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Q6ZWJ8 (KCP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kielin/chordin-like protein
Alternative name(s):
Cysteine-rich BMP regulator 2
Cysteine-rich motor neuron 2 protein
Short name=CRIM-2
Kielin/chordin-like protein 1
Short name=KCP-1
Gene names
Name:KCP
Synonyms:CRIM2, KCP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1503 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways By similarity.

Subunit structure

Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine/threonine protein kinase domains. Also able to interact with activin-A and TGFB1 By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Contains 1 TIL (trypsin inhibitory-like) domain.

Contains 17 VWFC domains.

Contains 1 VWFD domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Repeat
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZWJ8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZWJ8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1109: Missing.
     1314-1403: SEGLWPGRPC...AYASHCRQAG → QEGRGYPPGL...LKASCDGSRL
     1404-1503: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 15031477Kielin/chordin-like protein
PRO_0000318586

Regions

Domain136 – 19358VWFC 1
Domain190 – 25061VWFC 2
Domain250 – 30859VWFC 3
Domain308 – 36760VWFC 4
Domain364 – 42360VWFC 5
Domain423 – 48260VWFC 6
Domain482 – 54059VWFC 7
Domain540 – 59960VWFC 8
Domain602 – 66059VWFC 9
Domain660 – 71758VWFC 10
Domain717 – 77660VWFC 11
Domain776 – 83863VWFC 12
Domain835 – 89460VWFC 13
Domain894 – 95259VWFC 14
Domain952 – 102069VWFC 15
Domain1017 – 108064VWFC 16
Domain1084 – 114461VWFC 17
Domain1149 – 1361213VWFD
Domain1418 – 147861TIL
Coiled coil56 – 8833 Potential

Amino acid modifications

Glycosylation2781N-linked (GlcNAc...) Potential
Disulfide bond1172 ↔ 1180 By similarity

Natural variations

Alternative sequence1 – 11091109Missing in isoform 2.
VSP_036045
Alternative sequence1314 – 140390SEGLW…CRQAG → QEGRGYPPGLELPPVLLQME WSRRAQEQLLWDLELLTGVE LGLFWPPQAQFFGPRGQAQQ AWSQCCQPGGSTGGDPEQPI LKASCDGSRL in isoform 2.
VSP_036046
Alternative sequence1404 – 1503100Missing in isoform 2.
VSP_036047
Natural variant471G → E.
Corresponds to variant rs7787221 [ dbSNP | Ensembl ].
VAR_038783
Natural variant3971K → E.
Corresponds to variant rs7782976 [ dbSNP | Ensembl ].
VAR_059625
Natural variant6231D → V.
Corresponds to variant rs3734971 [ dbSNP | Ensembl ].
VAR_059626
Natural variant11281P → R.
Corresponds to variant rs7786641 [ dbSNP | Ensembl ].
VAR_059627

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 4301A320744B6E0B

FASTA1,503159,938
        10         20         30         40         50         60 
MAGVGAAALS LLLHLGALAL AAGAEGGAVP REPPGQQTTA HSSVLAGNSQ EQWHPLREWL 

        70         80         90        100        110        120 
GRLEAAVMEL REQNKDLQTR VRQLESCECH PASPQCWGLG RAWPEGARWE PDACTACVCQ 

       130        140        150        160        170        180 
DGAAHCGPQA HLPHCRGCSQ NGQTYGNGET FSPDACTTCR CLTGAVQCQG PSCSELNCLE 

       190        200        210        220        230        240 
SCTPPGECCP ICCTEGGSHW EHGQEWTTPG DPCRICRCLE GHIQCRQREC ASLCPYPARP 

       250        260        270        280        290        300 
LPGTCCPVCD GCFLNGREHR SGEPVGSGDP CSHCRCANGS VQCEPLPCPP VPCRHPGKIP 

       310        320        330        340        350        360 
GQCCPVCDGC EYQGHQYQSQ ETFRLQERGL CVRCSCQAGE VSCEEQECPV TPCALPASGR 

       370        380        390        400        410        420 
QLCPACELDG EEFAEGVQWE PDGRPCTACV CQDGVPKCGA VLCPPAPCQH PTQPPGACCP 

       430        440        450        460        470        480 
SCDSCTYHSQ VYANGQNFTD ADSPCHACHC QDGTVTCSLV DCPPTTCARP QSGPGQCCPR 

       490        500        510        520        530        540 
CPDCILEEEV FVDGESFSHP RDPCQECRCQ EGHAHCQPRP CPRAPCAHPL PGTCCPNDCS 

       550        560        570        580        590        600 
GCAFGGKEYP SGADFPHPSD PCRLCRCLSG NVQCLARRCV PLPCPEPVLL PGECCPQCPA 

       610        620        630        640        650        660 
PAGCPRPGAA HARHQEYFSP PGDPCRRCLC LDGSVSCQRL PCPPAPCAHP RQGPCCPSCD 

