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Protein

Transmembrane protease serine 11F

Gene

TMPRSS11F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable serine protease.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei248Charge relay systemBy similarity1
Active sitei293Charge relay systemBy similarity1
Active sitei389Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.321.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11F (EC:3.4.21.-)
Alternative name(s):
Airway trypsin-like protease 4
Gene namesi
Name:TMPRSS11F
Synonyms:HATL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:29994. TMPRSS11F.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 53Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini54 – 438ExtracellularSequence analysisAdd BLAST385

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198092.
PharmGKBiPA142670730.

Polymorphism and mutation databases

BioMutaiTMPRSS11F.
DMDMi206729902.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002993221 – 438Transmembrane protease serine 11FAdd BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi233 ↔ 249PROSITE-ProRule annotation
Disulfide bondi358 ↔ 374PROSITE-ProRule annotation
Disulfide bondi385 ↔ 413PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6ZWK6.
PeptideAtlasiQ6ZWK6.
PRIDEiQ6ZWK6.

PTM databases

iPTMnetiQ6ZWK6.
PhosphoSitePlusiQ6ZWK6.

Expressioni

Gene expression databases

BgeeiENSG00000198092.
CleanExiHS_TMPRSS11F.

Organism-specific databases

HPAiHPA026911.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 175SEAPROSITE-ProRule annotationAdd BLAST119
Domaini206 – 437Peptidase S1PROSITE-ProRule annotationAdd BLAST232

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ6ZWK6.
KOiK09752.
OMAiTHFVVED.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ6ZWK6.
TreeFamiTF351684.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZWK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMYAPVEFSE AEFSRAEYQR KQQFWDSVRL ALFTLAIVAI IGIAIGIVTH
60 70 80 90 100
FVVEDDKSFY YLASFKVTNI KYKENYGIRS SREFIERSHQ IERMMSRIFR
110 120 130 140 150
HSSVGGRFIK SHVIKLSPDE QGVDILIVLI FRYPSTDSAE QIKKKIEKAL
160 170 180 190 200
YQSLKTKQLS LTINKPSFRL TPIDSKKMRN LLNSRCGIRM TSSNMPLPAS
210 220 230 240 250
SSTQRIVQGR ETAMEGEWPW QASLQLIGSG HQCGASLISN TWLLTAAHCF
260 270 280 290 300
WKNKDPTQWI ATFGATITPP AVKRNVRKII LHENYHRETN ENDIALVQLS
310 320 330 340 350
TGVEFSNIVQ RVCLPDSSIK LPPKTSVFVT GFGSIVDDGP IQNTLRQARV
360 370 380 390 400
ETISTDVCNR KDVYDGLITP GMLCAGFMEG KIDACKGDSG GPLVYDNHDI
410 420 430
WYIVGIVSWG QSCALPKKPG VYTRVTKYRD WIASKTGM
Length:438
Mass (Da):49,410
Last modified:September 23, 2008 - v2
Checksum:iF36C3D3EFB4D1E9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163I → L in BAC85495 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0348004A → T.Corresponds to variant rs10030708dbSNPEnsembl.1
Natural variantiVAR_046636124D → N.Corresponds to variant rs1438391dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122625 mRNA. Translation: BAC85495.1.
AC096727 Genomic DNA. No translation available.
AC107054 Genomic DNA. No translation available.
CCDSiCCDS3520.1.
RefSeqiNP_997290.2. NM_207407.2.
UniGeneiHs.677557.

Genome annotation databases

EnsembliENST00000356291; ENSP00000348639; ENSG00000198092.
GeneIDi389208.
KEGGihsa:389208.
UCSCiuc003hdt.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122625 mRNA. Translation: BAC85495.1.
AC096727 Genomic DNA. No translation available.
AC107054 Genomic DNA. No translation available.
CCDSiCCDS3520.1.
RefSeqiNP_997290.2. NM_207407.2.
UniGeneiHs.677557.

3D structure databases

ProteinModelPortaliQ6ZWK6.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.321.

PTM databases

iPTMnetiQ6ZWK6.
PhosphoSitePlusiQ6ZWK6.

Polymorphism and mutation databases

BioMutaiTMPRSS11F.
DMDMi206729902.

Proteomic databases

PaxDbiQ6ZWK6.
PeptideAtlasiQ6ZWK6.
PRIDEiQ6ZWK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356291; ENSP00000348639; ENSG00000198092.
GeneIDi389208.
KEGGihsa:389208.
UCSCiuc003hdt.2. human.

Organism-specific databases

CTDi389208.
GeneCardsiTMPRSS11F.
HGNCiHGNC:29994. TMPRSS11F.
HPAiHPA026911.
neXtProtiNX_Q6ZWK6.
OpenTargetsiENSG00000198092.
PharmGKBiPA142670730.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ6ZWK6.
KOiK09752.
OMAiTHFVVED.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ6ZWK6.
TreeFamiTF351684.

Miscellaneous databases

GenomeRNAii389208.
PROiQ6ZWK6.

Gene expression databases

BgeeiENSG00000198092.
CleanExiHS_TMPRSS11F.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM11F_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWK6
Secondary accession number(s): A8MXX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.