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Q6ZWN5

- RS9_MOUSE

UniProt

Q6ZWN5 - RS9_MOUSE

Protein

40S ribosomal protein S9

Gene

Rps9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-KW
    2. structural constituent of ribosome Source: InterPro
    3. translation regulator activity Source: Ensembl

    GO - Biological processi

    1. positive regulation of cell proliferation Source: Ensembl
    2. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S9
    Gene namesi
    Name:Rps9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1924096. Rps9.

    Subcellular locationi

    Cytoplasm By similarity
    Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.By similarity

    GO - Cellular componenti

    1. cytosolic small ribosomal subunit Source: Ensembl
    2. nucleolus Source: Ensembl
    3. ribonucleoprotein complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 19419340S ribosomal protein S9PRO_0000132690Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei66 – 661N6-acetyllysine1 Publication
    Modified residuei116 – 1161N6-acetyllysine1 Publication
    Modified residuei155 – 1551N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ6ZWN5.
    PaxDbiQ6ZWN5.
    PRIDEiQ6ZWN5.

    PTM databases

    PhosphoSiteiQ6ZWN5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ZWN5.
    BgeeiQ6ZWN5.
    CleanExiMM_RPS9.
    GenevestigatoriQ6ZWN5.

    Interactioni

    Subunit structurei

    Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.By similarity

    Protein-protein interaction databases

    BioGridi218346. 9 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZWN5.
    SMRiQ6ZWN5. Positions 7-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini108 – 18275S4 RNA-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ribosomal protein S4P family.Curated
    Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0522.
    GeneTreeiENSGT00550000074829.
    HOGENOMiHOG000194525.
    HOVERGENiHBG001135.
    InParanoidiQ6ZWN5.
    KOiK02997.
    OMAiMAPRSYS.
    OrthoDBiEOG7KH9KZ.
    PhylomeDBiQ6ZWN5.
    TreeFamiTF300795.

    Family and domain databases

    Gene3Di3.10.290.10. 1 hit.
    InterProiIPR022801. Ribosomal_S4/S9.
    IPR005710. Ribosomal_S4/S9_euk/arc.
    IPR001912. Ribosomal_S4/S9_N.
    IPR018079. Ribosomal_S4_CS.
    IPR002942. S4_RNA-bd.
    [Graphical view]
    PANTHERiPTHR11831. PTHR11831. 1 hit.
    PfamiPF00163. Ribosomal_S4. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view]
    SMARTiSM00363. S4. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01018. rpsD_arch. 1 hit.
    PROSITEiPS00632. RIBOSOMAL_S4. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6ZWN5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVARSWVCR KTYVTPRRPF EKSRLDQELK LIGEYGLRNK REVWRVKFTL    50
    AKIRKAAREL LTLDEKDPRR LFEGNALLRR LVRIGVLDEG KMKLDYILGL 100
    KIEDFLERRL QTQVFKLGLA KSIHHARVLI RQRHIRVRKQ VVNIPSFIVR 150
    LDSQKHIDFS LRSPYGGGRP GRVKRKNAKK GQGGAGAGDD EEED 194
    Length:194
    Mass (Da):22,591
    Last modified:January 23, 2007 - v3
    Checksum:iE9CE3CBD59524F81
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti156 – 1561H → P in AAH31746. (PubMed:15489334)Curated
    Sequence conflicti163 – 1631S → F in AAH31746. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050591 mRNA. Translation: BAC34330.1.
    AK081889 mRNA. Translation: BAC38361.1.
    AK150800 mRNA. Translation: BAE29863.1.
    AK150988 mRNA. Translation: BAE30013.1.
    AK151029 mRNA. Translation: BAE30046.1.
    AK151621 mRNA. Translation: BAE30558.1.
    BC031746 mRNA. Translation: AAH31746.1.
    CCDSiCCDS20726.1.
    RefSeqiNP_084043.1. NM_029767.2.
    UniGeneiMm.13944.

    Genome annotation databases

    EnsembliENSMUST00000006496; ENSMUSP00000006496; ENSMUSG00000006333.
    ENSMUST00000108625; ENSMUSP00000104265; ENSMUSG00000006333.
    GeneIDi76846.
    KEGGimmu:76846.
    UCSCiuc009ewa.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050591 mRNA. Translation: BAC34330.1 .
    AK081889 mRNA. Translation: BAC38361.1 .
    AK150800 mRNA. Translation: BAE29863.1 .
    AK150988 mRNA. Translation: BAE30013.1 .
    AK151029 mRNA. Translation: BAE30046.1 .
    AK151621 mRNA. Translation: BAE30558.1 .
    BC031746 mRNA. Translation: AAH31746.1 .
    CCDSi CCDS20726.1.
    RefSeqi NP_084043.1. NM_029767.2.
    UniGenei Mm.13944.

    3D structure databases

    ProteinModelPortali Q6ZWN5.
    SMRi Q6ZWN5. Positions 7-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 218346. 9 interactions.

    PTM databases

    PhosphoSitei Q6ZWN5.

    Proteomic databases

    MaxQBi Q6ZWN5.
    PaxDbi Q6ZWN5.
    PRIDEi Q6ZWN5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006496 ; ENSMUSP00000006496 ; ENSMUSG00000006333 .
    ENSMUST00000108625 ; ENSMUSP00000104265 ; ENSMUSG00000006333 .
    GeneIDi 76846.
    KEGGi mmu:76846.
    UCSCi uc009ewa.1. mouse.

    Organism-specific databases

    CTDi 6203.
    MGIi MGI:1924096. Rps9.

    Phylogenomic databases

    eggNOGi COG0522.
    GeneTreei ENSGT00550000074829.
    HOGENOMi HOG000194525.
    HOVERGENi HBG001135.
    InParanoidi Q6ZWN5.
    KOi K02997.
    OMAi MAPRSYS.
    OrthoDBi EOG7KH9KZ.
    PhylomeDBi Q6ZWN5.
    TreeFami TF300795.

    Enzyme and pathway databases

    Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Miscellaneous databases

    ChiTaRSi RPS9. mouse.
    NextBioi 345919.
    PROi Q6ZWN5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6ZWN5.
    Bgeei Q6ZWN5.
    CleanExi MM_RPS9.
    Genevestigatori Q6ZWN5.

    Family and domain databases

    Gene3Di 3.10.290.10. 1 hit.
    InterProi IPR022801. Ribosomal_S4/S9.
    IPR005710. Ribosomal_S4/S9_euk/arc.
    IPR001912. Ribosomal_S4/S9_N.
    IPR018079. Ribosomal_S4_CS.
    IPR002942. S4_RNA-bd.
    [Graphical view ]
    PANTHERi PTHR11831. PTHR11831. 1 hit.
    Pfami PF00163. Ribosomal_S4. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view ]
    SMARTi SM00363. S4. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01018. rpsD_arch. 1 hit.
    PROSITEi PS00632. RIBOSOMAL_S4. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow, Head and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-66 AND LYS-116, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiRS9_MOUSE
    AccessioniPrimary (citable) accession number: Q6ZWN5
    Secondary accession number(s): Q3UBF1, Q8K2D1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 89 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3