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Q6ZWH5

- NEK10_HUMAN

UniProt

Q6ZWH5 - NEK10_HUMAN

Protein

Serine/threonine-protein kinase Nek10

Gene

NEK10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 3 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei548 – 5481ATPPROSITE-ProRule annotation
    Active sitei655 – 6551Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi525 – 5339ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein kinase activity Source: UniProt
    4. protein serine/threonine kinase activity Source: UniProtKB-KW
    5. protein tyrosine kinase activity Source: InterPro

    GO - Biological processi

    1. positive regulation of MAP kinase activity Source: UniProt
    2. positive regulation of protein autophosphorylation Source: UniProt
    3. protein phosphorylation Source: UniProt
    4. regulation of cell cycle G2/M phase transition Source: UniProt
    5. regulation of ERK1 and ERK2 cascade Source: UniProt

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ6ZWH5.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase Nek10 (EC:2.7.11.1)
    Alternative name(s):
    Never in mitosis A-related kinase 10
    Short name:
    NimA-related protein kinase 10
    Gene namesi
    Name:NEK10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:18592. NEK10.

    Subcellular locationi

    GO - Cellular componenti

    1. protein kinase complex Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38594.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11721172Serine/threonine-protein kinase Nek10PRO_0000259767Add
    BLAST

    Proteomic databases

    PaxDbiQ6ZWH5.
    PRIDEiQ6ZWH5.

    PTM databases

    PhosphoSiteiQ6ZWH5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ZWH5.
    BgeeiQ6ZWH5.
    CleanExiHS_NEK10.
    GenevestigatoriQ6ZWH5.

    Organism-specific databases

    HPAiHPA038941.

