Q6ZWH5 (NEK10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase Nek10
EC=2.7.11.1

Alternative name(s):
Never in mitosis A-related kinase 10
Short name=NimA-related protein kinase 10

Gene names

Name:

NEK10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1172 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Contains 1 ARM repeat. Contains 1 protein kinase domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZWH5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZWH5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     672-725: TDFGLAKQKQ...GCILYQMATL → SCLKCAAPLP...IMVPVQPAEP
     726-1172: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q6ZWH5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     190-218: YIFQKLAAVKDQREWVTTSGAHKTLVNLL → CKCYCRDTAIFVDLLEKAVWCLQQETRIL
     219-1172: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q6ZWH5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     698-712: PEVLKSEPYGEKADV → VQHLYLRSPAPALAT
     713-1172: Missing.

Isoform 5 (identifier: Q6ZWH5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP

Isoform 6 (identifier: Q6ZWH5-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP
     1004-1013: Missing.

Isoform 7 (identifier: Q6ZWH5-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP
     957-1013: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1172	1172	Serine/threonine-protein kinase Nek10		PRO_0000259767
Regions
	Repeat	209 – 251	43	ARM
	Domain	519 – 712	194	Protein kinase
	Nucleotide binding	525 – 533	9	ATP By similarity
	Coiled coil	481 – 514	34	Potential
Sites
	Active site	655	1	Proton acceptor By similarity
	Binding site	548	1	ATP By similarity
Natural variations
	Alternative sequence	1 – 688	688	Missing in isoform 5, isoform 6 and isoform 7.		VSP_035688
	Alternative sequence	190 – 218	29	YIFQK…LVNLL → CKCYCRDTAIFVDLLEKAVW CLQQETRIL in isoform 3.		VSP_021534
	Alternative sequence	219 – 1172	954	Missing in isoform 3.		VSP_021535
	Alternative sequence	672 – 725	54	TDFGL…QMATL → SCLKCAAPLPSLSCSCSGHI KRAGSSFAFCYHWELPDASQ EANAIMVPVQPAEP in isoform 2.		VSP_021536
	Alternative sequence	689 – 697	9	VVGTILYSC → MVPVQPAEP in isoform 5, isoform 6 and isoform 7.		VSP_035689
	Alternative sequence	698 – 712	15	PEVLK…EKADV → VQHLYLRSPAPALAT in isoform 4.		VSP_035690
	Alternative sequence	713 – 1172	460	Missing in isoform 4.		VSP_035691
	Alternative sequence	726 – 1172	447	Missing in isoform 2.		VSP_035692
	Alternative sequence	957 – 1013	57	Missing in isoform 7.		VSP_035693
	Alternative sequence	1004 – 1013	10	Missing in isoform 6.		VSP_035694
