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Q6ZWJ8

- KCP_HUMAN

UniProt

Q6ZWJ8 - KCP_HUMAN

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Protein

Kielin/chordin-like protein

Gene

KCP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Kielin/chordin-like protein
Alternative name(s):
Cysteine-rich BMP regulator 2
Cysteine-rich motor neuron 2 protein
Short name:
CRIM-2
Kielin/chordin-like protein 1
Short name:
KCP-1
Gene namesi
Name:KCP
Synonyms:CRIM2, KCP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:17585. KCP.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164721151.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 15031477Kielin/chordin-like proteinPRO_0000318586Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1172 ↔ 1180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6ZWJ8.
PRIDEiQ6ZWJ8.

PTM databases

PhosphoSiteiQ6ZWJ8.

Expressioni

Gene expression databases

CleanExiHS_CRIM2.
GenevestigatoriQ6ZWJ8.

Interactioni

Subunit structurei

Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine/threonine protein kinase domains. Also able to interact with activin-A and TGFB1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000396664.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWJ8.
SMRiQ6ZWJ8. Positions 112-173, 252-287, 1056-1121, 1410-1495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini136 – 19358VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini190 – 25061VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini250 – 30859VWFC 3PROSITE-ProRule annotationAdd
BLAST
Domaini308 – 36760VWFC 4PROSITE-ProRule annotationAdd
BLAST
Domaini364 – 42360VWFC 5PROSITE-ProRule annotationAdd
BLAST
Domaini423 – 48260VWFC 6PROSITE-ProRule annotationAdd
BLAST
Domaini482 – 54059VWFC 7PROSITE-ProRule annotationAdd
BLAST
Domaini540 – 59960VWFC 8PROSITE-ProRule annotationAdd
BLAST
Domaini602 – 66059VWFC 9PROSITE-ProRule annotationAdd
BLAST
Domaini660 – 71758VWFC 10PROSITE-ProRule annotationAdd
BLAST
Domaini717 – 77660VWFC 11PROSITE-ProRule annotationAdd
BLAST
Domaini776 – 83863VWFC 12PROSITE-ProRule annotationAdd
BLAST
Domaini835 – 89460VWFC 13PROSITE-ProRule annotationAdd
BLAST
Domaini894 – 95259VWFC 14PROSITE-ProRule annotationAdd
BLAST
Domaini952 – 102069VWFC 15PROSITE-ProRule annotationAdd
BLAST
Domaini1017 – 108064VWFC 16PROSITE-ProRule annotationAdd
BLAST
Domaini1084 – 114461VWFC 17PROSITE-ProRule annotationAdd
BLAST
Domaini1149 – 1361213VWFDPROSITE-ProRule annotationAdd
BLAST
Domaini1418 – 147861TILAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili56 – 8833Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 17 VWFC domains.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal

Phylogenomic databases

eggNOGiNOG283828.
InParanoidiQ6ZWJ8.
PhylomeDBiQ6ZWJ8.

