UniProtKB - Q6ZWK6 (TM11F_HUMAN)
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Protein
Transmembrane protease serine 11F
Gene
TMPRSS11F
Organism
Homo sapiens (Human)
Status
Functioni
Probable serine protease.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 248 | Charge relay systemBy similarity | 1 | |
Active sitei | 293 | Charge relay systemBy similarity | 1 | |
Active sitei | 389 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Protein family/group databases
MEROPSi | S01.321. |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protease serine 11F (EC:3.4.21.-)Alternative name(s): Airway trypsin-like protease 4 |
Gene namesi | Name:TMPRSS11F Synonyms:HATL4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000198092.5. |
HGNCi | HGNC:29994. TMPRSS11F. |
neXtProti | NX_Q6ZWK6. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 32 | CytoplasmicSequence analysisAdd BLAST | 32 | |
Transmembranei | 33 – 53 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 54 – 438 | ExtracellularSequence analysisAdd BLAST | 385 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000198092. |
PharmGKBi | PA142670730. |
Polymorphism and mutation databases
BioMutai | TMPRSS11F. |
DMDMi | 206729902. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299322 | 1 – 438 | Transmembrane protease serine 11FAdd BLAST | 438 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 233 ↔ 249 | PROSITE-ProRule annotation | ||
Disulfide bondi | 358 ↔ 374 | PROSITE-ProRule annotation | ||
Disulfide bondi | 385 ↔ 413 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | Q6ZWK6. |
PeptideAtlasi | Q6ZWK6. |
PRIDEi | Q6ZWK6. |
PTM databases
iPTMneti | Q6ZWK6. |
PhosphoSitePlusi | Q6ZWK6. |
Expressioni
Gene expression databases
Bgeei | ENSG00000198092. |
CleanExi | HS_TMPRSS11F. |
Organism-specific databases
HPAi | HPA026911. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 57 – 175 | SEAPROSITE-ProRule annotationAdd BLAST | 119 | |
Domaini | 206 – 437 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 232 |
Sequence similaritiesi
Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3627. Eukaryota. COG5640. LUCA. |
GeneTreei | ENSGT00900000140784. |
HOGENOMi | HOG000251823. |
HOVERGENi | HBG013304. |
InParanoidi | Q6ZWK6. |
KOi | K09752. |
OMAi | WGQSCAL. |
OrthoDBi | EOG091G0DF7. |
PhylomeDBi | Q6ZWK6. |
TreeFami | TF351684. |
Family and domain databases
CDDi | cd00190. Tryp_SPc. 1 hit. |
Gene3Di | 3.30.70.960. 1 hit. |
InterProi | View protein in InterPro IPR017329. Pept_S1A_HAT/DESC1. IPR009003. Peptidase_S1_PA. IPR001314. Peptidase_S1A. IPR000082. SEA_dom. IPR036364. SEA_dom_sf. IPR001254. Trypsin_dom. IPR018114. TRYPSIN_HIS. IPR033116. TRYPSIN_SER. |
Pfami | View protein in Pfam PF01390. SEA. 1 hit. PF00089. Trypsin. 1 hit. |
PIRSFi | PIRSF037941. TMPRSS11ABCDE. 1 hit. |
PRINTSi | PR00722. CHYMOTRYPSIN. |
SMARTi | View protein in SMART SM00020. Tryp_SPc. 1 hit. |
SUPFAMi | SSF50494. SSF50494. 1 hit. SSF82671. SSF82671. 1 hit. |
PROSITEi | View protein in PROSITE PS50024. SEA. 1 hit. PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q6ZWK6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMYAPVEFSE AEFSRAEYQR KQQFWDSVRL ALFTLAIVAI IGIAIGIVTH
60 70 80 90 100
FVVEDDKSFY YLASFKVTNI KYKENYGIRS SREFIERSHQ IERMMSRIFR
110 120 130 140 150
HSSVGGRFIK SHVIKLSPDE QGVDILIVLI FRYPSTDSAE QIKKKIEKAL
160 170 180 190 200
YQSLKTKQLS LTINKPSFRL TPIDSKKMRN LLNSRCGIRM TSSNMPLPAS
210 220 230 240 250
SSTQRIVQGR ETAMEGEWPW QASLQLIGSG HQCGASLISN TWLLTAAHCF
260 270 280 290 300
WKNKDPTQWI ATFGATITPP AVKRNVRKII LHENYHRETN ENDIALVQLS
310 320 330 340 350
TGVEFSNIVQ RVCLPDSSIK LPPKTSVFVT GFGSIVDDGP IQNTLRQARV
360 370 380 390 400
ETISTDVCNR KDVYDGLITP GMLCAGFMEG KIDACKGDSG GPLVYDNHDI
410 420 430
WYIVGIVSWG QSCALPKKPG VYTRVTKYRD WIASKTGM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 163 | I → L in BAC85495 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034800 | 4 | A → T. Corresponds to variant dbSNP:rs10030708Ensembl. | 1 | |
Natural variantiVAR_046636 | 124 | D → N. Corresponds to variant dbSNP:rs1438391Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK122625 mRNA. Translation: BAC85495.1. AC096727 Genomic DNA. No translation available. AC107054 Genomic DNA. No translation available. |
CCDSi | CCDS3520.1. |
RefSeqi | NP_997290.2. NM_207407.2. |
UniGenei | Hs.677557. |
Genome annotation databases
Ensembli | ENST00000356291; ENSP00000348639; ENSG00000198092. |
GeneIDi | 389208. |
KEGGi | hsa:389208. |
UCSCi | uc003hdt.2. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | TM11F_HUMAN | |
Accessioni | Q6ZWK6Primary (citable) accession number: Q6ZWK6 Secondary accession number(s): A8MXX2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | September 23, 2008 | |
Last modified: | February 28, 2018 | |
This is version 118 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |