSPPPGMAQH LLMDHLAICS ELEAKQVLLK 4400
    SLMKDADRVM ADLGLNERKV IQKALSEAQK HVSCLSDLVG QRRKYLNKAL 4450
    SEKTQFLMAV FQATSQIQQH ERKIVFREYI CLLPDDVSKQ VKTCKTAQAS 4500
    LKTYQNEVTG LCAQGRELMK GITKQEQEEV LGKLQELQTV YDTVLQKCSH 4550
    RLQELEKSLV SRKHFKEDFD KACHWLKQAD IVTFPEINLM NEKTELHAQL 4600
    DKYQSILEQS PEYENLLLTL QTTGQAMLPS LNEVDHSYLS EKLSALPQQF 4650
    NVIVALAKDK FYKTQEAILA RKEYTSLIEL TTQSLGDLED QFLKMRKMPS 4700
    DLIVEESVSL QQSCSALLGE VVALGEAVNE LNQKKESFRS TGQPWQPEKM 4750
    LQLATLYHRL KRQAEQRVSF LEDTTSVYKE HAQMCRQLES QLEVVKREQA 4800
    KVNEETLPAE EKLKVYHSLA GSLQDSGILL KRVATHLEDL SPHLDPTAYE 4850
    KAKSQVQSWQ EELKQMTSDV GELVTECESR MVQSIDFQTE MSRSLDWLRR 4900
    VKAELSGPVC LDLSLQDIQE EIRKIQIHQE EVLSSLRIMS ALSHKEQEKF 4950
    TKAKELISAD LEHTLAELQE LDGDVQEALR TRQATLTEIY SRCQRYYQVF 5000
    QAANDWLDDA QEMLQLAGNG LDVESAEENL RSHMEFFKTE GQFHSNMEEL 5050
    RGLVARLDPL IKATGKEELA QKMASLEKRS QGIIQESHTQ RDLLQRCMVQ 5100
    WQEYQKAREG VIELMNDAEK KLSEFAVLKT SSIHEAEEKL SKHKALVSVV 5150
    DSFHEKIVAL EEKASQLEQT GNDTSKATLS RSMTTVWQRW TRLRAVAQDQ 5200
    EKILEDAVDE WKRLSAKVKE TTEVINQLQG RLPGSSTEKA SKAELMTLLE 5250
    SHDTYLMDLE SQQLTLGVLQ QRALSMLQDR AFPGTEEEVP ILRAITALQD 5300
    QCLNMQEKVK NHGKLVKQEL QEREAVETRI NSVKSWVQET KDYLGNPTIE 5350
    IDTQLEELKR LLAEATSHQE SIEKIAEEQK NKYLGLYTVL PSEISLQLAE 5400
    VALDLKIHDQ IQEKVQEIEE GKAMSQEFSC KIQKVTKDLT TILTKLKAKT 5450
    DDLVHAKAEH KMLGEELDGC NSKLMELDAA IQTFSERHSQ LGQPLAKKIG 5500
    KLTELHQQTI RQAENRLSKL NQALSHMEEY NEMLETVRKW IEKAKVLVHG 5550
    NIAWNSASQL QEQYILHQTL LEESGEIDSD LEAMAEKVQH LANVYCTGKL 5600
    SQQVTQFGRE MEELRQAIRV RLRNLQDAAK DMKKFEGELR NLQVALEQAQ 5650
    TILTSPEVGR RSLKEQLCHR QHLLSEMESL KPKMQAVQLC QSALRIPEDV 5700
    VASLPLCHAA LRLQEEASQL QHTAIQQCNI MQAKKHSLIF PPKEAVVQYE 5750
    QYKQEMKHLQ QLIEEAHREI EDKPVATSNI QELQAQISLH EELAQKIKGY 5800
    QEQIDSLNSK CKMLTMKAKH ATMLLTVTEV EGLAEGTEDL DRELHPTPSA 5850
    HPSVVMMTAG RCHTLLSPVT EESGEEGTNS EISSPPACRS PSPVANTEAA 5900
    VNQDIAYYQA LSAEGLQTDA ARIPPSAAVS QELYEPGLEP SATAKLGDLQ 5950
    RSWETLKNVI SEKQRTLYEV LERQQKYQDS LQSISTKMEA MEMKLGESLE 6000
    PSRSPESQMA EHQALMDEVQ MLQDEINGLQ VSLAEELVAE SQESDPAEQL 6050
    ALQSTLTVLA ERMSTIRMKA AGKRQLLEEK LSDQLEEQRQ EQALQRYRCE 6100
    ADELDHWLLN TKATLDVALG TSQEPMDMDA QLVDCQNMLV EIEQKVVALS 6150
    QLSVHNENLL LEGKAHTKEE AEQLAVKLRL LKGSLGELQR ALHDRQLDMQ 6200
    GVTQEKEEND VDFTDTQSPG VQEWLAQART TRTHQRQSSL QQQKEFEQEL 6250
    AEQKSLLRSV ASRGEEILTQ HSTAEGSGGL GEKPDVLSQE LGIAEDQMRV 6300
    KWESLHQEFS AKQKLLQNIL EQEQEQVLYS SPNRLLSGVL PFRGEAQTQD 6350
    KTSVTSLLDG LSQAFGEASS QSGGTDRQSI HLEQKLYDGV SATSTWLNDV 6400
    EERLFVATAP LPEETEACLF NQEALAKDIK EMSEEMDKNK NLFSQAFPED 6450
    SDNRDVIEDT LGCLLGRLSL LDSVVDQRCH QMKERLQQIL RFQNDLKVLF 6500
    TSLADSKYII LQKLANVFEQ PIVEQMQAIQ QAEEGLRDLE GGISELKRWA 6550
    DKLQVEQSAV QELSKLQDMY DELLMTVSSR RSSLHQNLAL KSQYDKALQD 6600
    LVDLLDTGQE KMTGDQKIIV CSKEEIQQLL GKHKEYFQGL ESHMILTEIL 6650
    FRKIVGFAAV KETQFHTDCM AQASAVLKQA HKRGVELEYI LEMWSHLDEN 6700
    RQELSRQLEV IENSIPSVGL VEESEDRLVE RTNLYQHLKS SLNEYQPKLY 6750
    QALDDGKRLL MSVSCSELES QLNQLGEHWL SNTNKVSKEL HRLETILKHW 6800
    TRYQSEAAAL NHWLQCAKDR LAFWTQQSVT VPQELEMVRD HLSAFLEFSK 6850
    EVDAKSALKS SVTSTGNQLL RLKKVDTAAL RAELSRMDSQ WTDLLTGIPV 6900
    VQEKLHQLQM DKLPSRHAIS EVMSWISLME SVILKDEEDI RNAIGYKAIH 6950
    EYLQKYKGFK IDLNCKQLTA DFVNQSVLQI SSQDVESKRS DKTDFAEQLG 7000
    AMNKSWQLLQ GRVGEKIQML EGLLESWSEY ENSVQSLKAW FANQERKLKE 7050
    QHLLGDRNSV ENALKDCQEL EDLIKAKEKE VEKIEQNGLA LIQNKREEVS 7100
    GSVMSTLQEL RQTWISLDRT VEQLKIQLTS ALGQWSNHKA ACDEINGHLM 7150
    EARYSLSRFR LLTGSSEAVQ VQVDNLQNLH DELEKQEGGL QKFGSITNQL 7200
    LKECHPPVAE TLSSTLQEVN MRWNNLLEEI AEQLHSSKAL LQLWQRYKDY 7250
    SKQCASAIQR QEEQTSVLLK AATNKDIADD EVTKWIQDCN DLLKGLETVK 7300
    DSLFILRELG EQLGQQVDVS AAAAIQCEQL CFSQRLGALE QALCKQQAVL 7350
    QAGVVDYETF AKSLEALEVW MVEAEGILQG QDPTHSSDLS TIQERMEELK 7400
    GQMLKFSSLA PDLDRLNELG YRLPLNDKEI KRMQNLNRHW SLTSSQTTER 7450
    FSKLQSFLLQ HQTFLEKCET WMEFLVQTEH KLAVEISGNY QHLLEQQRAH 7500