Family and domain databases

InterProiIPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF00093. VWC. 8 hits.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00214. VWC. 16 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 1 hit.
PROSITEiPS01208. VWFC_1. 12 hits.
PS50184. VWFC_2. 15 hits.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZWJ8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGVGAAALS LLLHLGALAL AAGAEGGAVP REPPGQQTTA HSSVLAGNSQ
60 70 80 90 100
EQWHPLREWL GRLEAAVMEL REQNKDLQTR VRQLESCECH PASPQCWGLG
110 120 130 140 150
RAWPEGARWE PDACTACVCQ DGAAHCGPQA HLPHCRGCSQ NGQTYGNGET
160 170 180 190 200
FSPDACTTCR CLTGAVQCQG PSCSELNCLE SCTPPGECCP ICCTEGGSHW
210 220 230 240 250
EHGQEWTTPG DPCRICRCLE GHIQCRQREC ASLCPYPARP LPGTCCPVCD
260 270 280 290 300
GCFLNGREHR SGEPVGSGDP CSHCRCANGS VQCEPLPCPP VPCRHPGKIP
310 320 330 340 350
GQCCPVCDGC EYQGHQYQSQ ETFRLQERGL CVRCSCQAGE VSCEEQECPV
360 370 380 390 400
TPCALPASGR QLCPACELDG EEFAEGVQWE PDGRPCTACV CQDGVPKCGA
410 420 430 440 450
VLCPPAPCQH PTQPPGACCP SCDSCTYHSQ VYANGQNFTD ADSPCHACHC
460 470 480 490 500
QDGTVTCSLV DCPPTTCARP QSGPGQCCPR CPDCILEEEV FVDGESFSHP
510 520 530 540 550
RDPCQECRCQ EGHAHCQPRP CPRAPCAHPL PGTCCPNDCS GCAFGGKEYP
560 570 580 590 600
SGADFPHPSD PCRLCRCLSG NVQCLARRCV PLPCPEPVLL PGECCPQCPA
610 620 630 640 650
PAGCPRPGAA HARHQEYFSP PGDPCRRCLC LDGSVSCQRL PCPPAPCAHP
660 670 680 690 700
RQGPCCPSCD GCLYQGKEFA SGERFPSPTA ACHLCLCWEG SVSCEPKACA
710 720 730 740 750
PALCPFPARG DCCPDCDGCE YLGESYLSNQ EFPDPREPCN LCTCLGGFVT
760 770 780 790 800
CGRRPCEPPG CSHPLIPSGH CCPTCQGCRY HGVTTASGET LPDPLDPTCS
810 820 830 840 850
LCTCQEGSMR CQKKPCPPAL CPHPSPGPCF CPVCHSCLSQ GREHQDGEEF
860 870 880 890 900
EGPAGSCEWC RCQAGQVSCV RLQCPPLPCK LQVTERGSCC PRCRGCLAHG
910 920 930 940 950
EEHPEGSRWV PPDSACSSCV CHEGVVTCAR IQCISSCAQP RQGPHDCCPQ
960 970 980 990 1000
CSDCEHEGRK YEPGESFQPG ADPCEVCICE PQPEGPPSLR CHRRQCPSLV
1010 1020 1030 1040 1050
GCPPSQLLPP GPQHCCPTCA EALSNCSEGL LGSELAPPDP CYTCQCQDLT
1060 1070 1080 1090 1100
WLCIHQACPE LSCPLSERHT PPGSCCPVCR APTQSCVHQG REVASGERWT
1110 1120 1130 1140 1150
VDTCTSCSCM AGTVRCQSQR CSPLSCGPDK APALSPGSCC PRCLPRPASC
1160 1170 1180 1190 1200
MAFGDPHYRT FDGRLLHFQG SCSYVLAKDC HSGDFSVHVT NDDRGRSGVA
1210 1220 1230 1240 1250
WTQEVAVLLG DMAVRLLQDG AVTVDGHPVA LPFLQEPLLY VELRGHTVIL
1260 1270 1280 1290 1300
HAQPGLQVLW DGQSQVEVSV PGSYQGRTCG LCGNFNGFAQ DDLQGPEGLL
1310 1320 1330 1340 1350
LPSEAAFGNS WQVSEGLWPG RPCSAGREVD PCRAAGYRAR REANARCGVL
1360 1370 1380 1390 1400
KSSPFSRCHA VVPPEPFFAA CVYDLCACGP GSSADACLCD ALEAYASHCR
1410 1420 1430 1440 1450
QAGVTPTWRG PTLCVVGCPL ERGFVFDECG PPCPRTCFNQ HIPLGELAAH
1460 1470 1480 1490 1500
CVRPCVPGCQ CPAGLVEHEA HCIPPEACPQ VLLTGDQPLG ARPSPSREPQ

