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UniProtKB - Q6ZWQ9 (Q6ZWQ9_MOUSE)

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Protein
Submitted name:

MCG5400

Gene

Myl12a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi42 – 53PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • glutamate receptor binding Source: MGI
Complete GO annotation...

GO - Biological processi

  • protein targeting to plasma membrane Source: MGI
  • regulation of cell shape Source: MGI
Complete GO annotation...

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-3928664. Ephrin signaling.
R-MMU-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Submitted name:
MCG5400Imported
Submitted name:
Myosin, light chain 12A, regulatory, non-sarcomericImported
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Myl12aImported
Synonyms:2900073G15RikImported
ORF Names:mCG_5400Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914518. Myl12a.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • myosin II complex Source: MGI
  • stress fiber Source: MGI
  • Z disc Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

TopDownProteomicsiQ6ZWQ9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024048.

Interactioni

GO - Molecular functioni

  • glutamate receptor binding Source: MGI
Complete GO annotation...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024846.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 64EF-handInterPro annotationAdd BLAST36
Domaini98 – 133EF-handInterPro annotationAdd BLAST36
Domaini134 – 169EF-handInterPro annotationAdd BLAST36

Phylogenomic databases

eggNOGiKOG0031. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000119196.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
KOiK12757.
OMAiGFVDHED.
OrthoDBiEOG091G0QF6.
TreeFamiTF314218.

Family and domain databases

CDDicd00051. EFh. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q6ZWQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKRAKTKT TKKRPQRATS NVFAMFDQSQ IQEFKEAFNM IDQNRDGFID 
        60         70         80         90        100
KEDLHDMLAS MGKNPTDEYL DAMMNEAPGP INFTMFLTMF GEKLNGTDPE 
       110        120        130        140        150
DVIRNAFACF DEEAIGTIQE DYLRELLTTM GDRFTDEEVD ELYREAPIDK 
       160        170 
KGNFNYIEFT RILKHGAKDK DD
Length:172
Mass (Da):19,895
Last modified:July 5, 2004 - v1
Checksum:i50DB8144B916141A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154187 Genomic DNA. No translation available.
BC010265 mRNA. Translation: AAH10265.1.
BC029180 mRNA. Translation: AAH29180.1.
AK028020 mRNA. Translation: BAC25702.1.
AK045160 mRNA. Translation: BAC32243.1.
AK151265 mRNA. Translation: BAE30252.1.
AK159151 mRNA. Translation: BAE34858.1.
AK167553 mRNA. Translation: BAE39618.1.
AK168016 mRNA. Translation: BAE40003.1.
CH466537 Genomic DNA. Translation: EDL38371.1.
RefSeqiNP_080340.2. NM_026064.2.
UniGeneiMm.489605.

Genome annotation databases

EnsembliENSMUST00000024846; ENSMUSP00000024846; ENSMUSG00000024048.
ENSMUST00000123686; ENSMUSP00000116398; ENSMUSG00000024048.
ENSMUST00000148960; ENSMUSP00000123412; ENSMUSG00000024048.
GeneIDi67268.
KEGGimmu:67268.
UCSCiuc008dlw.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ6ZWQ9_MOUSE
AccessioniPrimary (citable) accession number: Q6ZWQ9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 5, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported