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Q6ZWB6

- KCTD8_HUMAN

UniProt

Q6ZWB6 - KCTD8_HUMAN

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Protein
BTB/POZ domain-containing protein KCTD8
Gene
KCTD8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization By similarity.

GO - Biological processi

  1. protein homooligomerization Source: InterPro
  2. regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD8
Gene namesi
Name:KCTD8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:22394. KCTD8.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. postsynaptic membrane Source: UniProtKB-SubCell
  3. presynaptic membrane Source: UniProtKB-SubCell
  4. receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909779.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473BTB/POZ domain-containing protein KCTD8
PRO_0000251481Add
BLAST

Proteomic databases

PaxDbiQ6ZWB6.
PRIDEiQ6ZWB6.

PTM databases

PhosphoSiteiQ6ZWB6.

Expressioni

Gene expression databases

BgeeiQ6ZWB6.
CleanExiHS_KCTD8.
GenevestigatoriQ6ZWB6.

Organism-specific databases

HPAiHPA031562.

Interactioni

Subunit structurei

Interacts as a tetramer with GABRB1 and GABRB2 By similarity.

Protein-protein interaction databases

BioGridi132113. 1 interaction.
IntActiQ6ZWB6. 1 interaction.
STRINGi9606.ENSP00000353129.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWB6.
SMRiQ6ZWB6. Positions 44-146.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 12279BTB
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 255Poly-Ser
Compositional biasi194 – 2007Poly-Gly

Sequence similaritiesi

Contains 1 BTB (POZ) domain.

Phylogenomic databases

eggNOGiNOG295576.
HOGENOMiHOG000041197.
HOVERGENiHBG052218.
InParanoidiQ6ZWB6.
OMAiDSTLATM.
OrthoDBiEOG7K3TM1.
PhylomeDBiQ6ZWB6.
TreeFamiTF315332.

Family and domain databases

Gene3Di3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ZWB6-1 [UniParc]FASTAAdd to Basket

« Hide

MALKDTGSGG STILPISEMV SSSSSPGASA AAAPGPCAPS PFPEVVELNV    50
GGQVYVTKHS TLLSVPDSTL ASMFSPSSPR GGARRRGELP RDSRARFFID 100
RDGFLFRYVL DYLRDKQLAL PEHFPEKERL LREAEYFQLT DLVKLLSPKV 150
TKQNSLNDEG CQSDLEDNVS QGSSDALLLR GAAAAVPSGP GAHGGGGGGG 200
AQDKRSGFLT LGYRGSYTTV RDNQADAKFR RVARIMVCGR IALAKEVFGD 250
TLNESRDPDR QPEKYTSRFY LKFTYLEQAF DRLSEAGFHM VACNSSGTAA 300
FVNQYRDDKI WSSYTEYIFF RPPQKIVSPK QEHEDRKHDK VTDKGSESGT 350
SCNELSTSSC DSHSEASTPQ DNPSSAQQAT AHQPNTLTLD RPSKKAPVQW 400
IPPPDKRRNS ELFQTLISKS RETNLSKKKV CEKLSVEEEM KKCIQDFKKI 450
HIPDYFPERK RQWQSELLQK YGL 473
Length:473
Mass (Da):52,440
Last modified:July 5, 2004 - v1
Checksum:iD5AA3F75716D3715
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti329 – 3291P → L.
Corresponds to variant rs13115990 [ dbSNP | Ensembl ].
VAR_027692

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK123347 mRNA. Translation: BAC85588.1.
BC132743 mRNA. Translation: AAI32744.1.
BC136793 mRNA. Translation: AAI36794.1.
CCDSiCCDS3467.1.
RefSeqiNP_938167.1. NM_198353.2.
UniGeneiHs.479644.

Genome annotation databases

EnsembliENST00000360029; ENSP00000353129; ENSG00000183783.
GeneIDi386617.
KEGGihsa:386617.
UCSCiuc003gwu.3. human.

Polymorphism databases

DMDMi74749707.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK123347 mRNA. Translation: BAC85588.1 .
BC132743 mRNA. Translation: AAI32744.1 .
BC136793 mRNA. Translation: AAI36794.1 .
CCDSi CCDS3467.1.
RefSeqi NP_938167.1. NM_198353.2.
UniGenei Hs.479644.

3D structure databases

ProteinModelPortali Q6ZWB6.
SMRi Q6ZWB6. Positions 44-146.
ModBasei Search...

Protein-protein interaction databases

BioGridi 132113. 1 interaction.
IntActi Q6ZWB6. 1 interaction.
STRINGi 9606.ENSP00000353129.

PTM databases

PhosphoSitei Q6ZWB6.

Polymorphism databases

DMDMi 74749707.

Proteomic databases

PaxDbi Q6ZWB6.
PRIDEi Q6ZWB6.

Protocols and materials databases

DNASUi 386617.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360029 ; ENSP00000353129 ; ENSG00000183783 .
GeneIDi 386617.
KEGGi hsa:386617.
UCSCi uc003gwu.3. human.

Organism-specific databases

CTDi 386617.
GeneCardsi GC04M044091.
HGNCi HGNC:22394. KCTD8.
HPAi HPA031562.
neXtProti NX_Q6ZWB6.
PharmGKBi PA134909779.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG295576.
HOGENOMi HOG000041197.
HOVERGENi HBG052218.
InParanoidi Q6ZWB6.
OMAi DSTLATM.
OrthoDBi EOG7K3TM1.
PhylomeDBi Q6ZWB6.
TreeFami TF315332.

Miscellaneous databases

GenomeRNAii 386617.
NextBioi 100945.
PROi Q6ZWB6.

Gene expression databases

Bgeei Q6ZWB6.
CleanExi HS_KCTD8.
Genevestigatori Q6ZWB6.

Family and domain databases

Gene3Di 3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view ]
Pfami PF02214. BTB_2. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKCTD8_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWB6
Secondary accession number(s): A2RU39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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