Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pleckstrin homology domain-containing family M member 3

Gene

PLEKHM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri669 – 72254Phorbol-ester/DAG-typeAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family M member 3
Short name:
PH domain-containing family M member 3
Gene namesi
Name:PLEKHM3
Synonyms:PLEKHM1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:34006. PLEKHM3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162399738.

Polymorphism and mutation databases

BioMutaiPLEKHM3.
DMDMi172046173.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 761761Pleckstrin homology domain-containing family M member 3PRO_0000326034Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei132 – 1321PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6ZWE6.
PeptideAtlasiQ6ZWE6.
PRIDEiQ6ZWE6.

PTM databases

iPTMnetiQ6ZWE6.
PhosphoSiteiQ6ZWE6.

Expressioni

Gene expression databases

BgeeiQ6ZWE6.
CleanExiHS_PLEKHM3.
ExpressionAtlasiQ6ZWE6. baseline and differential.

Organism-specific databases

HPAiHPA035046.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000417003.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini211 – 30898PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini361 – 45696PH 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi169 – 1757Poly-Gln

Sequence similaritiesi

Contains 2 PH domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri669 – 72254Phorbol-ester/DAG-typeAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1829. Eukaryota.
ENOG410ZMB5. LUCA.
GeneTreeiENSGT00550000074570.
HOGENOMiHOG000090264.
HOVERGENiHBG100733.
InParanoidiQ6ZWE6.
OMAiQGNTEHK.
OrthoDBiEOG72VH72.
PhylomeDBiQ6ZWE6.
TreeFamiTF317067.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR025258. Zf-RING_9.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF13901. zf-RING_9. 1 hit.
[Graphical view]
SMARTiSM01175. DUF4206. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZWE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALEVDDIS PALEVTEEFF STLDSNLEKA VQQAEVYGIQ EVPELVGHEV
60 70 80 90 100
LSNITDNGAM RNVTSLGKGG MIWDHCKSRL LETKAQNVFP AKEQFMVQRG
110 120 130 140 150
TTPDNLSWME QKEASTFNFF NICQRRRDRP RSVNDLLDET STFKPGHARS
160 170 180 190 200
RSDITQVDWR VVLKTTPLQQ QQQQQPLLQG PHVTRPSFLL PSPNKIEDAQ
210 220 230 240 250
GNTEHKQTFP NILKKGYLEI RKDHDSYWQS CYAELSPYNL YFYSLDSSGN
260 270 280 290 300
QNLYATYQLS HFQSISVLGN LEARMVDTVL YDNTQLQLKA ESPWEALDWG
310 320 330 340 350
QKLWEVVHAA VPGYMGRQNE LTISPGLGHH DDYTQNHSFQ KKTSGLLPPS
360 370 380 390 400
PVLDSSKQYQ NILKSGTLYR LTVQNNWKAF TFVLSRAYLM AFQPGKLDED
410 420 430 440 450
PLLSYNVDVC LAVQMDNLDG CDSCFQVIFP QDVLRLRAET RQRAQEWMEA
460 470 480 490 500
LKIAANVARS SEQNLQVTLR NKPKDQMGGH ELRKNKRQSV TTSFLSILTT
510 520 530 540 550
LSLERGLTAQ SFKCAGCQRS IGLSNGKAKV CNYSGWYYCS SCHVDDSFLI
560 570 580 590 600
PARIVHNWDT SKYKVSKQAK EFLEYVYEEP LIDIQQENAM LYHHAEPLAA
610 620 630 640 650
VLRLRQRLKS LRAYLFSCRA AVAEDLRRRI FPREYLLQQI HLYSLADLQQ
660 670 680 690 700
VIEGKLAPFL GKVIKFATSH VYSCSLCSQK GFICEICNNG EILYPFEDIS
710 720 730 740 750
TSRCESCGAV FHSECKEKSV PCPRCVRREL QKKQKSFWQR LNMDESLEEA
760
CTMFELSYQN T
Length:761
Mass (Da):87,166
Last modified:March 18, 2008 - v2
Checksum:i53A2BCF3580CAE14
GO
Isoform 2 (identifier: Q6ZWE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     704-761: CESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQRLNMDESLEEACTMFELSYQNT → FGDPYADLLQGYVA

Note: No experimental confirmation available.
Show »
Length:717
Mass (Da):81,845
Checksum:i3DE5F628348736F6
GO
Isoform 3 (identifier: Q6ZWE6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     517-523: CQRSIGL → MKQIFSL
     524-761: Missing.

Note: No experimental confirmation available.
Show »
Length:523
Mass (Da):59,587
Checksum:i158ED5CF6FB4554B
GO

Sequence cautioni

The sequence BAC85557.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei517 – 5237CQRSIGL → MKQIFSL in isoform 3. 1 PublicationVSP_032511
Alternative sequencei524 – 761238Missing in isoform 3. 1 PublicationVSP_032512Add
BLAST
Alternative sequencei704 – 76158CESCG…SYQNT → FGDPYADLLQGYVA in isoform 2. 1 PublicationVSP_032513Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083900 Genomic DNA. No translation available.
AC096772 Genomic DNA. No translation available.
BC020812 mRNA. Translation: AAH20812.1.
BC151137 mRNA. Translation: AAI51138.1.
AK123204 mRNA. Translation: BAC85557.1. Different initiation.
CCDSiCCDS42808.1. [Q6ZWE6-1]
RefSeqiNP_001073944.1. NM_001080475.2. [Q6ZWE6-1]
XP_011509462.1. XM_011511160.1. [Q6ZWE6-1]
XP_011509463.1. XM_011511161.1. [Q6ZWE6-1]
UniGeneiHs.159188.
Hs.709906.

Genome annotation databases

EnsembliENST00000427836; ENSP00000417003; ENSG00000178385. [Q6ZWE6-1]
GeneIDi389072.
KEGGihsa:389072.
UCSCiuc002vcl.3. human. [Q6ZWE6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083900 Genomic DNA. No translation available.
AC096772 Genomic DNA. No translation available.
BC020812 mRNA. Translation: AAH20812.1.
BC151137 mRNA. Translation: AAI51138.1.
AK123204 mRNA. Translation: BAC85557.1. Different initiation.
CCDSiCCDS42808.1. [Q6ZWE6-1]
RefSeqiNP_001073944.1. NM_001080475.2. [Q6ZWE6-1]
XP_011509462.1. XM_011511160.1. [Q6ZWE6-1]
XP_011509463.1. XM_011511161.1. [Q6ZWE6-1]
UniGeneiHs.159188.
Hs.709906.

3D structure databases

ProteinModelPortaliQ6ZWE6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000417003.

PTM databases

iPTMnetiQ6ZWE6.
PhosphoSiteiQ6ZWE6.

Polymorphism and mutation databases

BioMutaiPLEKHM3.
DMDMi172046173.

Proteomic databases

PaxDbiQ6ZWE6.
PeptideAtlasiQ6ZWE6.
PRIDEiQ6ZWE6.

Protocols and materials databases

DNASUi389072.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000427836; ENSP00000417003; ENSG00000178385. [Q6ZWE6-1]
GeneIDi389072.
KEGGihsa:389072.
UCSCiuc002vcl.3. human. [Q6ZWE6-1]

Organism-specific databases

CTDi389072.
GeneCardsiPLEKHM3.
HGNCiHGNC:34006. PLEKHM3.
HPAiHPA035046.
neXtProtiNX_Q6ZWE6.
PharmGKBiPA162399738.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1829. Eukaryota.
ENOG410ZMB5. LUCA.
GeneTreeiENSGT00550000074570.
HOGENOMiHOG000090264.
HOVERGENiHBG100733.
InParanoidiQ6ZWE6.
OMAiQGNTEHK.
OrthoDBiEOG72VH72.
PhylomeDBiQ6ZWE6.
TreeFamiTF317067.

Miscellaneous databases

ChiTaRSiPLEKHM3. human.
GenomeRNAii389072.
PROiQ6ZWE6.

Gene expression databases

BgeeiQ6ZWE6.
CleanExiHS_PLEKHM3.
ExpressionAtlasiQ6ZWE6. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR025258. Zf-RING_9.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF13901. zf-RING_9. 1 hit.
[Graphical view]
SMARTiSM01175. DUF4206. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 405-761 (ISOFORM 3).
    Tissue: Prostate.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-761 (ISOFORM 2).
    Tissue: Brain cortex.

Entry informationi

Entry nameiPKHM3_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWE6
Secondary accession number(s): B9EKV2, Q8WW68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: July 6, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.