TMPRSS11F

Functionⁱ

Probable serine protease.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	248	Charge relay systemBy similarity	1
Active siteⁱ	293	Charge relay systemBy similarity	1
Active siteⁱ	389	Charge relay systemBy similarity	1

GO - Molecular functionⁱ

serine-type endopeptidase activity Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Serine protease

Molecular function

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	S01.321.

MEROPSⁱ

S01.321.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protease serine 11F (EC:3.4.21.-) Alternative name(s): Airway trypsin-like protease 4
Gene namesⁱ	Name:TMPRSS11F Synonyms:HATL4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198092.5.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29994. TMPRSS11F.
neXtProtⁱ	NX_Q6ZWK6.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 32	CytoplasmicSequence analysisAdd BLAST	32
Transmembraneⁱ	33 – 53	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	54 – 438	ExtracellularSequence analysisAdd BLAST	385

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000198092.
PharmGKBⁱ	PA142670730.

Polymorphism and mutation databases

BioMutaⁱ	TMPRSS11F.
DMDMⁱ	206729902.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000299322	1 – 438	Transmembrane protease serine 11FAdd BLAST		438

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	233 ↔ 249	PROSITE-ProRule annotation
Disulfide bondⁱ	358 ↔ 374	PROSITE-ProRule annotation
Disulfide bondⁱ	385 ↔ 413	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	Q6ZWK6.
PeptideAtlas More...PeptideAtlasⁱ	Q6ZWK6.
PRIDEⁱ	Q6ZWK6.

PTM databases

iPTMnetⁱ	Q6ZWK6.
PhosphoSitePlusⁱ	Q6ZWK6.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000198092.
CleanExⁱ	HS_TMPRSS11F.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA026911.

HPAⁱ

HPA026911.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6ZWK6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	57 – 175	SEAPROSITE-ProRule annotationAdd BLAST		119
Domainⁱ	206 – 437	Peptidase S1PROSITE-ProRule annotationAdd BLAST		232

Sequence similaritiesⁱ

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3627. Eukaryota. COG5640. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140784.
HOGENOMⁱ	HOG000251823.
HOVERGENⁱ	HBG013304.
InParanoidⁱ	Q6ZWK6.
KEGG Orthology (KO) More...KOⁱ	K09752.
OMAⁱ	WGQSCAL.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DF7.
PhylomeDBⁱ	Q6ZWK6.
TreeFamⁱ	TF351684.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00190. Tryp_SPc. 1 hit.
Gene3Dⁱ	3.30.70.960. 1 hit.
InterProⁱ	View protein in InterPro IPR017329. Pept_S1A_HAT/DESC1. IPR009003. Peptidase_S1_PA. IPR001314. Peptidase_S1A. IPR000082. SEA_dom. IPR036364. SEA_dom_sf. IPR001254. Trypsin_dom. IPR018114. TRYPSIN_HIS. IPR033116. TRYPSIN_SER.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01390. SEA. 1 hit. PF00089. Trypsin. 1 hit.
PIRSFⁱ	PIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSⁱ	PR00722. CHYMOTRYPSIN.
SMARTⁱ	View protein in SMART SM00020. Tryp_SPc. 1 hit.
SUPFAMⁱ	SSF50494. SSF50494. 1 hit. SSF82671. SSF82671. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50024. SEA. 1 hit. PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6ZWK6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMYAPVEFSE AEFSRAEYQR KQQFWDSVRL ALFTLAIVAI IGIAIGIVTH 
        60         70         80         90        100
FVVEDDKSFY YLASFKVTNI KYKENYGIRS SREFIERSHQ IERMMSRIFR 
       110        120        130        140        150
HSSVGGRFIK SHVIKLSPDE QGVDILIVLI FRYPSTDSAE QIKKKIEKAL 
       160        170        180        190        200
YQSLKTKQLS LTINKPSFRL TPIDSKKMRN LLNSRCGIRM TSSNMPLPAS 
       210        220        230        240        250
SSTQRIVQGR ETAMEGEWPW QASLQLIGSG HQCGASLISN TWLLTAAHCF 
       260        270        280        290        300
WKNKDPTQWI ATFGATITPP AVKRNVRKII LHENYHRETN ENDIALVQLS 
       310        320        330        340        350
TGVEFSNIVQ RVCLPDSSIK LPPKTSVFVT GFGSIVDDGP IQNTLRQARV 
       360        370        380        390        400
ETISTDVCNR KDVYDGLITP GMLCAGFMEG KIDACKGDSG GPLVYDNHDI 
       410        420        430 
WYIVGIVSWG QSCALPKKPG VYTRVTKYRD WIASKTGM

Length:438

Mass (Da):49,410

Last modified:September 23, 2008 - v2

Checksum:ⁱF36C3D3EFB4D1E9A

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	163	I → L in BAC85495 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_034800	4	A → T. Corresponds to variant dbSNP:rs10030708Ensembl.		1
Natural variantⁱVAR_046636	124	D → N. Corresponds to variant dbSNP:rs1438391Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK122625 mRNA. Translation: BAC85495.1. AC096727 Genomic DNA. No translation available. AC107054 Genomic DNA. No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3520.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_997290.2. NM_207407.2.
UniGeneⁱ	Hs.677557.

Genome annotation databases

Ensemblⁱ	ENST00000356291; ENSP00000348639; ENSG00000198092.
GeneIDⁱ	389208.
KEGGⁱ	hsa:389208.
UCSC genome browser More...UCSCⁱ	uc003hdt.2. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q6ZWK6	UPI000B7B38C5 UPI0000D9B114 UPI0007DB9856 UPI00075FC9C1 A0A0D9QYW5 UPI00045E0D5F A0A2K6SVX0 UPI0002743EE9 A0A2K5RQU6 F6WP76 +19	Papio anubis (Olive baboon) Macaca mulatta (Rhesus macaque) Pan troglodytes (Chimpanzee) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Pan paniscus (Pygmy chimpanzee) (Bonobo) Cebus capucinus imitator Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Gorilla gorilla gorilla (Western lowland gorilla) And more	438	UniRef90_Q6ZWK6	Cluster: Transmembrane protease serine 11F	30

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q6ZWK6	UPI000B7B38C5 UPI0000D9B114 UPI0007DB9856 UPI00075FC9C1 A0A2K5CYU0 A0A2J8TL00 A0A2K5H6N3 H2PDA4 G1RD96 A0A2K6RGI4 +37	Papio anubis (Olive baboon) Macaca mulatta (Rhesus macaque) Pan troglodytes (Chimpanzee) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Aotus nancymaae (Ma's night monkey) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Colobus angolensis palliatus (Peters' Angolan colobus) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Gorilla gorilla gorilla (Western lowland gorilla) And more	438	UniRef50_Q6ZWK6	Cluster: Transmembrane protease serine 11F	48

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK122625 mRNA. Translation: BAC85495.1. AC096727 Genomic DNA. No translation available. AC107054 Genomic DNA. No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3520.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_997290.2. NM_207407.2.
UniGeneⁱ	Hs.677557.

3D structure databases

ProteinModelPortalⁱ	Q6ZWK6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	S01.321.

MEROPSⁱ

S01.321.

PTM databases

iPTMnetⁱ	Q6ZWK6.
PhosphoSitePlusⁱ	Q6ZWK6.

Polymorphism and mutation databases

BioMutaⁱ	TMPRSS11F.
DMDMⁱ	206729902.

Proteomic databases

PaxDbⁱ	Q6ZWK6.
PeptideAtlas More...PeptideAtlasⁱ	Q6ZWK6.
PRIDEⁱ	Q6ZWK6.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000356291; ENSP00000348639; ENSG00000198092.
GeneIDⁱ	389208.
KEGGⁱ	hsa:389208.
UCSC genome browser More...UCSCⁱ	uc003hdt.2. human.

Organism-specific databases

CTDⁱ	389208.
EuPathDBⁱ	HostDB:ENSG00000198092.5.
GeneCardsⁱ	TMPRSS11F.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29994. TMPRSS11F.
Human Protein Atlas More...HPAⁱ	HPA026911.
neXtProtⁱ	NX_Q6ZWK6.
Open Targets More...OpenTargetsⁱ	ENSG00000198092.
PharmGKBⁱ	PA142670730.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3627. Eukaryota. COG5640. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140784.
HOGENOMⁱ	HOG000251823.
HOVERGENⁱ	HBG013304.
InParanoidⁱ	Q6ZWK6.
KEGG Orthology (KO) More...KOⁱ	K09752.
OMAⁱ	WGQSCAL.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DF7.
PhylomeDBⁱ	Q6ZWK6.
TreeFamⁱ	TF351684.

Miscellaneous databases

ChiTaRSⁱ	TMPRSS11F. human.
GenomeRNAiⁱ	389208.
Protein Ontology More...PROⁱ	PR:Q6ZWK6.

Gene expression databases

Bgeeⁱ	ENSG00000198092.
CleanExⁱ	HS_TMPRSS11F.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00190. Tryp_SPc. 1 hit.
Gene3Dⁱ	3.30.70.960. 1 hit.
InterProⁱ	View protein in InterPro IPR017329. Pept_S1A_HAT/DESC1. IPR009003. Peptidase_S1_PA. IPR001314. Peptidase_S1A. IPR000082. SEA_dom. IPR036364. SEA_dom_sf. IPR001254. Trypsin_dom. IPR018114. TRYPSIN_HIS. IPR033116. TRYPSIN_SER.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01390. SEA. 1 hit. PF00089. Trypsin. 1 hit.
PIRSFⁱ	PIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSⁱ	PR00722. CHYMOTRYPSIN.
SMARTⁱ	View protein in SMART SM00020. Tryp_SPc. 1 hit.
SUPFAMⁱ	SSF50494. SSF50494. 1 hit. SSF82671. SSF82671. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50024. SEA. 1 hit. PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TM11F_HUMAN
Accessionⁱ	Q6ZWK6Primary (citable) accession number: Q6ZWK6 Secondary accession number(s): A8MXX2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
	Last sequence update:	September 23, 2008
	Last modified:	February 28, 2018
	This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6ZWK6 (TM11F_HUMAN)

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Transmembrane protease serine 11F

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Plasma Membrane

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