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Protein

Kielin/chordin-like protein

Gene

KCP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kielin/chordin-like protein
Alternative name(s):
Cysteine-rich BMP regulator 2
Cysteine-rich motor neuron 2 protein
Short name:
CRIM-2
Kielin/chordin-like protein 1
Short name:
KCP-1
Gene namesi
Name:KCP
Synonyms:CRIM2, KCP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:17585. KCP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi375616.
PharmGKBiPA164721151.

Polymorphism and mutation databases

BioMutaiKCP.
DMDMi218511989.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000031858627 – 1503Kielin/chordin-like proteinAdd BLAST1477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi278N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1172 ↔ 1180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ6ZWJ8.
PeptideAtlasiQ6ZWJ8.
PRIDEiQ6ZWJ8.

PTM databases

iPTMnetiQ6ZWJ8.
PhosphoSitePlusiQ6ZWJ8.

Expressioni

Gene expression databases

CleanExiHS_CRIM2.

Organism-specific databases

HPAiCAB025973.

Interactioni

Subunit structurei

Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine/threonine protein kinase domains. Also able to interact with activin-A and TGFB1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6ZWJ8.
SMRiQ6ZWJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 193VWFC 1PROSITE-ProRule annotationAdd BLAST58
Domaini190 – 250VWFC 2PROSITE-ProRule annotationAdd BLAST61
Domaini250 – 308VWFC 3PROSITE-ProRule annotationAdd BLAST59
Domaini308 – 367VWFC 4PROSITE-ProRule annotationAdd BLAST60
Domaini364 – 423VWFC 5PROSITE-ProRule annotationAdd BLAST60
Domaini423 – 482VWFC 6PROSITE-ProRule annotationAdd BLAST60
Domaini482 – 540VWFC 7PROSITE-ProRule annotationAdd BLAST59
Domaini540 – 599VWFC 8PROSITE-ProRule annotationAdd BLAST60
Domaini602 – 660VWFC 9PROSITE-ProRule annotationAdd BLAST59
Domaini660 – 717VWFC 10PROSITE-ProRule annotationAdd BLAST58
Domaini717 – 776VWFC 11PROSITE-ProRule annotationAdd BLAST60
Domaini776 – 838VWFC 12PROSITE-ProRule annotationAdd BLAST63
Domaini835 – 894VWFC 13PROSITE-ProRule annotationAdd BLAST60
Domaini894 – 952VWFC 14PROSITE-ProRule annotationAdd BLAST59
Domaini952 – 1020VWFC 15PROSITE-ProRule annotationAdd BLAST69
Domaini1017 – 1080VWFC 16PROSITE-ProRule annotationAdd BLAST64
Domaini1084 – 1144VWFC 17PROSITE-ProRule annotationAdd BLAST61
Domaini1149 – 1361VWFDPROSITE-ProRule annotationAdd BLAST213
Domaini1418 – 1478TILAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili56 – 88Sequence analysisAdd BLAST33

Sequence similaritiesi

Contains 17 VWFC domains.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal

Phylogenomic databases

InParanoidiQ6ZWJ8.
PhylomeDBiQ6ZWJ8.

