Q6ZWR6 (SYNE1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nesprin-1

Alternative name(s):
Enaptin
Myocyte nuclear envelope protein 1
Short name=Myne-1
Nuclear envelope spectrin repeat protein 1
Synaptic nuclear envelope protein 1
Short name=Syne-1

Gene names

Name:

Syne1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	8799 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. May be involved in the maintenance of nuclear organization and structural integrity. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm By similarity. Required for centrosome migration to the apical cell surface during early ciliogenesis. Ref.8
Subunit structure	Dimer. Component of LINC complexes composed of SUN domain-containing proteins (SUN1 or SUN2) coupled to KASH domain-containing proteins (SYNE1, SYNE2 or SYNE3) also called nesprins. May interact with MUSK. Interacts with EMD and LMNA in vitro By similarity. Interacts with F-actin via its N-terminal domain. Interacts with SYNE3. Ref.1 Ref.10
Subcellular location	Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side Potential. Nucleus. Nucleus envelope. Cytoplasm › cytoskeleton. Cytoplasm › myofibril › sarcomere By similarity. Note: The largest part of the protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. In skeletal and smooth muscles, a significant amount is found in the sarcomeres By similarity. Ref.1 Ref.2 Ref.5 Ref.9
Tissue specificity	Expressed in C2F3 and CH310T1/2 cells, brain and skeletal muscle (at protein level). Ref.2 Ref.10
Domain	The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains By similarity.
Sequence similarities	Belongs to the nesprin family. Contains 1 actin-binding domain. Contains 2 CH (calponin-homology) domains. Contains 9 HAT repeats. Contains 1 KASH domain. Contains 44 spectrin repeats. Contains 11 TPR repeats.
Sequence caution	The sequence AAG24393.1 differs from that shown. Reason: Frameshift at positions 6810, 7656 and 7658.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Membrane Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat TPR repeat Transmembrane Transmembrane helix
Ligand	Actin-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	establishment of nucleus localization Inferred from mutant phenotype PubMed 17267447. Source: MGI
Cellular_component	cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear envelope Inferred from direct assay Ref.1. Source: MGI nuclear outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell sarcomere Inferred from sequence alignment PubMed 12408964. Source: MGI
Molecular_function	protein homodimerization activity Inferred from direct assay Ref.10. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZWR6-1)

Also known as: Nesprin-1 Giant; Enaptin;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZWR6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-7828: Missing.
     7829-7878: IAVAQENKIQ...WQHLLDLMAA → MVVAEDLHGPRMAEDSSVDADLPDCDCDVS
     8218-8219: Missing.
     8328-8328: S → SDVVIPENPEAYVKLTENAIRNTS

Isoform 3 (identifier: Q6ZWR6-3)

Also known as: Syne-1A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-7828: Missing.
     7829-7878: IAVAQENKIQ...WQHLLDLMAA → MVVAEDLHGPRMAEDSSVDADLPDCDCDVS
     8218-8219: Missing.

Isoform 4 (identifier: Q6ZWR6-4)

Also known as: Syne-1B;

The sequence of this isoform differs from the canonical sequence as follows:
     8218-8219: Missing.

Note: Incomplete sequence.

Isoform 5 (identifier: Q6ZWR6-5)

Also known as: Enaptin-165;

The sequence of this isoform differs from the canonical sequence as follows:
     103-103: K → KSMYRGSP
     297-313: Missing.
     1435-1441: DIKTMEM → EYVLHHF
     1442-8799: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 8799	8799	Nesprin-1		PRO_0000392209
Regions
	Topological domain	1 – 8748	8748	Cytoplasmic Potential
	Transmembrane	8749 – 8769	21	Helical; Anchor for type IV membrane protein; Potential
	Topological domain	8770 – 8799	30	Perinuclear space Potential
	Domain	1 – 289	289	Actin-binding
	Domain	27 – 134	108	CH 1
	Domain	178 – 283	106	CH 2
	Repeat	592 – 624	33	HAT 1
	Repeat	915 – 949	35	TPR 1
	Repeat	1015 – 1048	34	TPR 2
	Repeat	1103 – 1135	33	HAT 2
	Repeat	1127 – 1229	103	Spectrin 1
	Repeat	1423 – 1455	33	HAT 3
	Repeat	1447 – 1546	100	Spectrin 2
	Repeat	1538 – 1572	35	TPR 3
	Repeat	1553 – 1649	97	Spectrin 3
	Repeat	1656 – 1759	104	Spectrin 4
	Repeat	2087 – 2191	105	Spectrin 5
	Repeat	2305 – 2402	98	Spectrin 6
	Repeat	2407 – 2509	103	Spectrin 7
	Repeat	2516 – 2618	103	Spectrin 8
	Repeat	2703 – 2742	40	HAT 4
	Repeat	2841 – 2982	142	Spectrin 9
	Repeat	2947 – 2980	34	TPR 4
	Repeat	3065 – 3167	103	Spectrin 10
	Repeat	3174 – 3274	101	Spectrin 11
	Repeat	3281 – 3383	103	Spectrin 12
	Repeat	3390 – 3486	97	Spectrin 13
	Repeat	3479 – 3512	34	TPR 5
	Repeat	3490 – 3593	104	Spectrin 14
	Repeat	3817 – 3916	100	Spectrin 15
	Repeat	3923 – 4030	108	Spectrin 16
	Repeat	4138 – 4236	99	Spectrin 17
	Repeat	4345 – 4447	103	Spectrin 18
	Repeat	4454 – 4556	103	Spectrin 19
	Repeat	4563 – 4665	103	Spectrin 20
	Repeat	4580 – 4613	34	TPR 6
	Repeat	4672 – 4772	101	Spectrin 21
	Repeat	4885 – 4987	103	Spectrin 22
	Repeat	4994 – 5095	102	Spectrin 23
	Repeat	5078 – 5110	33	HAT 5
	Repeat	5102 – 5205	104	Spectrin 24
	Repeat	5212 – 5317	106	Spectrin 25
	Repeat	5426 – 5521	96	Spectrin 26
	Repeat	5514 – 5547	34	TPR 7
	Repeat	5528 – 5626	99	Spectrin 27
	Repeat	5736 – 5769	34	TPR 8
	Repeat	5747 – 5867	121	Spectrin 28
	Repeat	5961 – 5994	34	TPR 9
	Repeat	5975 – 6078	104	Spectrin 29
	Repeat	6702 – 6794	93	Spectrin 30
	Repeat	6777 – 6809	33	HAT 6
	Repeat	6801 – 6906	106	Spectrin 31
	Repeat	6917 – 7021	105	Spectrin 32
	Repeat	7004 – 7036	33	HAT 7
	Repeat	7028 – 7129	102	Spectrin 33
	Repeat	7136 – 7238	103	Spectrin 34
	Repeat	7214 – 7253	40	HAT 8
	Repeat	7358 – 7455	98	Spectrin 35
	Repeat	7462 – 7562	101	Spectrin 36
	Repeat	7569 – 7672	104	Spectrin 37
	Repeat	7679 – 7779	101	Spectrin 38
	Repeat	7786 – 7884	99	Spectrin 39
	Repeat	7891 – 7998	108	Spectrin 40
	Repeat	7978 – 8010	33	HAT 9
	Repeat	8005 – 8107	103	Spectrin 41
	Repeat	8025 – 8058	34	TPR 10
	Repeat	8114 – 8214	101	Spectrin 42
	Repeat	8131 – 8165	35	TPR 11
	Repeat	8445 – 8548	104	Spectrin 43
	Repeat	8555 – 8659	105	Spectrin 44
	Domain	8740 – 8799	60	KASH
	Compositional bias	8665 – 8731	67	Ser-rich
Amino acid modifications
	Modified residue	8227	1	Phosphoserine Ref.7
	Modified residue	8278	1	Phosphothreonine By similarity
	Modified residue	8281	1	Phosphoserine By similarity
	Modified residue	8284	1	Phosphoserine By similarity
	Modified residue	8308	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	1 – 7828	7828	Missing in isoform 2 and isoform 3.		VSP_038791
	Alternative sequence	103	1	K → KSMYRGSP in isoform 5.		VSP_038792
	Alternative sequence	297 – 313	17	Missing in isoform 5.		VSP_038793
	Alternative sequence	1435 – 1441	7	DIKTMEM → EYVLHHF in isoform 5.		VSP_038794
	Alternative sequence	1442 – 8799	7358	Missing in isoform 5.		VSP_038795
	Alternative sequence	7829 – 7878	50	IAVAQ…DLMAA → MVVAEDLHGPRMAEDSSVDA DLPDCDCDVS in isoform 2 and isoform 3.		VSP_038796
	Alternative sequence	8218 – 8219	2	Missing in isoform 2, isoform 3 and isoform 4.		VSP_038797
	Alternative sequence	8328	1	S → SDVVIPENPEAYVKLTENAI RNTS in isoform 2.		VSP_038798
Experimental info
	Sequence conflict	1086	1	G → W in AAN03487. Ref.2
	Sequence conflict	1150	1	I → T in AAN03487. Ref.2
	Sequence conflict	7187	1	E → G in AAG24393. Ref.1
	Sequence conflict	7876	1	M → I in AAG24393. Ref.1
	Sequence conflict	8266	1	P → L in AAG24392. Ref.1
	Sequence conflict	8266	1	P → L in AAG24393. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Nesprin-1 Giant) (Enaptin) [UniParc]. Last modified March 23, 2010. Version 2. Checksum: 2A457DC081969CF0	FASTA	8,799	1,009,926
	10 20 30 40 50 60 MATSRASSRS HRDITNVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV DDLFEDMKDG 70 80 90 100 110 120 IKLLALLEVL SGQKLPCEQG HRVKRIHAVA NIGTALKFLE GRKIKLVNIN ATDIADGRPS 130 140 150 160 170 180 IVLGLMWTII LYFQIEELTS NLPQLQSLSS SASSVDSMVS TETASPPSKR KVAAKIQGNA 190 200 210 220 230 240 KKTLLKWVQH TAGKQMGIEV KDFGKSWRTG LAFHSVIHAI QPELVDLEKV KTRSNRENLE 250 260 270 280 290 300 DAFTIAETQL GIPRLLDPED VDVDKPDEKS IMTYVAQFLT QYPDIHGAGC DGQEDDVVFV 310 320 330 340 350 360 GFTNNIALLL GFQRDDRLIL KETKVWIEQF ERDFTRAQMT ESSLQDKYQA FKHFRVQYEM 370 380 390 400 410 420 KRKQVEHIIQ PLQRDGKLTL DQALVKQCWE RVSSRLFDWH IQLDKSLPAP LGTIGAWLYR 430 440 450 460 470 480 AEVALREEIT IQQVHEETAN TIQRKLEQHK DLLQNTDAHK RAFHEIYQTR SVNGIPMPPD 490 500 510 520 530 540 QLEDMAERFH FVSSTSELHL MKMEFLELKY RLLSLLVLAE SKLKSWIIKY GRRESVELLL 550 560 570 580 590 600 QSYISFIENS KFFEQYEVTY QILKQTADIY VKAEGSVEEA ENVMKFMSEA TAQWRNLSVE 610 620 630 640 650 660 VRSVRSMLEE VISNWDRYGD TVASLQAWLE DAEKMLSQSE HAKKDFFRNL PHWIQQHTAM 670 680 690 700 710 720 NDAGNFLIET CDEIVSRDLK QQLLLLNGRW RELFMEVKQY ARADEMDRMK KEYIDVTTTL 730 740 750 760 770 780 FGFATEAHRK LSEPLEVSFI NVKLLIQDLE DLEKRVPVMD AQYKMIAKKA HLFAKESPQE 790 800 810 820 830 840 EANEMLTTMS KLKEQLSKVK ECCSPLLYEA QQLTVPLEEL ETQITSFYDS LGKINEILSV 850 860 870 880 890 900 LEQEAQSSTL FKQKHQELLA SQENCKKSLT LIEKGSQSVQ KLVTSSQARK PWDHTKLQKQ 910 920 930 940 950 960 IADVHHAFQS MIKKTGDWKK HVEANSRLMK KFEESRAELE KVLRVAQEGL EEKGDPEELL 970 980 990 1000 1010 1020 RRHTEFFSQL DQRVLNAFLK ACDELTDILP EQEQQGLQEA VRKLHKQWKD LQGEAPYHLL 1030 1040 1050 1060 1070 1080 HLKIAVEKDR FSAAVEECRA ELEQETKLAP QEGSEKIIKE HRVFFSDKGP HHLCEKRLQL 1090 1100 1110 1120 1130 1140 IEELCGKLPV QDPVRDTCGA CHTALKELKA SIDNTYTMLV DDPDKWKDYT SRFSEFSSWV 1150 1160 1170 1180 1190 1200 SAKKACLKKI KDEPIDTGNH DEVKHMVDEI RNDITKKGES LSWLKSRLKY LIDISSENEA 1210 1220 1230 1240 1250 1260 QKRGDELAEL SSSFKALVAL LSEVEKLLSN FGECVQYKEI VKSSLEGLIS GPQESKEEAE 1270 1280 1290 1300 1310 1320 MILDSKNLLE AQQLLLHHQQ KTKMISAKKR DLQEQMEQAQ QGGQAGPGQE ELRKLESTLT 1330 1340 1350 1360 1370 1380 GLEQSRERQE RRIQVSLRKW ERFETNKETV VRYLFQTGSS HERFLSFSSL ESLSSELEQT 1390 1400 1410 1420 1430 1440 KEFSKRTESI ATQAENLVKE AAELPLGPRN KRVLQRQAKS IKEQVTTLED TLEEDIKTME 1450 1460 1470 1480 1490 1500 MVKSKWDHFG SNFETLSIWI LEKENELSSL EASASAADVQ ISQIKVTIQE IESKIDSIVG 1510 1520 1530 1540 1550 1560 LEEEAQSFAQ FVTTGESARI KAKLTQIRRY WEELQEHARG LEGTILGHLS QQQKFEENLR 1570 1580 1590 1600 1610 1620 KIRQSVSEFA ERLADPIKIC SSAAETYKVL QEHMDLCQAV ESLSSTVTMF SASAQKAVNR 1630 1640 1650 1660 1670 1680 ESCTQEAAAL QQQYEEILHK AKEMQTALED LLARWQRLEK GLSPFLTWLE RCEAIASSPE 1690 1700 1710 1720 1730 1740 KDISADRGKV ESELQLIQAL QNEVVSQASL YSNLLQLKEA LFSVASKEDV AVMKLQLEQL 1750 1760 1770 1780 1790 1800 DERWGDLPQI ISKRMHFLQS VLAEHKQFDE LLFSFSVWIK QFLGELQRTS EINLRDHQVA 1810 1820 1830 1840 1850 1860 LTRHKDHAAE IEKKRGEITH LQGHLSQLRS LGRAQDLHPL QSKVDDCFQL FEEASQVVER 1870 1880 1890 1900 1910 1920 RKLALAQLAE FLQSHACMST LLYQLRQTVE ATKSMSKKQS DSLKTDLHSA IQDVKTLESS 1930 1940 1950 1960 1970 1980 AISLDGTLTK AQCHLKSASP EERTSCRATT DQLSLEVERI QNLLGTKQSE ADALVALKEA 1990 2000 2010 2020 2030 2040 FREQKEELLR SIEDIEERMD RERLKVPTRQ ALQHRLRVFN QLEDELNSHE HELCWLKDKA 2050 2060 2070 2080 2090 2100 KQIAQKDVAF APEVDREING LEATWDDTRR QIHENQGQCC GLIDLVREYQ SLKSTVCNVL 2110 2120 2130 2140 2150 2160 EDASNVVVMR ATIKDQGDLK WAFSKHETSR NEMNSKQKEL DSFTSKGKHL LSELKKIHSG 2170 2180 2190 2200 2210 2220 DFSLVKTDME STLDKWLDVS ERIEENMDML RVSLSIWDDV LSRKDEIEGW SNSSLPKLAE 2230 2240 2250 2260 2270 2280 NISNLNNSLR AEELLKELES EVKIKALKLE DLHSKINNLK ELTKNPETPT ELQFIEADLR 2290 2300 2310 2320 2330 2340 QKLEHAKEIT EEARGTLKDF TAQRTQVERF VKDITAWLIN VEESLTRCAQ TETCEGLKKA 2350 2360 2370 2380 2390 2400 KDIRKELQSQ QNSITSTQEE LNSLCRKHHS VELESLGRAM TGLIKKHEAT SQLCSQTQAR 2410 2420 2430 2440 2450 2460 IQDSLEKHFS GSMKEFQEWF LGAKAAARES SNLTGDSQIL EARLHNLQGV LDSLSDGQSK 2470 2480 2490 2500 2510 2520 LDVVTQEGQT LYAHLPKQIV SSIQEQITKA NEEFQAFLKQ CLKEKQALQD CVSELGSFED 2530 2540 2550 2560 2570 2580 QHRKLNLWIH EMEERLKTEN LGESKHHISE KKNEVRKVEM FLGELLAARE SLDKLSQRGQ 2590 2600 2610 2620 2630 2640 LLSEESHSAG KGGCRSTQLL TSYQSLLRVT KEKLRSCQLA LKEHEALEEA TQSMWARVKD 2650 2660 2670 2680 2690 2700 VQDRLACAES TLGNKETLEG RLSQIQDILL MKGEGEVKLN LAIGKGDQAL RSSNKEGQQA 2710 2720 2730 2740 2750 2760 IQDQLEMLKK AWAEAMNSAV HAQSTLESVI DQWNDYLEKK SQLEQWMESV DQRLEHPLQL 2770 2780 2790 2800 2810 2820 QPGLKEKFSL LDHFQSIVSE AEDHTGALQQ LAAKSRELYQ KTQDESFKEA GQEELRTQFQ 2830 2840 2850 2860 2870 2880 DIMTVAKEKM RTVEDLVKDH LMYLDAVQEF ADWLHSAKEE LHRWSDTSGD PSATQKKLLK 2890 2900 2910 2920 2930 2940 IKELIDSREI GAGRLSRVES LAPAVKQNTA ASGCELLNSE MQALRADWRQ WEDCLFQTQS 2950 2960 2970 2980 2990 3000 SLESLVSEMA LSEQEFFGQV TQLEQALEQF CTLLKTWAQQ LTLLEGKNSD EEILECWHKG 3010 3020 3030 3040 3050 3060 REILDALQKA EPMTEDLKSQ LNELCRFSRD LSPYSEKVSG LIKEYNCLCL QASKGCQNKE 3070 3080 3090 3100 3110 3120 QILQERFQKA SRGFQQWLVN AKITTAKCFD LPQNLSEVSS SLQKIQEFLS ESENGQHKLN 3130 3140 3150 3160 3170 3180 TMLFKGELLS SLLTEEKAQA VQAKVLTAKE EWKSFHANLH QKESALENLK IQMKDFEVSA 3190 3200 3210 3220 3230 3240 ELVQNWLSKT ERLVQESSNR LYDLPAKRRE QQKLQSVLEE IQCYEPQLHR LKEKARQLWE 3250 3260 3270 3280 3290 3300 GQAASKSFVH RVSQLSSQYL ALSNVTKEKV SRLDRIIAEH NRFSQGVKEL QDWMSDAVHM 3310 3320 3330 3340 3350 3360 LDSYCLPTSD KSVLDSRMLK LEALLSVRQE KEIQMKMVVT RGEYVLQSTS LEGSAAVQQQ 3370 3380 3390 3400 3410 3420 LQAVKDMWES LLSAAIRCKS QLEGALSKWT SYQDDVRQFS SWMDSVEVSL TESEKQHTEL 3430 3440 3450 3460 3470 3480 REKITALGKA KLLNEEVLSH SSLLETIEVK RAAMTEHYVT QLELQDLQER HQALKEKAKE 3490 3500 3510 3520 3530 3540 AVTKLEKLVR LHQEYQRDLK AFESWLEQEQ EKLDRCSVHE GDTNAHETML RDLQELQVRC 3550 3560 3570 3580 3590 3600 AEGQALLNSV LHTREDVIPS GLPQAEDRVL ESLRQDWQVY QHRLAEARMQ LNNVVNKLRL 3610 3620 3630 3640 3650 3660 MEQKFQQADE WLKRMEEKIN FRSECQSSRS DKEIQLLQLK KWHEDLSAHR DEVEEVGTRA 3670 3680 3690 3700 3710 3720 QGILDETHIS SRMGCQATQL TSRYQALLLQ VLEQIKFFEE ELQCLEETES SLSSYSDWYG 3730 3740 3750 3760 3770 3780 STHKNFKNVA TKIDKVDESM MGKKLKTLEV LLKDMEKGHS LLKSAREKGE RAMKFLAEHE 3790 3800 3810 3820 3830 3840 AEALRKEIHT YMEQLKNLTS TVRKECMSLE KGLHLAKEFS DKYKVLAQWM AEYQEILCTP 3850 3860 3870 3880 3890 3900 EEPKMELYEK KAQLSKYKSL QQMVLSHEPS VTSVQEKSEA LLELVQDQSL KDKIQKLQSD 3910 3920 3930 3940 3950 3960 FQDLCSRAKE RVFSLEAKVK DHEDYNTELQ EVEKWLLQMS GRLVAPDLLE MSSLETITQQ 3970 3980 3990 4000 4010 4020 LAHHKAMMEE IAGFEDRLDN LKAKGDTLIG QCPEHLQAKQ KQTVQAHLQG TKDSYSAICS 4030 4040 4050 4060 4070 4080 TAQRVYRSLE YELQKHVSSQ DTLQQCQAWI SAVQPDLKPS PQPPLSRAEA VKQVKHFRAL 4090 4100 4110 4120 4130 4140 QEQARTYLDL LCSMCDLSNS SVKNTAKDIQ QTEQLIEQRL VQAQNLTQGW EEIKSLKAEL 4150 4160 4170 4180 4190 4200 WIYLQDADQQ LQNMKRRHTE LEINIAQNMV MQVKDFIKQL QCKQVSVSTI VEKVDKLTKN 4210 4220 4230 4240 4250 4260 QESPEHKEIT HLNDQWQDLC LQSDKLCAQR EQDLQRTSSY HDHMRVVEAF LEKFTTEWDS 4270 4280 4290 4300 4310 4320 LARSNAESTA IHLEALKKLA LALQEEMYAI DDLKDCKQKL IEQLGLDDRE LVREQTSHLE 4330 4340 4350 4360 4370 4380 QRWFQLQDLV KRKIQVSVTN LEELNVIQSR FQELMEWAEE QQPNIVEALK QSPPPGMAQH 4390 4400 4410 4420 4430 4440 LLMDHLAICS ELEAKQVLLK SLMKDADRVM ADLGLNERKV IQKALSEAQK HVSCLSDLVG 4450 4460 4470 4480 4490 4500 QRRKYLNKAL SEKTQFLMAV FQATSQIQQH ERKIVFREYI CLLPDDVSKQ VKTCKTAQAS 4510 4520 4530 4540 4550 4560 LKTYQNEVTG LCAQGRELMK GITKQEQEEV LGKLQELQTV YDTVLQKCSH RLQELEKSLV 4570 4580 4590 4600 4610 4620 SRKHFKEDFD KACHWLKQAD IVTFPEINLM NEKTELHAQL DKYQSILEQS PEYENLLLTL 4630 4640 4650 4660 4670 4680 QTTGQAMLPS LNEVDHSYLS EKLSALPQQF NVIVALAKDK FYKTQEAILA RKEYTSLIEL 4690 4700 4710 4720 4730 4740 TTQSLGDLED QFLKMRKMPS DLIVEESVSL QQSCSALLGE VVALGEAVNE LNQKKESFRS 4750 4760 4770 4780 4790 4800 TGQPWQPEKM LQLATLYHRL KRQAEQRVSF LEDTTSVYKE HAQMCRQLES QLEVVKREQA 4810 4820 4830 4840 4850 4860 KVNEETLPAE EKLKVYHSLA GSLQDSGILL KRVATHLEDL SPHLDPTAYE KAKSQVQSWQ 4870 4880 4890 4900 4910 4920 EELKQMTSDV GELVTECESR MVQSIDFQTE MSRSLDWLRR VKAELSGPVC LDLSLQDIQE 4930 4940 4950 4960 4970 4980 EIRKIQIHQE EVLSSLRIMS ALSHKEQEKF TKAKELISAD LEHTLAELQE LDGDVQEALR 4990 5000 5010 5020 5030 5040 TRQATLTEIY SRCQRYYQVF QAANDWLDDA QEMLQLAGNG LDVESAEENL RSHMEFFKTE 5050 5060 5070 5080 5090 5100 GQFHSNMEEL RGLVARLDPL IKATGKEELA QKMASLEKRS QGIIQESHTQ RDLLQRCMVQ 5110 5120 5130 5140 5150 5160 WQEYQKAREG VIELMNDAEK KLSEFAVLKT SSIHEAEEKL SKHKALVSVV DSFHEKIVAL 5170 5180 5190 5200 5210 5220 EEKASQLEQT GNDTSKATLS RSMTTVWQRW TRLRAVAQDQ EKILEDAVDE WKRLSAKVKE 5230 5240 5250 5260 