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Q6ZWH5

- NEK10_HUMAN

UniProt

Q6ZWH5 - NEK10_HUMAN

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Protein

Serine/threonine-protein kinase Nek10

Gene

NEK10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei548 – 5481ATPPROSITE-ProRule annotation
Active sitei655 – 6551Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi525 – 5339ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein kinase activity Source: UniProt
  4. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. positive regulation of MAP kinase activity Source: UniProt
  2. positive regulation of protein autophosphorylation Source: UniProt
  3. protein phosphorylation Source: UniProt
  4. regulation of cell cycle G2/M phase transition Source: UniProt
  5. regulation of ERK1 and ERK2 cascade Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ6ZWH5.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek10 (EC:2.7.11.1)
Alternative name(s):
Never in mitosis A-related kinase 10
Short name:
NimA-related protein kinase 10
Gene namesi
Name:NEK10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:18592. NEK10.

Subcellular locationi

GO - Cellular componenti

  1. protein kinase complex Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38594.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11721172Serine/threonine-protein kinase Nek10PRO_0000259767Add
BLAST

Proteomic databases

PaxDbiQ6ZWH5.
PRIDEiQ6ZWH5.

PTM databases

PhosphoSiteiQ6ZWH5.

Expressioni

Gene expression databases

BgeeiQ6ZWH5.
CleanExiHS_NEK10.
ExpressionAtlasiQ6ZWH5. baseline and differential.
GenevestigatoriQ6ZWH5.

Organism-specific databases

HPAiHPA038941.

Interactioni

Protein-protein interaction databases

BioGridi127428. 3 interactions.
STRINGi9606.ENSP00000343847.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWH5.
SMRiQ6ZWH5. Positions 455-776.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati209 – 25143ARMAdd
BLAST
Domaini519 – 712194Protein kinasePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili481 – 51434Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 ARM repeat.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118997.
HOVERGENiHBG108180.
InParanoidiQ6ZWH5.
KOiK08857.
OMAiDYHLLHH.
OrthoDBiEOG7Q5HCF.
TreeFamiTF336430.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZWH5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPDQDKKVKT TEKSTDKQQE ITIRDYSDLK RLRCLLNVQS SKQQLPAINF
60 70 80 90 100
DSAQNSMTKS EPAIRAGGHR ARGQWHESTE AVELENFSIN YKNERNFSKH
110 120 130 140 150
PQRKLFQEIF TALVKNRLIS REWVNRAPSI HFLRVLICLR LLMRDPCYQE
160 170 180 190 200
ILHSLGGIEN LAQYMEIVAN EYLGYGEEQH TVDKLVNMTY IFQKLAAVKD
210 220 230 240 250
QREWVTTSGA HKTLVNLLGA RDTNVLLGSL LALASLAESQ ECREKISELN
260 270 280 290 300
IVENLLMILH EYDLLSKRLT AELLRLLCAE PQVKEQVKLY EGIPVLLSLL
310 320 330 340 350
HSDHLKLLWS IVWILVQVCE DPETSVEIRI WGGIKQLLHI LQGDRNFVSD
360 370 380 390 400
HSSIGSLSSA NAAGRIQQLH LSEDLSPREI QENTFSLQAA CCAALTELVL
410 420 430 440 450
NDTNAHQVVQ ENGVYTIAKL ILPNKQKNAA KSNLLQCYAF RALRFLFSME
460 470 480 490 500
RNRPLFKRLF PTDLFEIFID IGHYVRDISA YEELVSKLNL LVEDELKQIA
510 520 530 540 550
ENIESINQNK APLKYIGNYA ILDHLGSGAF GCVYKVRKHS GQNLLAMKEV
560 570 580 590 600
NLHNPAFGKD KKDRDSSVRN IVSELTIIKE QLYHPNIVRY YKTFLENDRL
610 620 630 640 650
YIVMELIEGA PLGEHFSSLK EKHHHFTEER LWKIFIQLCL ALRYLHKEKR
660 670 680 690 700
IVHRDLTPNN IMLGDKDKVT VTDFGLAKQK QENSKLTSVV GTILYSCPEV
710 720 730 740 750
LKSEPYGEKA DVWAVGCILY QMATLSPPFY STNMLSLATK IVEAVYEPVP
760 770 780 790 800
EGIYSEKVTD TISRCLTPDA EARPDIVEVS SMISDVMMKY LDNLSTSQLS
810 820 830 840 850
LEKKLERERR RTQRYFMEAN RNTVTCHHEL AVLSHETFEK ASLSSSSSGA
860 870 880 890 900
ASLKSELSES ADLPPEGFQA SYGKDEDRAC DEILSDDNFN LENAEKDTYS
910 920 930 940 950
EVDDELDISD NSSSSSSSPL KESTFNILKR SFSASGGERQ SQTRDFTGGT
960 970 980 990 1000
GSRPRPALLP LDLLLKVPPH MLRAHIKEIE AELVTGWQSH SLPAVILRNL
1010 1020 1030 1040 1050
KDHGPQMGTF LWQASAGIAV SQRKVRQISD PIQQILIQLH KIIYITQLPP
1060 1070 1080 1090 1100
ALHHNLKRRV IERFKKSLFS QQSNPCNLKS EIKKLSQGSP EPIEPNFFTA
1110 1120 1130 1140 1150
DYHLLHRSSG GNSLSPNDPT GLPTSIELEE GITYEQMQTV IEEVLEESGY
1160 1170
YNFTSNRYHS YPWGTKNHPT KR
Length:1,172
Mass (Da):133,259
Last modified:March 21, 2012 - v3
Checksum:i28D76407922020C8
GO
Isoform 2 (identifier: Q6ZWH5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     672-725: TDFGLAKQKQ...GCILYQMATL → SCLKCAAPLP...IMVPVQPAEP
     726-1172: Missing.

