Q6ZWK6 (TM11F_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protease serine 11F
EC=3.4.21.-

Alternative name(s):
Airway trypsin-like protease 4

Gene names

Name:	TMPRSS11F
Synonyms:	HATL4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable serine protease By similarity.
Subcellular location	Membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. Contains 1 SEA domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: InterPro integral component of plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 438	438	Transmembrane protease serine 11F		PRO_0000299322
Regions
	Topological domain	1 – 32	32	Cytoplasmic Potential
	Transmembrane	33 – 53	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	54 – 438	385	Extracellular Potential
	Domain	57 – 175	119	SEA
	Domain	206 – 437	232	Peptidase S1
Sites
	Active site	248	1	Charge relay system By similarity
	Active site	293	1	Charge relay system By similarity
	Active site	389	1	Charge relay system By similarity
Amino acid modifications
	Disulfide bond	233 ↔ 249		By similarity
	Disulfide bond	358 ↔ 374		By similarity
	Disulfide bond	385 ↔ 413		By similarity
Natural variations
	Natural variant	4	1	A → T. Corresponds to variant rs10030708 [ dbSNP | Ensembl ].		VAR_034800
	Natural variant	124	1	D → N. Corresponds to variant rs1438391 [ dbSNP | Ensembl ].		VAR_046636
Experimental info
	Sequence conflict	163	1	I → L in BAC85495. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6ZWK6 [UniParc]. Last modified September 23, 2008. Version 2. Checksum: F36C3D3EFB4D1E9A	FASTA	438	49,410
	10 20 30 40 50 60 MMYAPVEFSE AEFSRAEYQR KQQFWDSVRL ALFTLAIVAI IGIAIGIVTH FVVEDDKSFY 70 80 90 100 110 120 YLASFKVTNI KYKENYGIRS SREFIERSHQ IERMMSRIFR HSSVGGRFIK SHVIKLSPDE 130 140 150 160 170 180 QGVDILIVLI FRYPSTDSAE QIKKKIEKAL YQSLKTKQLS LTINKPSFRL TPIDSKKMRN 190 200 210 220 230 240 LLNSRCGIRM TSSNMPLPAS SSTQRIVQGR ETAMEGEWPW QASLQLIGSG HQCGASLISN 250 260 270 280 290 300 TWLLTAAHCF WKNKDPTQWI ATFGATITPP AVKRNVRKII LHENYHRETN ENDIALVQLS 310 320 330 340 350 360 TGVEFSNIVQ RVCLPDSSIK LPPKTSVFVT GFGSIVDDGP IQNTLRQARV ETISTDVCNR 370 380 390 400 410 420 KDVYDGLITP GMLCAGFMEG KIDACKGDSG GPLVYDNHDI WYIVGIVSWG QSCALPKKPG 430 VYTRVTKYRD WIASKTGM

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Tongue.

[2]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK122625 mRNA. Translation: BAC85495.1. AC096727 Genomic DNA. No translation available. AC107054 Genomic DNA. No translation available.
RefSeq	NP_997290.2. NM_207407.2.
UniGene	Hs.677557.
3D structure databases
ProteinModelPortal	Q6ZWK6.
SMR	Q6ZWK6. Positions 57-438.
ModBase	Search...
MobiDB	Search...
Protein family/group databases
MEROPS	S01.321.
PTM databases
PhosphoSite	Q6ZWK6.
Polymorphism databases
DMDM	206729902.
Proteomic databases
PaxDb	Q6ZWK6.
PRIDE	Q6ZWK6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356291; ENSP00000348639; ENSG00000198092.
GeneID	389208.
KEGG	hsa:389208.
UCSC	uc003hdt.1. human.
Organism-specific databases
CTD	389208.
GeneCards	GC04M068918.
HGNC	HGNC:29994. TMPRSS11F.
HPA	HPA026911.
neXtProt	NX_Q6ZWK6.
PharmGKB	PA142670730.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5640.
HOGENOM	HOG000251823.
HOVERGEN	HBG013304.
KO	K09752.
OMA	THFVVED.
OrthoDB	EOG75B84T.
PhylomeDB	Q6ZWK6.
TreeFam	TF351684.
Gene expression databases
Bgee	Q6ZWK6.
CleanEx	HS_TMPRSS11F.
Genevestigator	Q6ZWK6.
Family and domain databases
Gene3D	3.30.70.960. 1 hit.
InterPro	IPR017329. Pept_S1A_HAT/DESC1. IPR001254. Peptidase_S1. IPR018114. Peptidase_S1_AS. IPR001314. Peptidase_S1A. IPR000082. SEA_dom. IPR009003. Trypsin-like_Pept_dom. [Graphical view]
Pfam	PF01390. SEA. 1 hit. PF00089. Trypsin. 1 hit. [Graphical view]
PIRSF	PIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00200. SEA. 1 hit. SM00020. Tryp_SPc. 1 hit. [Graphical view]
SUPFAM	SSF50494. SSF50494. 1 hit. SSF82671. SSF82671. 1 hit.
PROSITE	PS50024. SEA. 1 hit. PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	389208.
NextBio	102720.
PRO	Q6ZWK6.

Entry information

Entry name

TM11F_HUMAN

Accession

Primary (citable) accession number: Q6ZWK6
Secondary accession number(s): A8MXX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 23, 2008
Last modified:	March 19, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.