5270 5280 TTEVINQLQG RLPGSSTEKA SKAELMTLLE SHDTYLMDLE SQQLTLGVLQ QRALSMLQDR 5290 5300 5310 5320 5330 5340 AFPGTEEEVP ILRAITALQD QCLNMQEKVK NHGKLVKQEL QEREAVETRI NSVKSWVQET 5350 5360 5370 5380 5390 5400 KDYLGNPTIE IDTQLEELKR LLAEATSHQE SIEKIAEEQK NKYLGLYTVL PSEISLQLAE 5410 5420 5430 5440 5450 5460 VALDLKIHDQ IQEKVQEIEE GKAMSQEFSC KIQKVTKDLT TILTKLKAKT DDLVHAKAEH 5470 5480 5490 5500 5510 5520 KMLGEELDGC NSKLMELDAA IQTFSERHSQ LGQPLAKKIG KLTELHQQTI RQAENRLSKL 5530 5540 5550 5560 5570 5580 NQALSHMEEY NEMLETVRKW IEKAKVLVHG NIAWNSASQL QEQYILHQTL LEESGEIDSD 5590 5600 5610 5620 5630 5640 LEAMAEKVQH LANVYCTGKL SQQVTQFGRE MEELRQAIRV RLRNLQDAAK DMKKFEGELR 5650 5660 5670 5680 5690 5700 NLQVALEQAQ TILTSPEVGR RSLKEQLCHR QHLLSEMESL KPKMQAVQLC QSALRIPEDV 5710 5720 5730 5740 5750 5760 VASLPLCHAA LRLQEEASQL QHTAIQQCNI MQAKKHSLIF PPKEAVVQYE QYKQEMKHLQ 5770 5780 5790 5800 5810 5820 QLIEEAHREI EDKPVATSNI QELQAQISLH EELAQKIKGY QEQIDSLNSK CKMLTMKAKH 5830 5840 5850 5860 5870 5880 ATMLLTVTEV EGLAEGTEDL DRELHPTPSA HPSVVMMTAG RCHTLLSPVT EESGEEGTNS 5890 5900 5910 5920 5930 5940 EISSPPACRS PSPVANTEAA VNQDIAYYQA LSAEGLQTDA ARIPPSAAVS QELYEPGLEP 5950 5960 5970 5980 5990 6000 SATAKLGDLQ RSWETLKNVI SEKQRTLYEV LERQQKYQDS LQSISTKMEA MEMKLGESLE 6010 6020 6030 6040 6050 6060 PSRSPESQMA EHQALMDEVQ MLQDEINGLQ VSLAEELVAE SQESDPAEQL ALQSTLTVLA 6070 6080 6090 6100 6110 6120 ERMSTIRMKA AGKRQLLEEK LSDQLEEQRQ EQALQRYRCE ADELDHWLLN TKATLDVALG 6130 6140 6150 6160 6170 6180 TSQEPMDMDA QLVDCQNMLV EIEQKVVALS QLSVHNENLL LEGKAHTKEE AEQLAVKLRL 6190 6200 6210 6220 6230 6240 LKGSLGELQR ALHDRQLDMQ GVTQEKEEND VDFTDTQSPG VQEWLAQART TRTHQRQSSL 6250 6260 6270 6280 6290 6300 QQQKEFEQEL AEQKSLLRSV ASRGEEILTQ HSTAEGSGGL GEKPDVLSQE LGIAEDQMRV 6310 6320 6330 6340 6350 6360 KWESLHQEFS AKQKLLQNIL EQEQEQVLYS SPNRLLSGVL PFRGEAQTQD KTSVTSLLDG 6370 6380 6390 6400 6410 6420 LSQAFGEASS QSGGTDRQSI HLEQKLYDGV SATSTWLNDV EERLFVATAP LPEETEACLF 6430 6440 6450 6460 6470 6480 NQEALAKDIK EMSEEMDKNK NLFSQAFPED SDNRDVIEDT LGCLLGRLSL LDSVVDQRCH 6490 6500 6510 6520 6530 6540 QMKERLQQIL RFQNDLKVLF TSLADSKYII LQKLANVFEQ PIVEQMQAIQ QAEEGLRDLE 6550 6560 6570 6580 6590 6600 GGISELKRWA DKLQVEQSAV QELSKLQDMY DELLMTVSSR RSSLHQNLAL KSQYDKALQD 6610 6620 6630 6640 6650 6660 LVDLLDTGQE KMTGDQKIIV CSKEEIQQLL GKHKEYFQGL ESHMILTEIL FRKIVGFAAV 6670 6680 6690 6700 6710 6720 KETQFHTDCM AQASAVLKQA HKRGVELEYI LEMWSHLDEN RQELSRQLEV IENSIPSVGL 6730 6740 6750 6760 6770 6780 VEESEDRLVE RTNLYQHLKS SLNEYQPKLY QALDDGKRLL MSVSCSELES QLNQLGEHWL 6790 6800 6810 6820 6830 6840 SNTNKVSKEL HRLETILKHW TRYQSEAAAL NHWLQCAKDR LAFWTQQSVT VPQELEMVRD 6850 6860 6870 6880 6890 6900 HLSAFLEFSK EVDAKSALKS SVTSTGNQLL RLKKVDTAAL RAELSRMDSQ WTDLLTGIPV 6910 6920 6930 6940 6950 6960 VQEKLHQLQM DKLPSRHAIS EVMSWISLME SVILKDEEDI RNAIGYKAIH EYLQKYKGFK 6970 6980 6990 7000 7010 7020 IDLNCKQLTA DFVNQSVLQI SSQDVESKRS DKTDFAEQLG AMNKSWQLLQ GRVGEKIQML 7030 7040 7050 7060 7070 7080 EGLLESWSEY ENSVQSLKAW FANQERKLKE QHLLGDRNSV ENALKDCQEL EDLIKAKEKE 7090 7100 7110 7120 7130 7140 VEKIEQNGLA LIQNKREEVS GSVMSTLQEL RQTWISLDRT VEQLKIQLTS ALGQWSNHKA 7150 7160 7170 7180 7190 7200 ACDEINGHLM EARYSLSRFR LLTGSSEAVQ VQVDNLQNLH DELEKQEGGL QKFGSITNQL 7210 7220 7230 7240 7250 7260 LKECHPPVAE TLSSTLQEVN MRWNNLLEEI AEQLHSSKAL LQLWQRYKDY SKQCASAIQR 7270 7280 7290 7300 7310 7320 QEEQTSVLLK AATNKDIADD EVTKWIQDCN DLLKGLETVK DSLFILRELG EQLGQQVDVS 7330 7340 7350 7360 7370 7380 AAAAIQCEQL CFSQRLGALE QALCKQQAVL QAGVVDYETF AKSLEALEVW MVEAEGILQG 7390 7400 7410 7420 7430 7440 QDPTHSSDLS TIQERMEELK GQMLKFSSLA PDLDRLNELG YRLPLNDKEI KRMQNLNRHW 7450 7460 7470 7480 7490 7500 SLTSSQTTER FSKLQSFLLQ HQTFLEKCET WMEFLVQTEH KLAVEISGNY QHLLEQQRAH 7510 7520 7530 7540 7550 7560 ELFQAEMFSR QQILHSIIVD GQNLLEQGQV DDREEFSLKL TLLSNQWQGV IRRAQQRRGI 7570 7580 7590 7600 7610 7620 IDSQIRQWQR YREMAEKLRK WLAEVSHLPL SGLGNIPVPL QQVRMLFDEV QFKEKVFLRQ 7630 7640 7650 7660 7670 7680 QGSYILTVEA GKQLLLSADS GAEAALQAEL TDIQEKWKAA SMHLEEQKKK LAFLLKDWEK 7690 7700 7710 7720 7730 7740 CERGIANSLE KLRMFKKRLS QPLPDHHEEL HAEQMRCKEL ENAVGRWTDD LTELMLVRDA 7750 7760 7770 7780 7790 7800 LAVYLSAEDI SMLKERVELL QRQWEELCHQ VSLRRQQVSE RLNEWAVFSE KNKELCEWLT 7810 7820 7830 7840 7850 7860 QMESKVSQNG DILIEEMIEK LKKDYQEEIA VAQENKIQLQ EMGERLAKAS HESKASEIQY 7870 7880 7890 7900 7910 7920 KLSRVKDRWQ HLLDLMAARV KKLKETLVAV QQLDKNMGSL RTWLAHMESE LAKPIVYDSC 7930 7940 7950 7960 7970 7980 NSEEIQRKLN EQQELQRDIE KHSTGVASVL NLCEVLLHDC DACATDAECD SIQQATRNLD 7990 8000 8010 8020 8030 8040 RRWRNICAMS MERRLKIEET WRLWQKFLDD YSRFEDWLEV SERTAAFPSS SGVLYTVAKE 8050 8060 8070 8080 8090 8100 ELKKFEAFQR QVHESLTQLE LINKQYRRLA RENRTDSACS LRQMVHGGNQ RWDDLQKRVT 8110 8120 8130 8140 8150 8160 SILRRLKHFI SQREEFETAR DSILVWLTEM DLQLTNIEHF SECDVQAKIK QLKAFQQEIS 8170 8180 8190 8200 8210 8220 LNHNKIEQII AQGEQLIEKS EPLDAAVIEE ELDELRRYCQ EVFGRVERYH KKLIRLPVRL 8230 8240 8250 8260 8270 8280 PDDHDLSDRE LDLEDSTALS DLRWQDPSAD GMPSPQPSSN PSLSLPQPLR SERSGRDTPA 8290 8300 8310 8320 8330 8340 SVDSIPLEWD HDYDLSRDLE SASRTLPSED EEGEEDKEFY LRGAVGLSGD PSSLESQMRQ 8350 8360 8370 8380 8390 8400 LDKALDDSRF QIQQTANILR SKTPTGPDLD TSYKGYMKLL GECSGSIDSV RRLEHKLAEE 8410 8420 8430 8440 8450 8460 ESFPGFVNLN STETQTAGVI DRWELLQAQA MSKELRMKQN LQKWQQFNSD LNNIWAWLGE 8470 8480 8490 8500 8510 8520 TEEELDRLQH LALSTDIHTI ESHIKKLKEL QKAVDHRKAI ILSINLCSSE FTQADSKESH 8530 8540 8550 8560 8570 8580 DLQDRLSQMN GRWDRVCSLL EDWRGLLQDA LMQCQEFHEM SHALLLMLEN IDRRKNEIVP 8590 8600 8610 8620 8630 8640 IDSTLDPETL QDHHKQLMQI KQELLKSQLR VASLQDMSRQ LLVNAEGSDC LEAKEKVHVI 8650 8660 8670 8680 8690 8700 GNRLKLLLKE VSHHIKDLEK LLDMSSSQQD LSSWSSADEL DTSGSVSPTS GRSTPNRQKS 8710 8720 8730 8740 8750 8760 PRGKCSLSQP GPSVSSPKSR STRDGSDSSR SDPRPERVGR AFLFRILRAA LPFQLLLLLL 8770 8780 8790 IGLTCLVPMS EKDYSCALSN NFARSFHPML RYTNGPPPL
	Isoform 2 [UniParc]. Checksum: 6ED3F1A381AACC9A	FASTA	972	111,334
