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Protein

U6 snRNA-associated Sm-like protein LSm8

Gene

Lsm8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm8
Gene namesi
Name:Lsm8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1923772. Lsm8.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001255832 – 96U6 snRNA-associated Sm-like protein LSm8Add BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6ZWM4.
MaxQBiQ6ZWM4.
PaxDbiQ6ZWM4.
PeptideAtlasiQ6ZWM4.
PRIDEiQ6ZWM4.
TopDownProteomicsiQ6ZWM4.

PTM databases

PhosphoSitePlusiQ6ZWM4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044155.
ExpressionAtlasiQ6ZWM4. baseline and differential.
GenevisibleiQ6ZWM4. MM.

Interactioni

Subunit structurei

LSm subunits form a heteromer with a doughnut shape.By similarity

Protein-protein interaction databases

IntActiQ6ZWM4. 1 interactor.
MINTiMINT-4437330.
STRINGi10090.ENSMUSP00000057238.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWM4.
SMRiQ6ZWM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1784. Eukaryota.
ENOG41124H7. LUCA.
GeneTreeiENSGT00730000111212.
HOVERGENiHBG105578.
InParanoidiQ6ZWM4.
KOiK12627.
OMAiGYVDRRV.
OrthoDBiEOG091G126L.
PhylomeDBiQ6ZWM4.
TreeFamiTF314555.

Family and domain databases

CDDicd01727. LSm8. 1 hit.
InterProiView protein in InterPro
IPR034103. Lsm8.
IPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
PfamiView protein in Pfam
PF01423. LSM. 1 hit.
SMARTiView protein in SMART
SM00651. Sm. 1 hit.
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZWM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSALENYIN RTVAVITSDG RMIVGTLKGF DQTINLILDE SHERVFSSSQ
60 70 80 90
GVEQVVLGLY IVRGDNVAVI GEIDEETDSA LDLGNIRAEP LNSVAH
Length:96
Mass (Da):10,403
Last modified:January 23, 2007 - v3
Checksum:i15D26E6B75AA2EE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088664 mRNA. Translation: BAC40488.1.
AK167674 mRNA. Translation: BAE39723.1.
BC019458 mRNA. Translation: AAH19458.1.
CCDSiCCDS39433.1.
RefSeqiNP_598700.1. NM_133939.1.
UniGeneiMm.275158.

Genome annotation databases

EnsembliENSMUST00000056398; ENSMUSP00000057238; ENSMUSG00000044155.
GeneIDi76522.
KEGGimmu:76522.
UCSCiuc009bao.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLSM8_MOUSE
AccessioniPrimary (citable) accession number: Q6ZWM4
Secondary accession number(s): Q3TIX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: July 5, 2017
This is version 108 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families