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Q6ZWK6

- TM11F_HUMAN

UniProt

Q6ZWK6 - TM11F_HUMAN

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Protein

Transmembrane protease serine 11F

Gene

TMPRSS11F

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Probable serine protease.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei248 – 2481Charge relay systemBy similarity
Active sitei293 – 2931Charge relay systemBy similarity
Active sitei389 – 3891Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.321.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11F (EC:3.4.21.-)
Alternative name(s):
Airway trypsin-like protease 4
Gene namesi
Name:TMPRSS11F
Synonyms:HATL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:29994. TMPRSS11F.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei33 – 5321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini54 – 438385ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: InterPro
  2. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Transmembrane protease serine 11FPRO_0000299322Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi233 ↔ 249PROSITE-ProRule annotation
Disulfide bondi358 ↔ 374PROSITE-ProRule annotation
Disulfide bondi385 ↔ 413PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6ZWK6.
PRIDEiQ6ZWK6.

PTM databases

PhosphoSiteiQ6ZWK6.

Expressioni

Gene expression databases

BgeeiQ6ZWK6.
CleanExiHS_TMPRSS11F.
GenevestigatoriQ6ZWK6.

Organism-specific databases

HPAiHPA026911.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWK6.
SMRiQ6ZWK6. Positions 57-438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 175119SEAPROSITE-ProRule annotationAdd
BLAST
Domaini206 – 437232Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ6ZWK6.
KOiK09752.
OMAiTHFVVED.
OrthoDBiEOG75B84T.
PhylomeDBiQ6ZWK6.
TreeFamiTF351684.

Family and domain databases

Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00200. SEA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZWK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMYAPVEFSE AEFSRAEYQR KQQFWDSVRL ALFTLAIVAI IGIAIGIVTH
60 70 80 90 100
FVVEDDKSFY YLASFKVTNI KYKENYGIRS SREFIERSHQ IERMMSRIFR
110 120 130 140 150
HSSVGGRFIK SHVIKLSPDE QGVDILIVLI FRYPSTDSAE QIKKKIEKAL
160 170 180 190 200
YQSLKTKQLS LTINKPSFRL TPIDSKKMRN LLNSRCGIRM TSSNMPLPAS
210 220 230 240 250
SSTQRIVQGR ETAMEGEWPW QASLQLIGSG HQCGASLISN TWLLTAAHCF
260 270 280 290 300
WKNKDPTQWI ATFGATITPP AVKRNVRKII LHENYHRETN ENDIALVQLS
310 320 330 340 350
TGVEFSNIVQ RVCLPDSSIK LPPKTSVFVT GFGSIVDDGP IQNTLRQARV
360 370 380 390 400
ETISTDVCNR KDVYDGLITP GMLCAGFMEG KIDACKGDSG GPLVYDNHDI
410 420 430
WYIVGIVSWG QSCALPKKPG VYTRVTKYRD WIASKTGM
Length:438
Mass (Da):49,410
Last modified:September 23, 2008 - v2
Checksum:iF36C3D3EFB4D1E9A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti163 – 1631I → L in BAC85495. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41A → T.
Corresponds to variant rs10030708 [ dbSNP | Ensembl ].
VAR_034800
Natural varianti124 – 1241D → N.
Corresponds to variant rs1438391 [ dbSNP | Ensembl ].
VAR_046636

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122625 mRNA. Translation: BAC85495.1.
AC096727 Genomic DNA. No translation available.
AC107054 Genomic DNA. No translation available.
CCDSiCCDS3520.1.
RefSeqiNP_997290.2. NM_207407.2.
UniGeneiHs.677557.

Genome annotation databases

EnsembliENST00000356291; ENSP00000348639; ENSG00000198092.
GeneIDi389208.
KEGGihsa:389208.
UCSCiuc003hdt.1. human.

Polymorphism databases

DMDMi206729902.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122625 mRNA. Translation: BAC85495.1 .
AC096727 Genomic DNA. No translation available.
AC107054 Genomic DNA. No translation available.
CCDSi CCDS3520.1.
RefSeqi NP_997290.2. NM_207407.2.
UniGenei Hs.677557.

3D structure databases

ProteinModelPortali Q6ZWK6.
SMRi Q6ZWK6. Positions 57-438.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.321.

PTM databases

PhosphoSitei Q6ZWK6.

Polymorphism databases

DMDMi 206729902.

Proteomic databases

PaxDbi Q6ZWK6.
PRIDEi Q6ZWK6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356291 ; ENSP00000348639 ; ENSG00000198092 .
GeneIDi 389208.
KEGGi hsa:389208.
UCSCi uc003hdt.1. human.

Organism-specific databases

CTDi 389208.
GeneCardsi GC04M068918.
HGNCi HGNC:29994. TMPRSS11F.
HPAi HPA026911.
neXtProti NX_Q6ZWK6.
PharmGKBi PA142670730.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000118962.
HOGENOMi HOG000251823.
HOVERGENi HBG013304.
InParanoidi Q6ZWK6.
KOi K09752.
OMAi THFVVED.
OrthoDBi EOG75B84T.
PhylomeDBi Q6ZWK6.
TreeFami TF351684.

Miscellaneous databases

GenomeRNAii 389208.
NextBioi 102720.
PROi Q6ZWK6.

Gene expression databases

Bgeei Q6ZWK6.
CleanExi HS_TMPRSS11F.
Genevestigatori Q6ZWK6.

Family and domain databases

Gene3Di 3.30.70.960. 1 hit.
InterProi IPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view ]
PIRSFi PIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00200. SEA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEi PS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTM11F_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWK6
Secondary accession number(s): A8MXX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3