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Q6ZWH5 (NEK10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase Nek10

EC=2.7.11.1
Alternative name(s):
Never in mitosis A-related kinase 10
Short name=NimA-related protein kinase 10
Gene names
Name:NEK10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1172 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

Contains 1 ARM repeat.

Contains 1 protein kinase domain.

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZWH5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZWH5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     672-725: TDFGLAKQKQ...GCILYQMATL → SCLKCAAPLP...IMVPVQPAEP
     726-1172: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q6ZWH5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     190-218: YIFQKLAAVKDQREWVTTSGAHKTLVNLL → CKCYCRDTAIFVDLLEKAVWCLQQETRIL
     219-1172: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q6ZWH5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     698-712: PEVLKSEPYGEKADV → VQHLYLRSPAPALAT
     713-1172: Missing.
Isoform 5 (identifier: Q6ZWH5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP
Isoform 6 (identifier: Q6ZWH5-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP
     1004-1013: Missing.
Isoform 7 (identifier: Q6ZWH5-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP
     957-1013: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11721172Serine/threonine-protein kinase Nek10
PRO_0000259767

Regions

Repeat209 – 25143ARM
Domain519 – 712194Protein kinase
Nucleotide binding525 – 5339ATP By similarity
Coiled coil481 – 51434 Potential

Sites

Active site6551Proton acceptor By similarity
Binding site5481ATP By similarity

Natural variations

Alternative sequence1 – 688688Missing in isoform 5, isoform 6 and isoform 7.
VSP_035688
Alternative sequence190 – 21829YIFQK…LVNLL → CKCYCRDTAIFVDLLEKAVW CLQQETRIL in isoform 3.
VSP_021534
Alternative sequence219 – 1172954Missing in isoform 3.
VSP_021535
Alternative sequence672 – 72554TDFGL…QMATL → SCLKCAAPLPSLSCSCSGHI KRAGSSFAFCYHWELPDASQ EANAIMVPVQPAEP in isoform 2.
VSP_021536
Alternative sequence689 – 6979VVGTILYSC → MVPVQPAEP in isoform 5, isoform 6 and isoform 7.
VSP_035689
Alternative sequence698 – 71215PEVLK…EKADV → VQHLYLRSPAPALAT in isoform 4.
VSP_035690
Alternative sequence713 – 1172460Missing in isoform 4.
VSP_035691
Alternative sequence726 – 1172447Missing in isoform 2.
VSP_035692
Alternative sequence957 – 101357Missing in isoform 7.
VSP_035693
Alternative sequence1004 – 101310Missing in isoform 6.
VSP_035694
Natural variant501F → L. Ref.7
Corresponds to variant rs56125830 [ dbSNP | Ensembl ].
VAR_040928
Natural variant661A → V in an ovarian mucinous carcinoma sample; somatic mutation. Ref.7
VAR_040929
Natural variant671G → S. Ref.7
Corresponds to variant rs55958314 [ dbSNP | Ensembl ].
VAR_040930
Natural variant3791E → K in a metastatic melanoma sample; somatic mutation. Ref.7
VAR_040931
Natural variant5131L → S. Ref.6 Ref.7
Corresponds to variant rs10510592 [ dbSNP | Ensembl ].
VAR_040932
Natural variant6591N → S. Ref.7
Corresponds to variant rs55833401 [ dbSNP | Ensembl ].
VAR_040933
Natural variant7011L → V. Ref.7
Corresponds to variant rs34313679 [ dbSNP | Ensembl ].
VAR_040934

Experimental info

Sequence conflict2391S → G in CAD97860. Ref.6
Sequence conflict7621I → F in AAZ20184. Ref.2
Sequence conflict8981T → A in AAZ20184. Ref.2
Sequence conflict11551S → P in AAZ20184. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 21, 2012. Version 3.
Checksum: 28D76407922020C8