	Natural variant	50	1	F → L. Ref.7 Corresponds to variant rs56125830 [ dbSNP | Ensembl ].		VAR_040928
	Natural variant	66	1	A → V in an ovarian mucinous carcinoma sample; somatic mutation. Ref.7		VAR_040929
	Natural variant	67	1	G → S. Ref.7 Corresponds to variant rs55958314 [ dbSNP | Ensembl ].		VAR_040930
	Natural variant	379	1	E → K in a metastatic melanoma sample; somatic mutation. Ref.7		VAR_040931
	Natural variant	513	1	L → S. Ref.6 Ref.7 Corresponds to variant rs10510592 [ dbSNP | Ensembl ].		VAR_040932
	Natural variant	659	1	N → S. Ref.7 Corresponds to variant rs55833401 [ dbSNP | Ensembl ].		VAR_040933
	Natural variant	701	1	L → V. Ref.7		VAR_040934
Experimental info
	Sequence conflict	239	1	S → G in CAD97860. Ref.6
	Sequence conflict	762	1	I → F in AAZ20184. Ref.2
	Sequence conflict	898	1	T → A in AAZ20184. Ref.2
	Sequence conflict	1155	1	S → P in AAZ20184. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 21, 2012. Version 3. Checksum: 28D76407922020C8	FASTA	1,172	133,259
	10 20 30 40 50 60 MPDQDKKVKT TEKSTDKQQE ITIRDYSDLK RLRCLLNVQS SKQQLPAINF DSAQNSMTKS 70 80 90 100 110 120 EPAIRAGGHR ARGQWHESTE AVELENFSIN YKNERNFSKH PQRKLFQEIF TALVKNRLIS 130 140 150 160 170 180 REWVNRAPSI HFLRVLICLR LLMRDPCYQE ILHSLGGIEN LAQYMEIVAN EYLGYGEEQH 190 200 210 220 230 240 TVDKLVNMTY IFQKLAAVKD QREWVTTSGA HKTLVNLLGA RDTNVLLGSL LALASLAESQ 250 260 270 280 290 300 ECREKISELN IVENLLMILH EYDLLSKRLT AELLRLLCAE PQVKEQVKLY EGIPVLLSLL 310 320 330 340 350 360 HSDHLKLLWS IVWILVQVCE DPETSVEIRI WGGIKQLLHI LQGDRNFVSD HSSIGSLSSA 370 380 390 400 410 420 NAAGRIQQLH LSEDLSPREI QENTFSLQAA CCAALTELVL NDTNAHQVVQ ENGVYTIAKL 430 440 450 460 470 480 ILPNKQKNAA KSNLLQCYAF RALRFLFSME RNRPLFKRLF PTDLFEIFID IGHYVRDISA 490 500 510 520 530 540 YEELVSKLNL LVEDELKQIA ENIESINQNK APLKYIGNYA ILDHLGSGAF GCVYKVRKHS 550 560 570 580 590 600 GQNLLAMKEV NLHNPAFGKD KKDRDSSVRN IVSELTIIKE QLYHPNIVRY YKTFLENDRL 610 620 630 640 650 660 YIVMELIEGA PLGEHFSSLK EKHHHFTEER LWKIFIQLCL ALRYLHKEKR IVHRDLTPNN 670 680 690 700 710 720 IMLGDKDKVT VTDFGLAKQK QENSKLTSVV GTILYSCPEV LKSEPYGEKA DVWAVGCILY 730 740 750 760 770 780 QMATLSPPFY STNMLSLATK IVEAVYEPVP EGIYSEKVTD TISRCLTPDA EARPDIVEVS 790 800 810 820 830 840 SMISDVMMKY LDNLSTSQLS LEKKLERERR RTQRYFMEAN RNTVTCHHEL AVLSHETFEK 850 860 870 880 890 900 ASLSSSSSGA ASLKSELSES ADLPPEGFQA SYGKDEDRAC DEILSDDNFN LENAEKDTYS 910 920 930 940 950 960 EVDDELDISD NSSSSSSSPL KESTFNILKR SFSASGGERQ SQTRDFTGGT GSRPRPALLP 970 980 990 1000 1010 1020 LDLLLKVPPH MLRAHIKEIE AELVTGWQSH SLPAVILRNL KDHGPQMGTF LWQASAGIAV 1030 1040 1050 1060 1070 1080 SQRKVRQISD PIQQILIQLH KIIYITQLPP ALHHNLKRRV IERFKKSLFS QQSNPCNLKS 1090 1100 1110 1120 1130 1140 EIKKLSQGSP EPIEPNFFTA DYHLLHRSSG GNSLSPNDPT GLPTSIELEE GITYEQMQTV 1150 1160 1170 IEEVLEESGY YNFTSNRYHS YPWGTKNHPT KR
	Isoform 2 [UniParc]. Checksum: BBFE5EC46CAAB90B	FASTA	725	82,881
	10 20 30 40 50 60 MPDQDKKVKT TEKSTDKQQE ITIRDYSDLK RLRCLLNVQS SKQQLPAINF DSAQNSMTKS 70 80 90 100 110 120 EPAIRAGGHR ARGQWHESTE AVELENFSIN YKNERNFSKH PQRKLFQEIF TALVKNRLIS 130 140 150 160 170 180 REWVNRAPSI HFLRVLICLR LLMRDPCYQE ILHSLGGIEN LAQYMEIVAN EYLGYGEEQH 190 200 210 220 230 240 TVDKLVNMTY IFQKLAAVKD QREWVTTSGA HKTLVNLLGA RDTNVLLGSL LALASLAESQ 250 260 270 280 290 300 ECREKISELN IVENLLMILH EYDLLSKRLT AELLRLLCAE PQVKEQVKLY EGIPVLLSLL 310 320 330 340 350 360 HSDHLKLLWS IVWILVQVCE DPETSVEIRI WGGIKQLLHI LQGDRNFVSD HSSIGSLSSA 370 380 390 400 410 420 NAAGRIQQLH LSEDLSPREI QENTFSLQAA CCAALTELVL NDTNAHQVVQ ENGVYTIAKL 430 440 450 460 470 480 ILPNKQKNAA KSNLLQCYAF RALRFLFSME RNRPLFKRLF PTDLFEIFID IGHYVRDISA 490 500 510 520 530 540 YEELVSKLNL LVEDELKQIA ENIESINQNK APLKYIGNYA ILDHLGSGAF GCVYKVRKHS 550 560 570 580 590 600 GQNLLAMKEV NLHNPAFGKD KKDRDSSVRN IVSELTIIKE QLYHPNIVRY YKTFLENDRL 610 620 630 640 650 660 YIVMELIEGA PLGEHFSSLK EKHHHFTEER LWKIFIQLCL ALRYLHKEKR IVHRDLTPNN 670 680 690 700 710 720 IMLGDKDKVT VSCLKCAAPL PSLSCSCSGH IKRAGSSFAF CYHWELPDAS QEANAIMVPV QPAEP
	Isoform 3 [UniParc]. Checksum: 860A31E47BF3805E	FASTA	218	25,494
	10 20 30 40 50 60 MPDQDKKVKT TEKSTDKQQE ITIRDYSDLK RLRCLLNVQS SKQQLPAINF DSAQNSMTKS 70 80 90 100 110 120 EPAIRAGGHR ARGQWHESTE AVELENFSIN YKNERNFSKH PQRKLFQEIF TALVKNRLIS 130 140 150 160 170 180 REWVNRAPSI HFLRVLICLR LLMRDPCYQE ILHSLGGIEN LAQYMEIVAN EYLGYGEEQH 190 200 210 TVDKLVNMTC KCYCRDTAIF VDLLEKAVWC LQQETRIL
	Isoform 4 [UniParc]. Checksum: 58ECB713BC90B8A2	FASTA	712	81,624
	10 20 30 40 50 60 MPDQDKKVKT TEKSTDKQQE ITIRDYSDLK RLRCLLNVQS SKQQLPAINF DSAQNSMTKS 70 80 90 100 110 120 EPAIRAGGHR ARGQWHESTE AVELENFSIN YKNERNFSKH PQRKLFQEIF TALVKNRLIS 130 140 150 160 170 180 REWVNRAPSI HFLRVLICLR LLMRDPCYQE ILHSLGGIEN LAQYMEIVAN EYLGYGEEQH 190 200 210 220 230 240 TVDKLVNMTY IFQKLAAVKD QREWVTTSGA HKTLVNLLGA RDTNVLLGSL LALASLAESQ 250 260 270 280 290 300 ECREKISELN IVENLLMILH EYDLLSKRLT AELLRLLCAE PQVKEQVKLY EGIPVLLSLL 310 320 330 340 350 360 HSDHLKLLWS IVWILVQVCE DPETSVEIRI WGGIKQLLHI LQGDRNFVSD HSSIGSLSSA 370 380 390 400 410 420 NAAGRIQQLH LSEDLSPREI QENTFSLQAA CCAALTELVL NDTNAHQVVQ ENGVYTIAKL 430 440 450 460 470 480 ILPNKQKNAA KSNLLQCYAF RALRFLFSME RNRPLFKRLF PTDLFEIFID IGHYVRDISA 490 500 510 520 530 540 YEELVSKLNL LVEDELKQIA ENIESINQNK APLKYIGNYA ILDHLGSGAF GCVYKVRKHS 550 560 570 580 590 600 GQNLLAMKEV NLHNPAFGKD KKDRDSSVRN IVSELTIIKE QLYHPNIVRY YKTFLENDRL 610 620 630 640 650 660 YIVMELIEGA PLGEHFSSLK EKHHHFTEER LWKIFIQLCL ALRYLHKEKR IVHRDLTPNN 670 680 690 700 710 IMLGDKDKVT VTDFGLAKQK QENSKLTSVV GTILYSCVQH LYLRSPAPAL AT