    ELFQAEMFSR QQILHSIIVD GQNLLEQGQV DDREEFSLKL TLLSNQWQGV 7550
    IRRAQQRRGI IDSQIRQWQR YREMAEKLRK WLAEVSHLPL SGLGNIPVPL 7600
    QQVRMLFDEV QFKEKVFLRQ QGSYILTVEA GKQLLLSADS GAEAALQAEL 7650
    TDIQEKWKAA SMHLEEQKKK LAFLLKDWEK CERGIANSLE KLRMFKKRLS 7700
    QPLPDHHEEL HAEQMRCKEL ENAVGRWTDD LTELMLVRDA LAVYLSAEDI 7750
    SMLKERVELL QRQWEELCHQ VSLRRQQVSE RLNEWAVFSE KNKELCEWLT 7800
    QMESKVSQNG DILIEEMIEK LKKDYQEEIA VAQENKIQLQ EMGERLAKAS 7850
    HESKASEIQY KLSRVKDRWQ HLLDLMAARV KKLKETLVAV QQLDKNMGSL 7900
    RTWLAHMESE LAKPIVYDSC NSEEIQRKLN EQQELQRDIE KHSTGVASVL 7950
    NLCEVLLHDC DACATDAECD SIQQATRNLD RRWRNICAMS MERRLKIEET 8000
    WRLWQKFLDD YSRFEDWLEV SERTAAFPSS SGVLYTVAKE ELKKFEAFQR 8050
    QVHESLTQLE LINKQYRRLA RENRTDSACS LRQMVHGGNQ RWDDLQKRVT 8100
    SILRRLKHFI SQREEFETAR DSILVWLTEM DLQLTNIEHF SECDVQAKIK 8150
    QLKAFQQEIS LNHNKIEQII AQGEQLIEKS EPLDAAVIEE ELDELRRYCQ 8200
    EVFGRVERYH KKLIRLPVRL PDDHDLSDRE LDLEDSTALS DLRWQDPSAD 8250
    GMPSPQPSSN PSLSLPQPLR SERSGRDTPA SVDSIPLEWD HDYDLSRDLE 8300
    SASRTLPSED EEGEEDKEFY LRGAVGLSGD PSSLESQMRQ LDKALDDSRF 8350
    QIQQTANILR SKTPTGPDLD TSYKGYMKLL GECSGSIDSV RRLEHKLAEE 8400
    ESFPGFVNLN STETQTAGVI DRWELLQAQA MSKELRMKQN LQKWQQFNSD 8450
    LNNIWAWLGE TEEELDRLQH LALSTDIHTI ESHIKKLKEL QKAVDHRKAI 8500
    ILSINLCSSE FTQADSKESH DLQDRLSQMN GRWDRVCSLL EDWRGLLQDA 8550
    LMQCQEFHEM SHALLLMLEN IDRRKNEIVP IDSTLDPETL QDHHKQLMQI 8600
    KQELLKSQLR VASLQDMSRQ LLVNAEGSDC LEAKEKVHVI GNRLKLLLKE 8650
    VSHHIKDLEK LLDMSSSQQD LSSWSSADEL DTSGSVSPTS GRSTPNRQKS 8700
    PRGKCSLSQP GPSVSSPKSR STRDGSDSSR SDPRPERVGR AFLFRILRAA 8750
    LPFQLLLLLL IGLTCLVPMS EKDYSCALSN NFARSFHPML RYTNGPPPL 8799
    Length:8,799
    Mass (Da):1,009,926
    Last modified:March 23, 2010 - v2
    Checksum:i2A457DC081969CF0
    GO
    Isoform 2 (identifier: Q6ZWR6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-7828: Missing.
         7829-7878: IAVAQENKIQ...WQHLLDLMAA → MVVAEDLHGPRMAEDSSVDADLPDCDCDVS
         8218-8219: Missing.
         8328-8328: S → SDVVIPENPEAYVKLTENAIRNTS