Note: No experimental confirmation available.

Show »
Length:725
Mass (Da):82,881
Checksum:iBBFE5EC46CAAB90B
GO
Isoform 3 (identifier: Q6ZWH5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-218: YIFQKLAAVKDQREWVTTSGAHKTLVNLL → CKCYCRDTAIFVDLLEKAVWCLQQETRIL
     219-1172: Missing.

Note: No experimental confirmation available.

Show »
Length:218
Mass (Da):25,494
Checksum:i860A31E47BF3805E
GO
Isoform 4 (identifier: Q6ZWH5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-712: PEVLKSEPYGEKADV → VQHLYLRSPAPALAT
     713-1172: Missing.

Show »
Length:712
Mass (Da):81,624
Checksum:i58ECB713BC90B8A2
GO
Isoform 5 (identifier: Q6ZWH5-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP

Show »
Length:484
Mass (Da):54,221
Checksum:i8FDE78BFA255BEB3
GO
Isoform 6 (identifier: Q6ZWH5-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP
     1004-1013: Missing.

Show »
Length:474
Mass (Da):53,075
Checksum:iD698CFEC2B43130F
GO
Isoform 7 (identifier: Q6ZWH5-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     689-697: VVGTILYSC → MVPVQPAEP
     957-1013: Missing.

Show »
Length:427
Mass (Da):47,765
Checksum:i4F318F1B2DED28C9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti239 – 2391S → G in CAD97860. (PubMed:17974005)Curated
Sequence conflicti762 – 7621I → F in AAZ20184. 1 PublicationCurated
Sequence conflicti898 – 8981T → A in AAZ20184. 1 PublicationCurated
Sequence conflicti1155 – 11551S → P in AAZ20184. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501F → L.1 Publication
Corresponds to variant rs56125830 [ dbSNP | Ensembl ].
VAR_040928
Natural varianti66 – 661A → V in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication
VAR_040929
Natural varianti67 – 671G → S.1 Publication
Corresponds to variant rs55958314 [ dbSNP | Ensembl ].
VAR_040930
Natural varianti379 – 3791E → K in a metastatic melanoma sample; somatic mutation. 1 Publication
VAR_040931
Natural varianti513 – 5131L → S.2 Publications
Corresponds to variant rs10510592 [ dbSNP | Ensembl ].
VAR_040932
Natural varianti659 – 6591N → S.1 Publication
Corresponds to variant rs55833401 [ dbSNP | Ensembl ].
VAR_040933
Natural varianti701 – 7011L → V.1 Publication
Corresponds to variant rs34313679 [ dbSNP | Ensembl ].
VAR_040934

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 688688Missing in isoform 5, isoform 6 and isoform 7. 3 PublicationsVSP_035688Add
BLAST
Alternative sequencei190 – 21829YIFQK…LVNLL → CKCYCRDTAIFVDLLEKAVW CLQQETRIL in isoform 3. 1 PublicationVSP_021534Add
BLAST
Alternative sequencei219 – 1172954Missing in isoform 3. 1 PublicationVSP_021535Add
BLAST
Alternative sequencei672 – 72554TDFGL…QMATL → SCLKCAAPLPSLSCSCSGHI KRAGSSFAFCYHWELPDASQ EANAIMVPVQPAEP in isoform 2. 1 PublicationVSP_021536Add
BLAST
Alternative sequencei689 – 6979VVGTILYSC → MVPVQPAEP in isoform 5, isoform 6 and isoform 7. 3 PublicationsVSP_035689
Alternative sequencei698 – 71215PEVLK…EKADV → VQHLYLRSPAPALAT in isoform 4. 1 PublicationVSP_035690Add
BLAST
Alternative sequencei713 – 1172460Missing in isoform 4. 1 PublicationVSP_035691Add
BLAST
Alternative sequencei726 – 1172447Missing in isoform 2. 1 PublicationVSP_035692Add
BLAST
Alternative sequencei957 – 101357Missing in isoform 7. 1 PublicationVSP_035693Add
BLAST
Alternative sequencei1004 – 101310Missing in isoform 6. 1 PublicationVSP_035694

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057247 mRNA. Translation: BAB71395.1.
AK123061 mRNA. Translation: BAC85527.1.
AK128585 mRNA. Translation: BAC87513.1.
DQ104438 mRNA. Translation: AAZ20184.1.
AC133142 Genomic DNA. No translation available.
AC093555 Genomic DNA. No translation available.
AC098931 Genomic DNA. No translation available.
AC099535 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64376.1.
BC045758 mRNA. Translation: AAH45758.1.
BX537852 mRNA. Translation: CAD97860.1.
CCDSiCCDS46781.1. [Q6ZWH5-4]
RefSeqiNP_955379.2. NM_199347.2. [Q6ZWH5-4]
XP_006713057.1. XM_006712994.1. [Q6ZWH5-1]
XP_006713058.1. XM_006712995.1. [Q6ZWH5-1]
XP_006713059.1. XM_006712996.1. [Q6ZWH5-1]
UniGeneiHs.506115.
Hs.743887.

