Q6ZWJ8 (KCP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kielin/chordin-like protein

Alternative name(s):
Cysteine-rich BMP regulator 2
Cysteine-rich motor neuron 2 protein
Short name=CRIM-2
Kielin/chordin-like protein 1
Short name=KCP-1

Gene names

Name:	KCP
Synonyms:	CRIM2, KCP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1503 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways By similarity.
Subunit structure	Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine/threonine protein kinase domains. Also able to interact with activin-A and TGFB1 By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Contains 1 TIL (trypsin inhibitory-like) domain. Contains 17 VWFC domains. Contains 1 VWFD domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZWJ8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZWJ8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1109: Missing.
     1314-1403: SEGLWPGRPC...AYASHCRQAG → QEGRGYPPGL...LKASCDGSRL
     1404-1503: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 1503	1477	Kielin/chordin-like protein		PRO_0000318586
Regions
	Domain	136 – 193	58	VWFC 1
	Domain	190 – 250	61	VWFC 2
	Domain	250 – 308	59	VWFC 3
	Domain	308 – 367	60	VWFC 4
	Domain	364 – 423	60	VWFC 5
	Domain	423 – 482	60	VWFC 6
	Domain	482 – 540	59	VWFC 7
	Domain	540 – 599	60	VWFC 8
	Domain	602 – 660	59	VWFC 9
	Domain	660 – 717	58	VWFC 10
	Domain	717 – 776	60	VWFC 11
	Domain	776 – 838	63	VWFC 12
	Domain	835 – 894	60	VWFC 13
	Domain	894 – 952	59	VWFC 14
	Domain	952 – 1020	69	VWFC 15
	Domain	1017 – 1080	64	VWFC 16
	Domain	1084 – 1144	61	VWFC 17
	Domain	1149 – 1361	213	VWFD
	Domain	1418 – 1478	61	TIL
	Coiled coil	56 – 88	33	Potential
Amino acid modifications
	Glycosylation	278	1	N-linked (GlcNAc...) Potential
	Disulfide bond	1172 ↔ 1180		By similarity
Natural variations
	Alternative sequence	1 – 1109	1109	Missing in isoform 2.		VSP_036045
	Alternative sequence	1314 – 1403	90	SEGLW…CRQAG → QEGRGYPPGLELPPVLLQME WSRRAQEQLLWDLELLTGVE LGLFWPPQAQFFGPRGQAQQ AWSQCCQPGGSTGGDPEQPI LKASCDGSRL in isoform 2.		VSP_036046
	Alternative sequence	1404 – 1503	100	Missing in isoform 2.		VSP_036047
	Natural variant	47	1	G → E. Corresponds to variant rs7787221 [ dbSNP | Ensembl ].		VAR_038783
	Natural variant	397	1	K → E. Corresponds to variant rs7782976 [ dbSNP | Ensembl ].		VAR_059625
	Natural variant	623	1	D → V. Corresponds to variant rs3734971 [ dbSNP | Ensembl ].		VAR_059626
	Natural variant	1128	1	P → R. Corresponds to variant rs7786641 [ dbSNP | Ensembl ].		VAR_059627