	Isoform 5 [UniParc]. Checksum: 8FDE78BFA255BEB3	FASTA	484	54,221
	10 20 30 40 50 60 MVPVQPAEPP EVLKSEPYGE KADVWAVGCI LYQMATLSPP FYSTNMLSLA TKIVEAVYEP 70 80 90 100 110 120 VPEGIYSEKV TDTISRCLTP DAEARPDIVE VSSMISDVMM KYLDNLSTSQ LSLEKKLERE 130 140 150 160 170 180 RRRTQRYFME ANRNTVTCHH ELAVLSHETF EKASLSSSSS GAASLKSELS ESADLPPEGF 190 200 210 220 230 240 QASYGKDEDR ACDEILSDDN FNLENAEKDT YSEVDDELDI SDNSSSSSSS PLKESTFNIL 250 260 270 280 290 300 KRSFSASGGE RQSQTRDFTG GTGSRPRPAL LPLDLLLKVP PHMLRAHIKE IEAELVTGWQ 310 320 330 340 350 360 SHSLPAVILR NLKDHGPQMG TFLWQASAGI AVSQRKVRQI SDPIQQILIQ LHKIIYITQL 370 380 390 400 410 420 PPALHHNLKR RVIERFKKSL FSQQSNPCNL KSEIKKLSQG SPEPIEPNFF TADYHLLHRS 430 440 450 460 470 480 SGGNSLSPND PTGLPTSIEL EEGITYEQMQ TVIEEVLEES GYYNFTSNRY HSYPWGTKNH PTKR
	Isoform 6 [UniParc]. Checksum: D698CFEC2B43130F	FASTA	474	53,075
	10 20 30 40 50 60 MVPVQPAEPP EVLKSEPYGE KADVWAVGCI LYQMATLSPP FYSTNMLSLA TKIVEAVYEP 70 80 90 100 110 120 VPEGIYSEKV TDTISRCLTP DAEARPDIVE VSSMISDVMM KYLDNLSTSQ LSLEKKLERE 130 140 150 160 170 180 RRRTQRYFME ANRNTVTCHH ELAVLSHETF EKASLSSSSS GAASLKSELS ESADLPPEGF 190 200 210 220 230 240 QASYGKDEDR ACDEILSDDN FNLENAEKDT YSEVDDELDI SDNSSSSSSS PLKESTFNIL 250 260 270 280 290 300 KRSFSASGGE RQSQTRDFTG GTGSRPRPAL LPLDLLLKVP PHMLRAHIKE IEAELVTGWQ 310 320 330 340 350 360 SHSLPAVILR NLKDHASAGI AVSQRKVRQI SDPIQQILIQ LHKIIYITQL PPALHHNLKR 370 380 390 400 410 420 RVIERFKKSL FSQQSNPCNL KSEIKKLSQG SPEPIEPNFF TADYHLLHRS SGGNSLSPND 430 440 450 460 470 PTGLPTSIEL EEGITYEQMQ TVIEEVLEES GYYNFTSNRY HSYPWGTKNH PTKR
	Isoform 7 [UniParc]. Checksum: 4F318F1B2DED28C9	FASTA	427	47,765
	10 20 30 40 50 60 MVPVQPAEPP EVLKSEPYGE KADVWAVGCI LYQMATLSPP FYSTNMLSLA TKIVEAVYEP 70 80 90 100 110 120 VPEGIYSEKV TDTISRCLTP DAEARPDIVE VSSMISDVMM KYLDNLSTSQ LSLEKKLERE 130 140 150 160 170 180 RRRTQRYFME ANRNTVTCHH ELAVLSHETF EKASLSSSSS GAASLKSELS ESADLPPEGF 190 200 210 220 230 240 QASYGKDEDR ACDEILSDDN FNLENAEKDT YSEVDDELDI SDNSSSSSSS PLKESTFNIL 250 260 270 280 290 300 KRSFSASGGE RQSQTRDFTG GTGSRPRPAS AGIAVSQRKV RQISDPIQQI LIQLHKIIYI 310 320 330 340 350 360 TQLPPALHHN LKRRVIERFK KSLFSQQSNP CNLKSEIKKL SQGSPEPIEP NFFTADYHLL 370 380 390 400 410 420 HRSSGGNSLS PNDPTGLPTS IELEEGITYE QMQTVIEEVL EESGYYNFTS NRYHSYPWGT KNHPTKR

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5). Tissue: Testis and Trachea.
[2]	Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Huang B., Lin L., Yang S. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Testis.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 75-1172 (ISOFORM 2), VARIANT SER-513. Tissue: Liver.
[7]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-50; VAL-66; SER-67; LYS-379; SER-513; SER-659 AND VAL-701.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK057247 mRNA. Translation: BAB71395.1. AK123061 mRNA. Translation: BAC85527.1. AK128585 mRNA. Translation: BAC87513.1. DQ104438 mRNA. Translation: AAZ20184.1. AC133142 Genomic DNA. No translation available. AC093555 Genomic DNA. No translation available. AC098931 Genomic DNA. No translation available. AC099535 Genomic DNA. No translation available. CH471055 Genomic DNA. Translation: EAW64376.1. BC045758 mRNA. Translation: AAH45758.1. BX537852 mRNA. Translation: CAD97860.1.
IPI	IPI00065454. IPI00419203. IPI00646668. IPI00743191. IPI00807338. IPI00807359. IPI00915026.
RefSeq	NP_955379.2. NM_199347.2.
UniGene	Hs.506115. Hs.743887.
3D structure databases
ProteinModelPortal	Q6ZWH5.
SMR	Q6ZWH5. Positions 212-343, 455-816.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000343847.
PTM databases
PhosphoSite	Q6ZWH5.
Polymorphism databases
DMDM	215274052.
Proteomic databases
PaxDb	Q6ZWH5.
PRIDE	Q6ZWH5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295720; ENSP00000295720; ENSG00000163491. ENST00000341435; ENSP00000343847; ENSG00000163491. ENST00000383770; ENSP00000373280; ENSG00000163491. ENST00000383771; ENSP00000373281; ENSG00000163491. ENST00000429845; ENSP00000395849; ENSG00000163491.
GeneID	152110.
KEGG	hsa:152110.
UCSC	uc003cdt.2. human. uc010hfj.3. human. uc010hfk.3. human. uc021wuk.1. human.
Organism-specific databases
CTD	152110.
GeneCards	GC03M027128.
HGNC	HGNC:18592. NEK10.
HPA	HPA038941.
neXtProt	NX_Q6ZWH5.
PharmGKB	PA38594.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOVERGEN	HBG108180.
KO	K08857.
Enzyme and pathway databases
SignaLink	Q6ZWH5.
Gene expression databases
ArrayExpress	Q6ZWH5.
Bgee	Q6ZWH5.
CleanEx	HS_NEK10.
Genevestigator	Q6ZWH5.
GermOnline	ENSG00000163491. Homo sapiens.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008266. Tyr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS50176. ARM_REPEAT. False negative. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NEK10. human.
GenomeRNAi	152110.
NextBio	86891.

Entry information

Entry name

NEK10_HUMAN

Accession

Primary (citable) accession number: Q6ZWH5
Secondary accession number(s): A8MWG1 , B9ZVR0, Q45VJ4, Q6ZR11, Q7Z671, Q86XB1, Q96MB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	March 21, 2012
Last modified:	May 29, 2013
This is version 85 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.