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Protein

Nesprin-2

Gene

Syne2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. Specifically, Syne2 and Sun2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for centrosome migration to the apical cell surface during early ciliogenesis.3 Publications

GO - Molecular functioni

  • actin binding Source: UniProtKB

GO - Biological processi

  • centrosome localization Source: UniProtKB
  • cytoskeletal anchoring at nuclear membrane Source: MGI
  • establishment or maintenance of cell polarity Source: MGI
  • fibroblast migration Source: MGI
  • nuclear envelope organization Source: MGI
  • nuclear migration Source: MGI
  • nuclear migration along microfilament Source: UniProtKB
  • positive regulation of cell migration Source: UniProtKB
  • protein localization to nucleus Source: MGI
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-MMU-1221632. Meiotic synapsis.
R-MMU-1221633. Meiotic Synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
Nesprin-2
Alternative name(s):
Nuclear envelope spectrin repeat protein 2
Nucleus and actin connecting element protein
Short name:
Protein NUANCE
Synaptic nuclear envelope protein 2
Short name:
Syne-2
Gene namesi
Name:Syne2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2449316. Syne2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 68236823CytoplasmicPROSITE-ProRule annotationAdd
BLAST
Transmembranei6824 – 684421Helical; Anchor for type IV membrane proteinPROSITE-ProRule annotationAdd
BLAST
Topological domaini6845 – 687430Perinuclear spacePROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Nucleus, Sarcoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi128 – 1281I → A: Impairs interaction with F-actin; when assocoated with A-131. 1 Publication
Mutagenesisi131 – 1311I → A: Impairs interaction with F-actin; when assocoated with A-128. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 68746874Nesprin-2PRO_0000392210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4096 – 40961PhosphoserineCombined sources
Modified residuei5772 – 57721PhosphoserineBy similarity
Modified residuei6348 – 63481PhosphoserineBy similarity
Modified residuei6371 – 63711PhosphoserineCombined sources
Modified residuei6400 – 64001PhosphoserineCombined sources
Modified residuei6417 – 64171PhosphoserineCombined sources
Modified residuei6418 – 64181PhosphoserineCombined sources
Modified residuei6419 – 64191PhosphoserineCombined sources
Modified residuei6448 – 64481PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZWQ0.
MaxQBiQ6ZWQ0.
PaxDbiQ6ZWQ0.
PRIDEiQ6ZWQ0.

PTM databases

iPTMnetiQ6ZWQ0.
PhosphoSiteiQ6ZWQ0.

Expressioni

Tissue specificityi

C-terminal isoforms are highly expressed in the brain, hert and skeletal muscle. Isoform 1 (Nesprin-2 Giant) is most prevalent in the brain, skin, kidney and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ6ZWQ0.
ExpressionAtlasiQ6ZWQ0. baseline and differential.
GenevisibleiQ6ZWQ0. MM.

