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Q6ZWH5

- NEK10_HUMAN

UniProt

Q6ZWH5 - NEK10_HUMAN

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Protein
Serine/threonine-protein kinase Nek10
Gene
NEK10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei548 – 5481ATP By similarity
Active sitei655 – 6551Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi525 – 5339ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein kinase activity Source: UniProt
  4. protein serine/threonine kinase activity Source: UniProtKB-KW
  5. protein tyrosine kinase activity Source: InterPro

GO - Biological processi

  1. positive regulation of MAP kinase activity Source: UniProt
  2. positive regulation of protein autophosphorylation Source: UniProt
  3. protein phosphorylation Source: UniProt
  4. regulation of ERK1 and ERK2 cascade Source: UniProt
  5. regulation of cell cycle G2/M phase transition Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ6ZWH5.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek10 (EC:2.7.11.1)
Alternative name(s):
Never in mitosis A-related kinase 10
Short name:
NimA-related protein kinase 10
Gene namesi
Name:NEK10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:18592. NEK10.

Subcellular locationi

GO - Cellular componenti

  1. protein kinase complex Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38594.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11721172Serine/threonine-protein kinase Nek10
PRO_0000259767Add
BLAST

Proteomic databases

PaxDbiQ6ZWH5.
PRIDEiQ6ZWH5.

PTM databases

PhosphoSiteiQ6ZWH5.

Expressioni

Gene expression databases

ArrayExpressiQ6ZWH5.
BgeeiQ6ZWH5.
CleanExiHS_NEK10.
GenevestigatoriQ6ZWH5.

Organism-specific databases

HPAiHPA038941.

Interactioni

Protein-protein interaction databases

BioGridi127428. 3 interactions.
STRINGi9606.ENSP00000343847.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWH5.
SMRiQ6ZWH5. Positions 454-816.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati209 – 25143ARM
Add
BLAST
Domaini519 – 712194Protein kinase
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili481 – 51434 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 1 ARM repeat.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0515.
HOVERGENiHBG108180.
KOiK08857.
OMAiDYHLLHH.
OrthoDBiEOG7Q5HCF.
TreeFamiTF336430.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZWH5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPDQDKKVKT TEKSTDKQQE ITIRDYSDLK RLRCLLNVQS SKQQLPAINF     50
DSAQNSMTKS EPAIRAGGHR ARGQWHESTE AVELENFSIN YKNERNFSKH 100
PQRKLFQEIF TALVKNRLIS REWVNRAPSI HFLRVLICLR LLMRDPCYQE 150
ILHSLGGIEN LAQYMEIVAN EYLGYGEEQH TVDKLVNMTY IFQKLAAVKD 200
QREWVTTSGA HKTLVNLLGA RDTNVLLGSL LALASLAESQ ECREKISELN 250
IVENLLMILH EYDLLSKRLT AELLRLLCAE PQVKEQVKLY EGIPVLLSLL 300
HSDHLKLLWS IVWILVQVCE DPETSVEIRI WGGIKQLLHI LQGDRNFVSD 350
HSSIGSLSSA NAAGRIQQLH LSEDLSPREI QENTFSLQAA CCAALTELVL 400
NDTNAHQVVQ ENGVYTIAKL ILPNKQKNAA KSNLLQCYAF RALRFLFSME 450
RNRPLFKRLF PTDLFEIFID IGHYVRDISA YEELVSKLNL LVEDELKQIA 500
ENIESINQNK APLKYIGNYA ILDHLGSGAF GCVYKVRKHS GQNLLAMKEV 550
NLHNPAFGKD KKDRDSSVRN IVSELTIIKE QLYHPNIVRY YKTFLENDRL 600
YIVMELIEGA PLGEHFSSLK EKHHHFTEER LWKIFIQLCL ALRYLHKEKR 650
IVHRDLTPNN IMLGDKDKVT VTDFGLAKQK QENSKLTSVV GTILYSCPEV 700
LKSEPYGEKA DVWAVGCILY QMATLSPPFY STNMLSLATK IVEAVYEPVP 750
EGIYSEKVTD TISRCLTPDA EARPDIVEVS SMISDVMMKY LDNLSTSQLS 800
LEKKLERERR RTQRYFMEAN RNTVTCHHEL AVLSHETFEK ASLSSSSSGA 850
ASLKSELSES ADLPPEGFQA SYGKDEDRAC DEILSDDNFN LENAEKDTYS 900
EVDDELDISD NSSSSSSSPL KESTFNILKR SFSASGGERQ SQTRDFTGGT 950
GSRPRPALLP LDLLLKVPPH MLRAHIKEIE AELVTGWQSH SLPAVILRNL 1000
KDHGPQMGTF LWQASAGIAV SQRKVRQISD PIQQILIQLH KIIYITQLPP 1050
ALHHNLKRRV IERFKKSLFS QQSNPCNLKS EIKKLSQGSP EPIEPNFFTA 1100
DYHLLHRSSG GNSLSPNDPT GLPTSIELEE GITYEQMQTV IEEVLEESGY 1150
YNFTSNRYHS YPWGTKNHPT KR 1172
Length:1,172
Mass (Da):133,259
Last modified:March 21, 2012 - v3
Checksum:i28D76407922020C8
GO
Isoform 2 (identifier: Q6ZWH5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     672-725: TDFGLAKQKQ...GCILYQMATL → SCLKCAAPLP...IMVPVQPAEP
     726-1172: Missing.

Note: No experimental confirmation available.

Show »
Length:725
Mass (Da):82,881
Checksum:iBBFE5EC46CAAB90B
GO
Isoform 3 (identifier: Q6ZWH5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-218: YIFQKLAAVKDQREWVTTSGAHKTLVNLL → CKCYCRDTAIFVDLLEKAVWCLQQETRIL
     219-1172: Missing.

Note: No experimental confirmation available.

Show »
Length:218
Mass (Da):25,494
Checksum:i860A31E47BF3805E
GO
Isoform 4 (identifier: Q6ZWH5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-712: PEVLKSEPYGEKADV → VQHLYLRSPAPALAT
     713-1172: Missing.

Show »
Length:712
Mass (Da):81,624
Checksum:i58ECB713BC90B8A2
GO
Isoform 5 (identifier: Q6ZWH5-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP

Show »
Length:484
Mass (Da):54,221
Checksum:i8FDE78BFA255BEB3
GO
Isoform 6 (identifier: Q6ZWH5-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP
     1004-1013: Missing.

Show »
Length:474
Mass (Da):53,075
Checksum:iD698CFEC2B43130F
GO
Isoform 7 (identifier: Q6ZWH5-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP
     957-1013: Missing.

Show »
Length:427
Mass (Da):47,765
Checksum:i4F318F1B2DED28C9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501F → L.1 Publication
Corresponds to variant rs56125830 [ dbSNP | Ensembl ].
VAR_040928
Natural varianti66 – 661A → V in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication
VAR_040929
Natural varianti67 – 671G → S.1 Publication
Corresponds to variant rs55958314 [ dbSNP | Ensembl ].
VAR_040930
Natural varianti379 – 3791E → K in a metastatic melanoma sample; somatic mutation. 1 Publication
VAR_040931
Natural varianti513 – 5131L → S.2 Publications
Corresponds to variant rs10510592 [ dbSNP | Ensembl ].
VAR_040932
Natural varianti659 – 6591N → S.1 Publication
Corresponds to variant rs55833401 [ dbSNP | Ensembl ].
VAR_040933
Natural varianti701 – 7011L → V.1 Publication
Corresponds to variant rs34313679 [ dbSNP | Ensembl ].
VAR_040934

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 688688Missing in isoform 5, isoform 6 and isoform 7.
VSP_035688Add
BLAST
Alternative sequencei190 – 21829YIFQK…LVNLL → CKCYCRDTAIFVDLLEKAVW CLQQETRIL in isoform 3.
VSP_021534Add
BLAST
Alternative sequencei219 – 1172954Missing in isoform 3.
VSP_021535Add
BLAST
Alternative sequencei672 – 72554TDFGL…QMATL → SCLKCAAPLPSLSCSCSGHI KRAGSSFAFCYHWELPDASQ EANAIMVPVQPAEP in isoform 2.
VSP_021536Add
BLAST
Alternative sequencei689 – 6979VVGTILYSC → MVPVQPAEP in isoform 5, isoform 6 and isoform 7.
VSP_035689
Alternative sequencei698 – 71215PEVLK…EKADV → VQHLYLRSPAPALAT in isoform 4.
VSP_035690Add
BLAST
Alternative sequencei713 – 1172460Missing in isoform 4.
VSP_035691Add
BLAST
Alternative sequencei726 – 1172447Missing in isoform 2.
VSP_035692Add
BLAST
Alternative sequencei957 – 101357Missing in isoform 7.
VSP_035693Add
BLAST
Alternative sequencei1004 – 101310Missing in isoform 6.
VSP_035694

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti239 – 2391S → G in CAD97860. 1 Publication
Sequence conflicti762 – 7621I → F in AAZ20184. 1 Publication
Sequence conflicti898 – 8981T → A in AAZ20184. 1 Publication
Sequence conflicti1155 – 11551S → P in AAZ20184. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057247 mRNA. Translation: BAB71395.1.
AK123061 mRNA. Translation: BAC85527.1.
AK128585 mRNA. Translation: BAC87513.1.
DQ104438 mRNA. Translation: AAZ20184.1.
AC133142 Genomic DNA. No translation available.
AC093555 Genomic DNA. No translation available.
AC098931 Genomic DNA. No translation available.
AC099535 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64376.1.
BC045758 mRNA. Translation: AAH45758.1.
BX537852 mRNA. Translation: CAD97860.1.
CCDSiCCDS46781.1. [Q6ZWH5-4]
RefSeqiNP_955379.2. NM_199347.2. [Q6ZWH5-4]
XP_006713057.1. XM_006712994.1. [Q6ZWH5-1]
XP_006713058.1. XM_006712995.1. [Q6ZWH5-1]
XP_006713059.1. XM_006712996.1. [Q6ZWH5-1]
UniGeneiHs.506115.
Hs.743887.

Genome annotation databases

EnsembliENST00000295720; ENSP00000295720; ENSG00000163491. [Q6ZWH5-5]
ENST00000341435; ENSP00000343847; ENSG00000163491. [Q6ZWH5-4]
ENST00000383770; ENSP00000373280; ENSG00000163491. [Q6ZWH5-7]
ENST00000383771; ENSP00000373281; ENSG00000163491. [Q6ZWH5-6]
ENST00000429845; ENSP00000395849; ENSG00000163491. [Q6ZWH5-1]
GeneIDi152110.
KEGGihsa:152110.
UCSCiuc003cdt.2. human. [Q6ZWH5-4]
uc010hfj.3. human. [Q6ZWH5-7]
uc010hfk.3. human. [Q6ZWH5-5]
uc021wuk.1. human. [Q6ZWH5-3]

Polymorphism databases

DMDMi380865464.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057247 mRNA. Translation: BAB71395.1 .
AK123061 mRNA. Translation: BAC85527.1 .
AK128585 mRNA. Translation: BAC87513.1 .
DQ104438 mRNA. Translation: AAZ20184.1 .
AC133142 Genomic DNA. No translation available.
AC093555 Genomic DNA. No translation available.
AC098931 Genomic DNA. No translation available.
AC099535 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64376.1 .
BC045758 mRNA. Translation: AAH45758.1 .
BX537852 mRNA. Translation: CAD97860.1 .
CCDSi CCDS46781.1. [Q6ZWH5-4 ]
RefSeqi NP_955379.2. NM_199347.2. [Q6ZWH5-4 ]
XP_006713057.1. XM_006712994.1. [Q6ZWH5-1 ]
XP_006713058.1. XM_006712995.1. [Q6ZWH5-1 ]
XP_006713059.1. XM_006712996.1. [Q6ZWH5-1 ]
UniGenei Hs.506115.
Hs.743887.

3D structure databases

ProteinModelPortali Q6ZWH5.
SMRi Q6ZWH5. Positions 454-816.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127428. 3 interactions.
STRINGi 9606.ENSP00000343847.

PTM databases

PhosphoSitei Q6ZWH5.

Polymorphism databases

DMDMi 380865464.

Proteomic databases

PaxDbi Q6ZWH5.
PRIDEi Q6ZWH5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295720 ; ENSP00000295720 ; ENSG00000163491 . [Q6ZWH5-5 ]
ENST00000341435 ; ENSP00000343847 ; ENSG00000163491 . [Q6ZWH5-4 ]
ENST00000383770 ; ENSP00000373280 ; ENSG00000163491 . [Q6ZWH5-7 ]
ENST00000383771 ; ENSP00000373281 ; ENSG00000163491 . [Q6ZWH5-6 ]
ENST00000429845 ; ENSP00000395849 ; ENSG00000163491 . [Q6ZWH5-1 ]
GeneIDi 152110.
KEGGi hsa:152110.
UCSCi uc003cdt.2. human. [Q6ZWH5-4 ]
uc010hfj.3. human. [Q6ZWH5-7 ]
uc010hfk.3. human. [Q6ZWH5-5 ]
uc021wuk.1. human. [Q6ZWH5-3 ]

Organism-specific databases

CTDi 152110.
GeneCardsi GC03M027128.
HGNCi HGNC:18592. NEK10.
HPAi HPA038941.
neXtProti NX_Q6ZWH5.
PharmGKBi PA38594.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOVERGENi HBG108180.
KOi K08857.
OMAi DYHLLHH.
OrthoDBi EOG7Q5HCF.
TreeFami TF336430.

Enzyme and pathway databases

SignaLinki Q6ZWH5.

Miscellaneous databases

ChiTaRSi NEK10. human.
GenomeRNAii 152110.
NextBioi 86891.
PROi Q6ZWH5.

Gene expression databases

ArrayExpressi Q6ZWH5.
Bgeei Q6ZWH5.
CleanExi HS_NEK10.
Genevestigatori