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Protein

Pleckstrin homology domain-containing family M member 3

Gene

PLEKHM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri669 – 722Phorbol-ester/DAG-typeAdd BLAST54

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family M member 3
Short name:
PH domain-containing family M member 3
Gene namesi
Name:PLEKHM3
Synonyms:PLEKHM1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000178385.13
HGNCiHGNC:34006 PLEKHM3
neXtProtiNX_Q6ZWE6

Pathology & Biotechi

Organism-specific databases

DisGeNETi389072
OpenTargetsiENSG00000178385
PharmGKBiPA162399738

Polymorphism and mutation databases

BioMutaiPLEKHM3
DMDMi172046173

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003260341 – 761Pleckstrin homology domain-containing family M member 3Add BLAST761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei132PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6ZWE6
PeptideAtlasiQ6ZWE6
PRIDEiQ6ZWE6

PTM databases

iPTMnetiQ6ZWE6
PhosphoSitePlusiQ6ZWE6

Expressioni

Gene expression databases

BgeeiENSG00000178385
CleanExiHS_PLEKHM3
ExpressionAtlasiQ6ZWE6 baseline and differential

Organism-specific databases

HPAiHPA035046

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000417003

Structurei

3D structure databases

ProteinModelPortaliQ6ZWE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini211 – 308PH 1PROSITE-ProRule annotationAdd BLAST98
Domaini361 – 456PH 2PROSITE-ProRule annotationAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi169 – 175Poly-Gln7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri669 – 722Phorbol-ester/DAG-typeAdd BLAST54

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1829 Eukaryota
ENOG410ZMB5 LUCA
GeneTreeiENSGT00550000074570
HOGENOMiHOG000090264
HOVERGENiHBG100733
InParanoidiQ6ZWE6
OMAiQGNTEHK
OrthoDBiEOG091G0HFZ
PhylomeDBiQ6ZWE6
TreeFamiTF317067

Family and domain databases

CDDicd14674 PH_PLEKHM3_1, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037812 PLEKHM3_PH_1
IPR025258 Zf-RING_9
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF13901 zf-RING_9, 1 hit
SMARTiView protein in SMART
SM01175 DUF4206, 1 hit
SM00233 PH, 2 hits
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZWE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALEVDDIS PALEVTEEFF STLDSNLEKA VQQAEVYGIQ EVPELVGHEV
60 70 80 90 100
LSNITDNGAM RNVTSLGKGG MIWDHCKSRL LETKAQNVFP AKEQFMVQRG
110 120 130 140 150
TTPDNLSWME QKEASTFNFF NICQRRRDRP RSVNDLLDET STFKPGHARS
160 170 180 190 200
RSDITQVDWR VVLKTTPLQQ QQQQQPLLQG PHVTRPSFLL PSPNKIEDAQ
210 220 230 240 250
GNTEHKQTFP NILKKGYLEI RKDHDSYWQS CYAELSPYNL YFYSLDSSGN
260 270 280 290 300
QNLYATYQLS HFQSISVLGN LEARMVDTVL YDNTQLQLKA ESPWEALDWG
310 320 330 340 350
QKLWEVVHAA VPGYMGRQNE LTISPGLGHH DDYTQNHSFQ KKTSGLLPPS
360 370 380 390 400
PVLDSSKQYQ NILKSGTLYR LTVQNNWKAF TFVLSRAYLM AFQPGKLDED
410 420 430 440 450
PLLSYNVDVC LAVQMDNLDG CDSCFQVIFP QDVLRLRAET RQRAQEWMEA
460 470 480 490 500
LKIAANVARS SEQNLQVTLR NKPKDQMGGH ELRKNKRQSV TTSFLSILTT
510 520 530 540 550
LSLERGLTAQ SFKCAGCQRS IGLSNGKAKV CNYSGWYYCS SCHVDDSFLI
560 570 580 590 600
PARIVHNWDT SKYKVSKQAK EFLEYVYEEP LIDIQQENAM LYHHAEPLAA
610 620 630 640 650
VLRLRQRLKS LRAYLFSCRA AVAEDLRRRI FPREYLLQQI HLYSLADLQQ
660 670 680 690 700
VIEGKLAPFL GKVIKFATSH VYSCSLCSQK GFICEICNNG EILYPFEDIS
710 720 730 740 750
TSRCESCGAV FHSECKEKSV PCPRCVRREL QKKQKSFWQR LNMDESLEEA
760
CTMFELSYQN T
Length:761
Mass (Da):87,166
Last modified:March 18, 2008 - v2
Checksum:i53A2BCF3580CAE14
GO
Isoform 2 (identifier: Q6ZWE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     704-761: CESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQRLNMDESLEEACTMFELSYQNT → FGDPYADLLQGYVA

Note: No experimental confirmation available.
Show »
Length:717
Mass (Da):81,845
Checksum:i3DE5F628348736F6
GO
Isoform 3 (identifier: Q6ZWE6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     517-523: CQRSIGL → MKQIFSL
     524-761: Missing.

Note: No experimental confirmation available.
Show »
Length:523
Mass (Da):59,587
Checksum:i158ED5CF6FB4554B
GO

Sequence cautioni

The sequence BAC85557 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032511517 – 523CQRSIGL → MKQIFSL in isoform 3. 1 Publication7
Alternative sequenceiVSP_032512524 – 761Missing in isoform 3. 1 PublicationAdd BLAST238
Alternative sequenceiVSP_032513704 – 761CESCG…SYQNT → FGDPYADLLQGYVA in isoform 2. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083900 Genomic DNA No translation available.
AC096772 Genomic DNA No translation available.
BC020812 mRNA Translation: AAH20812.1
BC151137 mRNA Translation: AAI51138.1
AK123204 mRNA Translation: BAC85557.1 Different initiation.
CCDSiCCDS42808.1 [Q6ZWE6-1]
RefSeqiNP_001073944.1, NM_001080475.2 [Q6ZWE6-1]
XP_011509462.1, XM_011511160.2 [Q6ZWE6-1]
UniGeneiHs.159188
Hs.709906

Genome annotation databases

EnsembliENST00000427836; ENSP00000417003; ENSG00000178385 [Q6ZWE6-1]
GeneIDi389072
KEGGihsa:389072
UCSCiuc002vcl.3 human [Q6ZWE6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPKHM3_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWE6
Secondary accession number(s): B9EKV2, Q8WW68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: April 25, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health