Interactioni

Subunit structurei

Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN domain-containing proteins interact with A-type lamins of the nuclear lamina, while at the other end of the complex, nesprins interact with unique cytoskeletal components. Interacts with EMD, LMNA, MKS3 and F-actin via its N-terminal domain (By similarity). Interacts with TMEM67. Several isoforms form complexes within the nuclear envelope (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi235364. 4 interactions.
DIPiDIP-61049N.
STRINGi10090.ENSMUSP00000047697.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWQ0.
SMRiQ6ZWQ0. Positions 28-286, 5306-5355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 286286Actin-bindingAdd
BLAST
Domaini31 – 136106CH 1PROSITE-ProRule annotationAdd
BLAST
Domaini183 – 288106CH 2PROSITE-ProRule annotationAdd
BLAST
Repeati299 – 38082Spectrin 1Add
BLAST
Repeati381 – 47494Spectrin 2Add
BLAST
Repeati475 – 577103Spectrin 3Add
BLAST
Repeati578 – 680103Spectrin 4Add
BLAST
Repeati727 – 834108Spectrin 5Add
BLAST
Repeati835 – 92894Spectrin 6Add
BLAST
Repeati929 – 1030102Spectrin 7Add
BLAST
Repeati1120 – 121192Spectrin 8Add
BLAST
Repeati1262 – 132261Spectrin 9Add
BLAST
Repeati1323 – 140987Spectrin 10Add
BLAST
Repeati1410 – 1514105Spectrin 11Add
BLAST
Repeati1515 – 1626112Spectrin 12Add
BLAST
Repeati1627 – 1728102Spectrin 13Add
BLAST
Repeati1729 – 182092Spectrin 14Add
BLAST
Repeati1821 – 1928108Spectrin 15Add
BLAST
Repeati1929 – 202698Spectrin 16Add
BLAST
Repeati2027 – 212296Spectrin 17Add
BLAST
Repeati2123 – 2233111Spectrin 18Add
BLAST
Repeati2234 – 2350117Spectrin 19Add
BLAST
Repeati2422 – 250382Spectrin 20Add
BLAST
Repeati2504 – 2610107Spectrin 21Add
BLAST
Repeati2611 – 270797Spectrin 22Add
BLAST
Repeati2708 – 2821114Spectrin 23Add
BLAST
Repeati2822 – 2923102Spectrin 24Add
BLAST
Repeati2924 – 3027104Spectrin 25Add
BLAST
Repeati3028 – 3133106Spectrin 26Add
BLAST
Repeati3134 – 3239106Spectrin 27Add
BLAST
Repeati3240 – 3343104Spectrin 28Add
BLAST
Repeati3344 – 3456113Spectrin 29Add
BLAST
Repeati3457 – 3563107Spectrin 30Add
BLAST
Repeati3564 – 3669106Spectrin 31Add
BLAST
Repeati3670 – 376798Spectrin 32Add
BLAST
Repeati3768 – 3870103Spectrin 33Add
BLAST
Repeati3871 – 3976106Spectrin 34Add
BLAST
Repeati3977 – 407498Spectrin 35Add
BLAST
Repeati4218 – 4337120Spectrin 36Add
BLAST
Repeati4507 – 4626120Spectrin 37Add
BLAST
Repeati4627 – 471488Spectrin 38Add
BLAST
Repeati4715 – 4823109Spectrin 39Add
BLAST
Repeati4824 – 4929106Spectrin 40Add
BLAST
Repeati4930 – 5037108Spectrin 41Add
BLAST
Repeati5038 – 5150113Spectrin 42Add
BLAST
Repeati5151 – 5252102Spectrin 43Add
BLAST
Repeati5253 – 5377125Spectrin 44Add
BLAST
Repeati5378 – 547396Spectrin 45Add
BLAST
Repeati5474 – 5576103Spectrin 46Add
BLAST
Repeati5577 – 5691115Spectrin 47Add
BLAST
Repeati5692 – 578695Spectrin 48Add
BLAST
Repeati5787 – 5894108Spectrin 49Add
BLAST
Repeati5895 – 6004110Spectrin 50Add
BLAST
Repeati6005 – 6122118Spectrin 51Add
BLAST
Repeati6123 – 6230108Spectrin 52Add
BLAST
Repeati6231 – 6342112Spectrin 53Add
BLAST
Repeati6450 – 653485Spectrin 54Add
BLAST
Repeati6535 – 6650116Spectrin 55Add
BLAST
Repeati6651 – 6767117Spectrin 56Add
BLAST
Domaini6815 – 687460KASHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili299 – 67676469Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6790 – 67978Poly-Glu
Compositional biasi6826 – 683813Poly-LeuAdd
BLAST

Domaini

The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains.By similarity

Sequence similaritiesi

Belongs to the nesprin family.Curated
Contains 1 actin-binding domain.Curated
Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation
Contains 1 KASH domain.PROSITE-ProRule annotation
Contains 56 spectrin repeats.Curated

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0516. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.
HOGENOMiHOG000154474.
HOVERGENiHBG056327.
InParanoidiQ6ZWQ0.
KOiK19346.
OMAiCASEIHM.
PhylomeDBiQ6ZWQ0.
TreeFamiTF329280.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR012315. KASH.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
IPR030266. SYNE2.
[Graphical view]
PANTHERiPTHR11915:SF317. PTHR11915:SF317. 13 hits.
PfamiPF00307. CH. 2 hits.
PF10541. KASH. 1 hit.
PF00435. Spectrin. 2 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM01249. KASH. 1 hit.
SM00150. SPEC. 17 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS51049. KASH. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZWQ0-1) [UniParc]FASTAAdd to basket

Also known as: Nesprin-2 Giant, Nesp2G, NUANCE

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASPVLPTE DGEGFLGIDD LHFSLQAEQE DTQKKTFTCW INSQLAKHTP
60 70 80 90 100
PSVVSDLFAD IKKGHVLLDL LEVLSGQQLP RDKGSNTFQC RINIEHALTF
110 120 130 140 150
LKNRSIKLIN IHVADIVEGN PSIILGLIWT IILHFHIEKL AQTLSCDYNQ
160 170 180 190 200
PSPEVVSVAA SSPTSSPPTK KCSKAQAQAR WQWSAKKALL QWAQEQCARS
210 220 230 240 250
ESVNVTDFKS SWRNGMAFLA VIHALRPDLI DMDSMRHRSN KDNLKEAFRI
260 270 280 290 300
AEHELKIPKL LEPEDVDVVN PDEKSIMTYV AQFLKYSKDA PGPGDSTQAK
310 320 330 340 350
VRDALVWLTL QEKRFQKMLK DSASETYCNK YHSLLSFMES LNEEKESFID
360 370 380 390 400
VLSLKGRMGE LNEDESRLRQ GWTSLMHQVA AWRAQLDDAL PSPLKETEAW
410 420 430 440 450
LKDIEGVVQE GVPTSQSYSE ARTLIQGKLS SFKSLMGSFD YHSDVLMAFQ
460 470 480 490 500
SNAEKSLPAV PPVKLEEMTR RINNVLGKNF IPLLEFHDSK CSVLALLDEA
510 520 530 540 550
KAKLDVWNGT YESKESVEVL LEDWHKFTGE KKFLIQLDAS FQKCEEMYKN
560 570 580 590 600
SARECESIRE EYMMLEKNVH SCRQYIHNTK ATLQRALMSW ATFEEDLALL
610 620 630 640 650
KASFDLTKKE QIKEVPVETL LQWNTKHTSL NEVGSFLIGV SSREVAASIS
660 670 680 690 700
KELRRLNKRW RKFITKTPLL KLPLVKIQDQ PPGNSSGTSL SKESAMAAEP
710 720 730 740 750
GGSRGEDVKA AEKQEVEDEE SAGQLKVNEE VEGLIKQVTI WESQTKSILD
760 770 780 790 800
LLQHGDHADG SSADTLQHLI AKGSVYEELL ARTEDTLQMD VQSPSNLEPF
810 820 830 840 850
QNVLRAGLQA KIQEAKQGVQ ITMVELSAVL KNLSDEPLEL DLGLKVEEAQ
860 870 880 890 900
KELEVSILRA EQLLGQRERP GGFLLKYKEA LEILNTNSLA KYLRAVEELK
910 920 930 940 950
RTVPGGAKLQ LEEQSRVASA KWEPLRHEIS LYLQQLKIAI EEEKLRDNIA
960 970 980 990 1000
RLEKQINKEK KLIRRGRTRG LRKEHEACLS PESIKCQLEH HVGVLRVLCE
1010 1020 1030 1040 1050
ELTSPEDQQE LKRALRDYEQ KIARLLKCAS EIHTTLQSSQ GGALEERSAL
1060 1070 1080 1090 1100
ITTENGRRDA DGEVPLEIPD NQLSTEKAME PIKNFSQTSE LKPQQEESIM
1110 1120 1130 1140 1150
EKEGKDCSAS LSDLQERYDT QRGLLEQHLQ DSKSRVTSDF ASEQERSSAC
1160 1170 1180 1190 1200
LQSKLAELQV LLADTDAHWE KFEITSLNLR RLMSDAEKPV LNQERDLLKG
1210 1220 1230 1240 1250
NEQVLHGLLN TRMESLEMAL QIVLPLEKEC SLLCASDLPL CTVAVQDLHP
1260 1270 1280 1290 1300
VEIDGVYQNL RDIRDSIAKQ IRVCTSLEEP SNSVPRELHT LDQCAIQDIV
1310 1320 1330 1340 1350
LKCRLQLETM NQKVEMREDA LDALEGFLAS LRAAKLSAEL PADRPAPKAP
1360 1370 1380 1390 1400
EVLSEDILLM KEKAGPLDER LRTLGINIKD AEGGENTTCE RLVGALSVNL
1410 1420 1430 1440 1450
VAMDGQSKEE GPPEDKKLLE ACSSKNLELF KNIQDLQNQI SKIGLKDPTA
1460 1470 1480 1490 1500
PAVKHRKKSL LRLDKDLDGL EEEKVRIQKI AGSLPRFKDG SEKNVIQQCE
1510 1520 1530 1540 1550
DTAALWESTK ASVTESLEQC GSALELLRQY QNIKNNLTAL IQKEEGIISQ
1560 1570 1580 1590 1600
QASYMGKDNL KKKIAEIETV KEEFSDHLEV VDKINQICKN LQYHLNKMKT
1610 1620 1630 1640 1650
FEDPPFEKEA NAIVDRWLDI NEKTEEYGEN LGRALALWDK LFIIKNNIDE
1660 1670 1680 1690 1700
WTEQILGKAE SHELTEEDRG RLKEELKVLE EQSAEFSRRV ADIQSLLQSN
1710 1720 1730 1740 1750
EKPLELQVME SSVLSKMKDV KTHVAGGSNS YAPSGSTAEL REDLDQAKTQ
1760 1770 1780 1790 1800
MGMTESLLNA LSPSDSLEIF TKLEEIQQQI FQQKHSMTVL ENQIGCLTPE
1810 1820 1830 1840 1850
LSELKRQYAS VSNLFNTKKN ALQDHFATFL NEQCKNFNDW FSNVKTNLQE
1860 1870 1880 1890 1900
CFEPPETKLS LEQRLQKLSD FLTLGGGNSK IQQVETVLQH VKMLLPKAHV
1910 1920 1930 1940 1950
KELDSWLRSQ ELELENMESI CQARAGELNN SFQQLLRLED DCRSLSKWLT
1960 1970 1980 1990 2000
NQEENWGKME VSGERMDLFS QALTRKREQF ETVAQLSDSL KEHGLTEGEE
2010 2020 2030 2040 2050
TIKESTHLID RYQALWRQLH EIEEEDKLPA AEDQSFNDLA DDVIHWIKEI
2060 2070 2080 2090 2100
KESLMALNSS EGKMPLEERI QKIKEIIALK PEGDAKIQMV MRQAEHCEAP
2110 2120 2130 2140 2150
LAQETFTDLS NQWDSTLHLA NTYLSHQEKL VLEGEKYLQS KEDLRLMLTE
2160 2170 2180 2190 2200
LKKQQEAGFA LQPGLPEKQA QLKIYKKFLQ KAQDLTSLLE ELKSQGNYLL
2210 2220 2230 2240 2250
ECTKNPSFSE EPWLEVKHLH ESLLQQLQDS VQKLEGHVQE HSSYQVCLTD
2260 2270 2280 2290 2300
LSSTLDDISK EYFSLCDGSK DQIMAKERMQ KLQELESRLR FQGGALKKAS
2310 2320 2330 2340 2350
ALAKSIKQNT SSVGQKIIKD DIRSLKYKQK DLENRIESAK QETENGLNSI
2360 2370 2380 2390 2400
LKSKSSTEKH VKFSLPVEEM PATSEVPKPT RESAAVGESG GARETNTNSA
2410 2420 2430 2440 2450
VEMILSKQLS LNVQESMQNA QDEREVNELQ NQPLELDIML RNEQLKGMEE
2460 2470 2480 2490 2500
LSTHLEARRA AIELLEQSQH LNQTEEQALV LPAARPSVCH LGSLQQELHT
2510 2520 2530 2540 2550
LKKTKERQYG LLSGFQDQLV MAEASLNTSL AEVESLKIGS LDSATYLGKI
2560 2570 2580 2590 2600
KKFLGSVENQ QGSLSKLRTE WAHLSSLLAA ADQKLVESQM KHLEHGWELV
2610 2620 2630 2640 2650
EQLAHRKCFQ QATEHSELTC LLEKLQDLKV SLHQQQQRLT LSLNSPGQQA
2660 2670 2680 2690 2700
AIVDMVTPAA ELQAIKCEFS GLKWQAELHM KRLWGEKDKK TLEDAINNLN
2710 2720 2730 2740 2750
KQMEALEPLN REVENRIKKC ELQNRIKETL SWVKNTMAEL VVPIALLPDN
2760 2770 2780 2790 2800
ILSQIRKCKL IHDGILGNQQ AVELLVEEVR GITPSLAPCE GDGLNALLED
2810 2820 2830 2840 2850
LQSQHQALLL KSTERSQQLE LKLEEKSKLF AIIGKVQLTL EESETLMSPT
2860 2870 2880 2890 2900
GDRASTEAEL ERRLAILKAS QQQLQDTESA LSAHLQELTN AYKDANVFER
2910 2920 2930 2940 2950
LFLDDQLKNL KARTNRTQRF LQNNGSELKQ KMESYREFHD KAAVLQKEAE
2960 2970 2980 2990 3000
CILHGGLLPL RQELEQDAKE QLGNLRDKLA AIRGSLSQVL TSEEVFDTIG
3010 3020 3030 3040 3050
LSWDGSLLAR LQTQVLERER EVEGKIKQLD TFLIARDRHQ ASISKIRAVD
3060 3070 3080 3090 3100
LQIKKGAESL LKVPSMSPES TLLNAQTLIQ KIEKSKRLRD EIIRKLSKNE
3110 3120 3130 3140 3150
AFDDSFKESE MQRLKLCAEE NSRLQEALQN MLLELQPREM GEKEFREKLE
3160 3170 3180 3190 3200
NALHVLKQIQ SRLQQPLCVN LGVQHIQHEK ETWEAFGEQV EAEMCGLRAV
3210 3220 3230 3240 3250
RITEEQREEN DSGTGGMEAK LRDIEGLHME LSKSISLRAD VLNDAYDSAN
3260 3270 3280 3290 3300
RYDELVAGAL RIITSLEATL LSYRVDLHNP QKTLELAHLK QEELQSSVAD
3310 3320 3330 3340 3350
LRSLTETLGA ISSPEAKEQL RCTLEVLAAK NSALKAGLEA QEAEEERCLE
3360 3370 3380 3390 3400
NYKCFRKMKE EICSRLRKME MDLGQSIFPL PRSYKEALAR LEQSKALTSN
3410 3420 3430 3440 3450
LLSTKEDLVK LRQLLRHLRC RSTENDATCA LGVASALWEK WLSLLEAARE
3460 3470 3480 3490 3500
WQQWGGELKR EWKFISEEIE REAIILETLQ EDLPEISKTN AAPTEELWQL
3510 3520 3530 3540 3550
LDSLCQHQES VEKQQLLLAL LLQRVRSIQN IPEGTETGET IPALQEIGSM
3560 3570 3580 3590 3600
QERCDRLLHT TRKNKDLVQA EIQAQQSFLK EIKDVKRVFE QISTSFPNLA
3610 3620 3630 3640 3650
PEGHPERAEQ FEELRSILQK GKLSFENIME KLRIKYSEMY SIVPAEIGSQ
3660 3670 3680 3690 3700
VEECRSALED AEEKMSSEVS KSSPSSIMRR KIERINNGLH CVEKMLQQKS
3710 3720 3730 3740 3750
RNIEEAHEIQ KKIWDELDLW HSKLNELDSE VQDFVEQDPG QAQEWMDNLM
3760 3770 3780 3790 3800
APFQQHQQVS QRAESRTSQL NKATIKMEEY NDLLKSTEVW IEKTSCLLAN
3810 3820 3830 3840 3850
PACYDSSRTL SHRASTLQMA LEDSEQKHSL LHSIFTDLED LSIIFETDDL
3860 3870 3880 3890 3900
IQTIHELSDQ VAALQQQIME ALPHVQQVAD DVVAIESEVK AMEKKVAKIK
3910 3920 3930 3940 3950
AILLSKEIFD FPPEEHLKHG EVILENIHPM KKTIAEIMTY QVELRLPQTG
3960 3970 3980 3990 4000
TKPLPVFQRT SQLLQDVKLL ENVTQEQNEL LKVVIKQTAE CDEEIDSLKQ
4010 4020 4030 4040 4050
MLTNYSAEIS PEHVSQNQVA DLPSLQGEME RLEKQILNLN QKKEDLLVDL
4060 4070 4080 4090 4100
KTAVLNLHEH LKQEQQEVGD KPSAGASECT VAERDASERK LSRTNSMSFL
4110 4120 4130 4140 4150
PVVKEEAEES SVKSEDGRRR TEPPSASWSF LGKHSKDLEG DGASSSSSAT
4160 4170 4180 4190 4200
IVQDADGRIS TCDSSMVHII APDSGSTEEG PAPSPRLSQT DEGATPPIEA
4210 4220 4230 4240 4250
ALLDFPREQG AFESTVERSR PRPADILRVC KTQVAKLELW LQQANVAFEP
4260 4270 4280 4290 4300
ETVDADMQQV VEEELAGCQA MLTEIEYKVA SLLETCKDQG LGDCGTTQQE
4310 4320 4330 4340 4350
AEALSWKLKT VKCNLEKVQM VLQEKFSEDQ HPSTLKKPSE PHDVDQPAGL
4360 4370 4380 4390 4400
SELDSVLTER PQFSRQKDAP QPQILELKPS EQKDLIKFTE LNAKKTWLQG
4410 4420 4430 4440 4450
HQENEDANRQ SASSSKVPSP GNAASDSTLP LQAQSGDKWQ YLHHELTSRP
4460 4470 4480 4490 4500
NPSVPQLVEP QVALTTSTLP SVSVYNFRCP TADELQAYTT QLEELRQEAN
4510 4520 4530 4540 4550
TIQTQGSMTE ETYISLDKRL FELFLSLSRC LGSVEGLLQR PGLLREDACA
4560 4570 4580 4590 4600
QQVFFQKLAL ELKKLYLALG DKKDDFLKAV TWPGKEATLL PECIDALTVS
4610 4620 4630 4640 4650
LESVQSRAAW RDASLKAGLE HSRSYQNEVK RLYSQLIKKK TALQQSLNEI
4660 4670 4680 4690 4700
SGQSISKQLQ KADVHTAELQ NSEKQVAKLR DEGERLRFPH GLLQDVYKLE
4710 4720 4730 4740 4750
DVLDSMWGIL RARYLELSSP FLSKSLQTLL QGMAELVSIG KGKLAADPLQ
4760 4770 4780 4790 4800
HAKSKAALQA QLQDHKAFFQ KLVADMLLIQ TYSATMFPPS LQKGEGFGAE
4810 4820 4830 4840 4850
QVAEVRALEE EACLRGAQLQ SMLQKWEEFD DNYASLEKDL EALISSLPSV
4860 4870 4880 4890 4900
SLVEETEERL LERISFYQQI KRNIDGKHAR LCQTLNEGRQ LAASVSCPEP
4910 4920 4930 4940 4950
EGQIARLEEQ WLSLNKRIDQ ELHRLQTLLK HLLSYSRDSD ELTRWLETSQ
4960 4970 4980 4990 5000
QTLNYWKEQS LNVSQDLNTI RSNIDRFFKF SKEVDERSSL KSAVMSTGNQ
5010 5020 5030 5040 5050
LLHLKEADTA TLRASLAQFE QKWTVLITQL PDIQEKLHQL QMEKLPSREA
5060 5070 5080 5090 5100
ISEMISWMNA VEPQAAGKDT ELSKSSASQV KHLLQKLKEF RMEMDYKQWV
5110 5120 5130 5140 5150
VDFVNQSLLQ LSTCDVESKR YERTEFAEHL GEMNRQWQRV HGTLNRKIQH
5160 5170 5180 5190 5200
LEQLLESITE NENKVQNLNS WLEAQEERLK MLQKPESAVS MEKLLLDCQD
5210 5220 5230 5240 5250
IENQLALKSK ALDELRQSSL TMDGGDVPLL EDMASGIVEL FQKKNNVTSQ
5260 5270 5280 5290 5300
VHQLRASVQS VLQEWKACDK LYDEATMRTT QLTYSMEHSK PAVLSLQALA
5310 5320 5330 5340 5350
CQVQNLEALQ DEAENGERSW EKLQEVIGRL KASCPSMAGI IEEKCQDAHS
5360 5370 5380 5390 5400
RWTQVNQDLA DQLQEARGQL QLWKAPHNAH AEAAAWLQQQ EAKFQQLANT
5410 5420 5430 5440 5450
NLSGDNLADI LPRALKDIKG LQSDLQKTKE AFLENSTLSD QLPQPEERST
5460 5470 5480 5490 5500
PGLHSGQRHS LQTAAYLEKM LLAKSNEFEI VLAQFKDFTD RLAYSKDLIV
5510 5520 5530 5540 5550
HKEENLNKLY HEEKEEVPDL FLNHVLALTA QSPDIERLNE ESLRLPLSDV
5560 5570 5580 5590 5600
TIKTLQSLNR QWIRATATAL DHYSELQGNG LNEKFLHYCE RWIQVLEKIQ
5610 5620 5630 5640 5650
ESLSVEVAHS LPALLEQQKT YEILEAEVST NQAVADAYVT QSLQLLDTAE
5660 5670 5680 5690 5700
IEKRPEFVSE FSKLSDQWQR AARGVRQRKC DISRLVTQWR FFTTSVEDLL
5710 5720 5730 5740 5750
RFLADTSQLL SAVKEQDCYS LCQTRRLVHE LKSKEIHLQR WRTTYALALE
5760 5770 5780 5790 5800
AGEKLRNTPS PETREFVDGQ ISRLQESWKD TELSLGEVIS RLQSTAETWD
5810 5820 5830 5840 5850
QCKKKIKKLK KRLQALKAQS EDPLPELHEA LHEEKELIKE VEKSLANWTH
5860 5870 5880 5890 5900
SLKELQTMKA DLSQHILAED VTVLKEQIQL LHRQWEDLCL RVAIRKQEIE
5910 5920 5930 5940 5950
DRLNSWIVFN EKNKELCAWL VQMENKVLQT ADVSIEEMIE KLQKDCMEEI
5960 5970 5980 5990 6000
SLFTENKLQL KQMGDQLIKA SSKAKAAELE EKLSKINDRW QHLFDVIGSR
6010 6020 6030 6040 6050
VKKLKETFAF IQQLDKNMSN LRTWLARIES ELSKPVVYDV CDNQEIQKRL
6060 6070 6080 6090 6100
AEQQDLQRDI EQHSAGVESV FNICDVLLHD SDACANETEC DSIQQTTRSL
6110 6120 6130 6140 6150
DRRWRNICAM SMERRMKIEE TWRLWQKFLD DYSRFEDWLK SAERTAACPN
6160 6170 6180 6190 6200
SSEVLYTNAK EELKRFEAFQ RQIHERLTQL ELINKQYRRL ARENRTDTAS
6210 6220 6230 6240 6250
KLKQMVHEGN QRWDNLQKRV TAILRRLRYF TNQREEFEGT RESILVWLTE
6260 6270 6280 6290 6300
MDLQLTNVEH FSESDAEDKM RQLNGFQQEI TLNTNKIDQL IVFGEQLIQK
6310 6320 6330 6340 6350
SEPLDAVLIE DELEELHRYC QEVFGRVSRF HRRLTSHTPG LDDEKEASEN
6360 6370 6380 6390 6400
ETDIEDPREI QADSWRKRRE SEEPTSPQSL CHLVPPALGH ERSGCETPVS
6410 6420 6430 6440 6450
VDSIPLEWDH TGDVGGSSSH EDDEEGPFYS ALSGKSISEG HPWHVPDSPS
6460 6470 6480 6490 6500
HSKHHYKHME GDRTEAPVPT DASTPFKSDY VKLLLRQGTD DSKEGLKEAQ
6510 6520 6530 6540 6550
QEDEQLATLT GQQPGAFDRW ELIQAQELHS KLRLKQTVQQ LKSDIGSIAA
6560 6570 6580 6590 6600
WLGKTEAELE ALKLAEPPSD IQEIALRVKR LQEILKAFDT YKALMVSVNV
6610 6620 6630 6640 6650
SHKEYLPSQS PEATELQNRL HQLSLSWDSV QGVLDSWRGD LRQSLMQCQD
6660 6670 6680 6690 6700
FHQLSQDLLL WLATAESRRQ KAHVTSPEAD RQVLLECQKD LMRLEKELVA
6710 6720 6730 6740 6750
RQPQVSSLRE ISSSLLVKGQ GEDYIEAEEK VHVIEKKLKQ LQEQVAQDLM
6760 6770 6780 6790 6800
SLQRSLDPDA SLTSFDEVDS GEQLPAAFAK SPRPRWTFLE EEEEEEETDS
6810 6820 6830 6840 6850
RMPHLDSPGS SQPRRSFLSR VIRAALPLQL LLLLLLLLAC LLPASEDDYS
6860 6870
CTQANNFARS FYPMLRYTNG PPPT
Length:6,874
Mass (Da):782,725
Last modified:March 23, 2010 - v2
Checksum:i379792E42B95B7DB
GO
Isoform 2 (identifier: Q6ZWQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     472-482: INNVLGKNFIP → FVIVPVHKLCE
     483-6874: Missing.