    Interactioni

    Protein-protein interaction databases

    BioGridi127428. 3 interactions.
    STRINGi9606.ENSP00000343847.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZWH5.
    SMRiQ6ZWH5. Positions 454-816.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati209 – 25143ARMAdd
    BLAST
    Domaini519 – 712194Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili481 – 51434Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ARM repeat.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG108180.
    KOiK08857.
    OMAiDYHLLHH.
    OrthoDBiEOG7Q5HCF.
    TreeFamiTF336430.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZWH5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPDQDKKVKT TEKSTDKQQE ITIRDYSDLK RLRCLLNVQS SKQQLPAINF     50
    DSAQNSMTKS EPAIRAGGHR ARGQWHESTE AVELENFSIN YKNERNFSKH 100
    PQRKLFQEIF TALVKNRLIS REWVNRAPSI HFLRVLICLR LLMRDPCYQE 150
    ILHSLGGIEN LAQYMEIVAN EYLGYGEEQH TVDKLVNMTY IFQKLAAVKD 200
    QREWVTTSGA HKTLVNLLGA RDTNVLLGSL LALASLAESQ ECREKISELN 250
    IVENLLMILH EYDLLSKRLT AELLRLLCAE PQVKEQVKLY EGIPVLLSLL 300
    HSDHLKLLWS IVWILVQVCE DPETSVEIRI WGGIKQLLHI LQGDRNFVSD 350
    HSSIGSLSSA NAAGRIQQLH LSEDLSPREI QENTFSLQAA CCAALTELVL 400
    NDTNAHQVVQ ENGVYTIAKL ILPNKQKNAA KSNLLQCYAF RALRFLFSME 450
    RNRPLFKRLF PTDLFEIFID IGHYVRDISA YEELVSKLNL LVEDELKQIA 500
    ENIESINQNK APLKYIGNYA ILDHLGSGAF GCVYKVRKHS GQNLLAMKEV 550
    NLHNPAFGKD KKDRDSSVRN IVSELTIIKE QLYHPNIVRY YKTFLENDRL 600
    YIVMELIEGA PLGEHFSSLK EKHHHFTEER LWKIFIQLCL ALRYLHKEKR 650
    IVHRDLTPNN IMLGDKDKVT VTDFGLAKQK QENSKLTSVV GTILYSCPEV 700
    LKSEPYGEKA DVWAVGCILY QMATLSPPFY STNMLSLATK IVEAVYEPVP 750
    EGIYSEKVTD TISRCLTPDA EARPDIVEVS SMISDVMMKY LDNLSTSQLS 800
    LEKKLERERR RTQRYFMEAN RNTVTCHHEL AVLSHETFEK ASLSSSSSGA 850
    ASLKSELSES ADLPPEGFQA SYGKDEDRAC DEILSDDNFN LENAEKDTYS 900
    EVDDELDISD NSSSSSSSPL KESTFNILKR SFSASGGERQ SQTRDFTGGT 950
    GSRPRPALLP LDLLLKVPPH MLRAHIKEIE AELVTGWQSH SLPAVILRNL 1000
    KDHGPQMGTF LWQASAGIAV SQRKVRQISD PIQQILIQLH KIIYITQLPP 1050
    ALHHNLKRRV IERFKKSLFS QQSNPCNLKS EIKKLSQGSP EPIEPNFFTA 1100
    DYHLLHRSSG GNSLSPNDPT GLPTSIELEE GITYEQMQTV IEEVLEESGY 1150
    YNFTSNRYHS YPWGTKNHPT KR 1172
    Length:1,172
    Mass (Da):133,259
    Last modified:March 21, 2012 - v3
    Checksum:i28D76407922020C8
    GO
    Isoform 2 (identifier: Q6ZWH5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         672-725: TDFGLAKQKQ...GCILYQMATL → SCLKCAAPLP...IMVPVQPAEP
         726-1172: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:725
    Mass (Da):82,881
    Checksum:iBBFE5EC46CAAB90B
    GO
    Isoform 3 (identifier: Q6ZWH5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         190-218: YIFQKLAAVKDQREWVTTSGAHKTLVNLL → CKCYCRDTAIFVDLLEKAVWCLQQETRIL
         219-1172: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:218
    Mass (Da):25,494
    Checksum:i860A31E47BF3805E
    GO
    Isoform 4 (identifier: Q6ZWH5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         698-712: PEVLKSEPYGEKADV → VQHLYLRSPAPALAT
         713-1172: Missing.

    Show »
    Length:712
    Mass (Da):81,624
    Checksum:i58ECB713BC90B8A2
    GO
    Isoform 5 (identifier: Q6ZWH5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-688: Missing.
         689-697: VVGTILYSC → MVPVQPAEP

    Show »
    Length:484
    Mass (Da):54,221
    Checksum:i8FDE78BFA255BEB3
    GO
    Isoform 6 (identifier: Q6ZWH5-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-688: Missing.
         689-697: VVGTILYSC → MVPVQPAEP
         1004-1013: Missing.

    Show »
    Length:474
    Mass (Da):53,075
    Checksum:iD698CFEC2B43130F
    GO
    Isoform 7 (identifier: Q6ZWH5-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-688: Missing.
         689-697: VVGTILYSC → MVPVQPAEP
         957-1013: Missing.

    Show »
    Length:427
    Mass (Da):47,765
    Checksum:i4F318F1B2DED28C9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti239 – 2391S → G in CAD97860. (PubMed:17974005)Curated
    Sequence conflicti762 – 7621I → F in AAZ20184. 1 PublicationCurated
    Sequence conflicti898 – 8981T → A in AAZ20184. 1 PublicationCurated
    Sequence conflicti1155 – 11551S → P in AAZ20184. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501F → L.1 Publication
    Corresponds to variant rs56125830 [ dbSNP | Ensembl ].
    VAR_040928
    Natural varianti66 – 661A → V in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication
    VAR_040929
    Natural varianti67 – 671G → S.1 Publication
    Corresponds to variant rs55958314 [ dbSNP | Ensembl ].
    VAR_040930
    Natural varianti379 – 3791E → K in a metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_040931
    Natural varianti513 – 5131L → S.2 Publications
    Corresponds to variant rs10510592 [ dbSNP | Ensembl ].
    VAR_040932
    Natural varianti659 – 6591N → S.1 Publication
    Corresponds to variant rs55833401 [ dbSNP | Ensembl ].
    VAR_040933
    Natural varianti701 – 7011L → V.1 Publication
    Corresponds to variant rs34313679 [ dbSNP | Ensembl ].
    VAR_040934

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 688688Missing in isoform 5, isoform 6 and isoform 7. 3 PublicationsVSP_035688Add
    BLAST
    Alternative sequencei190 – 21829YIFQK…LVNLL → CKCYCRDTAIFVDLLEKAVW CLQQETRIL in isoform 3. 1 PublicationVSP_021534Add
    BLAST
    Alternative sequencei219 – 1172954Missing in isoform 3. 1 PublicationVSP_021535Add
    BLAST
    Alternative sequencei672 – 72554TDFGL…QMATL → SCLKCAAPLPSLSCSCSGHI KRAGSSFAFCYHWELPDASQ EANAIMVPVQPAEP in isoform 2. 1 PublicationVSP_021536Add
    BLAST
    Alternative sequencei689 – 6979VVGTILYSC → MVPVQPAEP in isoform 5, isoform 6 and isoform 7. 3 PublicationsVSP_035689
    Alternative sequencei698 – 71215PEVLK…EKADV → VQHLYLRSPAPALAT in isoform 4. 1 PublicationVSP_035690Add
    BLAST
    Alternative sequencei713 – 1172460Missing in isoform 4. 1 PublicationVSP_035691Add
    BLAST
    Alternative sequencei726 – 1172447Missing in isoform 2. 1 PublicationVSP_035692Add
    BLAST
    Alternative sequencei957 – 101357Missing in isoform 7. 1 PublicationVSP_035693Add
    BLAST
    Alternative sequencei1004 – 101310Missing in isoform 6. 1 PublicationVSP_035694

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057247 mRNA. Translation: BAB71395.1.
    AK123061 mRNA. Translation: BAC85527.1.
    AK128585 mRNA. Translation: BAC87513.1.
    DQ104438 mRNA. Translation: AAZ20184.1.
    AC133142 Genomic DNA. No translation available.
    AC093555 Genomic DNA. No translation available.
    AC098931 Genomic DNA. No translation available.
    AC099535 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64376.1.
    BC045758 mRNA. Translation: AAH45758.1.
    BX537852 mRNA. Translation: CAD97860.1.
    CCDSiCCDS46781.1. [Q6ZWH5-4]
    RefSeqiNP_955379.2. NM_199347.2. [Q6ZWH5-4]
    XP_006713057.1. XM_006712994.1. [Q6ZWH5-1]
    XP_006713058.1. XM_006712995.1. [Q6ZWH5-1]
    XP_006713059.1. XM_006712996.1. [Q6ZWH5-1]
    UniGeneiHs.506115.
    Hs.743887.

    Genome annotation databases

    EnsembliENST00000295720; ENSP00000295720; ENSG00000163491. [Q6ZWH5-5]
    ENST00000341435; ENSP00000343847; ENSG00000163491. [Q6ZWH5-4]
    ENST00000383770; ENSP00000373280; ENSG00000163491. [Q6ZWH5-7]
    ENST00000383771; ENSP00000373281; ENSG00000163491. [Q6ZWH5-6]
    ENST00000429845; ENSP00000395849; ENSG00000163491. [Q6ZWH5-1]
    GeneIDi152110.
    KEGGihsa:152110.
    UCSCiuc003cdt.2. human. [Q6ZWH5-4]
    uc010hfj.3. human. [Q6ZWH5-7]
    uc010hfk.3. human. [Q6ZWH5-5]
    uc021wuk.1. human. [Q6ZWH5-3]

    Polymorphism databases

    DMDMi380865464.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057247 mRNA. Translation: BAB71395.1 .
    AK123061 mRNA. Translation: BAC85527.1 .
    AK128585 mRNA. Translation: BAC87513.1 .
    DQ104438 mRNA. Translation: AAZ20184.1 .
    AC133142 Genomic DNA. No translation available.
    AC093555 Genomic DNA. No translation available.
    AC098931 Genomic DNA. No translation available.
    AC099535 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64376.1 .
    BC045758 mRNA. Translation: AAH45758.1 .
    BX537852 mRNA. Translation: CAD97860.1 .
    CCDSi CCDS46781.1. [Q6ZWH5-4 ]
    RefSeqi NP_955379.2. NM_199347.2. [Q6ZWH5-4 ]
    XP_006713057.1. XM_006712994.1. [Q6ZWH5-1 ]
    XP_006713058.1. XM_006712995.1. [Q6ZWH5-1 ]
    XP_006713059.1. XM_006712996.1. [Q6ZWH5-1 ]
    UniGenei Hs.506115.
    Hs.743887.

    3D structure databases

    ProteinModelPortali Q6ZWH5.
    SMRi Q6ZWH5. Positions 454-816.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127428. 3 interactions.
    STRINGi 9606.ENSP00000343847.

    PTM databases

    PhosphoSitei Q6ZWH5.

    Polymorphism databases

    DMDMi 380865464.

    Proteomic databases

    PaxDbi Q6ZWH5.
    PRIDEi Q6ZWH5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295720 ; ENSP00000295720 ; ENSG00000163491 . [Q6ZWH5-5 ]
    ENST00000341435 ; ENSP00000343847 ; ENSG00000163491 . [Q6ZWH5-4 ]
    ENST00000383770 ; ENSP00000373280 ; ENSG00000163491 . [Q6ZWH5-7 ]
    ENST00000383771 ; ENSP00000373281 ; ENSG00000163491 . [Q6ZWH5-6 ]
    ENST00000429845 ; ENSP00000395849 ; ENSG00000163491 . [Q6ZWH5-1 ]
    GeneIDi 152110.
    KEGGi hsa:152110.
    UCSCi uc003cdt.2. human. [Q6ZWH5-4 ]
    uc010hfj.3. human. [Q6ZWH5-7 ]
    uc010hfk.3. human. [Q6ZWH5-5 ]
    uc021wuk.1. human. [Q6ZWH5-3 ]

    Organism-specific databases

    CTDi 152110.
    GeneCardsi GC03M027128.
    HGNCi HGNC:18592. NEK10.
    HPAi HPA038941.
    neXtProti NX_Q6ZWH5.
    PharmGKBi PA38594.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG108180.
    KOi K08857.
    OMAi DYHLLHH.
    OrthoDBi EOG7Q5HCF.
    TreeFami TF336430.

    Enzyme and pathway databases

    SignaLinki Q6ZWH5.

    Miscellaneous databases

    ChiTaRSi NEK10. human.
    GenomeRNAii 152110.
    NextBioi 86891.
    PROi Q6ZWH5.

    Gene expression databases

    ArrayExpressi Q6ZWH5.
    Bgeei Q6ZWH5.
    CleanExi HS_NEK10.
    Genevestigatori Q6ZWH5.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5).
      Tissue: Testis and Trachea.
    2. Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Huang B., Lin L., Yang S.
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
      Tissue: Testis.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 75-1172 (ISOFORM 2), VARIANT SER-513.
      Tissue: Liver.
    7. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-50; VAL-66; SER-67; LYS-379; SER-513; SER-659 AND VAL-701.

    Entry informationi

    Entry nameiNEK10_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZWH5
    Secondary accession number(s): A8MWG1
    , B9ZVR0, Q45VJ4, Q6ZR11, Q7Z671, Q86XB1, Q96MB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 100 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3