	10 20 30 40 50 60 MVVAEDLHGP RMAEDSSVDA DLPDCDCDVS RVKKLKETLV AVQQLDKNMG SLRTWLAHME 70 80 90 100 110 120 SELAKPIVYD SCNSEEIQRK LNEQQELQRD IEKHSTGVAS VLNLCEVLLH DCDACATDAE 130 140 150 160 170 180 CDSIQQATRN LDRRWRNICA MSMERRLKIE ETWRLWQKFL DDYSRFEDWL EVSERTAAFP 190 200 210 220 230 240 SSSGVLYTVA KEELKKFEAF QRQVHESLTQ LELINKQYRR LARENRTDSA CSLRQMVHGG 250 260 270 280 290 300 NQRWDDLQKR VTSILRRLKH FISQREEFET ARDSILVWLT EMDLQLTNIE HFSECDVQAK 310 320 330 340 350 360 IKQLKAFQQE ISLNHNKIEQ IIAQGEQLIE KSEPLDAAVI EEELDELRRY CQEVFGRVER 370 380 390 400 410 420 YHKKLIRLPL PDDHDLSDRE LDLEDSTALS DLRWQDPSAD GMPSPQPSSN PSLSLPQPLR 430 440 450 460 470 480 SERSGRDTPA SVDSIPLEWD HDYDLSRDLE SASRTLPSED EEGEEDKEFY LRGAVGLSDV 490 500 510 520 530 540 VIPENPEAYV KLTENAIRNT SGDPSSLESQ MRQLDKALDD SRFQIQQTAN ILRSKTPTGP 550 560 570 580 590 600 DLDTSYKGYM KLLGECSGSI DSVRRLEHKL AEEESFPGFV NLNSTETQTA GVIDRWELLQ 610 620 630 640 650 660 AQAMSKELRM KQNLQKWQQF NSDLNNIWAW LGETEEELDR LQHLALSTDI HTIESHIKKL 670 680 690 700 710 720 KELQKAVDHR KAIILSINLC SSEFTQADSK ESHDLQDRLS QMNGRWDRVC SLLEDWRGLL 730 740 750 760 770 780 QDALMQCQEF HEMSHALLLM LENIDRRKNE IVPIDSTLDP ETLQDHHKQL MQIKQELLKS 790 800 810 820 830 840 QLRVASLQDM SRQLLVNAEG SDCLEAKEKV HVIGNRLKLL LKEVSHHIKD LEKLLDMSSS 850 860 870 880 890 900 QQDLSSWSSA DELDTSGSVS PTSGRSTPNR QKSPRGKCSL SQPGPSVSSP KSRSTRDGSD 910 920 930 940 950 960 SSRSDPRPER VGRAFLFRIL RAALPFQLLL LLLIGLTCLV PMSEKDYSCA LSNNFARSFH 970 PMLRYTNGPP PL
	Isoform 3 (Syne-1A) [UniParc]. Checksum: 40ABE338F614825E	FASTA	949	108,779
	10 20 30 40 50 60 MVVAEDLHGP RMAEDSSVDA DLPDCDCDVS RVKKLKETLV AVQQLDKNMG SLRTWLAHME 70 80 90 100 110 120 SELAKPIVYD SCNSEEIQRK LNEQQELQRD IEKHSTGVAS VLNLCEVLLH DCDACATDAE 130 140 150 160 170 180 CDSIQQATRN LDRRWRNICA MSMERRLKIE ETWRLWQKFL DDYSRFEDWL EVSERTAAFP 190 200 210 220 230 240 SSSGVLYTVA KEELKKFEAF QRQVHESLTQ LELINKQYRR LARENRTDSA CSLRQMVHGG 250 260 270 280 290 300 NQRWDDLQKR VTSILRRLKH FISQREEFET ARDSILVWLT EMDLQLTNIE HFSECDVQAK 310 320 330 340 350 360 IKQLKAFQQE ISLNHNKIEQ IIAQGEQLIE KSEPLDAAVI EEELDELRRY CQEVFGRVER 370 380 390 400 410 420 YHKKLIRLPL PDDHDLSDRE LDLEDSTALS DLRWQDPSAD GMPSPQPSSN PSLSLPQPLR 430 440 450 460 470 480 SERSGRDTPA SVDSIPLEWD HDYDLSRDLE SASRTLPSED EEGEEDKEFY LRGAVGLSGD 490 500 510 520 530 540 PSSLESQMRQ LDKALDDSRF QIQQTANILR SKTPTGPDLD TSYKGYMKLL GECSGSIDSV 550 560 570 580 590 600 RRLEHKLAEE ESFPGFVNLN STETQTAGVI DRWELLQAQA MSKELRMKQN LQKWQQFNSD 610 620 630 640 650 660 LNNIWAWLGE TEEELDRLQH LALSTDIHTI ESHIKKLKEL QKAVDHRKAI ILSINLCSSE 670 680 690 700 710 720 FTQADSKESH DLQDRLSQMN GRWDRVCSLL EDWRGLLQDA LMQCQEFHEM SHALLLMLEN 730 740 750 760 770 780 IDRRKNEIVP IDSTLDPETL QDHHKQLMQI KQELLKSQLR VASLQDMSRQ LLVNAEGSDC 790 800 810 820 830 840 LEAKEKVHVI GNRLKLLLKE VSHHIKDLEK LLDMSSSQQD LSSWSSADEL DTSGSVSPTS 850 860 870 880 890 900 GRSTPNRQKS PRGKCSLSQP GPSVSSPKSR STRDGSDSSR SDPRPERVGR AFLFRILRAA 910 920 930 940 LPFQLLLLLL IGLTCLVPMS EKDYSCALSN NFARSFHPML RYTNGPPPL
	Isoform 4 (Syne-1B) [UniParc]. Checksum: 08970A024A161721	FASTA	8,797	1,009,670
	10 20 30 40 50 60 MATSRASSRS HRDITNVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV DDLFEDMKDG 70 80 90 100 110 120 IKLLALLEVL SGQKLPCEQG HRVKRIHAVA NIGTALKFLE GRKIKLVNIN ATDIADGRPS 130 140 150 160 170 180 IVLGLMWTII LYFQIEELTS NLPQLQSLSS SASSVDSMVS TETASPPSKR KVAAKIQGNA 190 200 210 220 230 240 KKTLLKWVQH TAGKQMGIEV KDFGKSWRTG LAFHSVIHAI QPELVDLEKV KTRSNRENLE 250 260 270 280 290 300 DAFTIAETQL GIPRLLDPED VDVDKPDEKS IMTYVAQFLT QYPDIHGAGC DGQEDDVVFV 310 320 330 340 350 360 GFTNNIALLL GFQRDDRLIL KETKVWIEQF ERDFTRAQMT ESSLQDKYQA FKHFRVQYEM 370 380 390 400 410 420 KRKQVEHIIQ PLQRDGKLTL DQALVKQCWE RVSSRLFDWH IQLDKSLPAP LGTIGAWLYR 430 440 450 460 470 480 AEVALREEIT IQQVHEETAN TIQRKLEQHK DLLQNTDAHK RAFHEIYQTR SVNGIPMPPD 490 500 510 520 530 540 QLEDMAERFH FVSSTSELHL MKMEFLELKY RLLSLLVLAE SKLKSWIIKY GRRESVELLL 550 560 570 580 590 600 QSYISFIENS KFFEQYEVTY QILKQTADIY VKAEGSVEEA ENVMKFMSEA TAQWRNLSVE 610 620 630 640 650 660 VRSVRSMLEE VISNWDRYGD TVASLQAWLE DAEKMLSQSE HAKKDFFRNL PHWIQQHTAM 670 680 690 700 710 720 NDAGNFLIET CDEIVSRDLK QQLLLLNGRW RELFMEVKQY ARADEMDRMK KEYIDVTTTL 730 740 750 760 770 780 FGFATEAHRK LSEPLEVSFI NVKLLIQDLE DLEKRVPVMD AQYKMIAKKA HLFAKESPQE 790 800 810 820 830 840 EANEMLTTMS KLKEQLSKVK ECCSPLLYEA QQLTVPLEEL ETQITSFYDS LGKINEILSV 850 860 870 880 890 900 LEQEAQSSTL FKQKHQELLA SQENCKKSLT LIEKGSQSVQ KLVTSSQARK PWDHTKLQKQ 910 920 930 940 950 960 IADVHHAFQS MIKKTGDWKK HVEANSRLMK KFEESRAELE KVLRVAQEGL EEKGDPEELL 970 980 990 1000 1010 1020 RRHTEFFSQL DQRVLNAFLK ACDELTDILP EQEQQGLQEA VRKLHKQWKD LQGEAPYHLL 1030 1040 1050 1060 1070 1080 HLKIAVEKDR FSAAVEECRA ELEQETKLAP QEGSEKIIKE HRVFFSDKGP HHLCEKRLQL 1090 1100 1110 1120 1130 1140 IEELCGKLPV QDPVRDTCGA CHTALKELKA SIDNTYTMLV DDPDKWKDYT SRFSEFSSWV 1150 1160 1170 1180 1190 1200 SAKKACLKKI KDEPIDTGNH DEVKHMVDEI RNDITKKGES LSWLKSRLKY LIDISSENEA 1210 1220 1230 1240 1250 1260 QKRGDELAEL SSSFKALVAL LSEVEKLLSN FGECVQYKEI VKSSLEGLIS GPQESKEEAE 1270 1280 1290 1300 1310 1320 MILDSKNLLE AQQLLLHHQQ KTKMISAKKR DLQEQMEQAQ QGGQAGPGQE ELRKLESTLT 1330 1340 1350 1360 1370 1380 GLEQSRERQE RRIQVSLRKW ERFETNKETV VRYLFQTGSS HERFLSFSSL ESLSSELEQT 1390 1400 1410 1420 1430 1440 KEFSKRTESI ATQAENLVKE AAELPLGPRN KRVLQRQAKS IKEQVTTLED TLEEDIKTME 1450 1460 1470 1480 1490 1500 MVKSKWDHFG SNFETLSIWI LEKENELSSL EASASAADVQ ISQIKVTIQE IESKIDSIVG 1510 1520 1530 1540 1550 1560 LEEEAQSFAQ FVTTGESARI KAKLTQIRRY WEELQEHARG LEGTILGHLS QQQKFEENLR 1570 1580 1590 1600 1610 1620 KIRQSVSEFA ERLADPIKIC SSAAETYKVL QEHMDLCQAV ESLSSTVTMF SASAQKAVNR 1630 1640 1650 1660 1670 1680 ESCTQEAAAL QQQYEEILHK AKEMQTALED LLARWQRLEK GLSPFLTWLE RCEAIASSPE 1690 1700 1710 1720 1730 1740 KDISADRGKV ESELQLIQAL QNEVVSQASL YSNLLQLKEA LFSVASKEDV AVMKLQLEQL 1750 1760 1770 1780 1790 1800 DERWGDLPQI ISKRMHFLQS VLAEHKQFDE LLFSFSVWIK QFLGELQRTS EINLRDHQVA 1810 1820 1830 1840 1850 1860 LTRHKDHAAE IEKKRGEITH LQGHLSQLRS LGRAQDLHPL QSKVDDCFQL FEEASQVVER 1870 1880 1890 1900 1910 1920 RKLALAQLAE FLQSHACMST LLYQLRQTVE ATKSMSKKQS DSLKTDLHSA IQDVKTLESS 1930 1940 1950 1960 1970 1980 AISLDGTLTK AQCHLKSASP EERTSCRATT DQLSLEVERI QNLLGTKQSE ADALVALKEA 1990 2000 2010 2020 2030 2040 FREQKEELLR SIEDIEERMD RERLKVPTRQ ALQHRLRVFN QLEDELNSHE HELCWLKDKA 2050 2060 2070 2080 2090 2100 KQIAQKDVAF APEVDREING LEATWDDTRR QIHENQGQCC GLIDLVREYQ SLKSTVCNVL 2110 2120 2130 2140 2150 2160 EDASNVVVMR ATIKDQGDLK WAFSKHETSR NEMNSKQKEL DSFTSKGKHL LSELKKIHSG 2170 2180 2190 2200 2210 2220 DFSLVKTDME STLDKWLDVS ERIEENMDML RVSLSIWDDV LSRKDEIEGW SNSSLPKLAE 2230 2240 2250 2260 2270 2280 NISNLNNSLR AEELLKELES EVKIKALKLE DLHSKINNLK ELTKNPETPT ELQFIEADLR 2290 2300 2310 2320 2330 2340 QKLEHAKEIT EEARGTLKDF TAQRTQVERF VKDITAWLIN VEESLTRCAQ TETCEGLKKA 2350 2360 2370 2380 2390 2400 KDIRKELQSQ QNSITSTQEE LNSLCRKHHS VELESLGRAM TGLIKKHEAT SQLCSQTQAR 2410 2420 2430 2440 2450 2460 IQDSLEKHFS GSMKEFQEWF LGAKAAARES SNLTGDSQIL EARLHNLQGV LDSLSDGQSK 2470 2480 2490 2500 2510 2520 LDVVTQEGQT LYAHLPKQIV SSIQEQITKA NEEFQAFLKQ CLKEKQALQD CVSELGSFED 2530 2540 2550 2560 2570 2580 QHRKLNLWIH EMEERLKTEN LGESKHHISE KKNEVRKVEM FLGELLAARE SLDKLSQRGQ 2590 2600 2610 2620 2630 2640 LLSEESHSAG KGGCRSTQLL TSYQSLLRVT KEKLRSCQLA LKEHEALEEA TQSMWARVKD 2650 2660 2670 2680 2690 2700 VQDRLACAES TLGNKETLEG RLSQIQDILL MKGEGEVKLN LAIGKGDQAL RSSNKEGQQA 2710 2720 2730 2740 2750 2760 IQDQLEMLKK AWAEAMNSAV HAQSTLESVI DQWNDYLEKK SQLEQWMESV DQRLEHPLQL 2770 2780 2790 2800 2810 2820 QPGLKEKFSL LDHFQSIVSE AEDHTGALQQ LAAKSRELYQ KTQDESFKEA GQEELRTQFQ 2830 2840 2850 2860 2870 2880 DIMTVAKEKM RTVEDLVKDH LMYLDAVQEF ADWLHSAKEE LHRWSDTSGD PSATQKKLLK 2890 2900 2910 2920 2930 2940 IKELIDSREI GAGRLSRVES LAPAVKQNTA ASGCELLNSE MQALRADWRQ WEDCLFQTQS 2950 2960 2970 2980 2990 3000 SLESLVSEMA LSEQEFFGQV TQLEQALEQF CTLLKTWAQQ LTLLEGKNSD EEILECWHKG 3010 3020 3030 3040 3050 3060 REILDALQKA EPMTEDLKSQ LNELCRFSRD LSPYSEKVSG LIKEYNCLCL QASKGCQNKE 3070 3080 3090 3100 3110 3120 QILQERFQKA SRGFQQWLVN AKITTAKCFD LPQNLSEVSS SLQKIQEFLS ESENGQHKLN 3130 3140 3150 3160 3170 3180 TMLFKGELLS SLLTEEKAQA VQAKVLTAKE EWKSFHANLH QKESALENLK IQMKDFEVSA 3190 3200 3210 3220 3230 3240 ELVQNWLSKT ERLVQESSNR LYDLPAKRRE QQKLQSVLEE IQCYEPQLHR LKEKARQLWE 3250 3260 3270 3280 3290 3300 GQAASKSFVH RVSQLSSQYL ALSNVTKEKV SRLDRIIAEH NRFSQGVKEL QDWMSDAVHM 3310 3320 3330 3340 3350 3360 LDSYCLPTSD KSVLDSRMLK LEALLSVRQE KEIQMKMVVT RGEYVLQSTS LEGSAAVQQQ 3370 3380 3390 3400 3410 3420 LQAVKDMWES LLSAAIRCKS QLEGALSKWT SYQDDVRQFS SWMDSVEVSL TESEKQHTEL 3430 3440 3450 3460 3470 3480 REKITALGKA KLLNEEVLSH SSLLETIEVK RAAMTEHYVT QLELQDLQER HQALKEKAKE 3490 3500 3510 3520 3530 3540 AVTKLEKLVR LHQEYQRDLK AFESWLEQEQ EKLDRCSVHE GDTNAHETML RDLQELQVRC 3550 3560 3570 3580 3590 3600 AEGQALLNSV LHTREDVIPS GLPQAEDRVL ESLRQDWQVY QHRLAEARMQ LNNVVNKLRL 3610 3620 3630 3640 3650 3660 MEQKFQQADE WLKRMEEKIN FRSECQSSRS DKEIQLLQLK KWHEDLSAHR DEVEEVGTRA 3670 3680 3690 3700 3710 3720 QGILDETHIS SRMGCQATQL TSRYQALLLQ VLEQIKFFEE ELQCLEETES SLSSYSDWYG 3730 3740 3750 3760 3770 3780 STHKNFKNVA TKIDKVDESM MGKKLKTLEV LLKDMEKGHS LLKSAREKGE RAMKFLAEHE 3790 3800 3810 3820 3830 3840 AEALRKEIHT YMEQLKNLTS TVRKECMSLE KGLHLAKEFS DKYKVLAQWM AEYQEILCTP 3850 3860 3870 3880 3890 3900 EEPKMELYEK KAQLSKYKSL QQMVLSHEPS VTSVQEKSEA LLELVQDQSL KDKIQKLQSD 3910 3920 3930 3940 3950 3960 FQDLCSRAKE RVFSLEAKVK DHEDYNTELQ EVEKWLLQMS GRLVAPDLLE MSSLETITQQ 3970 3980 3990 4000 4010 4020 LAHHKAMMEE IAGFEDRLDN LKAKGDTLIG QCPEHLQAKQ KQTVQAHLQG TKDSYSAICS 4030 4040 4050 4060 4070 4080 TAQRVYRSLE YELQKHVSSQ DTLQQCQAWI SAVQPDLKPS PQPPLSRAEA VKQVKHFRAL 4090 4100 4110 4120 4130 4140 QEQARTYLDL LCSMCDLSNS SVKNTAKDIQ QTEQLIEQRL VQAQNLTQGW EEIKSLKAEL 4150 4160 4170 4180 4190 4200 WIYLQDADQQ LQNMKRRHTE LEINIAQNMV MQVKDFIKQL QCKQVSVSTI VEKVDKLTKN 4210 4220 4230 4240 4250 4260 QESPEHKEIT HLNDQWQDLC LQSDKLCAQR EQDLQRTSSY HDHMRVVEAF LEKFTTEWDS 4270 4280 4290 4300 4310 4320 LARSNAESTA IHLEALKKLA LALQEEMYAI DDLKDCKQKL IEQLGLDDRE LVREQTSHLE 4330 4340 4350 4360 4370 4380 QRWFQLQDLV KRKIQVSVTN LEELNVIQSR FQELMEWAEE QQPNIVEALK QSPPPGMAQH 4390 4400 4410 4420 4430 4440 LLMDHLAICS ELEAKQVLLK SLMKDADRVM ADLGLNERKV IQKALSEAQK HVSCLSDLVG 4450 4460 4470 4480 4490 4500 QRRKYLNKAL SEKTQFLMAV FQATSQIQQH ERKIVFREYI CLLPDDVSKQ VKTCKTAQAS 4510 4520 4530 4540 4550 4560 LKTYQNEVTG LCAQGRELMK GITKQEQEEV LGKLQELQTV YDTVLQKCSH RLQELEKSLV 4570 4580 4590 4600 4610 4620 SRKHFKEDFD KACHWLKQAD IVTFPEINLM NEKTELHAQL DKYQSILEQS PEYENLLLTL 4630 4640 4650 4660 4670 4680 QTTGQAMLPS LNEVDHSYLS EKLSALPQQF NVIVALAKDK FYKTQEAILA RKEYTSLIEL 4690 4700 4710 4720 4730 4740 TTQSLGDLED QFLKMRKMPS DLIVEESVSL QQSCSALLGE VVALGEAVNE LNQKKESFRS 4750 4760 4770 4780 4790 4800 TGQPWQPEKM LQLATLYHRL KRQAEQRVSF LEDTTSVYKE HAQMCRQLES QLEVVKREQA 4810 4820 4830 4840 4850 4860 KVNEETLPAE EKLKVYHSLA GSLQDSGILL KRVATHLEDL SPHLDPTAYE KAKSQVQSWQ 4870 4880 4890 4900 4910 4920 EELKQMTSDV GELVTECESR MVQSIDFQTE MSRSLDWLRR VKAELSGPVC LDLSLQDIQE 4930 4940 4950 4960 4970 4980 EIRKIQIHQE EVLSSLRIMS ALSHKEQEKF TKAKELISAD LEHTLAELQE LDGDVQEALR 4990 5000 5010 5020 5030 5040 TRQATLTEIY SRCQRYYQVF QAANDWLDDA QEMLQLAGNG LDVESAEENL RSHMEFFKTE 5050 5060 5070 5080 5090 5100 GQFHSNMEEL RGLVARLDPL IKATGKEELA QKMASLEKRS QGIIQESHTQ RDLLQRCMVQ 5110 5120 5130 5140 5150 5160 WQEYQKAREG VIELMNDAEK KLSEFAVLKT SSIHEAEEKL SKHKALVSVV DSFHEKIVAL 5170 5180 5190 5200 5210 5220 EEKASQLEQT GNDTSKATLS RSMTTVWQRW TRLRAVAQDQ EKILEDAVDE WKRLSAKVKE 5230 5240 5250 5260 5270 5280 TTEVINQLQG RLPGSSTEKA SKAELMTLLE SHDTYLMDLE SQQLTLGVLQ QRALSMLQDR 5290 5300 5310 5320 5330 5340 AFPGTEEEVP ILRAITALQD QCLNMQEKVK NHGKLVKQEL QEREAVETRI NSVKSWVQET 5350 5360 5370 5380 5390 5400 KDYLGNPTIE IDTQLEELKR LLAEATSHQE SIEKIAEEQK NKYLGLYTVL PSEISLQLAE 5410 5420 5430 5440 5450 5460 VALDLKIHDQ IQEKVQEIEE GKAMSQEFSC KIQKVTKDLT TILTKLKAKT DDLVHAKAEH 5470 5480 5490 5500 5510 5520 KMLGEELDGC NSKLMELDAA IQTFSERHSQ LGQPLAKKIG KLTELHQQTI RQAENRLSKL 5530 5540 5550 5560 5570 5580 NQALSHMEEY NEMLETVRKW IEKAKVLVHG NIAWNSASQL QEQYILHQTL LEESGEIDSD 5590 5600 5610 5620 5630 5640 LEAMAEKVQH LANVYCTGKL SQQVTQFGRE MEELRQAIRV RLRNLQDAAK DMKKFEGELR 5650 5660 5670 5680 5690 5700 NLQVALEQAQ TILTSPEVGR RSLKEQLCHR QHLLSEMESL KPKMQAVQLC QSALRIPEDV 5710 5720 5730 5740 5750 5760 VASLPLCHAA LRLQEEASQL QHTAIQQCNI MQAKKHSLIF PPKEAVVQYE QYKQEMKHLQ 5770 5780 5790 5800 5810 5820 QLIEEAHREI EDKPVATSNI QELQAQISLH EELAQKIKGY QEQIDSLNSK CKMLTMKAKH 5830 5840 5850 5860 5870 5880 ATMLLTVTEV EGLAEGTEDL DRELHPTPSA HPSVVMMTAG RCHTLLSPVT EESGEEGTNS 5890 5900 5910 5920 5930 5940 EISSPPACRS PSPVANTEAA VNQDIAYYQA LSAEGLQTDA ARIPPSAAVS QELYEPGLEP 5950 5960 5970 5980 5990 6000 SATAKLGDLQ RSWETLKNVI SEKQRTLYEV LERQQKYQDS LQSISTKMEA MEMKLGESLE 6010 6020 6030 6040 6050 6060 PSRSPESQMA EHQALMDEVQ MLQDEINGLQ VSLAEELVAE SQESDPAEQL ALQSTLTVLA 6070 6080 6090 6100 6110 6120 ERMSTIRMKA AGKRQLLEEK LSDQLEEQRQ EQALQRYRCE ADELDHWLLN TKATLDVALG 6130 6140 6150 6160 6170 6180 TSQEPMDMDA QLVDCQNMLV EIEQKVVALS QLSVHNENLL LEGKAHTKEE AEQLAVKLRL 6190 6200 6210 6220 6230 6240 LKGSLGELQR ALHDRQLDMQ GVTQEKEEND VDFTDTQSPG VQEWLAQART TRTHQRQSSL 6250 6260 6270 6280 6290 6300 QQQKEFEQEL AEQKSLLRSV ASRGEEILTQ HSTAEGSGGL GEKPDVLSQE LGIAEDQMRV 6310 6320 6330 