       670        680        690        700        710        720 
GCLYQGKEFA SGERFPSPTA ACHLCLCWEG SVSCEPKACA PALCPFPARG DCCPDCDGCE 

       730        740        750        760        770        780 
YLGESYLSNQ EFPDPREPCN LCTCLGGFVT CGRRPCEPPG CSHPLIPSGH CCPTCQGCRY 

       790        800        810        820        830        840 
HGVTTASGET LPDPLDPTCS LCTCQEGSMR CQKKPCPPAL CPHPSPGPCF CPVCHSCLSQ 

       850        860        870        880        890        900 
GREHQDGEEF EGPAGSCEWC RCQAGQVSCV RLQCPPLPCK LQVTERGSCC PRCRGCLAHG 

       910        920        930        940        950        960 
EEHPEGSRWV PPDSACSSCV CHEGVVTCAR IQCISSCAQP RQGPHDCCPQ CSDCEHEGRK 

       970        980        990       1000       1010       1020 
YEPGESFQPG ADPCEVCICE PQPEGPPSLR CHRRQCPSLV GCPPSQLLPP GPQHCCPTCA 

      1030       1040       1050       1060       1070       1080 
EALSNCSEGL LGSELAPPDP CYTCQCQDLT WLCIHQACPE LSCPLSERHT PPGSCCPVCR 

      1090       1100       1110       1120       1130       1140 
APTQSCVHQG REVASGERWT VDTCTSCSCM AGTVRCQSQR CSPLSCGPDK APALSPGSCC 

      1150       1160       1170       1180       1190       1200 
PRCLPRPASC MAFGDPHYRT FDGRLLHFQG SCSYVLAKDC HSGDFSVHVT NDDRGRSGVA 

      1210       1220       1230       1240       1250       1260 
WTQEVAVLLG DMAVRLLQDG AVTVDGHPVA LPFLQEPLLY VELRGHTVIL HAQPGLQVLW 

      1270       1280       1290       1300       1310       1320 
DGQSQVEVSV PGSYQGRTCG LCGNFNGFAQ DDLQGPEGLL LPSEAAFGNS WQVSEGLWPG 

      1330       1340       1350       1360       1370       1380 
RPCSAGREVD PCRAAGYRAR REANARCGVL KSSPFSRCHA VVPPEPFFAA CVYDLCACGP 

      1390       1400       1410       1420       1430       1440 
GSSADACLCD ALEAYASHCR QAGVTPTWRG PTLCVVGCPL ERGFVFDECG PPCPRTCFNQ 

      1450       1460       1470       1480       1490       1500 
HIPLGELAAH CVRPCVPGCQ CPAGLVEHEA HCIPPEACPQ VLLTGDQPLG ARPSPSREPQ 


ETP 

« Hide

Isoform 2 [UniParc].

Checksum: 12152D81A55C0925
Show »

FASTA29431,744

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Thalamus.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK122706 mRNA. Translation: BAC85504.1.
AK090684 mRNA. Translation: BAC03505.1.
CH471070 Genomic DNA. Translation: EAW83694.1.
RefSeqNP_001129386.1. NM_001135914.1. [Q6ZWJ8-1]
NP_955381.2. NM_199349.2.
UniGeneHs.371746.

3D structure databases

ProteinModelPortalQ6ZWJ8.
SMRQ6ZWJ8. Positions 93-350, 421-484, 836-894, 1083-1148, 1417-1478.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000396664.

PTM databases

PhosphoSiteQ6ZWJ8.

Polymorphism databases

DMDM218511989.

Proteomic databases

PaxDbQ6ZWJ8.
PRIDEQ6ZWJ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID375616.
KEGGhsa:375616.
UCSCuc011kor.2. human. [Q6ZWJ8-1]

Organism-specific databases

CTD375616.
GeneCardsGC07M128503.
HGNCHGNC:17585. KCP.
MIM609344. gene.
neXtProtNX_Q6ZWJ8.
PharmGKBPA164721151.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG283828.
InParanoidQ6ZWJ8.
PhylomeDBQ6ZWJ8.

Gene expression databases

CleanExHS_CRIM2.
GenevestigatorQ6ZWJ8.

Family and domain databases

InterProIPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamPF00093. VWC. 8 hits.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTSM00832. C8. 1 hit.
SM00214. VWC. 16 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMSSF57567. SSF57567. 1 hit.
PROSITEPS01208. VWFC_1. 12 hits.
PS50184. VWFC_2. 15 hits.
PS51233. VWFD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi375616.
NextBio100559.
PROQ6ZWJ8.
SOURCESearch...

Entry information

Entry nameKCP_HUMAN
AccessionPrimary (citable) accession number: Q6ZWJ8
Secondary accession number(s): Q8NBE0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 16, 2008
Last modified: May 14, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM