Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6ZWJ8

- KCP_HUMAN

UniProt

Q6ZWJ8 - KCP_HUMAN

Protein

Kielin/chordin-like protein

Gene

KCP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kielin/chordin-like protein
    Alternative name(s):
    Cysteine-rich BMP regulator 2
    Cysteine-rich motor neuron 2 protein
    Short name:
    CRIM-2
    Kielin/chordin-like protein 1
    Short name:
    KCP-1
    Gene namesi
    Name:KCP
    Synonyms:CRIM2, KCP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:17585. KCP.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164721151.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 15031477Kielin/chordin-like proteinPRO_0000318586Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1172 ↔ 1180PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ6ZWJ8.
    PRIDEiQ6ZWJ8.

    PTM databases

    PhosphoSiteiQ6ZWJ8.

    Expressioni

    Gene expression databases

    CleanExiHS_CRIM2.
    GenevestigatoriQ6ZWJ8.

    Interactioni

    Subunit structurei

    Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine/threonine protein kinase domains. Also able to interact with activin-A and TGFB1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000396664.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZWJ8.
    SMRiQ6ZWJ8. Positions 93-350, 421-484, 836-894, 1083-1148, 1417-1478.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini136 – 19358VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini190 – 25061VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini250 – 30859VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini308 – 36760VWFC 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini364 – 42360VWFC 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini423 – 48260VWFC 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini482 – 54059VWFC 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini540 – 59960VWFC 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini602 – 66059VWFC 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini660 – 71758VWFC 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini717 – 77660VWFC 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini776 – 83863VWFC 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini835 – 89460VWFC 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini894 – 95259VWFC 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini952 – 102069VWFC 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini1017 – 108064VWFC 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini1084 – 114461VWFC 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini1149 – 1361213VWFDPROSITE-ProRule annotationAdd
    BLAST
    Domaini1418 – 147861TILAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili56 – 8833Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 17 VWFC domains.PROSITE-ProRule annotation
    Contains 1 VWFD domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG283828.
    InParanoidiQ6ZWJ8.
    PhylomeDBiQ6ZWJ8.

    Family and domain databases

    InterProiIPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF00093. VWC. 8 hits.
    PF00094. VWD. 1 hit.
    [Graphical view]
    SMARTiSM00832. C8. 1 hit.
    SM00214. VWC. 16 hits.
    SM00216. VWD. 1 hit.
    [Graphical view]
    SUPFAMiSSF57567. SSF57567. 1 hit.
    PROSITEiPS01208. VWFC_1. 12 hits.
    PS50184. VWFC_2. 15 hits.
    PS51233. VWFD. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZWJ8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGVGAAALS LLLHLGALAL AAGAEGGAVP REPPGQQTTA HSSVLAGNSQ     50
    EQWHPLREWL GRLEAAVMEL REQNKDLQTR VRQLESCECH PASPQCWGLG 100
    RAWPEGARWE PDACTACVCQ DGAAHCGPQA HLPHCRGCSQ NGQTYGNGET 150
    FSPDACTTCR CLTGAVQCQG PSCSELNCLE SCTPPGECCP ICCTEGGSHW 200
    EHGQEWTTPG DPCRICRCLE GHIQCRQREC ASLCPYPARP LPGTCCPVCD 250
    GCFLNGREHR SGEPVGSGDP CSHCRCANGS VQCEPLPCPP VPCRHPGKIP 300
    GQCCPVCDGC EYQGHQYQSQ ETFRLQERGL CVRCSCQAGE VSCEEQECPV 350
    TPCALPASGR QLCPACELDG EEFAEGVQWE PDGRPCTACV CQDGVPKCGA 400
    VLCPPAPCQH PTQPPGACCP SCDSCTYHSQ VYANGQNFTD ADSPCHACHC 450
    QDGTVTCSLV DCPPTTCARP QSGPGQCCPR CPDCILEEEV FVDGESFSHP 500
    RDPCQECRCQ EGHAHCQPRP CPRAPCAHPL PGTCCPNDCS GCAFGGKEYP 550
    SGADFPHPSD PCRLCRCLSG NVQCLARRCV PLPCPEPVLL PGECCPQCPA 600
    PAGCPRPGAA HARHQEYFSP PGDPCRRCLC LDGSVSCQRL PCPPAPCAHP 650
    RQGPCCPSCD GCLYQGKEFA SGERFPSPTA ACHLCLCWEG SVSCEPKACA 700
    PALCPFPARG DCCPDCDGCE YLGESYLSNQ EFPDPREPCN LCTCLGGFVT 750
    CGRRPCEPPG CSHPLIPSGH CCPTCQGCRY HGVTTASGET LPDPLDPTCS 800
    LCTCQEGSMR CQKKPCPPAL CPHPSPGPCF CPVCHSCLSQ GREHQDGEEF 850
    EGPAGSCEWC RCQAGQVSCV RLQCPPLPCK LQVTERGSCC PRCRGCLAHG 900
    EEHPEGSRWV PPDSACSSCV CHEGVVTCAR IQCISSCAQP RQGPHDCCPQ 950
    CSDCEHEGRK YEPGESFQPG ADPCEVCICE PQPEGPPSLR CHRRQCPSLV 1000
    GCPPSQLLPP GPQHCCPTCA EALSNCSEGL LGSELAPPDP CYTCQCQDLT 1050
    WLCIHQACPE LSCPLSERHT PPGSCCPVCR APTQSCVHQG REVASGERWT 1100
    VDTCTSCSCM AGTVRCQSQR CSPLSCGPDK APALSPGSCC PRCLPRPASC 1150
    MAFGDPHYRT FDGRLLHFQG SCSYVLAKDC HSGDFSVHVT NDDRGRSGVA 1200
    WTQEVAVLLG DMAVRLLQDG AVTVDGHPVA LPFLQEPLLY VELRGHTVIL 1250
    HAQPGLQVLW DGQSQVEVSV PGSYQGRTCG LCGNFNGFAQ DDLQGPEGLL 1300
    LPSEAAFGNS WQVSEGLWPG RPCSAGREVD PCRAAGYRAR REANARCGVL 1350
    KSSPFSRCHA VVPPEPFFAA CVYDLCACGP GSSADACLCD ALEAYASHCR 1400
    QAGVTPTWRG PTLCVVGCPL ERGFVFDECG PPCPRTCFNQ HIPLGELAAH 1450
    CVRPCVPGCQ CPAGLVEHEA HCIPPEACPQ VLLTGDQPLG ARPSPSREPQ 1500
    ETP 1503
    Length:1,503
    Mass (Da):159,938
    Last modified:December 16, 2008 - v2
    Checksum:i4301A320744B6E0B
    GO
    Isoform 2 (identifier: Q6ZWJ8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1109: Missing.
         1314-1403: SEGLWPGRPC...AYASHCRQAG → QEGRGYPPGL...LKASCDGSRL
         1404-1503: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:294
    Mass (Da):31,744
    Checksum:i12152D81A55C0925
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti47 – 471G → E.
    Corresponds to variant rs7787221 [ dbSNP | Ensembl ].
    VAR_038783
    Natural varianti397 – 3971K → E.
    Corresponds to variant rs7782976 [ dbSNP | Ensembl ].
    VAR_059625
    Natural varianti623 – 6231D → V.
    Corresponds to variant rs3734971 [ dbSNP | Ensembl ].
    VAR_059626
    Natural varianti1128 – 11281P → R.
    Corresponds to variant rs7786641 [ dbSNP | Ensembl ].
    VAR_059627

