Q6ZWP6 (Q6ZWP6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Acyl-Coenzyme A dehydrogenase family, member 8, isoform CRA_a EMBL EAW67833.1

Submitted name:
Isobutyryl-CoA dehydrogenase, mitochondrial Ensembl ENSP00000363884
Submitted name:
cDNA FLJ90159 fis, clone HEMBB1002465, weakly similar to ACYL-COA DEHYDROGENASE (EC 1.3.99.-) EMBL BAC11107.1

Gene names

Name:	ACAD8 EMBL EAW67833.1 Ensembl ENSP00000363884
ORF Names:	hCG_37259 EMBL EAW67833.1

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAC11107.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the acyl-CoA dehydrogenase family. RuleBase RU004309

Ontologies

Keywords
Ligand	FAD RuleBase RU003714 Flavoprotein RuleBase RU003714
Molecular function	Oxidoreductase RuleBase RU003714
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6ZWP6 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 731C090A54E4BCAB	FASTA	288	31,024
	10 20 30 40 50 60 MLWSGCRRFG ARLGCLPGGL RVLVQTGHRS LTSCIDRSGS DAASLLTSAK KQGDHYILNG 70 80 90 100 110 120 SKAFISGAGE SDIYVVMCRT GGPGPKGISC IVVEKGTPGL SFGKKEKKVG WNSQPTRAVI 130 140 150 160 170 180 FEDCAVPVAN RIGSEGQGFL IAVRGLNGGR INIASCSLGA AHASVILTRD HLNVRKQFGE 190 200 210 220 230 240 PLASNQYLQF TLADMATRLV AARLMVRNAA VALQEERKDA VALCSMAKLF ATDECFAICN 250 260 270 280 QALQMHGGYG YLKDYAVQQY VRDSRVHQIL EGSNEVMRIL ISRSLLQE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"NEDO human cDNA sequencing project." Isogai T., Ota T., Nishikawa T., Hayashi K., Otsuki T., Sugiyama T., Suzuki Y., Nagai K., Sugano S., Ishii S., Kawai-Hio Y., Saito K., Yamamoto J., Wakamatsu A., Nakamura Y., Kojima S., Nagahari K., Masuho Y. , Ono T., Okano K., Yoshikawa Y., Aotsuka S., Sasaki N., Hattori A., Okumura K., Iwayanagi T., Ninomiya K. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Whole embryo EMBL BAC11107.1.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP000859 Genomic DNA. No translation available. AK074640 mRNA. Translation: BAC11107.1. CH471065 Genomic DNA. Translation: EAW67833.1.
IPI	IPI00446874.
RefSeq	NP_055199.1. NM_014384.2.
UniGene	Hs.14791.
3D structure databases
SMR	Q6ZWP6. Positions 38-288.
ModBase	Search...
Proteomic databases
PRIDE	Q6ZWP6.
Protocols and materials databases
DNASU	27034.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374752; ENSP00000363884; ENSG00000151498.
GeneID	27034.
KEGG	hsa:27034.
UCSC	uc001qhl.3. human.
Organism-specific databases
CTD	27034.
HGNC	HGNC:87. ACAD8.
PharmGKB	PA24423.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000131659.
HOVERGEN	HBG000224.
KO	K11538.
OrthoDB	EOG4F7NK6.
Gene expression databases
ArrayExpress	Q6ZWP6.
Family and domain databases
Gene3D	2.40.110.10. 1 hit.
InterPro	IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_cen-dom. IPR009075. AcylCo_DH/oxidase_C. IPR009100. AcylCoA_DH/oxidase. [Graphical view]
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
SUPFAM	SSF56645. AcylCoA_dehyd_NM. 1 hit. SSF47203. AcylCoADH_C_like. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	27034.
NextBio	49582.

Entry information

Entry name

Q6ZWP6_HUMAN

Accession

Primary (citable) accession number: Q6ZWP6

Entry history

Integrated into UniProtKB/TrEMBL:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.