ETP
Length:1,503
Mass (Da):159,938
Last modified:December 16, 2008 - v2
Checksum:i4301A320744B6E0B
GO
Isoform 2 (identifier: Q6ZWJ8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1109: Missing.
     1314-1403: SEGLWPGRPC...AYASHCRQAG → QEGRGYPPGL...LKASCDGSRL
     1404-1503: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:294
Mass (Da):31,744
Checksum:i12152D81A55C0925
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471G → E.
Corresponds to variant rs7787221 [ dbSNP | Ensembl ].
VAR_038783
Natural varianti397 – 3971K → E.
Corresponds to variant rs7782976 [ dbSNP | Ensembl ].
VAR_059625
Natural varianti623 – 6231D → V.
Corresponds to variant rs3734971 [ dbSNP | Ensembl ].
VAR_059626
Natural varianti1128 – 11281P → R.
Corresponds to variant rs7786641 [ dbSNP | Ensembl ].
VAR_059627

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11091109Missing in isoform 2. 1 PublicationVSP_036045Add
BLAST
Alternative sequencei1314 – 140390SEGLW…CRQAG → QEGRGYPPGLELPPVLLQME WSRRAQEQLLWDLELLTGVE LGLFWPPQAQFFGPRGQAQQ AWSQCCQPGGSTGGDPEQPI LKASCDGSRL in isoform 2. 1 PublicationVSP_036046Add
BLAST
Alternative sequencei1404 – 1503100Missing in isoform 2. 1 PublicationVSP_036047Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122706 mRNA. Translation: BAC85504.1.
AK090684 mRNA. Translation: BAC03505.1.
CH471070 Genomic DNA. Translation: EAW83694.1.
RefSeqiNP_001129386.1. NM_001135914.1. [Q6ZWJ8-1]
NP_955381.2. NM_199349.2.
UniGeneiHs.371746.

Genome annotation databases

GeneIDi375616.
KEGGihsa:375616.
UCSCiuc011kor.2. human. [Q6ZWJ8-1]

Polymorphism databases

DMDMi218511989.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122706 mRNA. Translation: BAC85504.1 .
AK090684 mRNA. Translation: BAC03505.1 .
CH471070 Genomic DNA. Translation: EAW83694.1 .
RefSeqi NP_001129386.1. NM_001135914.1. [Q6ZWJ8-1 ]
NP_955381.2. NM_199349.2.
UniGenei Hs.371746.

3D structure databases

ProteinModelPortali Q6ZWJ8.
SMRi Q6ZWJ8. Positions 112-173, 252-287, 1056-1121, 1410-1495.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000396664.

PTM databases

PhosphoSitei Q6ZWJ8.

Polymorphism databases

DMDMi 218511989.

Proteomic databases

PaxDbi Q6ZWJ8.
PRIDEi Q6ZWJ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 375616.
KEGGi hsa:375616.
UCSCi uc011kor.2. human. [Q6ZWJ8-1 ]

Organism-specific databases

CTDi 375616.
GeneCardsi GC07M128503.
HGNCi HGNC:17585. KCP.
MIMi 609344. gene.
neXtProti NX_Q6ZWJ8.
PharmGKBi PA164721151.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283828.
InParanoidi Q6ZWJ8.
PhylomeDBi Q6ZWJ8.

Miscellaneous databases

GenomeRNAii 375616.
NextBioi 100559.
PROi Q6ZWJ8.
SOURCEi Search...

Gene expression databases

CleanExi HS_CRIM2.
Genevestigatori Q6ZWJ8.

Family and domain databases

InterProi IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF00093. VWC. 8 hits.
PF00094. VWD. 1 hit.
[Graphical view ]
SMARTi SM00832. C8. 1 hit.
SM00214. VWC. 16 hits.
SM00216. VWD. 1 hit.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 1 hit.
PROSITEi PS01208. VWFC_1. 12 hits.
PS50184. VWFC_2. 15 hits.
PS51233. VWFD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Thalamus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKCP_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWJ8
Secondary accession number(s): Q8NBE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3