    Show »
    Length:972
    Mass (Da):111,334
    Checksum:i6ED3F1A381AACC9A
    GO
    Isoform 3 (identifier: Q6ZWR6-3) [UniParc]FASTAAdd to Basket

    Also known as: Syne-1A

    The sequence of this isoform differs from the canonical sequence as follows:
         1-7828: Missing.
         7829-7878: IAVAQENKIQ...WQHLLDLMAA → MVVAEDLHGPRMAEDSSVDADLPDCDCDVS
         8218-8219: Missing.

    Show »
    Length:949
    Mass (Da):108,779
    Checksum:i40ABE338F614825E
    GO
    Isoform 4 (identifier: Q6ZWR6-4) [UniParc]FASTAAdd to Basket

    Also known as: Syne-1B

    The sequence of this isoform differs from the canonical sequence as follows:
         8218-8219: Missing.

    Note: Incomplete sequence.

    Show »
    Length:8,797
    Mass (Da):1,009,670
    Checksum:i08970A024A161721
    GO
    Isoform 5 (identifier: Q6ZWR6-5) [UniParc]FASTAAdd to Basket

    Also known as: Enaptin-165

    The sequence of this isoform differs from the canonical sequence as follows:
         103-103: K → KSMYRGSP
         297-313: Missing.
         1435-1441: DIKTMEM → EYVLHHF
         1442-8799: Missing.

    Show »
    Length:1,431
    Mass (Da):165,244
    Checksum:i0D4C7DA8ADAE612F
    GO

    Sequence cautioni

    The sequence AAG24393.1 differs from that shown. Reason: Frameshift at positions 6810, 7656 and 7658.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1086 – 10861G → W in AAN03487. (PubMed:15093733)Curated
    Sequence conflicti1150 – 11501I → T in AAN03487. (PubMed:15093733)Curated
    Sequence conflicti7187 – 71871E → G in AAG24393. (PubMed:10878022)Curated
    Sequence conflicti7876 – 78761M → I in AAG24393. (PubMed:10878022)Curated
    Sequence conflicti8266 – 82661P → L in AAG24392. (PubMed:10878022)Curated
    Sequence conflicti8266 – 82661P → L in AAG24393. (PubMed:10878022)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 78287828Missing in isoform 2 and isoform 3. 2 PublicationsVSP_038791Add
    BLAST
    Alternative sequencei103 – 1031K → KSMYRGSP in isoform 5. 1 PublicationVSP_038792
    Alternative sequencei297 – 31317Missing in isoform 5. 1 PublicationVSP_038793Add
    BLAST
    Alternative sequencei1435 – 14417DIKTMEM → EYVLHHF in isoform 5. 1 PublicationVSP_038794
    Alternative sequencei1442 – 87997358Missing in isoform 5. 1 PublicationVSP_038795Add
    BLAST
    Alternative sequencei7829 – 787850IAVAQ…DLMAA → MVVAEDLHGPRMAEDSSVDA DLPDCDCDVS in isoform 2 and isoform 3. 2 PublicationsVSP_038796Add
    BLAST
    Alternative sequencei8218 – 82192Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsVSP_038797
    Alternative sequencei8328 – 83281S → SDVVIPENPEAYVKLTENAI RNTS in isoform 2. 1 PublicationVSP_038798

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF281869 mRNA. Translation: AAG24392.1.
    AF281870 mRNA. Translation: AAG24393.1. Frameshift.
    AF535143 mRNA. Translation: AAN03487.1.
    AK036828 mRNA. Translation: BAC29595.1.
    AC156392 Genomic DNA. No translation available.
    AC156393 Genomic DNA. No translation available.
    AC157020 Genomic DNA. No translation available.
    AC159748 Genomic DNA. No translation available.
    AC161829 Genomic DNA. No translation available.
    AC162381 Genomic DNA. No translation available.
    AC162385 Genomic DNA. No translation available.
    CCDSiCCDS56679.1. [Q6ZWR6-3]
    CCDS56680.1. [Q6ZWR6-5]
    RefSeqiNP_001073154.1. NM_001079686.1.
    UniGeneiMm.331626.

    Genome annotation databases

    EnsembliENSMUST00000041639; ENSMUSP00000039440; ENSMUSG00000096054. [Q6ZWR6-5]
    ENSMUST00000095899; ENSMUSP00000093587; ENSMUSG00000019769. [Q6ZWR6-3]
    GeneIDi64009.
    KEGGimmu:64009.
    UCSCiuc007egn.1. mouse. [Q6ZWR6-5]
    uc007egt.2. mouse. [Q6ZWR6-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF281869 mRNA. Translation: AAG24392.1 .
    AF281870 mRNA. Translation: AAG24393.1 . Frameshift.
    AF535143 mRNA. Translation: AAN03487.1 .
    AK036828 mRNA. Translation: BAC29595.1 .
    AC156392 Genomic DNA. No translation available.
    AC156393 Genomic DNA. No translation available.
    AC157020 Genomic DNA. No translation available.
    AC159748 Genomic DNA. No translation available.
    AC161829 Genomic DNA. No translation available.
    AC162381 Genomic DNA. No translation available.
    AC162385 Genomic DNA. No translation available.
    CCDSi CCDS56679.1. [Q6ZWR6-3 ]
    CCDS56680.1. [Q6ZWR6-5 ]
    RefSeqi NP_001073154.1. NM_001079686.1.
    UniGenei Mm.331626.

