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Q6ZWJ8

- KCP_HUMAN

UniProt

Q6ZWJ8 - KCP_HUMAN

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Protein
Kielin/chordin-like protein
Gene
KCP, CRIM2, KCP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Kielin/chordin-like protein
Alternative name(s):
Cysteine-rich BMP regulator 2
Cysteine-rich motor neuron 2 protein
Short name:
CRIM-2
Kielin/chordin-like protein 1
Short name:
KCP-1
Gene namesi
Name:KCP
Synonyms:CRIM2, KCP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:17585. KCP.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164721151.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 15031477Kielin/chordin-like protein
PRO_0000318586Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi278 – 2781N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1172 ↔ 1180 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6ZWJ8.
PRIDEiQ6ZWJ8.

PTM databases

PhosphoSiteiQ6ZWJ8.

Expressioni

Gene expression databases

CleanExiHS_CRIM2.
GenevestigatoriQ6ZWJ8.

Interactioni

Subunit structurei

Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine/threonine protein kinase domains. Also able to interact with activin-A and TGFB1 By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000396664.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWJ8.
SMRiQ6ZWJ8. Positions 93-350, 421-484, 836-894, 1083-1148, 1417-1478.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini136 – 19358VWFC 1
Add
BLAST
Domaini190 – 25061VWFC 2
Add
BLAST
Domaini250 – 30859VWFC 3
Add
BLAST
Domaini308 – 36760VWFC 4
Add
BLAST
Domaini364 – 42360VWFC 5
Add
BLAST
Domaini423 – 48260VWFC 6
Add
BLAST
Domaini482 – 54059VWFC 7
Add
BLAST
Domaini540 – 59960VWFC 8
Add
BLAST
Domaini602 – 66059VWFC 9
Add
BLAST
Domaini660 – 71758VWFC 10
Add
BLAST
Domaini717 – 77660VWFC 11
Add
BLAST
Domaini776 – 83863VWFC 12
Add
BLAST
Domaini835 – 89460VWFC 13
Add
BLAST
Domaini894 – 95259VWFC 14
Add
BLAST
Domaini952 – 102069VWFC 15
Add
BLAST
Domaini1017 – 108064VWFC 16
Add
BLAST
Domaini1084 – 114461VWFC 17
Add
BLAST
Domaini1149 – 1361213VWFD
Add
BLAST
Domaini1418 – 147861TIL
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili56 – 8833 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 17 VWFC domains.
Contains 1 VWFD domain.

Keywords - Domaini

Coiled coil, Repeat, Signal

Phylogenomic databases

eggNOGiNOG283828.
InParanoidiQ6ZWJ8.
PhylomeDBiQ6ZWJ8.

Family and domain databases

InterProiIPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF00093. VWC. 8 hits.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00214. VWC. 16 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 1 hit.
PROSITEiPS01208. VWFC_1. 12 hits.
PS50184. VWFC_2. 15 hits.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZWJ8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAGVGAAALS LLLHLGALAL AAGAEGGAVP REPPGQQTTA HSSVLAGNSQ     50
EQWHPLREWL GRLEAAVMEL REQNKDLQTR VRQLESCECH PASPQCWGLG 100
RAWPEGARWE PDACTACVCQ DGAAHCGPQA HLPHCRGCSQ NGQTYGNGET 150
FSPDACTTCR CLTGAVQCQG PSCSELNCLE SCTPPGECCP ICCTEGGSHW 200
EHGQEWTTPG DPCRICRCLE GHIQCRQREC ASLCPYPARP LPGTCCPVCD 250
GCFLNGREHR SGEPVGSGDP CSHCRCANGS VQCEPLPCPP VPCRHPGKIP 300
GQCCPVCDGC EYQGHQYQSQ ETFRLQERGL CVRCSCQAGE VSCEEQECPV 350
TPCALPASGR QLCPACELDG EEFAEGVQWE PDGRPCTACV CQDGVPKCGA 400
VLCPPAPCQH PTQPPGACCP SCDSCTYHSQ VYANGQNFTD ADSPCHACHC 450
QDGTVTCSLV DCPPTTCARP QSGPGQCCPR CPDCILEEEV FVDGESFSHP 500
RDPCQECRCQ EGHAHCQPRP CPRAPCAHPL PGTCCPNDCS GCAFGGKEYP 550
SGADFPHPSD PCRLCRCLSG NVQCLARRCV PLPCPEPVLL PGECCPQCPA 600
PAGCPRPGAA HARHQEYFSP PGDPCRRCLC LDGSVSCQRL PCPPAPCAHP 650
RQGPCCPSCD GCLYQGKEFA SGERFPSPTA ACHLCLCWEG SVSCEPKACA 700
PALCPFPARG DCCPDCDGCE YLGESYLSNQ EFPDPREPCN LCTCLGGFVT 750
CGRRPCEPPG CSHPLIPSGH CCPTCQGCRY HGVTTASGET LPDPLDPTCS 800
LCTCQEGSMR CQKKPCPPAL CPHPSPGPCF CPVCHSCLSQ GREHQDGEEF 850
EGPAGSCEWC RCQAGQVSCV RLQCPPLPCK LQVTERGSCC PRCRGCLAHG 900
EEHPEGSRWV PPDSACSSCV CHEGVVTCAR IQCISSCAQP RQGPHDCCPQ 950
CSDCEHEGRK YEPGESFQPG ADPCEVCICE PQPEGPPSLR CHRRQCPSLV 1000
GCPPSQLLPP GPQHCCPTCA EALSNCSEGL LGSELAPPDP CYTCQCQDLT 1050
WLCIHQACPE LSCPLSERHT PPGSCCPVCR APTQSCVHQG REVASGERWT 1100
VDTCTSCSCM AGTVRCQSQR CSPLSCGPDK APALSPGSCC PRCLPRPASC 1150
MAFGDPHYRT FDGRLLHFQG SCSYVLAKDC HSGDFSVHVT NDDRGRSGVA 1200
WTQEVAVLLG DMAVRLLQDG AVTVDGHPVA LPFLQEPLLY VELRGHTVIL 1250
HAQPGLQVLW DGQSQVEVSV PGSYQGRTCG LCGNFNGFAQ DDLQGPEGLL 1300
LPSEAAFGNS WQVSEGLWPG RPCSAGREVD PCRAAGYRAR REANARCGVL 1350
KSSPFSRCHA VVPPEPFFAA CVYDLCACGP GSSADACLCD ALEAYASHCR 1400
QAGVTPTWRG PTLCVVGCPL ERGFVFDECG PPCPRTCFNQ HIPLGELAAH 1450
CVRPCVPGCQ CPAGLVEHEA HCIPPEACPQ VLLTGDQPLG ARPSPSREPQ 1500
ETP 1503
Length:1,503
Mass (Da):159,938
Last modified:December 16, 2008 - v2
Checksum:i4301A320744B6E0B
GO
Isoform 2 (identifier: Q6ZWJ8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1109: Missing.
     1314-1403: SEGLWPGRPC...AYASHCRQAG → QEGRGYPPGL...LKASCDGSRL
     1404-1503: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:294
Mass (Da):31,744
Checksum:i12152D81A55C0925
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471G → E.
Corresponds to variant rs7787221 [ dbSNP | Ensembl ].
VAR_038783
Natural varianti397 – 3971K → E.
Corresponds to variant rs7782976 [ dbSNP | Ensembl ].
VAR_059625
Natural varianti623 – 6231D → V.
Corresponds to variant rs3734971 [ dbSNP | Ensembl ].
VAR_059626
Natural varianti1128 – 11281P → R.
Corresponds to variant rs7786641 [ dbSNP | Ensembl ].
VAR_059627

