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Protein

Cytochrome P450 4V2

Gene

CYP4V2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592). Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592).2 Publications

Catalytic activityi

Docosahexaenoate + NADPH + O2 = 22-hydroxydocosahexaenoate + NADP+ + H2O.1 Publication

Cofactori

hemeBy similarity

Enzyme regulationi

Inhibited by N-hydroxy-N'-(4-n-butyl-2-methylphenyl formamidine)(HET0016) with an IC50 of 38 nM.1 Publication

Kineticsi

Vmax is the nearly the same for myristic acid and for lauric acid and reduced about 30% for palmitic acid.1 Publication

  1. KM=65 µM for myristic acid1 Publication
  2. KM=140 µM for lauric acid1 Publication
  3. KM=430 µM for palmitic acid1 Publication

Pathwayi

Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei329 – 3291Heme (covalent; via 1 link)By similarity
Metal bindingi467 – 4671Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

GO - Biological processi

  1. fatty acid omega-oxidation Source: UniProtKB
  2. response to stimulus Source: UniProtKB-KW
  3. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Lipid metabolism, Sensory transduction, Vision

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BRENDAi1.14.13.199. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4V2 (EC:1.14.13.-)
Alternative name(s):
Docosahexaenoic acid omega-hydroxylase CYP4V2Curated (EC:1.14.13.1991 Publication)
Gene namesi
Name:CYP4V2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:23198. CYP4V2.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein Curated

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Bietti crystalline corneoretinal dystrophy (BCD)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive ocular disease characterized by retinal degeneration and marginal corneal dystrophy. Typical features include multiple glistening intraretinal crystals scattered over the fundus, a characteristic degeneration of the retina, and sclerosis of the choroidal vessels, ultimately resulting in progressive night blindness and constriction of the visual field. Most patients have similar crystals at the corneoscleral limbus. Patients develop decreased vision, nyctalopia, and paracentral scotomata between the 2nd and 4th decade of life. Later, they develop peripheral visual field loss and marked visual impairment, usually progressing to legal blindness by the 5th or 6th decade of life.

See also OMIM:210370
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441W → R in BCD. 1 Publication
VAR_023084
Natural varianti61 – 611G → S in BCD. 1 Publication
VAR_023085
Natural varianti79 – 791E → D in BCD. 1 Publication
VAR_023086
Natural varianti111 – 1111I → T in BCD. 1 Publication
VAR_023087
Natural varianti123 – 1231M → V in BCD. 1 Publication
Corresponds to variant rs149684063 [ dbSNP | Ensembl ].
VAR_023088
Natural varianti331 – 3311H → P in BCD; impaired omega hydroxylase activity. 2 Publications
VAR_023089
Natural varianti341 – 3411S → P in BCD. 1 Publication
VAR_023090
Natural varianti508 – 5081R → H in BCD. 1 Publication
VAR_023091

Keywords - Diseasei

Corneal dystrophy, Disease mutation

Organism-specific databases

MIMi210370. phenotype.
Orphaneti41751. Bietti crystalline dystrophy.
PharmGKBiPA134912942.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Cytochrome P450 4V2PRO_0000051859Add
BLAST

Proteomic databases

MaxQBiQ6ZWL3.
PaxDbiQ6ZWL3.
PRIDEiQ6ZWL3.

PTM databases

PhosphoSiteiQ6ZWL3.

Expressioni

Tissue specificityi

Broadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes.2 Publications

Gene expression databases

BgeeiQ6ZWL3.
ExpressionAtlasiQ6ZWL3. baseline and differential.
GenevestigatoriQ6ZWL3.

Organism-specific databases

HPAiHPA029122.

Interactioni

Protein-protein interaction databases

BioGridi130113. 3 interactions.
IntActiQ6ZWL3. 1 interaction.
STRINGi9606.ENSP00000368079.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWL3.
SMRiQ6ZWL3. Positions 48-520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000233834.
HOVERGENiHBG000182.
InParanoidiQ6ZWL3.
KOiK07427.
OMAiHEAIREE.
OrthoDBiEOG7CNZFK.
PhylomeDBiQ6ZWL3.
TreeFamiTF105088.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZWL3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGLWLGLVW QKLLLWGAAS ALSLAGASLV LSLLQRVASY ARKWQQMRPI
60 70 80 90 100
PTVARAYPLV GHALLMKPDG REFFQQIIEY TEEYRHMPLL KLWVGPVPMV
110 120 130 140 150
ALYNAENVEV ILTSSKQIDK SSMYKFLEPW LGLGLLTSTG NKWRSRRKML
160 170 180 190 200
TPTFHFTILE DFLDIMNEQA NILVKKLEKH INQEAFNCFF YITLCALDII
210 220 230 240 250
CETAMGKNIG AQSNDDSEYV RAVYRMSEMI FRRIKMPWLW LDLWYLMFKE
260 270 280 290 300
GWEHKKSLQI LHTFTNSVIA ERANEMNANE DCRGDGRGSA PSKNKRRAFL
310 320 330 340 350
DLLLSVTDDE GNRLSHEDIR EEVDTFMFEG HDTTAAAINW SLYLLGSNPE
360 370 380 390 400
VQKKVDHELD DVFGKSDRPA TVEDLKKLRY LECVIKETLR LFPSVPLFAR
410 420 430 440 450
SVSEDCEVAG YRVLKGTEAV IIPYALHRDP RYFPNPEEFQ PERFFPENAQ
460 470 480 490 500
GRHPYAYVPF SAGPRNCIGQ KFAVMEEKTI LSCILRHFWI ESNQKREELG
510 520
LEGQLILRPS NGIWIKLKRR NADER
Length:525
Mass (Da):60,724
Last modified:May 18, 2010 - v2
Checksum:iA26F0A517C9569AD
GO
Isoform 2 (identifier: Q6ZWL3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-63: Missing.

Note: No experimental confirmation available.

Show »
Length:503
Mass (Da):58,166
Checksum:i117B6B2EC969AF96
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221L → V.1 Publication
Corresponds to variant rs1055138 [ dbSNP | Ensembl ].
VAR_038606
Natural varianti44 – 441W → R in BCD. 1 Publication
VAR_023084
Natural varianti61 – 611G → S in BCD. 1 Publication
VAR_023085
Natural varianti79 – 791E → D in BCD. 1 Publication
VAR_023086
Natural varianti111 – 1111I → T in BCD. 1 Publication
VAR_023087
Natural varianti123 – 1231M → V in BCD. 1 Publication
Corresponds to variant rs149684063 [ dbSNP | Ensembl ].
VAR_023088
Natural varianti213 – 2131S → N.1 Publication
Corresponds to variant rs34331648 [ dbSNP | Ensembl ].
VAR_038607
Natural varianti259 – 2591Q → K.3 Publications
Corresponds to variant rs13146272 [ dbSNP | Ensembl ].
VAR_033821
Natural varianti275 – 2751E → K.1 Publication
Corresponds to variant rs34745240 [ dbSNP | Ensembl ].
VAR_055379
Natural varianti331 – 3311H → P in BCD; impaired omega hydroxylase activity. 2 Publications
VAR_023089
Natural varianti341 – 3411S → P in BCD. 1 Publication
VAR_023090
Natural varianti372 – 3721V → I.1 Publication
Corresponds to variant rs61755911 [ dbSNP | Ensembl ].
VAR_055380
Natural varianti443 – 4431R → Q.1 Publication
Corresponds to variant rs72646291 [ dbSNP | Ensembl ].
VAR_055381
Natural varianti508 – 5081R → H in BCD. 1 Publication
VAR_023091

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei42 – 6322Missing in isoform 2. 1 PublicationVSP_014918Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY422002 mRNA. Translation: AAR31180.1.
AK122600 mRNA. Translation: BAC85487.1.
AK126473 mRNA. Translation: BAC86562.1.
FJ440682 Genomic DNA. Translation: ACK44069.1.
AC110771 Genomic DNA. No translation available.
BC060857 mRNA. Translation: AAH60857.1.
CCDSiCCDS34119.1. [Q6ZWL3-1]
RefSeqiNP_997235.3. NM_207352.3. [Q6ZWL3-1]
UniGeneiHs.587231.

Genome annotation databases

EnsembliENST00000378802; ENSP00000368079; ENSG00000145476. [Q6ZWL3-1]
GeneIDi285440.
KEGGihsa:285440.
UCSCiuc003iyw.4. human. [Q6ZWL3-1]

Polymorphism databases

DMDMi296434466.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY422002 mRNA. Translation: AAR31180.1.
AK122600 mRNA. Translation: BAC85487.1.
AK126473 mRNA. Translation: BAC86562.1.
FJ440682 Genomic DNA. Translation: ACK44069.1.
AC110771 Genomic DNA. No translation available.
BC060857 mRNA. Translation: AAH60857.1.
CCDSiCCDS34119.1. [Q6ZWL3-1]
RefSeqiNP_997235.3. NM_207352.3. [Q6ZWL3-1]
UniGeneiHs.587231.

3D structure databases

ProteinModelPortaliQ6ZWL3.
SMRiQ6ZWL3. Positions 48-520.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130113. 3 interactions.
IntActiQ6ZWL3. 1 interaction.
STRINGi9606.ENSP00000368079.

PTM databases

PhosphoSiteiQ6ZWL3.

Polymorphism databases

DMDMi296434466.

Proteomic databases

MaxQBiQ6ZWL3.
PaxDbiQ6ZWL3.
PRIDEiQ6ZWL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378802; ENSP00000368079; ENSG00000145476. [Q6ZWL3-1]
GeneIDi285440.
KEGGihsa:285440.
UCSCiuc003iyw.4. human. [Q6ZWL3-1]

Organism-specific databases

CTDi285440.
GeneCardsiGC04P187112.
GeneReviewsiCYP4V2.
H-InvDBHIX0004688.
HGNCiHGNC:23198. CYP4V2.
HPAiHPA029122.
MIMi210370. phenotype.
608614. gene.
neXtProtiNX_Q6ZWL3.
Orphaneti41751. Bietti crystalline dystrophy.
PharmGKBiPA134912942.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000233834.
HOVERGENiHBG000182.
InParanoidiQ6ZWL3.
KOiK07427.
OMAiHEAIREE.
OrthoDBiEOG7CNZFK.
PhylomeDBiQ6ZWL3.
TreeFamiTF105088.

Enzyme and pathway databases

BRENDAi1.14.13.199. 2681.

Miscellaneous databases

GeneWikiiCYP4V2.
GenomeRNAii285440.
NextBioi95523.
PROiQ6ZWL3.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZWL3.
ExpressionAtlasiQ6ZWL3. baseline and differential.
GenevestigatoriQ6ZWL3.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS BCD ARG-44; SER-61; ASP-79; THR-111; VAL-123; LYS-259; PRO-331; PRO-341 AND HIS-508.
    Tissue: Retina.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LYS-259.
    Tissue: Kidney and Uterus.
  3. NIEHS SNPs program
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-22; ASN-213; LYS-275; ILE-372 AND GLN-443.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-259.
    Tissue: Placenta.
  6. "Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase."
    Nakano M., Kelly E.J., Rettie A.E.
    Drug Metab. Dispos. 37:2119-2122(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: CATALYTIC ACTIVITY, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBSTRATE SPECIFICITY, ENZYME REGULATION.
  7. "CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of omega-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant."
    Nakano M., Kelly E.J., Wiek C., Hanenberg H., Rettie A.E.
    Mol. Pharmacol. 82:679-686(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, CHARACTERIZATION OF VARIANT BCD PRO-331.
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCP4V2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWL3
Secondary accession number(s): B7U6W2, Q6ZTM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: May 18, 2010
Last modified: April 1, 2015
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.