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: 4301A320744B6E0B	FASTA	1,503	159,938
	10 20 30 40 50 60 MAGVGAAALS LLLHLGALAL AAGAEGGAVP REPPGQQTTA HSSVLAGNSQ EQWHPLREWL 70 80 90 100 110 120 GRLEAAVMEL REQNKDLQTR VRQLESCECH PASPQCWGLG RAWPEGARWE PDACTACVCQ 130 140 150 160 170 180 DGAAHCGPQA HLPHCRGCSQ NGQTYGNGET FSPDACTTCR CLTGAVQCQG PSCSELNCLE 190 200 210 220 230 240 SCTPPGECCP ICCTEGGSHW EHGQEWTTPG DPCRICRCLE GHIQCRQREC ASLCPYPARP 250 260 270 280 290 300 LPGTCCPVCD GCFLNGREHR SGEPVGSGDP CSHCRCANGS VQCEPLPCPP VPCRHPGKIP 310 320 330 340 350 360 GQCCPVCDGC EYQGHQYQSQ ETFRLQERGL CVRCSCQAGE VSCEEQECPV TPCALPASGR 370 380 390 400 410 420 QLCPACELDG EEFAEGVQWE PDGRPCTACV CQDGVPKCGA VLCPPAPCQH PTQPPGACCP 430 440 450 460 470 480 SCDSCTYHSQ VYANGQNFTD ADSPCHACHC QDGTVTCSLV DCPPTTCARP QSGPGQCCPR 490 500 510 520 530 540 CPDCILEEEV FVDGESFSHP RDPCQECRCQ EGHAHCQPRP CPRAPCAHPL PGTCCPNDCS 550 560 570 580 590 600 GCAFGGKEYP SGADFPHPSD PCRLCRCLSG NVQCLARRCV PLPCPEPVLL PGECCPQCPA 610 620 630 640 650 660 PAGCPRPGAA HARHQEYFSP PGDPCRRCLC LDGSVSCQRL PCPPAPCAHP RQGPCCPSCD 670 680 690 700 710 720 GCLYQGKEFA SGERFPSPTA ACHLCLCWEG SVSCEPKACA PALCPFPARG DCCPDCDGCE 730 740 750 760 770 780 YLGESYLSNQ EFPDPREPCN LCTCLGGFVT CGRRPCEPPG CSHPLIPSGH CCPTCQGCRY 790 800 810 820 830 840 HGVTTASGET LPDPLDPTCS LCTCQEGSMR CQKKPCPPAL CPHPSPGPCF CPVCHSCLSQ 850 860 870 880 890 900 GREHQDGEEF EGPAGSCEWC RCQAGQVSCV RLQCPPLPCK LQVTERGSCC PRCRGCLAHG 910 920 930 940 950 960 EEHPEGSRWV PPDSACSSCV CHEGVVTCAR IQCISSCAQP RQGPHDCCPQ CSDCEHEGRK 970 980 990 1000 1010 1020 YEPGESFQPG ADPCEVCICE PQPEGPPSLR CHRRQCPSLV GCPPSQLLPP GPQHCCPTCA 1030 1040 1050 1060 1070 1080 EALSNCSEGL LGSELAPPDP CYTCQCQDLT WLCIHQACPE LSCPLSERHT PPGSCCPVCR 1090 1100 1110 1120 1130 1140 APTQSCVHQG REVASGERWT VDTCTSCSCM AGTVRCQSQR CSPLSCGPDK APALSPGSCC 1150 1160 1170 1180 1190 1200 PRCLPRPASC MAFGDPHYRT FDGRLLHFQG SCSYVLAKDC HSGDFSVHVT NDDRGRSGVA 1210 1220 1230 1240 1250 1260 WTQEVAVLLG DMAVRLLQDG AVTVDGHPVA LPFLQEPLLY VELRGHTVIL HAQPGLQVLW 1270 1280 1290 1300 1310 1320 DGQSQVEVSV PGSYQGRTCG LCGNFNGFAQ DDLQGPEGLL LPSEAAFGNS WQVSEGLWPG 1330 1340 1350 1360 1370 1380 RPCSAGREVD PCRAAGYRAR REANARCGVL KSSPFSRCHA VVPPEPFFAA CVYDLCACGP 1390 1400 1410 1420 1430 1440 GSSADACLCD ALEAYASHCR QAGVTPTWRG PTLCVVGCPL ERGFVFDECG PPCPRTCFNQ 1450 1460 1470 1480 1490 1500 HIPLGELAAH CVRPCVPGCQ CPAGLVEHEA HCIPPEACPQ VLLTGDQPLG ARPSPSREPQ ETP
	Isoform 2 [UniParc]. Checksum: 12152D81A55C0925	FASTA	294	31,744
	10 20 30 40 50 60 MAGTVRCQSQ RCSPLSCGPD KAPALSPGSC CPRCLPRPAS CMAFGDPHYR TFDGRLLHFQ 70 80 90 100 110 120 GSCSYVLAKD CHSGDFSVHV TNDDRGRSGV AWTQEVAVLL GDMAVRLLQD GAVTVDGHPV 130 140 150 160 170 180 ALPFLQEPLL YVELRGHTVI LHAQPGLQVL WDGQSQVEVS VPGSYQGRTC GLCGNFNGFA 190 200 210 220 230 240 QDDLQGPEGL LLPSEAAFGN SWQVQEGRGY PPGLELPPVL LQMEWSRRAQ EQLLWDLELL 250 260 270 280 290 TGVELGLFWP PQAQFFGPRG QAQQAWSQCC QPGGSTGGDP EQPILKASCD GSRL

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Thalamus.

[2]

Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK122706 mRNA. Translation: BAC85504.1. AK090684 mRNA. Translation: BAC03505.1. CH471070 Genomic DNA. Translation: EAW83694.1.
IPI	IPI00168230. IPI00914663.
RefSeq	NP_001129386.1. NM_001135914.1. NP_955381.2. NM_199349.2.
UniGene	Hs.371746.
3D structure databases
ProteinModelPortal	Q6ZWJ8.
SMR	Q6ZWJ8. Positions 98-129, 134-309, 423-482, 627-664, 897-933, 1083-1147, 1417-1478.
ModBase	Search...
PTM databases
PhosphoSite	Q6ZWJ8.
Polymorphism databases
DMDM	218511989.
Proteomic databases
PaxDb	Q6ZWJ8.
PRIDE	Q6ZWJ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	375616.
KEGG	hsa:375616.
UCSC	uc011kor.2. human.
Organism-specific databases
CTD	375616.
GeneCards	GC07M128503.
HGNC	HGNC:17585. KCP.
MIM	609344. gene.
neXtProt	NX_Q6ZWJ8.
PharmGKB	PA164721151.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG283828.
InParanoid	Q6ZWJ8.
Gene expression databases
CleanEx	HS_CRIM2.
Genevestigator	Q6ZWJ8.
Family and domain databases
InterPro	IPR002919. TIL_dom. IPR014853. Unchr_dom_Cys-rich. IPR001007. VWF_C. IPR001846. VWF_type-D. [Graphical view]
Pfam	PF00093. VWC. 8 hits. PF00094. VWD. 1 hit. [Graphical view]
SMART	SM00832. C8. 1 hit. SM00214. VWC. 16 hits. SM00216. VWD. 1 hit. [Graphical view]
SUPFAM	SSF57567. Cysrich_TIL. 1 hit.
PROSITE	PS01208. VWFC_1. 12 hits. PS50184. VWFC_2. 15 hits. PS51233. VWFD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	375616.
NextBio	100559.
SOURCE	Search...

Entry information

Entry name

KCP_HUMAN

Accession

Primary (citable) accession number: Q6ZWJ8
Secondary accession number(s): Q8NBE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	December 16, 2008
Last modified:	May 1, 2013
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.