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Q6ZWB6

- KCTD8_HUMAN

UniProt

Q6ZWB6 - KCTD8_HUMAN

Protein

BTB/POZ domain-containing protein KCTD8

Gene

KCTD8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization By similarity.By similarity

    GO - Biological processi

    1. protein homooligomerization Source: InterPro
    2. regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BTB/POZ domain-containing protein KCTD8
    Gene namesi
    Name:KCTD8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:22394. KCTD8.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. postsynaptic membrane Source: UniProtKB-SubCell
    3. presynaptic membrane Source: UniProtKB-SubCell
    4. receptor complex Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134909779.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 473473BTB/POZ domain-containing protein KCTD8PRO_0000251481Add
    BLAST

    Proteomic databases

    PaxDbiQ6ZWB6.
    PRIDEiQ6ZWB6.

    PTM databases

    PhosphoSiteiQ6ZWB6.

    Expressioni

    Gene expression databases

    BgeeiQ6ZWB6.
    CleanExiHS_KCTD8.
    GenevestigatoriQ6ZWB6.

    Organism-specific databases

    HPAiHPA031562.

    Interactioni

    Subunit structurei

    Interacts as a tetramer with GABRB1 and GABRB2.By similarity

    Protein-protein interaction databases

    BioGridi132113. 1 interaction.
    IntActiQ6ZWB6. 1 interaction.
    STRINGi9606.ENSP00000353129.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZWB6.
    SMRiQ6ZWB6. Positions 44-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 12279BTBAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi21 – 255Poly-Ser
    Compositional biasi194 – 2007Poly-Gly

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.Curated

    Phylogenomic databases

    eggNOGiNOG295576.
    HOGENOMiHOG000041197.
    HOVERGENiHBG052218.
    InParanoidiQ6ZWB6.
    OMAiDSTLATM.
    OrthoDBiEOG7K3TM1.
    PhylomeDBiQ6ZWB6.
    TreeFamiTF315332.

    Family and domain databases

    Gene3Di3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR003131. T1-type_BTB.
    [Graphical view]
    PfamiPF02214. BTB_2. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6ZWB6-1 [UniParc]FASTAAdd to Basket

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    MALKDTGSGG STILPISEMV SSSSSPGASA AAAPGPCAPS PFPEVVELNV    50
    GGQVYVTKHS TLLSVPDSTL ASMFSPSSPR GGARRRGELP RDSRARFFID 100
    RDGFLFRYVL DYLRDKQLAL PEHFPEKERL LREAEYFQLT DLVKLLSPKV 150
    TKQNSLNDEG CQSDLEDNVS QGSSDALLLR GAAAAVPSGP GAHGGGGGGG 200
    AQDKRSGFLT LGYRGSYTTV RDNQADAKFR RVARIMVCGR IALAKEVFGD 250
    TLNESRDPDR QPEKYTSRFY LKFTYLEQAF DRLSEAGFHM VACNSSGTAA 300
    FVNQYRDDKI WSSYTEYIFF RPPQKIVSPK QEHEDRKHDK VTDKGSESGT 350
    SCNELSTSSC DSHSEASTPQ DNPSSAQQAT AHQPNTLTLD RPSKKAPVQW 400
    IPPPDKRRNS ELFQTLISKS RETNLSKKKV CEKLSVEEEM KKCIQDFKKI 450
    HIPDYFPERK RQWQSELLQK YGL 473
    Length:473
    Mass (Da):52,440
    Last modified:July 5, 2004 - v1
    Checksum:iD5AA3F75716D3715
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti329 – 3291P → L.
    Corresponds to variant rs13115990 [ dbSNP | Ensembl ].
    VAR_027692

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK123347 mRNA. Translation: BAC85588.1.
    BC132743 mRNA. Translation: AAI32744.1.
    BC136793 mRNA. Translation: AAI36794.1.
    CCDSiCCDS3467.1.
    RefSeqiNP_938167.1. NM_198353.2.
    UniGeneiHs.479644.

    Genome annotation databases

    EnsembliENST00000360029; ENSP00000353129; ENSG00000183783.
    GeneIDi386617.
    KEGGihsa:386617.
    UCSCiuc003gwu.3. human.

    Polymorphism databases

    DMDMi74749707.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK123347 mRNA. Translation: BAC85588.1 .
    BC132743 mRNA. Translation: AAI32744.1 .
    BC136793 mRNA. Translation: AAI36794.1 .
    CCDSi CCDS3467.1.
    RefSeqi NP_938167.1. NM_198353.2.
    UniGenei Hs.479644.

    3D structure databases

    ProteinModelPortali Q6ZWB6.
    SMRi Q6ZWB6. Positions 44-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 132113. 1 interaction.
    IntActi Q6ZWB6. 1 interaction.
    STRINGi 9606.ENSP00000353129.

    PTM databases

    PhosphoSitei Q6ZWB6.

    Polymorphism databases

    DMDMi 74749707.

    Proteomic databases

    PaxDbi Q6ZWB6.
    PRIDEi Q6ZWB6.

    Protocols and materials databases

    DNASUi 386617.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360029 ; ENSP00000353129 ; ENSG00000183783 .
    GeneIDi 386617.
    KEGGi hsa:386617.
    UCSCi uc003gwu.3. human.

    Organism-specific databases

    CTDi 386617.
    GeneCardsi GC04M044091.
    HGNCi HGNC:22394. KCTD8.
    HPAi HPA031562.
    neXtProti NX_Q6ZWB6.
    PharmGKBi PA134909779.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295576.
    HOGENOMi HOG000041197.
    HOVERGENi HBG052218.
    InParanoidi Q6ZWB6.
    OMAi DSTLATM.
    OrthoDBi EOG7K3TM1.
    PhylomeDBi Q6ZWB6.
    TreeFami TF315332.

    Miscellaneous databases

    GenomeRNAii 386617.
    NextBioi 100945.
    PROi Q6ZWB6.

    Gene expression databases

    Bgeei Q6ZWB6.
    CleanExi HS_KCTD8.
    Genevestigatori Q6ZWB6.

    Family and domain databases

    Gene3Di 3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR003131. T1-type_BTB.
    [Graphical view ]
    Pfami PF02214. BTB_2. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiKCTD8_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZWB6
    Secondary accession number(s): A2RU39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3