Family and domain databases

InterProiIPR031132. Kcp.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
[Graphical view]
PANTHERiPTHR11339:SF280. PTHR11339:SF280. 2 hits.
PfamiPF00093. VWC. 8 hits.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00214. VWC. 18 hits.
SM00215. VWC_out. 7 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 1 hit.
PROSITEiPS01208. VWFC_1. 12 hits.
PS50184. VWFC_2. 15 hits.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZWJ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGVGAAALS LLLHLGALAL AAGAEGGAVP REPPGQQTTA HSSVLAGNSQ
60 70 80 90 100
EQWHPLREWL GRLEAAVMEL REQNKDLQTR VRQLESCECH PASPQCWGLG
110 120 130 140 150
RAWPEGARWE PDACTACVCQ DGAAHCGPQA HLPHCRGCSQ NGQTYGNGET
160 170 180 190 200
FSPDACTTCR CLTGAVQCQG PSCSELNCLE SCTPPGECCP ICCTEGGSHW
210 220 230 240 250
EHGQEWTTPG DPCRICRCLE GHIQCRQREC ASLCPYPARP LPGTCCPVCD
260 270 280 290 300
GCFLNGREHR SGEPVGSGDP CSHCRCANGS VQCEPLPCPP VPCRHPGKIP
310 320 330 340 350
GQCCPVCDGC EYQGHQYQSQ ETFRLQERGL CVRCSCQAGE VSCEEQECPV
360 370 380 390 400
TPCALPASGR QLCPACELDG EEFAEGVQWE PDGRPCTACV CQDGVPKCGA
410 420 430 440 450
VLCPPAPCQH PTQPPGACCP SCDSCTYHSQ VYANGQNFTD ADSPCHACHC
460 470 480 490 500
QDGTVTCSLV DCPPTTCARP QSGPGQCCPR CPDCILEEEV FVDGESFSHP
510 520 530 540 550
RDPCQECRCQ EGHAHCQPRP CPRAPCAHPL PGTCCPNDCS GCAFGGKEYP
560 570 580 590 600
SGADFPHPSD PCRLCRCLSG NVQCLARRCV PLPCPEPVLL PGECCPQCPA
610 620 630 640 650
PAGCPRPGAA HARHQEYFSP PGDPCRRCLC LDGSVSCQRL PCPPAPCAHP
660 670 680 690 700
RQGPCCPSCD GCLYQGKEFA SGERFPSPTA ACHLCLCWEG SVSCEPKACA
710 720 730 740 750
PALCPFPARG DCCPDCDGCE YLGESYLSNQ EFPDPREPCN LCTCLGGFVT
760 770 780 790 800
CGRRPCEPPG CSHPLIPSGH CCPTCQGCRY HGVTTASGET LPDPLDPTCS
810 820 830 840 850
LCTCQEGSMR CQKKPCPPAL CPHPSPGPCF CPVCHSCLSQ GREHQDGEEF
860 870 880 890 900
EGPAGSCEWC RCQAGQVSCV RLQCPPLPCK LQVTERGSCC PRCRGCLAHG
910 920 930 940 950
EEHPEGSRWV PPDSACSSCV CHEGVVTCAR IQCISSCAQP RQGPHDCCPQ
960 970 980 990 1000
CSDCEHEGRK YEPGESFQPG ADPCEVCICE PQPEGPPSLR CHRRQCPSLV
1010 1020 1030 1040 1050
GCPPSQLLPP GPQHCCPTCA EALSNCSEGL LGSELAPPDP CYTCQCQDLT
1060 1070 1080 1090 1100
WLCIHQACPE LSCPLSERHT PPGSCCPVCR APTQSCVHQG REVASGERWT
1110 1120 1130 1140 1150
VDTCTSCSCM AGTVRCQSQR CSPLSCGPDK APALSPGSCC PRCLPRPASC
1160 1170 1180 1190 1200
MAFGDPHYRT FDGRLLHFQG SCSYVLAKDC HSGDFSVHVT NDDRGRSGVA
1210 1220 1230 1240 1250
WTQEVAVLLG DMAVRLLQDG AVTVDGHPVA LPFLQEPLLY VELRGHTVIL
1260 1270 1280 1290 1300
HAQPGLQVLW DGQSQVEVSV PGSYQGRTCG LCGNFNGFAQ DDLQGPEGLL
1310 1320 1330 1340 1350
LPSEAAFGNS WQVSEGLWPG RPCSAGREVD PCRAAGYRAR REANARCGVL
1360 1370 1380 1390 1400
KSSPFSRCHA VVPPEPFFAA CVYDLCACGP GSSADACLCD ALEAYASHCR
1410 1420 1430 1440 1450
QAGVTPTWRG PTLCVVGCPL ERGFVFDECG PPCPRTCFNQ HIPLGELAAH
1460 1470 1480 1490 1500
CVRPCVPGCQ CPAGLVEHEA HCIPPEACPQ VLLTGDQPLG ARPSPSREPQ

ETP
Length:1,503
Mass (Da):159,938
Last modified:December 16, 2008 - v2
Checksum:i4301A320744B6E0B
GO
Isoform 2 (identifier: Q6ZWJ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1109: Missing.
     1314-1403: SEGLWPGRPC...AYASHCRQAG → QEGRGYPPGL...LKASCDGSRL
     1404-1503: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:294
Mass (Da):31,744
Checksum:i12152D81A55C0925
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03878347G → E.Corresponds to variant rs7787221dbSNPEnsembl.1
Natural variantiVAR_059625397K → E.Corresponds to variant rs7782976dbSNPEnsembl.1
Natural variantiVAR_059626623D → V.Corresponds to variant rs3734971dbSNPEnsembl.1
Natural variantiVAR_0596271128P → R.Corresponds to variant rs7786641dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0360451 – 1109Missing in isoform 2. 1 PublicationAdd BLAST1109
Alternative sequenceiVSP_0360461314 – 1403SEGLW…CRQAG → QEGRGYPPGLELPPVLLQME WSRRAQEQLLWDLELLTGVE LGLFWPPQAQFFGPRGQAQQ AWSQCCQPGGSTGGDPEQPI LKASCDGSRL in isoform 2. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_0360471404 – 1503Missing in isoform 2. 1 PublicationAdd BLAST100

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122706 mRNA. Translation: BAC85504.1.
AK090684 mRNA. Translation: BAC03505.1.
CH471070 Genomic DNA. Translation: EAW83694.1.
RefSeqiNP_001129386.1. NM_001135914.1. [Q6ZWJ8-1]
NP_955381.2. NM_199349.2.
UniGeneiHs.371746.

Genome annotation databases

GeneIDi375616.
KEGGihsa:375616.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122706 mRNA. Translation: BAC85504.1.
AK090684 mRNA. Translation: BAC03505.1.
CH471070 Genomic DNA. Translation: EAW83694.1.
RefSeqiNP_001129386.1. NM_001135914.1. [Q6ZWJ8-1]
NP_955381.2. NM_199349.2.
UniGeneiHs.371746.

3D structure databases

ProteinModelPortaliQ6ZWJ8.
SMRiQ6ZWJ8.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6ZWJ8.
PhosphoSitePlusiQ6ZWJ8.

Polymorphism and mutation databases

BioMutaiKCP.
DMDMi218511989.

Proteomic databases

EPDiQ6ZWJ8.
PeptideAtlasiQ6ZWJ8.
PRIDEiQ6ZWJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi375616.
KEGGihsa:375616.

Organism-specific databases

CTDi375616.
DisGeNETi375616.
GeneCardsiKCP.
HGNCiHGNC:17585. KCP.
HPAiCAB025973.
MIMi609344. gene.
neXtProtiNX_Q6ZWJ8.
PharmGKBiPA164721151.
GenAtlasiSearch...

Phylogenomic databases

InParanoidiQ6ZWJ8.
PhylomeDBiQ6ZWJ8.

Miscellaneous databases

ChiTaRSiKCP. human.
GenomeRNAii375616.
PROiQ6ZWJ8.
SOURCEiSearch...

Gene expression databases

CleanExiHS_CRIM2.

Family and domain databases

InterProiIPR031132. Kcp.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
[Graphical view]
PANTHERiPTHR11339:SF280. PTHR11339:SF280. 2 hits.
PfamiPF00093. VWC. 8 hits.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00214. VWC. 18 hits.
SM00215. VWC_out. 7 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 1 hit.
PROSITEiPS01208. VWFC_1. 12 hits.
PS50184. VWFC_2. 15 hits.
PS51233. VWFD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKCP_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWJ8
Secondary accession number(s): Q8NBE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 16, 2008
Last modified: November 2, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.