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Protein

Ret finger protein-like 4B

Gene

RFPL4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri11 – 5343RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ret finger protein-like 4B
Alternative name(s):
RING finger protein 211
Gene namesi
Name:RFPL4B
Synonyms:RNF211
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:33264. RFPL4B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162401195.

Polymorphism and mutation databases

BioMutaiRFPL4B.
DMDMi212287933.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Ret finger protein-like 4BPRO_0000274600Add
BLAST

Proteomic databases

PaxDbiQ6ZWI9.
PRIDEiQ6ZWI9.

PTM databases

PhosphoSiteiQ6ZWI9.

Expressioni

Gene expression databases

BgeeiQ6ZWI9.
CleanExiHS_RFPL4B.

Organism-specific databases

HPAiHPA059324.

Interactioni

Protein-protein interaction databases

BioGridi138138. 44 interactions.
STRINGi9606.ENSP00000423391.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWI9.
SMRiQ6ZWI9. Positions 1-62, 96-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 263188B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri11 – 5343RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118993.
HOGENOMiHOG000230861.
InParanoidiQ6ZWI9.
OMAiKIHHDLT.
OrthoDBiEOG75F4F2.
PhylomeDBiQ6ZWI9.
TreeFamiTF317532.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZWI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRLQAELS CPVCLDFFSC SISLSCTHVF CFDCIQRYIL ENHDFRAMCP
60 70 80 90 100
LCRDVVKVPA LEEWQVSVLT LMTKQHNSRL EQSLHVREEL RHFREDVTLD
110 120 130 140 150
AATASSLLVF SNDLRSAQCK KIHHDLTKDP RLACVLGTPC FSSGQHYWEV
160 170 180 190 200
EVGEVKSWSL GVCKEPADRK SNDLFPEHGF WISMKAGAIH ANTHLERIPA
210 220 230 240 250
SPRLRRVGIF LDADLEEIQF FDVDNNVLIY THDGFFSLEL LCPFFCLELL
260
GEGESGNVLT ICP
Length:263
Mass (Da):29,922
Last modified:July 22, 2008 - v2
Checksum:i86B45A0564CA3DBB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771E → G in BAC85513 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti234 – 2341G → D.
Corresponds to variant rs11153361 [ dbSNP | Ensembl ].
VAR_044525

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122906 mRNA. Translation: BAC85513.1.
BC132796 mRNA. Translation: AAI32797.1.
BC132798 mRNA. Translation: AAI32799.1.
CCDSiCCDS34515.1.
RefSeqiNP_001013756.2. NM_001013734.2.
UniGeneiHs.448264.

Genome annotation databases

EnsembliENST00000441065; ENSP00000423391; ENSG00000251258.
GeneIDi442247.
KEGGihsa:442247.
UCSCiuc003pvx.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122906 mRNA. Translation: BAC85513.1.
BC132796 mRNA. Translation: AAI32797.1.
BC132798 mRNA. Translation: AAI32799.1.
CCDSiCCDS34515.1.
RefSeqiNP_001013756.2. NM_001013734.2.
UniGeneiHs.448264.

3D structure databases

ProteinModelPortaliQ6ZWI9.
SMRiQ6ZWI9. Positions 1-62, 96-263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138138. 44 interactions.
STRINGi9606.ENSP00000423391.

PTM databases

PhosphoSiteiQ6ZWI9.

Polymorphism and mutation databases

BioMutaiRFPL4B.
DMDMi212287933.

Proteomic databases

PaxDbiQ6ZWI9.
PRIDEiQ6ZWI9.

Protocols and materials databases

DNASUi442247.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000441065; ENSP00000423391; ENSG00000251258.
GeneIDi442247.
KEGGihsa:442247.
UCSCiuc003pvx.1. human.

Organism-specific databases

CTDi442247.
GeneCardsiRFPL4B.
HGNCiHGNC:33264. RFPL4B.
HPAiHPA059324.
neXtProtiNX_Q6ZWI9.
PharmGKBiPA162401195.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118993.
HOGENOMiHOG000230861.
InParanoidiQ6ZWI9.
OMAiKIHHDLT.
OrthoDBiEOG75F4F2.
PhylomeDBiQ6ZWI9.
TreeFamiTF317532.

Miscellaneous databases

GenomeRNAii442247.
NextBioi110919.
PROiQ6ZWI9.

Gene expression databases

BgeeiQ6ZWI9.
CleanExiHS_RFPL4B.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiRFPLB_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWI9
Secondary accession number(s): A2RU91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 22, 2008
Last modified: May 11, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.