mCG_126872

Functionⁱ

Catalytic activityⁱ

[a protein]-serine/threonine phosphate + H₂O = [a protein]-serine/threonine + phosphate.UniRule annotationSAAS annotation

GO - Molecular functionⁱ

lamin binding Source: Ensembl
metal ion binding Source: UniProtKB-KW
protein complex binding Source: Ensembl
protein C-terminus binding Source: Ensembl
protein domain specific binding Source: Ensembl
protein kinase binding Source: Ensembl
protein N-terminus binding Source: Ensembl
protein phosphatase 1 binding Source: Ensembl
protein serine/threonine phosphatase activity Source: Ensembl
RNA binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

circadian regulation of gene expression Source: Ensembl
entrainment of circadian clock by photoperiod Source: Ensembl
neuron differentiation Source: Ensembl
regulation of nucleocytoplasmic transport Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphataseSAAS annotation
Ligand	ManganeseSAAS annotation, Metal-bindingSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation)
Gene namesⁱ	ORF Names:mCG_126872Imported, mCG_129661Imported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Subcellular locationⁱ

GO - Cellular componentⁱ

dendritic spine Source: Ensembl
focal adhesion Source: Ensembl
mitochondrial outer membrane Source: Ensembl
nuclear chromosome, telomeric region Source: Ensembl
nucleolus Source: Ensembl
protein complex Source: Ensembl
PTW/PP1 phosphatase complex Source: Ensembl

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6ZWM8.

MaxQBⁱ

Q6ZWM8.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000004455.
ExpressionAtlasⁱ	Q6ZWM8. baseline and differential.

Interactionⁱ

GO - Molecular functionⁱ

lamin binding Source: Ensembl
protein complex binding Source: Ensembl
protein C-terminus binding Source: Ensembl
protein domain specific binding Source: Ensembl
protein kinase binding Source: Ensembl
protein N-terminus binding Source: Ensembl
protein phosphatase 1 binding Source: Ensembl

Complete GO annotation...

Structureⁱ

3D structure databases

SMRⁱ	Q6ZWM8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	121 – 126	SER_THR_PHOSPHATASEInterPro annotation		6

Sequence similaritiesⁱ

Belongs to the PPP phosphatase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	ENOG410IN85. Eukaryota. ENOG410XPVF. LUCA.
HOVERGENⁱ	HBG000216.
KEGG Orthology (KO) More...KOⁱ	K06269.

Family and domain databases

Gene3Dⁱ	3.60.21.10. 1 hit.
InterProⁱ	View protein in InterPro IPR004843. Calcineurin-like_PHP_ApaH. IPR029052. Metallo-depent_PP-like. IPR006186. Ser/Thr-sp_prot-phosphatase. IPR031675. STPPase_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00149. Metallophos. 1 hit. PF16891. STPPase_N. 1 hit.
PRINTSⁱ	PR00114. STPHPHTASE.
SMARTⁱ	View protein in SMART SM00156. PP2Ac. 1 hit.
SUPFAMⁱ	SSF56300. SSF56300. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6ZWM8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADIDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP 
        60         70         80         90        100
ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS 
       110        120        130        140        150
LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK 
       160        170        180        190        200
TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL 
       210        220        230        240        250
LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV 
       260        270        280        290        300
VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE 
       310        320 
KKKPNATRPV TPPRGMITKQ AKK

Length:323

Mass (Da):36,984

Last modified:July 5, 2004 - v1

Checksum:ⁱ4E28412C16898615

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK076009 mRNA. Translation: BAC36117.1. AK088229 mRNA. Translation: BAC40224.1. AK147131 mRNA. Translation: BAE27701.1. AK152422 mRNA. Translation: BAE31206.1. AK153363 mRNA. Translation: BAE31935.1. AK169336 mRNA. Translation: BAE41088.1. CH466531 Genomic DNA. Translation: EDL17180.1. CH466529 Genomic DNA. Translation: EDL19697.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_038664.2. NM_013636.3.
UniGeneⁱ	Mm.280784.

Genome annotation databases

GeneIDⁱ	19047.
KEGGⁱ	mmu:19047.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK076009 mRNA. Translation: BAC36117.1. AK088229 mRNA. Translation: BAC40224.1. AK147131 mRNA. Translation: BAE27701.1. AK152422 mRNA. Translation: BAE31206.1. AK153363 mRNA. Translation: BAE31935.1. AK169336 mRNA. Translation: BAE41088.1. CH466531 Genomic DNA. Translation: EDL17180.1. CH466529 Genomic DNA. Translation: EDL19697.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_038664.2. NM_013636.3.
UniGeneⁱ	Mm.280784.

3D structure databases

SMRⁱ	Q6ZWM8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6ZWM8.

MaxQBⁱ

Q6ZWM8.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	19047.
KEGGⁱ	mmu:19047.

Organism-specific databases

CTDⁱ	5501.

CTDⁱ

5501.

Phylogenomic databases

eggNOGⁱ	ENOG410IN85. Eukaryota. ENOG410XPVF. LUCA.
HOVERGENⁱ	HBG000216.
KEGG Orthology (KO) More...KOⁱ	K06269.

Gene expression databases

Bgeeⁱ	ENSMUSG00000004455.
ExpressionAtlasⁱ	Q6ZWM8. baseline and differential.

Family and domain databases

Gene3Dⁱ	3.60.21.10. 1 hit.
InterProⁱ	View protein in InterPro IPR004843. Calcineurin-like_PHP_ApaH. IPR029052. Metallo-depent_PP-like. IPR006186. Ser/Thr-sp_prot-phosphatase. IPR031675. STPPase_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00149. Metallophos. 1 hit. PF16891. STPPase_N. 1 hit.
PRINTSⁱ	PR00114. STPHPHTASE.
SMARTⁱ	View protein in SMART SM00156. PP2Ac. 1 hit.
SUPFAMⁱ	SSF56300. SSF56300. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00125. SER_THR_PHOSPHATASE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q6ZWM8_MOUSE
Accessionⁱ	Q6ZWM8Primary (citable) accession number: Q6ZWM8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 5, 2004
	Last sequence update:	July 5, 2004
	Last modified:	July 5, 2017
	This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6ZWM8 (Q6ZWM8_MOUSE)

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Serine/threonine-protein phosphatase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