Genome annotation databases

EnsembliENST00000295720; ENSP00000295720; ENSG00000163491. [Q6ZWH5-5]
ENST00000341435; ENSP00000343847; ENSG00000163491. [Q6ZWH5-4]
ENST00000383771; ENSP00000373281; ENSG00000163491. [Q6ZWH5-6]
ENST00000429845; ENSP00000395849; ENSG00000163491. [Q6ZWH5-1]
GeneIDi152110.
KEGGihsa:152110.
UCSCiuc003cdt.2. human. [Q6ZWH5-4]
uc010hfj.3. human. [Q6ZWH5-7]
uc010hfk.3. human. [Q6ZWH5-5]
uc021wuk.1. human. [Q6ZWH5-3]

Polymorphism databases

DMDMi380865464.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057247 mRNA. Translation: BAB71395.1 .
AK123061 mRNA. Translation: BAC85527.1 .
AK128585 mRNA. Translation: BAC87513.1 .
DQ104438 mRNA. Translation: AAZ20184.1 .
AC133142 Genomic DNA. No translation available.
AC093555 Genomic DNA. No translation available.
AC098931 Genomic DNA. No translation available.
AC099535 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64376.1 .
BC045758 mRNA. Translation: AAH45758.1 .
BX537852 mRNA. Translation: CAD97860.1 .
CCDSi CCDS46781.1. [Q6ZWH5-4 ]
RefSeqi NP_955379.2. NM_199347.2. [Q6ZWH5-4 ]
XP_006713057.1. XM_006712994.1. [Q6ZWH5-1 ]
XP_006713058.1. XM_006712995.1. [Q6ZWH5-1 ]
XP_006713059.1. XM_006712996.1. [Q6ZWH5-1 ]
UniGenei Hs.506115.
Hs.743887.

3D structure databases

ProteinModelPortali Q6ZWH5.
SMRi Q6ZWH5. Positions 455-776.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127428. 3 interactions.
STRINGi 9606.ENSP00000343847.

Chemistry

ChEMBLi CHEMBL3108655.

PTM databases

PhosphoSitei Q6ZWH5.

Polymorphism databases

DMDMi 380865464.

Proteomic databases

PaxDbi Q6ZWH5.
PRIDEi Q6ZWH5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295720 ; ENSP00000295720 ; ENSG00000163491 . [Q6ZWH5-5 ]
ENST00000341435 ; ENSP00000343847 ; ENSG00000163491 . [Q6ZWH5-4 ]
ENST00000383771 ; ENSP00000373281 ; ENSG00000163491 . [Q6ZWH5-6 ]
ENST00000429845 ; ENSP00000395849 ; ENSG00000163491 . [Q6ZWH5-1 ]
GeneIDi 152110.
KEGGi hsa:152110.
UCSCi uc003cdt.2. human. [Q6ZWH5-4 ]
uc010hfj.3. human. [Q6ZWH5-7 ]
uc010hfk.3. human. [Q6ZWH5-5 ]
uc021wuk.1. human. [Q6ZWH5-3 ]

Organism-specific databases

CTDi 152110.
GeneCardsi GC03M027128.
HGNCi HGNC:18592. NEK10.
HPAi HPA038941.
neXtProti NX_Q6ZWH5.
PharmGKBi PA38594.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118997.
HOVERGENi HBG108180.
InParanoidi Q6ZWH5.
KOi K08857.
OMAi DYHLLHH.
OrthoDBi EOG7Q5HCF.
TreeFami TF336430.

Enzyme and pathway databases

SignaLinki Q6ZWH5.

Miscellaneous databases

ChiTaRSi NEK10. human.
GenomeRNAii 152110.
NextBioi 86891.
PROi Q6ZWH5.

Gene expression databases

Bgeei Q6ZWH5.
CleanExi HS_NEK10.
ExpressionAtlasi Q6ZWH5. baseline and differential.
Genevestigatori Q6ZWH5.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5).
    Tissue: Testis and Trachea.
  2. Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Huang B., Lin L., Yang S.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
    Tissue: Testis.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 75-1172 (ISOFORM 2), VARIANT SER-513.
    Tissue: Liver.
  7. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-50; VAL-66; SER-67; LYS-379; SER-513; SER-659 AND VAL-701.

Entry informationi

Entry nameiNEK10_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWH5
Secondary accession number(s): A8MWG1
, B9ZVR0, Q45VJ4, Q6ZR11, Q7Z671, Q86XB1, Q96MB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 21, 2012
Last modified: October 29, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3