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11091109Missing in isoform 2.
VSP_036045Add
BLAST
Alternative sequencei1314 – 140390SEGLW…CRQAG → QEGRGYPPGLELPPVLLQME WSRRAQEQLLWDLELLTGVE LGLFWPPQAQFFGPRGQAQQ AWSQCCQPGGSTGGDPEQPI LKASCDGSRL in isoform 2.
VSP_036046Add
BLAST
Alternative sequencei1404 – 1503100Missing in isoform 2.
VSP_036047Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122706 mRNA. Translation: BAC85504.1.
AK090684 mRNA. Translation: BAC03505.1.
CH471070 Genomic DNA. Translation: EAW83694.1.
RefSeqiNP_001129386.1. NM_001135914.1. [Q6ZWJ8-1]
NP_955381.2. NM_199349.2.
UniGeneiHs.371746.

Genome annotation databases

GeneIDi375616.
KEGGihsa:375616.
UCSCiuc011kor.2. human. [Q6ZWJ8-1]

Polymorphism databases

DMDMi218511989.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122706 mRNA. Translation: BAC85504.1 .
AK090684 mRNA. Translation: BAC03505.1 .
CH471070 Genomic DNA. Translation: EAW83694.1 .
RefSeqi NP_001129386.1. NM_001135914.1. [Q6ZWJ8-1 ]
NP_955381.2. NM_199349.2.
UniGenei Hs.371746.

3D structure databases

ProteinModelPortali Q6ZWJ8.
SMRi Q6ZWJ8. Positions 93-350, 421-484, 836-894, 1083-1148, 1417-1478.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000396664.

PTM databases

PhosphoSitei Q6ZWJ8.

Polymorphism databases

DMDMi 218511989.

Proteomic databases

PaxDbi Q6ZWJ8.
PRIDEi Q6ZWJ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 375616.
KEGGi hsa:375616.
UCSCi uc011kor.2. human. [Q6ZWJ8-1 ]

Organism-specific databases

CTDi 375616.
GeneCardsi GC07M128503.
HGNCi HGNC:17585. KCP.
MIMi 609344. gene.
neXtProti NX_Q6ZWJ8.
PharmGKBi PA164721151.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283828.
InParanoidi Q6ZWJ8.
PhylomeDBi Q6ZWJ8.

Miscellaneous databases

GenomeRNAii 375616.
NextBioi 100559.
PROi Q6ZWJ8.
SOURCEi Search...

Gene expression databases

CleanExi HS_CRIM2.
Genevestigatori Q6ZWJ8.

Family and domain databases

InterProi IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF00093. VWC. 8 hits.
PF00094. VWD. 1 hit.
[Graphical view ]
SMARTi SM00832. C8. 1 hit.
SM00214. VWC. 16 hits.
SM00216. VWD. 1 hit.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 1 hit.
PROSITEi PS01208. VWFC_1. 12 hits.
PS50184. VWFC_2. 15 hits.
PS51233. VWFD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Thalamus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKCP_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWJ8
Secondary accession number(s): Q8NBE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 16, 2008
Last modified: May 14, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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