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Protein

U6 snRNA-associated Sm-like protein LSm8

Gene

Lsm8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm8
Gene namesi
Name:Lsm8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1923772. Lsm8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 9695U6 snRNA-associated Sm-like protein LSm8PRO_0000125583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6ZWM4.
MaxQBiQ6ZWM4.
PaxDbiQ6ZWM4.
PeptideAtlasiQ6ZWM4.
PRIDEiQ6ZWM4.
TopDownProteomicsiQ6ZWM4.

PTM databases

PhosphoSiteiQ6ZWM4.

Expressioni

Gene expression databases

BgeeiQ6ZWM4.
ExpressionAtlasiQ6ZWM4. baseline and differential.
GenevisibleiQ6ZWM4. MM.

Interactioni

Subunit structurei

LSm subunits form a heteromer with a doughnut shape.By similarity

Protein-protein interaction databases

IntActiQ6ZWM4. 1 interaction.
MINTiMINT-4437330.
STRINGi10090.ENSMUSP00000057238.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWM4.
SMRiQ6ZWM4. Positions 2-74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1784. Eukaryota.
ENOG41124H7. LUCA.
GeneTreeiENSGT00730000111212.
HOVERGENiHBG105578.
InParanoidiQ6ZWM4.
KOiK12627.
OMAiSYVNHTV.
OrthoDBiEOG7SV0XS.
PhylomeDBiQ6ZWM4.
TreeFamiTF314555.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZWM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSALENYIN RTVAVITSDG RMIVGTLKGF DQTINLILDE SHERVFSSSQ
60 70 80 90
GVEQVVLGLY IVRGDNVAVI GEIDEETDSA LDLGNIRAEP LNSVAH
Length:96
Mass (Da):10,403
Last modified:January 23, 2007 - v3
Checksum:i15D26E6B75AA2EE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088664 mRNA. Translation: BAC40488.1.
AK167674 mRNA. Translation: BAE39723.1.
BC019458 mRNA. Translation: AAH19458.1.
CCDSiCCDS39433.1.
RefSeqiNP_598700.1. NM_133939.1.
UniGeneiMm.275158.

Genome annotation databases

EnsembliENSMUST00000056398; ENSMUSP00000057238; ENSMUSG00000044155.
GeneIDi76522.
KEGGimmu:76522.
UCSCiuc009bao.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088664 mRNA. Translation: BAC40488.1.
AK167674 mRNA. Translation: BAE39723.1.
BC019458 mRNA. Translation: AAH19458.1.
CCDSiCCDS39433.1.
RefSeqiNP_598700.1. NM_133939.1.
UniGeneiMm.275158.

3D structure databases

ProteinModelPortaliQ6ZWM4.
SMRiQ6ZWM4. Positions 2-74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6ZWM4. 1 interaction.
MINTiMINT-4437330.
STRINGi10090.ENSMUSP00000057238.

PTM databases

PhosphoSiteiQ6ZWM4.

Proteomic databases

EPDiQ6ZWM4.
MaxQBiQ6ZWM4.
PaxDbiQ6ZWM4.
PeptideAtlasiQ6ZWM4.
PRIDEiQ6ZWM4.
TopDownProteomicsiQ6ZWM4.

Protocols and materials databases

DNASUi76522.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056398; ENSMUSP00000057238; ENSMUSG00000044155.
GeneIDi76522.
KEGGimmu:76522.
UCSCiuc009bao.1. mouse.

Organism-specific databases

CTDi51691.
MGIiMGI:1923772. Lsm8.

Phylogenomic databases

eggNOGiKOG1784. Eukaryota.
ENOG41124H7. LUCA.
GeneTreeiENSGT00730000111212.
HOVERGENiHBG105578.
InParanoidiQ6ZWM4.
KOiK12627.
OMAiSYVNHTV.
OrthoDBiEOG7SV0XS.
PhylomeDBiQ6ZWM4.
TreeFamiTF314555.

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiQ6ZWM4.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZWM4.
ExpressionAtlasiQ6ZWM4. baseline and differential.
GenevisibleiQ6ZWM4. MM.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Placenta and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiLSM8_MOUSE
AccessioniPrimary (citable) accession number: Q6ZWM4
Secondary accession number(s): Q3TIX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.