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Protein

Ret finger protein-like 4B

Gene

RFPL4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 53RING-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ret finger protein-like 4B
Alternative name(s):
RING finger protein 211
Gene namesi
Name:RFPL4B
Synonyms:RNF211
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000251258.1.
HGNCiHGNC:33264. RFPL4B.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000251258.
PharmGKBiPA162401195.

Polymorphism and mutation databases

BioMutaiRFPL4B.
DMDMi212287933.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002746001 – 263Ret finger protein-like 4BAdd BLAST263

Proteomic databases

PaxDbiQ6ZWI9.
PRIDEiQ6ZWI9.

PTM databases

iPTMnetiQ6ZWI9.
PhosphoSitePlusiQ6ZWI9.

Expressioni

Gene expression databases

BgeeiENSG00000251258.
CleanExiHS_RFPL4B.

Organism-specific databases

HPAiHPA059324.
HPA066464.

Interactioni

Protein-protein interaction databases

BioGridi138138. 44 interactors.
STRINGi9606.ENSP00000423391.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWI9.
SMRiQ6ZWI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 263B30.2/SPRYPROSITE-ProRule annotationAdd BLAST188

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 53RING-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118993.
HOGENOMiHOG000230861.
InParanoidiQ6ZWI9.
OMAiKIHHDLT.
OrthoDBiEOG091G0HQI.
PhylomeDBiQ6ZWI9.
TreeFamiTF317532.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin_SPRY.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF00622. SPRY. 1 hit.
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiView protein in SMART
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS50188. B302_SPRY. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ZWI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRLQAELS CPVCLDFFSC SISLSCTHVF CFDCIQRYIL ENHDFRAMCP
60 70 80 90 100
LCRDVVKVPA LEEWQVSVLT LMTKQHNSRL EQSLHVREEL RHFREDVTLD
110 120 130 140 150
AATASSLLVF SNDLRSAQCK KIHHDLTKDP RLACVLGTPC FSSGQHYWEV
160 170 180 190 200
EVGEVKSWSL GVCKEPADRK SNDLFPEHGF WISMKAGAIH ANTHLERIPA
210 220 230 240 250
SPRLRRVGIF LDADLEEIQF FDVDNNVLIY THDGFFSLEL LCPFFCLELL
260
GEGESGNVLT ICP
Length:263
Mass (Da):29,922
Last modified:July 22, 2008 - v2
Checksum:i86B45A0564CA3DBB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177E → G in BAC85513 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044525234G → D. Corresponds to variant dbSNP:rs11153361Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122906 mRNA. Translation: BAC85513.1.
BC132796 mRNA. Translation: AAI32797.1.
BC132798 mRNA. Translation: AAI32799.1.
CCDSiCCDS34515.1.
RefSeqiNP_001013756.2. NM_001013734.2.
XP_016866386.1. XM_017010897.1.
XP_016866387.1. XM_017010898.1.
UniGeneiHs.448264.

Genome annotation databases

EnsembliENST00000441065; ENSP00000423391; ENSG00000251258.
GeneIDi442247.
KEGGihsa:442247.
UCSCiuc003pvx.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRFPLB_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWI9
Secondary accession number(s): A2RU91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 22, 2008
Last modified: September 27, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations