Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase Nek10

Gene

NEK10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei548ATPPROSITE-ProRule annotation1
Active sitei655Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi525 – 533ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • chromosome segregation Source: GO_Central
  • microtubule-based process Source: GO_Central
  • positive regulation of MAP kinase activity Source: UniProtKB
  • positive regulation of protein autophosphorylation Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • regulation of cell cycle G2/M phase transition Source: UniProtKB
  • regulation of ERK1 and ERK2 cascade Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS08859-MONOMER.
SignaLinkiQ6ZWH5.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek10 (EC:2.7.11.1)
Alternative name(s):
Never in mitosis A-related kinase 10
Short name:
NimA-related protein kinase 10
Gene namesi
Name:NEK10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18592. NEK10.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: GO_Central
  • cytoplasm Source: GO_Central
  • nucleus Source: GO_Central
  • protein kinase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi152110.
OpenTargetsiENSG00000163491.
PharmGKBiPA38594.

Chemistry databases

ChEMBLiCHEMBL3108655.

Polymorphism and mutation databases

BioMutaiNEK10.
DMDMi380865464.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002597671 – 1172Serine/threonine-protein kinase Nek10Add BLAST1172

Proteomic databases

PaxDbiQ6ZWH5.
PeptideAtlasiQ6ZWH5.
PRIDEiQ6ZWH5.

PTM databases

iPTMnetiQ6ZWH5.
PhosphoSitePlusiQ6ZWH5.

Expressioni

Gene expression databases

BgeeiENSG00000163491.
CleanExiHS_NEK10.
ExpressionAtlasiQ6ZWH5. baseline and differential.
GenevisibleiQ6ZWH5. HS.

Organism-specific databases

HPAiHPA038941.

Interactioni

Protein-protein interaction databases

BioGridi127428. 2 interactors.
IntActiQ6ZWH5. 2 interactors.
STRINGi9606.ENSP00000343847.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWH5.
SMRiQ6ZWH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati209 – 251ARMAdd BLAST43
Domaini519 – 712Protein kinasePROSITE-ProRule annotationAdd BLAST194

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili481 – 514Sequence analysisAdd BLAST34

Sequence similaritiesi

Contains 1 ARM repeat.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0589. Eukaryota.
ENOG410Y7JF. LUCA.
GeneTreeiENSGT00760000118997.
HOVERGENiHBG108180.
InParanoidiQ6ZWH5.
KOiK08857.
OMAiDYHLLHH.
OrthoDBiEOG091G01FT.
TreeFamiTF336430.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZWH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPDQDKKVKT TEKSTDKQQE ITIRDYSDLK RLRCLLNVQS SKQQLPAINF
60 70 80 90 100
DSAQNSMTKS EPAIRAGGHR ARGQWHESTE AVELENFSIN YKNERNFSKH
110 120 130 140 150
PQRKLFQEIF TALVKNRLIS REWVNRAPSI HFLRVLICLR LLMRDPCYQE
160 170 180 190 200
ILHSLGGIEN LAQYMEIVAN EYLGYGEEQH TVDKLVNMTY IFQKLAAVKD
210 220 230 240 250
QREWVTTSGA HKTLVNLLGA RDTNVLLGSL LALASLAESQ ECREKISELN
260 270 280 290 300
IVENLLMILH EYDLLSKRLT AELLRLLCAE PQVKEQVKLY EGIPVLLSLL
310 320 330 340 350
HSDHLKLLWS IVWILVQVCE DPETSVEIRI WGGIKQLLHI LQGDRNFVSD
360 370 380 390 400
HSSIGSLSSA NAAGRIQQLH LSEDLSPREI QENTFSLQAA CCAALTELVL
410 420 430 440 450
NDTNAHQVVQ ENGVYTIAKL ILPNKQKNAA KSNLLQCYAF RALRFLFSME
460 470 480 490 500
RNRPLFKRLF PTDLFEIFID IGHYVRDISA YEELVSKLNL LVEDELKQIA
510 520 530 540 550
ENIESINQNK APLKYIGNYA ILDHLGSGAF GCVYKVRKHS GQNLLAMKEV
560 570 580 590 600
NLHNPAFGKD KKDRDSSVRN IVSELTIIKE QLYHPNIVRY YKTFLENDRL
610 620 630 640 650
YIVMELIEGA PLGEHFSSLK EKHHHFTEER LWKIFIQLCL ALRYLHKEKR
660 670 680 690 700
IVHRDLTPNN IMLGDKDKVT VTDFGLAKQK QENSKLTSVV GTILYSCPEV
710 720 730 740 750
LKSEPYGEKA DVWAVGCILY QMATLSPPFY STNMLSLATK IVEAVYEPVP
760 770 780 790 800
EGIYSEKVTD TISRCLTPDA EARPDIVEVS SMISDVMMKY LDNLSTSQLS
810 820 830 840 850
LEKKLERERR RTQRYFMEAN RNTVTCHHEL AVLSHETFEK ASLSSSSSGA
860 870 880 890 900
ASLKSELSES ADLPPEGFQA SYGKDEDRAC DEILSDDNFN LENAEKDTYS
910 920 930 940 950
EVDDELDISD NSSSSSSSPL KESTFNILKR SFSASGGERQ SQTRDFTGGT
960 970 980 990 1000
GSRPRPALLP LDLLLKVPPH MLRAHIKEIE AELVTGWQSH SLPAVILRNL
1010 1020 1030 1040 1050
KDHGPQMGTF LWQASAGIAV SQRKVRQISD PIQQILIQLH KIIYITQLPP
1060 1070 1080 1090 1100
ALHHNLKRRV IERFKKSLFS QQSNPCNLKS EIKKLSQGSP EPIEPNFFTA
1110 1120 1130 1140 1150
DYHLLHRSSG GNSLSPNDPT GLPTSIELEE GITYEQMQTV IEEVLEESGY
1160 1170
YNFTSNRYHS YPWGTKNHPT KR
Length:1,172
Mass (Da):133,259
Last modified:March 21, 2012 - v3
Checksum:i28D76407922020C8
GO
Isoform 2 (identifier: Q6ZWH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     672-725: TDFGLAKQKQ...GCILYQMATL → SCLKCAAPLP...IMVPVQPAEP
     726-1172: Missing.

Note: No experimental confirmation available.
Show »
Length:725
Mass (Da):82,881
Checksum:iBBFE5EC46CAAB90B
GO
Isoform 3 (identifier: Q6ZWH5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-218: YIFQKLAAVKDQREWVTTSGAHKTLVNLL → CKCYCRDTAIFVDLLEKAVWCLQQETRIL
     219-1172: Missing.

Note: No experimental confirmation available.
Show »
Length:218
Mass (Da):25,494
Checksum:i860A31E47BF3805E
GO
Isoform 4 (identifier: Q6ZWH5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-712: PEVLKSEPYGEKADV → VQHLYLRSPAPALAT
     713-1172: Missing.

Show »
Length:712
Mass (Da):81,624
Checksum:i58ECB713BC90B8A2
GO
Isoform 5 (identifier: Q6ZWH5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP

Show »
Length:484
Mass (Da):54,221
Checksum:i8FDE78BFA255BEB3
GO
Isoform 6 (identifier: Q6ZWH5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP
     1004-1013: Missing.

Show »
Length:474
Mass (Da):53,075
Checksum:iD698CFEC2B43130F
GO
Isoform 7 (identifier: Q6ZWH5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP
     957-1013: Missing.

Show »
Length:427
Mass (Da):47,765
Checksum:i4F318F1B2DED28C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239S → G in CAD97860 (PubMed:17974005).Curated1
Sequence conflicti762I → F in AAZ20184 (Ref. 2) Curated1
Sequence conflicti898T → A in AAZ20184 (Ref. 2) Curated1
Sequence conflicti1155S → P in AAZ20184 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04092850F → L.1 PublicationCorresponds to variant rs56125830dbSNPEnsembl.1
Natural variantiVAR_04092966A → V in an ovarian mucinous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant rs201821707dbSNPEnsembl.1
Natural variantiVAR_04093067G → S.1 PublicationCorresponds to variant rs55958314dbSNPEnsembl.1
Natural variantiVAR_040931379E → K in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040932513L → S.2 PublicationsCorresponds to variant rs10510592dbSNPEnsembl.1
Natural variantiVAR_040933659N → S.1 PublicationCorresponds to variant rs55833401dbSNPEnsembl.1
Natural variantiVAR_040934701L → V.1 PublicationCorresponds to variant rs34313679dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0356881 – 688Missing in isoform 5, isoform 6 and isoform 7. 3 PublicationsAdd BLAST688
Alternative sequenceiVSP_021534190 – 218YIFQK…LVNLL → CKCYCRDTAIFVDLLEKAVW CLQQETRIL in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_021535219 – 1172Missing in isoform 3. 1 PublicationAdd BLAST954
Alternative sequenceiVSP_021536672 – 725TDFGL…QMATL → SCLKCAAPLPSLSCSCSGHI KRAGSSFAFCYHWELPDASQ EANAIMVPVQPAEP in isoform 2. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_035689689 – 697VVGTILYSC → MVPVQPAEP in isoform 5, isoform 6 and isoform 7. 3 Publications9
Alternative sequenceiVSP_035690698 – 712PEVLK…EKADV → VQHLYLRSPAPALAT in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_035691713 – 1172Missing in isoform 4. 1 PublicationAdd BLAST460
Alternative sequenceiVSP_035692726 – 1172Missing in isoform 2. 1 PublicationAdd BLAST447
Alternative sequenceiVSP_035693957 – 1013Missing in isoform 7. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0356941004 – 1013Missing in isoform 6. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057247 mRNA. Translation: BAB71395.1.
AK123061 mRNA. Translation: BAC85527.1.
AK128585 mRNA. Translation: BAC87513.1.
DQ104438 mRNA. Translation: AAZ20184.1.
AC133142 Genomic DNA. No translation available.
AC093555 Genomic DNA. No translation available.
AC098931 Genomic DNA. No translation available.
AC099535 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64376.1.
BC045758 mRNA. Translation: AAH45758.1.
BX537852 mRNA. Translation: CAD97860.1.
CCDSiCCDS46781.1. [Q6ZWH5-4]
CCDS77713.1. [Q6ZWH5-5]
RefSeqiNP_001026911.1. NM_001031741.3. [Q6ZWH5-6]
NP_001291313.1. NM_001304384.1. [Q6ZWH5-5]
NP_689747.3. NM_152534.4. [Q6ZWH5-1]
NP_955379.2. NM_199347.3. [Q6ZWH5-4]
XP_016861250.1. XM_017005761.1. [Q6ZWH5-1]
XP_016861251.1. XM_017005762.1. [Q6ZWH5-1]
XP_016861252.1. XM_017005763.1. [Q6ZWH5-1]
XP_016861253.1. XM_017005764.1. [Q6ZWH5-1]
XP_016861254.1. XM_017005765.1. [Q6ZWH5-1]
UniGeneiHs.506115.
Hs.743887.

Genome annotation databases

EnsembliENST00000295720; ENSP00000295720; ENSG00000163491. [Q6ZWH5-5]
ENST00000341435; ENSP00000343847; ENSG00000163491. [Q6ZWH5-4]
ENST00000383771; ENSP00000373281; ENSG00000163491. [Q6ZWH5-6]
ENST00000429845; ENSP00000395849; ENSG00000163491. [Q6ZWH5-1]
GeneIDi152110.
KEGGihsa:152110.
UCSCiuc003cdt.3. human. [Q6ZWH5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057247 mRNA. Translation: BAB71395.1.
AK123061 mRNA. Translation: BAC85527.1.
AK128585 mRNA. Translation: BAC87513.1.
DQ104438 mRNA. Translation: AAZ20184.1.
AC133142 Genomic DNA. No translation available.
AC093555 Genomic DNA. No translation available.
AC098931 Genomic DNA. No translation available.
AC099535 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64376.1.
BC045758 mRNA. Translation: AAH45758.1.
BX537852 mRNA. Translation: CAD97860.1.
CCDSiCCDS46781.1. [Q6ZWH5-4]
CCDS77713.1. [Q6ZWH5-5]
RefSeqiNP_001026911.1. NM_001031741.3. [Q6ZWH5-6]
NP_001291313.1. NM_001304384.1. [Q6ZWH5-5]
NP_689747.3. NM_152534.4. [Q6ZWH5-1]
NP_955379.2. NM_199347.3. [Q6ZWH5-4]
XP_016861250.1. XM_017005761.1. [Q6ZWH5-1]
XP_016861251.1. XM_017005762.1. [Q6ZWH5-1]
XP_016861252.1. XM_017005763.1. [Q6ZWH5-1]
XP_016861253.1. XM_017005764.1. [Q6ZWH5-1]
XP_016861254.1. XM_017005765.1. [Q6ZWH5-1]
UniGeneiHs.506115.
Hs.743887.

3D structure databases

ProteinModelPortaliQ6ZWH5.
SMRiQ6ZWH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127428. 2 interactors.
IntActiQ6ZWH5. 2 interactors.
STRINGi9606.ENSP00000343847.

Chemistry databases

ChEMBLiCHEMBL3108655.

PTM databases

iPTMnetiQ6ZWH5.
PhosphoSitePlusiQ6ZWH5.

Polymorphism and mutation databases

BioMutaiNEK10.
DMDMi380865464.

Proteomic databases

PaxDbiQ6ZWH5.
PeptideAtlasiQ6ZWH5.
PRIDEiQ6ZWH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295720; ENSP00000295720; ENSG00000163491. [Q6ZWH5-5]
ENST00000341435; ENSP00000343847; ENSG00000163491. [Q6ZWH5-4]
ENST00000383771; ENSP00000373281; ENSG00000163491. [Q6ZWH5-6]
ENST00000429845; ENSP00000395849; ENSG00000163491. [Q6ZWH5-1]
GeneIDi152110.
KEGGihsa:152110.
UCSCiuc003cdt.3. human. [Q6ZWH5-1]

Organism-specific databases

CTDi152110.
DisGeNETi152110.
GeneCardsiNEK10.
HGNCiHGNC:18592. NEK10.
HPAiHPA038941.
neXtProtiNX_Q6ZWH5.
OpenTargetsiENSG00000163491.
PharmGKBiPA38594.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0589. Eukaryota.
ENOG410Y7JF. LUCA.
GeneTreeiENSGT00760000118997.
HOVERGENiHBG108180.
InParanoidiQ6ZWH5.
KOiK08857.
OMAiDYHLLHH.
OrthoDBiEOG091G01FT.
TreeFamiTF336430.

Enzyme and pathway databases

BioCyciZFISH:HS08859-MONOMER.
SignaLinkiQ6ZWH5.

Miscellaneous databases

ChiTaRSiNEK10. human.
GenomeRNAii152110.
PROiQ6ZWH5.

Gene expression databases

BgeeiENSG00000163491.
CleanExiHS_NEK10.
ExpressionAtlasiQ6ZWH5. baseline and differential.
GenevisibleiQ6ZWH5. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEK10_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWH5
Secondary accession number(s): A8MWG1
, B9ZVR0, Q45VJ4, Q6ZR11, Q7Z671, Q86XB1, Q96MB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 21, 2012
Last modified: November 2, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.