Show »
Length:482
Mass (Da):54,303
Checksum:i831CAE7F3FAEED80
GO
Isoform 3 (identifier: Q6ZWQ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4994: Missing.
     6781-6789: SPRPRWTFL → FGV

Show »
Length:1,874
Mass (Da):216,116
Checksum:iDDB0DAC2C23CC801
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 49944994Missing in isoform 3. 1 PublicationVSP_038799Add
BLAST
Alternative sequencei472 – 48211INNVLGKNFIP → FVIVPVHKLCE in isoform 2. 1 PublicationVSP_038800Add
BLAST
Alternative sequencei483 – 68746392Missing in isoform 2. 1 PublicationVSP_038801Add
BLAST
Alternative sequencei6781 – 67899SPRPRWTFL → FGV in isoform 3. 1 PublicationVSP_038802

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052521 mRNA. Translation: BAC35023.1.
AC115714 Genomic DNA. No translation available.
AC159897 Genomic DNA. No translation available.
AC164121 Genomic DNA. No translation available.
AC166991 Genomic DNA. No translation available.
BC082586 mRNA. Translation: AAH82586.1.
CCDSiCCDS49091.1. [Q6ZWQ0-1]
RefSeqiNP_001005510.2. NM_001005510.2. [Q6ZWQ0-1]
UniGeneiMm.26652.

Genome annotation databases

EnsembliENSMUST00000044217; ENSMUSP00000047697; ENSMUSG00000063450. [Q6ZWQ0-1]
GeneIDi319565.
KEGGimmu:319565.
UCSCiuc007nxm.1. mouse. [Q6ZWQ0-2]
uc007nxp.1. mouse. [Q6ZWQ0-1]
uc007nxs.1. mouse. [Q6ZWQ0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052521 mRNA. Translation: BAC35023.1.
AC115714 Genomic DNA. No translation available.
AC159897 Genomic DNA. No translation available.
AC164121 Genomic DNA. No translation available.
AC166991 Genomic DNA. No translation available.
BC082586 mRNA. Translation: AAH82586.1.
CCDSiCCDS49091.1. [Q6ZWQ0-1]
RefSeqiNP_001005510.2. NM_001005510.2. [Q6ZWQ0-1]
UniGeneiMm.26652.

3D structure databases

ProteinModelPortaliQ6ZWQ0.
SMRiQ6ZWQ0. Positions 28-286, 5306-5355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi235364. 4 interactions.
DIPiDIP-61049N.
STRINGi10090.ENSMUSP00000047697.

PTM databases

iPTMnetiQ6ZWQ0.
PhosphoSiteiQ6ZWQ0.

Proteomic databases

EPDiQ6ZWQ0.
MaxQBiQ6ZWQ0.
PaxDbiQ6ZWQ0.
PRIDEiQ6ZWQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044217; ENSMUSP00000047697; ENSMUSG00000063450. [Q6ZWQ0-1]
GeneIDi319565.
KEGGimmu:319565.
UCSCiuc007nxm.1. mouse. [Q6ZWQ0-2]
uc007nxp.1. mouse. [Q6ZWQ0-1]
uc007nxs.1. mouse. [Q6ZWQ0-3]

Organism-specific databases

CTDi23224.
MGIiMGI:2449316. Syne2.

Phylogenomic databases

eggNOGiKOG0516. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.
HOGENOMiHOG000154474.
HOVERGENiHBG056327.
InParanoidiQ6ZWQ0.
KOiK19346.
OMAiCASEIHM.
PhylomeDBiQ6ZWQ0.
TreeFamiTF329280.

Enzyme and pathway databases

ReactomeiR-MMU-1221632. Meiotic synapsis.
R-MMU-1221633. Meiotic Synapsis.

Miscellaneous databases

PROiQ6ZWQ0.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZWQ0.
ExpressionAtlasiQ6ZWQ0. baseline and differential.
GenevisibleiQ6ZWQ0. MM.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR012315. KASH.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
IPR030266. SYNE2.
[Graphical view]
PANTHERiPTHR11915:SF317. PTHR11915:SF317. 13 hits.
PfamiPF00307. CH. 2 hits.
PF10541. KASH. 1 hit.
PF00435. Spectrin. 2 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM01249. KASH. 1 hit.
SM00150. SPEC. 17 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS51049. KASH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Eye.
  4. Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
  5. "Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton."
    Dawe H.R., Adams M., Wheway G., Szymanska K., Logan C.V., Noegel A.A., Gull K., Johnson C.A.
    J. Cell Sci. 122:2716-2726(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TMEM67, FUNCTION.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4096; SER-6371; SER-6400; SER-6417; SER-6418 AND SER-6419, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen and Testis.
  7. "Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement."
    Luxton G.W., Gomes E.R., Folker E.S., Vintinner E., Gundersen G.G.
    Science 329:956-959(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH F-ACTIN, MUTAGENESIS OF ILE-128 AND ILE-131.

Entry informationi

Entry nameiSYNE2_MOUSE
AccessioniPrimary (citable) accession number: Q6ZWQ0
Secondary accession number(s): Q640M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: June 8, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.