    3D structure databases

    ProteinModelPortali Q6ZWR6.
    SMRi Q6ZWR6. Positions 23-283, 997-1042.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211015. 1 interaction.
    DIPi DIP-60966N.
    STRINGi 10090.ENSMUSP00000051825.

    PTM databases

    PhosphoSitei Q6ZWR6.

    Proteomic databases

    MaxQBi Q6ZWR6.
    PaxDbi Q6ZWR6.
    PRIDEi Q6ZWR6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041639 ; ENSMUSP00000039440 ; ENSMUSG00000096054 . [Q6ZWR6-5 ]
    ENSMUST00000095899 ; ENSMUSP00000093587 ; ENSMUSG00000019769 . [Q6ZWR6-3 ]
    GeneIDi 64009.
    KEGGi mmu:64009.
    UCSCi uc007egn.1. mouse. [Q6ZWR6-5 ]
    uc007egt.2. mouse. [Q6ZWR6-2 ]

    Organism-specific databases

    CTDi 23345.
    MGIi MGI:1927152. Syne1.

    Phylogenomic databases

    eggNOGi COG5069.
    GeneTreei ENSGT00750000117361.
    HOGENOMi HOG000120125.
    HOVERGENi HBG106534.
    InParanoidi Q9ERT7.
    OMAi CATESEC.
    OrthoDBi EOG72JWF7.
    PhylomeDBi Q6ZWR6.
    TreeFami TF317709.
    TF337116.

    Enzyme and pathway databases

    Reactomei REACT_198626. Meiotic synapsis.
    REACT_75800. Meiotic Synapsis.

    Miscellaneous databases

    ChiTaRSi SYNE1. mouse.
    NextBioi 319851.
    PROi Q6ZWR6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6ZWR6.
    Bgeei Q6ZWR6.
    Genevestigatori Q6ZWR6.

    Family and domain databases

    Gene3Di 1.10.418.10. 2 hits.
    InterProi IPR001589. Actinin_actin-bd_CS.
    IPR001715. CH-domain.
    IPR012315. KASH.
    IPR018159. Spectrin/alpha-actinin.
    IPR002017. Spectrin_repeat.
    [Graphical view ]
    Pfami PF00307. CH. 2 hits.
    PF10541. KASH. 1 hit.
    PF00435. Spectrin. 10 hits.
    [Graphical view ]
    SMARTi SM00033. CH. 2 hits.
    SM00150. SPEC. 42 hits.
    [Graphical view ]
    SUPFAMi SSF47576. SSF47576. 2 hits.
    PROSITEi PS00019. ACTININ_1. 1 hit.
    PS00020. ACTININ_2. 1 hit.
    PS50021. CH. 2 hits.
    PS51049. KASH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction."
      Apel E.D., Lewis R.M., Grady R.M., Sanes J.R.
      J. Biol. Chem. 275:31986-31995(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 6808-8799 (ISOFORM 4), INTERACTION WITH MUSK, SUBCELLULAR LOCATION.
    2. "Enaptin, a giant actin-binding protein, is an element of the nuclear membrane and the actin cytoskeleton."
      Padmakumar V.C., Abraham S., Braune S., Noegel A.A., Tunggal B., Karakesisoglou I., Korenbaum E.
      Exp. Cell Res. 295:330-339(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), TISSUE SPECIFICITY, ACTIN-BINDING, SUBCELLULAR LOCATION.
      Strain: BALB/c.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Vagina.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "Nuclear membrane proteins with potential disease links found by subtractive proteomics."
      Schirmer E.C., Florens L., Guan T., Yates J.R. III, Gerace L.
      Science 301:1380-1382(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8308, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    7. "Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton."
      Dawe H.R., Adams M., Wheway G., Szymanska K., Logan C.V., Noegel A.A., Gull K., Johnson C.A.
      J. Cell Sci. 122:2716-2726(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice."
      Lei K., Zhang X., Ding X., Guo X., Chen M., Zhu B., Xu T., Zhuang Y., Xu R., Han M.
      Proc. Natl. Acad. Sci. U.S.A. 106:10207-10212(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    9. Cited for: SELF-ASSOCIATION, INTERACTION WITH SYNE3, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSYNE1_MOUSE
    AccessioniPrimary (citable) accession number: Q6ZWR6
    Secondary accession number(s): Q8K3T7, Q9ERT7, Q9ERT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 23, 2010
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3