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11091109Missing in isoform 2. 1 PublicationVSP_036045Add
    BLAST
    Alternative sequencei1314 – 140390SEGLW…CRQAG → QEGRGYPPGLELPPVLLQME WSRRAQEQLLWDLELLTGVE LGLFWPPQAQFFGPRGQAQQ AWSQCCQPGGSTGGDPEQPI LKASCDGSRL in isoform 2. 1 PublicationVSP_036046Add
    BLAST
    Alternative sequencei1404 – 1503100Missing in isoform 2. 1 PublicationVSP_036047Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122706 mRNA. Translation: BAC85504.1.
    AK090684 mRNA. Translation: BAC03505.1.
    CH471070 Genomic DNA. Translation: EAW83694.1.
    RefSeqiNP_001129386.1. NM_001135914.1. [Q6ZWJ8-1]
    NP_955381.2. NM_199349.2.
    UniGeneiHs.371746.

    Genome annotation databases

    GeneIDi375616.
    KEGGihsa:375616.
    UCSCiuc011kor.2. human. [Q6ZWJ8-1]

    Polymorphism databases

    DMDMi218511989.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122706 mRNA. Translation: BAC85504.1 .
    AK090684 mRNA. Translation: BAC03505.1 .
    CH471070 Genomic DNA. Translation: EAW83694.1 .
    RefSeqi NP_001129386.1. NM_001135914.1. [Q6ZWJ8-1 ]
    NP_955381.2. NM_199349.2.
    UniGenei Hs.371746.

    3D structure databases

    ProteinModelPortali Q6ZWJ8.
    SMRi Q6ZWJ8. Positions 93-350, 421-484, 836-894, 1083-1148, 1417-1478.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000396664.

    PTM databases

    PhosphoSitei Q6ZWJ8.

    Polymorphism databases

    DMDMi 218511989.

    Proteomic databases

    PaxDbi Q6ZWJ8.
    PRIDEi Q6ZWJ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 375616.
    KEGGi hsa:375616.
    UCSCi uc011kor.2. human. [Q6ZWJ8-1 ]

    Organism-specific databases

    CTDi 375616.
    GeneCardsi GC07M128503.
    HGNCi HGNC:17585. KCP.
    MIMi 609344. gene.
    neXtProti NX_Q6ZWJ8.
    PharmGKBi PA164721151.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283828.
    InParanoidi Q6ZWJ8.
    PhylomeDBi Q6ZWJ8.

    Miscellaneous databases

    GenomeRNAii 375616.
    NextBioi 100559.
    PROi Q6ZWJ8.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_CRIM2.
    Genevestigatori Q6ZWJ8.

    Family and domain databases

    InterProi IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF00093. VWC. 8 hits.
    PF00094. VWD. 1 hit.
    [Graphical view ]
    SMARTi SM00832. C8. 1 hit.
    SM00214. VWC. 16 hits.
    SM00216. VWD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57567. SSF57567. 1 hit.
    PROSITEi PS01208. VWFC_1. 12 hits.
    PS50184. VWFC_2. 15 hits.
    PS51233. VWFD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Thalamus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiKCP_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZWJ8
    Secondary accession number(s): Q8NBE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3