6340 6350 6360 KWESLHQEFS AKQKLLQNIL EQEQEQVLYS SPNRLLSGVL PFRGEAQTQD KTSVTSLLDG 6370 6380 6390 6400 6410 6420 LSQAFGEASS QSGGTDRQSI HLEQKLYDGV SATSTWLNDV EERLFVATAP LPEETEACLF 6430 6440 6450 6460 6470 6480 NQEALAKDIK EMSEEMDKNK NLFSQAFPED SDNRDVIEDT LGCLLGRLSL LDSVVDQRCH 6490 6500 6510 6520 6530 6540 QMKERLQQIL RFQNDLKVLF TSLADSKYII LQKLANVFEQ PIVEQMQAIQ QAEEGLRDLE 6550 6560 6570 6580 6590 6600 GGISELKRWA DKLQVEQSAV QELSKLQDMY DELLMTVSSR RSSLHQNLAL KSQYDKALQD 6610 6620 6630 6640 6650 6660 LVDLLDTGQE KMTGDQKIIV CSKEEIQQLL GKHKEYFQGL ESHMILTEIL FRKIVGFAAV 6670 6680 6690 6700 6710 6720 KETQFHTDCM AQASAVLKQA HKRGVELEYI LEMWSHLDEN RQELSRQLEV IENSIPSVGL 6730 6740 6750 6760 6770 6780 VEESEDRLVE RTNLYQHLKS SLNEYQPKLY QALDDGKRLL MSVSCSELES QLNQLGEHWL 6790 6800 6810 6820 6830 6840 SNTNKVSKEL HRLETILKHW TRYQSEAAAL NHWLQCAKDR LAFWTQQSVT VPQELEMVRD 6850 6860 6870 6880 6890 6900 HLSAFLEFSK EVDAKSALKS SVTSTGNQLL RLKKVDTAAL RAELSRMDSQ WTDLLTGIPV 6910 6920 6930 6940 6950 6960 VQEKLHQLQM DKLPSRHAIS EVMSWISLME SVILKDEEDI RNAIGYKAIH EYLQKYKGFK 6970 6980 6990 7000 7010 7020 IDLNCKQLTA DFVNQSVLQI SSQDVESKRS DKTDFAEQLG AMNKSWQLLQ GRVGEKIQML 7030 7040 7050 7060 7070 7080 EGLLESWSEY ENSVQSLKAW FANQERKLKE QHLLGDRNSV ENALKDCQEL EDLIKAKEKE 7090 7100 7110 7120 7130 7140 VEKIEQNGLA LIQNKREEVS GSVMSTLQEL RQTWISLDRT VEQLKIQLTS ALGQWSNHKA 7150 7160 7170 7180 7190 7200 ACDEINGHLM EARYSLSRFR LLTGSSEAVQ VQVDNLQNLH DELEKQEGGL QKFGSITNQL 7210 7220 7230 7240 7250 7260 LKECHPPVAE TLSSTLQEVN MRWNNLLEEI AEQLHSSKAL LQLWQRYKDY SKQCASAIQR 7270 7280 7290 7300 7310 7320 QEEQTSVLLK AATNKDIADD EVTKWIQDCN DLLKGLETVK DSLFILRELG EQLGQQVDVS 7330 7340 7350 7360 7370 7380 AAAAIQCEQL CFSQRLGALE QALCKQQAVL QAGVVDYETF AKSLEALEVW MVEAEGILQG 7390 7400 7410 7420 7430 7440 QDPTHSSDLS TIQERMEELK GQMLKFSSLA PDLDRLNELG YRLPLNDKEI KRMQNLNRHW 7450 7460 7470 7480 7490 7500 SLTSSQTTER FSKLQSFLLQ HQTFLEKCET WMEFLVQTEH KLAVEISGNY QHLLEQQRAH 7510 7520 7530 7540 7550 7560 ELFQAEMFSR QQILHSIIVD GQNLLEQGQV DDREEFSLKL TLLSNQWQGV IRRAQQRRGI 7570 7580 7590 7600 7610 7620 IDSQIRQWQR YREMAEKLRK WLAEVSHLPL SGLGNIPVPL QQVRMLFDEV QFKEKVFLRQ 7630 7640 7650 7660 7670 7680 QGSYILTVEA GKQLLLSADS GAEAALQAEL TDIQEKWKAA SMHLEEQKKK LAFLLKDWEK 7690 7700 7710 7720 7730 7740 CERGIANSLE KLRMFKKRLS QPLPDHHEEL HAEQMRCKEL ENAVGRWTDD LTELMLVRDA 7750 7760 7770 7780 7790 7800 LAVYLSAEDI SMLKERVELL QRQWEELCHQ VSLRRQQVSE RLNEWAVFSE KNKELCEWLT 7810 7820 7830 7840 7850 7860 QMESKVSQNG DILIEEMIEK LKKDYQEEIA VAQENKIQLQ EMGERLAKAS HESKASEIQY 7870 7880 7890 7900 7910 7920 KLSRVKDRWQ HLLDLMAARV KKLKETLVAV QQLDKNMGSL RTWLAHMESE LAKPIVYDSC 7930 7940 7950 7960 7970 7980 NSEEIQRKLN EQQELQRDIE KHSTGVASVL NLCEVLLHDC DACATDAECD SIQQATRNLD 7990 8000 8010 8020 8030 8040 RRWRNICAMS MERRLKIEET WRLWQKFLDD YSRFEDWLEV SERTAAFPSS SGVLYTVAKE 8050 8060 8070 8080 8090 8100 ELKKFEAFQR QVHESLTQLE LINKQYRRLA RENRTDSACS LRQMVHGGNQ RWDDLQKRVT 8110 8120 8130 8140 8150 8160 SILRRLKHFI SQREEFETAR DSILVWLTEM DLQLTNIEHF SECDVQAKIK QLKAFQQEIS 8170 8180 8190 8200 8210 8220 LNHNKIEQII AQGEQLIEKS EPLDAAVIEE ELDELRRYCQ EVFGRVERYH KKLIRLPLPD 8230 8240 8250 8260 8270 8280 DHDLSDRELD LEDSTALSDL RWQDPSADGM PSPQPSSNPS LSLPQPLRSE RSGRDTPASV 8290 8300 8310 8320 8330 8340 DSIPLEWDHD YDLSRDLESA SRTLPSEDEE GEEDKEFYLR GAVGLSGDPS SLESQMRQLD 8350 8360 8370 8380 8390 8400 KALDDSRFQI QQTANILRSK TPTGPDLDTS YKGYMKLLGE CSGSIDSVRR LEHKLAEEES 8410 8420 8430 8440 8450 8460 FPGFVNLNST ETQTAGVIDR WELLQAQAMS KELRMKQNLQ KWQQFNSDLN NIWAWLGETE 8470 8480 8490 8500 8510 8520 EELDRLQHLA LSTDIHTIES HIKKLKELQK AVDHRKAIIL SINLCSSEFT QADSKESHDL 8530 8540 8550 8560 8570 8580 QDRLSQMNGR WDRVCSLLED WRGLLQDALM QCQEFHEMSH ALLLMLENID RRKNEIVPID 8590 8600 8610 8620 8630 8640 STLDPETLQD HHKQLMQIKQ ELLKSQLRVA SLQDMSRQLL VNAEGSDCLE AKEKVHVIGN 8650 8660 8670 8680 8690 8700 RLKLLLKEVS HHIKDLEKLL DMSSSQQDLS SWSSADELDT SGSVSPTSGR STPNRQKSPR 8710 8720 8730 8740 8750 8760 GKCSLSQPGP SVSSPKSRST RDGSDSSRSD PRPERVGRAF LFRILRAALP FQLLLLLLIG 8770 8780 8790 LTCLVPMSEK DYSCALSNNF ARSFHPMLRY TNGPPPL
	Isoform 5 (Enaptin-165) [UniParc]. Checksum: 0D4C7DA8ADAE612F	FASTA	1,431	165,244
	10 20 30 40 50 60 MATSRASSRS HRDITNVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV DDLFEDMKDG 70 80 90 100 110 120 IKLLALLEVL SGQKLPCEQG HRVKRIHAVA NIGTALKFLE GRKSMYRGSP IKLVNINATD 130 140 150 160 170 180 IADGRPSIVL GLMWTIILYF QIEELTSNLP QLQSLSSSAS SVDSMVSTET ASPPSKRKVA 190 200 210 220 230 240 AKIQGNAKKT LLKWVQHTAG KQMGIEVKDF GKSWRTGLAF HSVIHAIQPE LVDLEKVKTR 250 260 270 280 290 300 SNRENLEDAF TIAETQLGIP RLLDPEDVDV DKPDEKSIMT YVAQFLTQYP DIHGAGCDGQ 310 320 330 340 350 360 EDDRDDRLIL KETKVWIEQF ERDFTRAQMT ESSLQDKYQA FKHFRVQYEM KRKQVEHIIQ 370 380 390 400 410 420 PLQRDGKLTL DQALVKQCWE RVSSRLFDWH IQLDKSLPAP LGTIGAWLYR AEVALREEIT 430 440 450 460 470 480 IQQVHEETAN TIQRKLEQHK DLLQNTDAHK RAFHEIYQTR SVNGIPMPPD QLEDMAERFH 490 500 510 520 530 540 FVSSTSELHL MKMEFLELKY RLLSLLVLAE SKLKSWIIKY GRRESVELLL QSYISFIENS 550 560 570 580 590 600 KFFEQYEVTY QILKQTADIY VKAEGSVEEA ENVMKFMSEA TAQWRNLSVE VRSVRSMLEE 610 620 630 640 650 660 VISNWDRYGD TVASLQAWLE DAEKMLSQSE HAKKDFFRNL PHWIQQHTAM NDAGNFLIET 670 680 690 700 710 720 CDEIVSRDLK QQLLLLNGRW RELFMEVKQY ARADEMDRMK KEYIDVTTTL FGFATEAHRK 730 740 750 760 770 780 LSEPLEVSFI NVKLLIQDLE DLEKRVPVMD AQYKMIAKKA HLFAKESPQE EANEMLTTMS 790 800 810 820 830 840 KLKEQLSKVK ECCSPLLYEA QQLTVPLEEL ETQITSFYDS LGKINEILSV LEQEAQSSTL 850 860 870 880 890 900 FKQKHQELLA SQENCKKSLT LIEKGSQSVQ KLVTSSQARK PWDHTKLQKQ IADVHHAFQS 910 920 930 940 950 960 MIKKTGDWKK HVEANSRLMK KFEESRAELE KVLRVAQEGL EEKGDPEELL RRHTEFFSQL 970 980 990 1000 1010 1020 DQRVLNAFLK ACDELTDILP EQEQQGLQEA VRKLHKQWKD LQGEAPYHLL HLKIAVEKDR 1030 1040 1050 1060 1070 1080 FSAAVEECRA ELEQETKLAP QEGSEKIIKE HRVFFSDKGP HHLCEKRLQL IEELCGKLPV 1090 1100 1110 1120 1130 1140 QDPVRDTCGA CHTALKELKA SIDNTYTMLV DDPDKWKDYT SRFSEFSSWV SAKKACLKKI 1150 1160 1170 1180 1190 1200 KDEPIDTGNH DEVKHMVDEI RNDITKKGES LSWLKSRLKY LIDISSENEA QKRGDELAEL 1210 1220 1230 1240 1250 1260 SSSFKALVAL LSEVEKLLSN FGECVQYKEI VKSSLEGLIS GPQESKEEAE MILDSKNLLE 1270 1280 1290 1300 1310 1320 AQQLLLHHQQ KTKMISAKKR DLQEQMEQAQ QGGQAGPGQE ELRKLESTLT GLEQSRERQE 1330 1340 1350 1360 1370 1380 RRIQVSLRKW ERFETNKETV VRYLFQTGSS HERFLSFSSL ESLSSELEQT KEFSKRTESI 1390 1400 1410 1420 1430 ATQAENLVKE AAELPLGPRN KRVLQRQAKS IKEQVTTLED TLEEEYVLHH F

