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Protein

BTB/POZ domain-containing protein KCTD8

Gene

KCTD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD8
Gene namesi
Name:KCTD8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000183783.6.
HGNCiHGNC:22394. KCTD8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183783.
PharmGKBiPA134909779.

Chemistry databases

GuidetoPHARMACOLOGYi1917.

Polymorphism and mutation databases

BioMutaiKCTD8.
DMDMi74749707.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002514811 – 473BTB/POZ domain-containing protein KCTD8Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphoserineBy similarity1
Modified residuei80Omega-N-methylarginineBy similarity1
Modified residuei410PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ6ZWB6.
PaxDbiQ6ZWB6.
PeptideAtlasiQ6ZWB6.
PRIDEiQ6ZWB6.

PTM databases

iPTMnetiQ6ZWB6.
PhosphoSitePlusiQ6ZWB6.

Expressioni

Gene expression databases

BgeeiENSG00000183783.
CleanExiHS_KCTD8.
ExpressionAtlasiQ6ZWB6. baseline and differential.

Organism-specific databases

HPAiHPA031562.

Interactioni

Subunit structurei

Interacts as a tetramer with GABRB1 and GABRB2.By similarity

Protein-protein interaction databases

BioGridi132113. 2 interactors.
CORUMiQ6ZWB6.
IntActiQ6ZWB6. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWB6.
SMRiQ6ZWB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 122BTBAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 25Poly-Ser5
Compositional biasi194 – 200Poly-Gly7

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000041197.
HOVERGENiHBG052218.
InParanoidiQ6ZWB6.
KOiK21918.
OMAiDHEERKH.
OrthoDBiEOG091G0P3F.
PhylomeDBiQ6ZWB6.
TreeFamiTF315332.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ_sf.
IPR003131. T1-type_BTB.
PfamiView protein in Pfam
PF02214. BTB_2. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ZWB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKDTGSGG STILPISEMV SSSSSPGASA AAAPGPCAPS PFPEVVELNV
60 70 80 90 100
GGQVYVTKHS TLLSVPDSTL ASMFSPSSPR GGARRRGELP RDSRARFFID
110 120 130 140 150
RDGFLFRYVL DYLRDKQLAL PEHFPEKERL LREAEYFQLT DLVKLLSPKV
160 170 180 190 200
TKQNSLNDEG CQSDLEDNVS QGSSDALLLR GAAAAVPSGP GAHGGGGGGG
210 220 230 240 250
AQDKRSGFLT LGYRGSYTTV RDNQADAKFR RVARIMVCGR IALAKEVFGD
260 270 280 290 300
TLNESRDPDR QPEKYTSRFY LKFTYLEQAF DRLSEAGFHM VACNSSGTAA
310 320 330 340 350
FVNQYRDDKI WSSYTEYIFF RPPQKIVSPK QEHEDRKHDK VTDKGSESGT
360 370 380 390 400
SCNELSTSSC DSHSEASTPQ DNPSSAQQAT AHQPNTLTLD RPSKKAPVQW
410 420 430 440 450
IPPPDKRRNS ELFQTLISKS RETNLSKKKV CEKLSVEEEM KKCIQDFKKI
460 470
HIPDYFPERK RQWQSELLQK YGL
Length:473
Mass (Da):52,440
Last modified:July 5, 2004 - v1
Checksum:iD5AA3F75716D3715
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027692329P → L. Corresponds to variant dbSNP:rs13115990Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123347 mRNA. Translation: BAC85588.1.
BC132743 mRNA. Translation: AAI32744.1.
BC136793 mRNA. Translation: AAI36794.1.
CCDSiCCDS3467.1.
RefSeqiNP_938167.1. NM_198353.2.
UniGeneiHs.479644.

Genome annotation databases

EnsembliENST00000360029; ENSP00000353129; ENSG00000183783.
GeneIDi386617.
KEGGihsa:386617.
UCSCiuc003gwu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKCTD8_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWB6
Secondary accession number(s): A2RU39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations