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Q6ZWK6

- TM11F_HUMAN

UniProt

Q6ZWK6 - TM11F_HUMAN

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Protein
Transmembrane protease serine 11F
Gene
TMPRSS11F, HATL4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable serine protease By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei248 – 2481Charge relay system By similarity
Active sitei293 – 2931Charge relay system By similarity
Active sitei389 – 3891Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.321.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protease serine 11F (EC:3.4.21.-)
    Alternative name(s):
    Airway trypsin-like protease 4
    Gene namesi
    Synonyms:HATL4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:29994. TMPRSS11F.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei33 – 5321Helical; Signal-anchor for type II membrane protein; Reviewed prediction
    Add
    BLAST
    Topological domaini54 – 438385Extracellular Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. extracellular region Source: InterPro
    2. integral component of plasma membrane Source: InterPro
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670730.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 438438Transmembrane protease serine 11F
    PRO_0000299322Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi233 ↔ 249 By similarity
    Disulfide bondi358 ↔ 374 By similarity
    Disulfide bondi385 ↔ 413 By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ6ZWK6.
    PRIDEiQ6ZWK6.

    PTM databases

    PhosphoSiteiQ6ZWK6.

    Expressioni

    Gene expression databases

    BgeeiQ6ZWK6.
    CleanExiHS_TMPRSS11F.
    GenevestigatoriQ6ZWK6.

    Organism-specific databases

    HPAiHPA026911.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZWK6.
    SMRiQ6ZWK6. Positions 57-438.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini57 – 175119SEA
    Add
    BLAST
    Domaini206 – 437232Peptidase S1
    Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.
    Contains 1 SEA domain.

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251823.
    HOVERGENiHBG013304.
    KOiK09752.
    OMAiTHFVVED.
    OrthoDBiEOG75B84T.
    PhylomeDBiQ6ZWK6.
    TreeFamiTF351684.

    Family and domain databases

    Gene3Di3.30.70.960. 1 hit.
    InterProiIPR017329. Pept_S1A_HAT/DESC1.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR000082. SEA_dom.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF01390. SEA. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00200. SEA. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF82671. SSF82671. 1 hit.
    PROSITEiPS50024. SEA. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6ZWK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMYAPVEFSE AEFSRAEYQR KQQFWDSVRL ALFTLAIVAI IGIAIGIVTH    50
    FVVEDDKSFY YLASFKVTNI KYKENYGIRS SREFIERSHQ IERMMSRIFR 100
    HSSVGGRFIK SHVIKLSPDE QGVDILIVLI FRYPSTDSAE QIKKKIEKAL 150
    YQSLKTKQLS LTINKPSFRL TPIDSKKMRN LLNSRCGIRM TSSNMPLPAS 200
    SSTQRIVQGR ETAMEGEWPW QASLQLIGSG HQCGASLISN TWLLTAAHCF 250
    WKNKDPTQWI ATFGATITPP AVKRNVRKII LHENYHRETN ENDIALVQLS 300
    TGVEFSNIVQ RVCLPDSSIK LPPKTSVFVT GFGSIVDDGP IQNTLRQARV 350
    ETISTDVCNR KDVYDGLITP GMLCAGFMEG KIDACKGDSG GPLVYDNHDI 400
    WYIVGIVSWG QSCALPKKPG VYTRVTKYRD WIASKTGM 438
    Length:438
    Mass (Da):49,410
    Last modified:September 23, 2008 - v2
    Checksum:iF36C3D3EFB4D1E9A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41A → T.
    Corresponds to variant rs10030708 [ dbSNP | Ensembl ].
    VAR_034800
    Natural varianti124 – 1241D → N.
    Corresponds to variant rs1438391 [ dbSNP | Ensembl ].
    VAR_046636

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti163 – 1631I → L in BAC85495. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122625 mRNA. Translation: BAC85495.1.
    AC096727 Genomic DNA. No translation available.
    AC107054 Genomic DNA. No translation available.
    CCDSiCCDS3520.1.
    RefSeqiNP_997290.2. NM_207407.2.
    UniGeneiHs.677557.

    Genome annotation databases

    EnsembliENST00000356291; ENSP00000348639; ENSG00000198092.
    GeneIDi389208.
    KEGGihsa:389208.
    UCSCiuc003hdt.1. human.

    Polymorphism databases

    DMDMi206729902.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122625 mRNA. Translation: BAC85495.1 .
    AC096727 Genomic DNA. No translation available.
    AC107054 Genomic DNA. No translation available.
    CCDSi CCDS3520.1.
    RefSeqi NP_997290.2. NM_207407.2.
    UniGenei Hs.677557.

    3D structure databases

    ProteinModelPortali Q6ZWK6.
    SMRi Q6ZWK6. Positions 57-438.
    ModBasei Search...

    Protein family/group databases

    MEROPSi S01.321.

    PTM databases

    PhosphoSitei Q6ZWK6.

    Polymorphism databases

    DMDMi 206729902.

    Proteomic databases

    PaxDbi Q6ZWK6.
    PRIDEi Q6ZWK6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356291 ; ENSP00000348639 ; ENSG00000198092 .
    GeneIDi 389208.
    KEGGi hsa:389208.
    UCSCi uc003hdt.1. human.

    Organism-specific databases

    CTDi 389208.
    GeneCardsi GC04M068918.
    HGNCi HGNC:29994. TMPRSS11F.
    HPAi HPA026911.
    neXtProti NX_Q6ZWK6.
    PharmGKBi PA142670730.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251823.
    HOVERGENi HBG013304.
    KOi K09752.
    OMAi THFVVED.
    OrthoDBi EOG75B84T.
    PhylomeDBi Q6ZWK6.
    TreeFami TF351684.

    Miscellaneous databases

    GenomeRNAii 389208.
    NextBioi 102720.
    PROi Q6ZWK6.

    Gene expression databases

    Bgeei Q6ZWK6.
    CleanExi HS_TMPRSS11F.
    Genevestigatori Q6ZWK6.

    Family and domain databases

    Gene3Di 3.30.70.960. 1 hit.
    InterProi IPR017329. Pept_S1A_HAT/DESC1.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR000082. SEA_dom.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF01390. SEA. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037941. TMPRSS11ABCDE. 1 hit.
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00200. SEA. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF82671. SSF82671. 1 hit.
    PROSITEi PS50024. SEA. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiTM11F_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZWK6
    Secondary accession number(s): A8MXX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 23, 2008
    Last modified: July 9, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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