References

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[4]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[5]	"Nuclear membrane proteins with potential disease links found by subtractive proteomics." Schirmer E.C., Florens L., Guan T., Yates J.R. III, Gerace L. Science 301:1380-1382(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
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[7]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8227, MASS SPECTROMETRY. Tissue: Melanoma.
[8]	"Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton." Dawe H.R., Adams M., Wheway G., Szymanska K., Logan C.V., Noegel A.A., Gull K., Johnson C.A. J. Cell Sci. 122:2716-2726(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[9]	"SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice." Lei K., Zhang X., Ding X., Guo X., Chen M., Zhu B., Xu T., Zhuang Y., Xu R., Han M. Proc. Natl. Acad. Sci. U.S.A. 106:10207-10212(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[10]	"Cytoskeletal interactions at the nuclear envelope mediated by nesprins." Taranum S., Sur I., Muller R., Lu W., Rashmi R.N., Munck M., Neumann S., Karakesisoglou I., Noegel A.A. Int. J. Cell Biol. 2012:736524-736524(2012) [PubMed] [Europe PMC] [Abstract] Cited for: SELF-ASSOCIATION, INTERACTION WITH SYNE3, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF281869 mRNA. Translation: AAG24392.1. AF281870 mRNA. Translation: AAG24393.1. Frameshift. AF535143 mRNA. Translation: AAN03487.1. AK036828 mRNA. Translation: BAC29595.1. AC156392 Genomic DNA. No translation available. AC156393 Genomic DNA. No translation available. AC157020 Genomic DNA. No translation available. AC159748 Genomic DNA. No translation available. AC161829 Genomic DNA. No translation available. AC162381 Genomic DNA. No translation available. AC162385 Genomic DNA. No translation available.
IPI	IPI00403993. IPI00461474. IPI00473373. IPI00816892. IPI00890038.
RefSeq	NP_001073154.1. NM_001079686.1.
UniGene	Mm.331626.
3D structure databases
ProteinModelPortal	Q6ZWR6.
SMR	Q6ZWR6. Positions 23-283.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000051825.
PTM databases
PhosphoSite	Q6ZWR6.
Proteomic databases
PaxDb	Q6ZWR6.
PRIDE	Q6ZWR6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000041639; ENSMUSP00000039440; ENSMUSG00000096054. ENSMUST00000095899; ENSMUSP00000093587; ENSMUSG00000019769.
GeneID	64009.
KEGG	mmu:64009.
UCSC	uc007egn.1. mouse. uc007egt.1. mouse.
Organism-specific databases
CTD	23345.
MGI	MGI:1927152. Syne1.
Phylogenomic databases
eggNOG	COG5069.
GeneTree	ENSGT00690000102001.
HOGENOM	HOG000120125.
HOVERGEN	HBG106534.
InParanoid	Q9ERT7.
OMA	DIQSIEL.
OrthoDB	EOG4ZKJK9.
Enzyme and pathway databases
Reactome	REACT_118161. Cell Cycle. REACT_120463. Meiosis. REACT_75800. Meiotic Synapsis (mouse).
Gene expression databases
ArrayExpress	Q6ZWR6.
Bgee	Q6ZWR6.
Genevestigator	Q6ZWR6.
Family and domain databases
Gene3D	1.10.418.10. 2 hits.
InterPro	IPR001589. Actinin_actin-bd_CS. IPR001715. CH-domain. IPR012315. KASH. IPR018159. Spectrin/alpha-actinin. IPR002017. Spectrin_repeat. [Graphical view]
Pfam	PF00307. CH. 2 hits. PF10541. KASH. 1 hit. PF00435. Spectrin. 10 hits. [Graphical view]
SMART	SM00033. CH. 2 hits. SM00150. SPEC. 42 hits. [Graphical view]
SUPFAM	SSF47576. Calponin-homology. 1 hit.
PROSITE	PS00019. ACTININ_1. 1 hit. PS00020. ACTININ_2. 1 hit. PS50021. CH. 2 hits. PS51049. KASH. 1 hit. PS50005. TPR. False negative. PS50293. TPR_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SYNE1. mouse.
NextBio	319851.
SOURCE	Search...

Entry information

Entry name

SYNE1_MOUSE

Accession

Primary (citable) accession number: Q6ZWR6
Secondary accession number(s): Q8K3T7, Q9ERT7, Q9ERT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 23, 2010
Last sequence update:	March 23, 2010
Last modified:	May 1, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program