FASTA1,172133,259
        10         20         30         40         50         60 
MPDQDKKVKT TEKSTDKQQE ITIRDYSDLK RLRCLLNVQS SKQQLPAINF DSAQNSMTKS 

        70         80         90        100        110        120 
EPAIRAGGHR ARGQWHESTE AVELENFSIN YKNERNFSKH PQRKLFQEIF TALVKNRLIS 

       130        140        150        160        170        180 
REWVNRAPSI HFLRVLICLR LLMRDPCYQE ILHSLGGIEN LAQYMEIVAN EYLGYGEEQH 

       190        200        210        220        230        240 
TVDKLVNMTY IFQKLAAVKD QREWVTTSGA HKTLVNLLGA RDTNVLLGSL LALASLAESQ 

       250        260        270        280        290        300 
ECREKISELN IVENLLMILH EYDLLSKRLT AELLRLLCAE PQVKEQVKLY EGIPVLLSLL 

       310        320        330        340        350        360 
HSDHLKLLWS IVWILVQVCE DPETSVEIRI WGGIKQLLHI LQGDRNFVSD HSSIGSLSSA 

       370        380        390        400        410        420 
NAAGRIQQLH LSEDLSPREI QENTFSLQAA CCAALTELVL NDTNAHQVVQ ENGVYTIAKL 

       430        440        450        460        470        480 
ILPNKQKNAA KSNLLQCYAF RALRFLFSME RNRPLFKRLF PTDLFEIFID IGHYVRDISA 

       490        500        510        520        530        540 
YEELVSKLNL LVEDELKQIA ENIESINQNK APLKYIGNYA ILDHLGSGAF GCVYKVRKHS 

       550        560        570        580        590        600 
GQNLLAMKEV NLHNPAFGKD KKDRDSSVRN IVSELTIIKE QLYHPNIVRY YKTFLENDRL 

       610        620        630        640        650        660 
YIVMELIEGA PLGEHFSSLK EKHHHFTEER LWKIFIQLCL ALRYLHKEKR IVHRDLTPNN 

       670        680        690        700        710        720 
IMLGDKDKVT VTDFGLAKQK QENSKLTSVV GTILYSCPEV LKSEPYGEKA DVWAVGCILY 

       730        740        750        760        770        780 
QMATLSPPFY STNMLSLATK IVEAVYEPVP EGIYSEKVTD TISRCLTPDA EARPDIVEVS 

       790        800        810        820        830        840 
SMISDVMMKY LDNLSTSQLS LEKKLERERR RTQRYFMEAN RNTVTCHHEL AVLSHETFEK 

       850        860        870        880        890        900 
ASLSSSSSGA ASLKSELSES ADLPPEGFQA SYGKDEDRAC DEILSDDNFN LENAEKDTYS 

       910        920        930        940        950        960 
EVDDELDISD NSSSSSSSPL KESTFNILKR SFSASGGERQ SQTRDFTGGT GSRPRPALLP 

       970        980        990       1000       1010       1020 
LDLLLKVPPH MLRAHIKEIE AELVTGWQSH SLPAVILRNL KDHGPQMGTF LWQASAGIAV 

      1030       1040       1050       1060       1070       1080 
SQRKVRQISD PIQQILIQLH KIIYITQLPP ALHHNLKRRV IERFKKSLFS QQSNPCNLKS 

      1090       1100       1110       1120       1130       1140 
EIKKLSQGSP EPIEPNFFTA DYHLLHRSSG GNSLSPNDPT GLPTSIELEE GITYEQMQTV 

      1150       1160       1170 
IEEVLEESGY YNFTSNRYHS YPWGTKNHPT KR 

« Hide

Isoform 2 [UniParc].

Checksum: BBFE5EC46CAAB90B
Show »

FASTA72582,881
Isoform 3 [UniParc].

Checksum: 860A31E47BF3805E
Show »

FASTA21825,494
Isoform 4 [UniParc].

Checksum: 58ECB713BC90B8A2
Show »

FASTA71281,624
Isoform 5 [UniParc].

Checksum: 8FDE78BFA255BEB3
Show »

FASTA48454,221
Isoform 6 [UniParc].

Checksum: D698CFEC2B43130F
Show »

FASTA47453,075
Isoform 7 [UniParc].

Checksum: 4F318F1B2DED28C9
Show »

FASTA42747,765

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5).
Tissue: Testis and Trachea.
[2]Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Huang B., Lin L., Yang S.
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
[3]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
Tissue: Testis.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 75-1172 (ISOFORM 2), VARIANT SER-513.
Tissue: Liver.
[7]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-50; VAL-66; SER-67; LYS-379; SER-513; SER-659 AND VAL-701.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK057247 mRNA. Translation: BAB71395.1.
AK123061 mRNA. Translation: BAC85527.1.
AK128585 mRNA. Translation: BAC87513.1.
DQ104438 mRNA. Translation: AAZ20184.1.
AC133142 Genomic DNA. No translation available.
AC093555 Genomic DNA. No translation available.
AC098931 Genomic DNA. No translation available.
AC099535 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64376.1.
BC045758 mRNA. Translation: AAH45758.1.
BX537852 mRNA. Translation: CAD97860.1.
CCDSCCDS46781.1. [Q6ZWH5-4]
RefSeqNP_955379.2. NM_199347.2. [Q6ZWH5-4]
XP_006713057.1. XM_006712994.1. [Q6ZWH5-1]
XP_006713058.1. XM_006712995.1. [Q6ZWH5-1]
XP_006713059.1. XM_006712996.1. [Q6ZWH5-1]
UniGeneHs.506115.
Hs.743887.

3D structure databases

ProteinModelPortalQ6ZWH5.
SMRQ6ZWH5. Positions 454-816.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127428. 3 interactions.
STRING9606.ENSP00000343847.

PTM databases

PhosphoSiteQ6ZWH5.

Polymorphism databases

DMDM380865464.

Proteomic databases

PaxDbQ6ZWH5.
PRIDEQ6ZWH5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295720; ENSP00000295720; ENSG00000163491. [Q6ZWH5-5]
ENST00000341435; ENSP00000343847; ENSG00000163491. [Q6ZWH5-4]
ENST00000383770; ENSP00000373280; ENSG00000163491. [Q6ZWH5-7]
ENST00000383771; ENSP00000373281; ENSG00000163491. [Q6ZWH5-6]
ENST00000429845; ENSP00000395849; ENSG00000163491. [Q6ZWH5-1]
GeneID152110.
KEGGhsa:152110.
UCSCuc003cdt.2. human. [Q6ZWH5-4]
uc010hfj.3. human. [Q6ZWH5-7]
uc010hfk.3. human. [Q6ZWH5-5]
uc021wuk.1. human. [Q6ZWH5-3]

Organism-specific databases

CTD152110.
GeneCardsGC03M027128.
HGNCHGNC:18592. NEK10.
HPAHPA038941.
neXtProtNX_Q6ZWH5.
PharmGKBPA38594.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOVERGENHBG108180.
KOK08857.
OMADYHLLHH.
OrthoDBEOG7Q5HCF.
TreeFamTF336430.

Enzyme and pathway databases

SignaLinkQ6ZWH5.

Gene expression databases

ArrayExpressQ6ZWH5.
BgeeQ6ZWH5.
CleanExHS_NEK10.
GenevestigatorQ6ZWH5.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNEK10. human.
GenomeRNAi152110.
NextBio86891.
PROQ6ZWH5.

Entry information

Entry nameNEK10_HUMAN
AccessionPrimary (citable) accession number: Q6ZWH5
Secondary accession number(s): A8MWG1 expand/collapse secondary AC list , B9ZVR0, Q45VJ4, Q6ZR11, Q7Z671, Q86XB1, Q96MB3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 21, 2012
Last modified: July 9, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM