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Protein

BTB/POZ domain-containing protein KCTD8

Gene

KCTD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33341-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD8
Gene namesi
Name:KCTD8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:22394. KCTD8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183783.
PharmGKBiPA134909779.

Polymorphism and mutation databases

BioMutaiKCTD8.
DMDMi74749707.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002514811 – 473BTB/POZ domain-containing protein KCTD8Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphoserineBy similarity1
Modified residuei80Omega-N-methylarginineBy similarity1
Modified residuei410PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ6ZWB6.
PaxDbiQ6ZWB6.
PeptideAtlasiQ6ZWB6.
PRIDEiQ6ZWB6.

PTM databases

iPTMnetiQ6ZWB6.
PhosphoSitePlusiQ6ZWB6.

Expressioni

Gene expression databases

BgeeiENSG00000183783.
CleanExiHS_KCTD8.
ExpressionAtlasiQ6ZWB6. baseline and differential.

Organism-specific databases

HPAiHPA031562.

Interactioni

Subunit structurei

Interacts as a tetramer with GABRB1 and GABRB2.By similarity

Protein-protein interaction databases

BioGridi132113. 2 interactors.
IntActiQ6ZWB6. 2 interactors.
STRINGi9606.ENSP00000353129.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWB6.
SMRiQ6ZWB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 122BTBAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 25Poly-Ser5
Compositional biasi194 – 200Poly-Gly7

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000041197.
HOVERGENiHBG052218.
InParanoidiQ6ZWB6.
OMAiDHEERKH.
OrthoDBiEOG091G0P3F.
PhylomeDBiQ6ZWB6.
TreeFamiTF315332.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ZWB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKDTGSGG STILPISEMV SSSSSPGASA AAAPGPCAPS PFPEVVELNV
60 70 80 90 100
GGQVYVTKHS TLLSVPDSTL ASMFSPSSPR GGARRRGELP RDSRARFFID
110 120 130 140 150
RDGFLFRYVL DYLRDKQLAL PEHFPEKERL LREAEYFQLT DLVKLLSPKV
160 170 180 190 200
TKQNSLNDEG CQSDLEDNVS QGSSDALLLR GAAAAVPSGP GAHGGGGGGG
210 220 230 240 250
AQDKRSGFLT LGYRGSYTTV RDNQADAKFR RVARIMVCGR IALAKEVFGD
260 270 280 290 300
TLNESRDPDR QPEKYTSRFY LKFTYLEQAF DRLSEAGFHM VACNSSGTAA
310 320 330 340 350
FVNQYRDDKI WSSYTEYIFF RPPQKIVSPK QEHEDRKHDK VTDKGSESGT
360 370 380 390 400
SCNELSTSSC DSHSEASTPQ DNPSSAQQAT AHQPNTLTLD RPSKKAPVQW
410 420 430 440 450
IPPPDKRRNS ELFQTLISKS RETNLSKKKV CEKLSVEEEM KKCIQDFKKI
460 470
HIPDYFPERK RQWQSELLQK YGL
Length:473
Mass (Da):52,440
Last modified:July 5, 2004 - v1
Checksum:iD5AA3F75716D3715
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027692329P → L.Corresponds to variant rs13115990dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123347 mRNA. Translation: BAC85588.1.
BC132743 mRNA. Translation: AAI32744.1.
BC136793 mRNA. Translation: AAI36794.1.
CCDSiCCDS3467.1.
RefSeqiNP_938167.1. NM_198353.2.
UniGeneiHs.479644.

Genome annotation databases

EnsembliENST00000360029; ENSP00000353129; ENSG00000183783.
GeneIDi386617.
KEGGihsa:386617.
UCSCiuc003gwu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123347 mRNA. Translation: BAC85588.1.
BC132743 mRNA. Translation: AAI32744.1.
BC136793 mRNA. Translation: AAI36794.1.
CCDSiCCDS3467.1.
RefSeqiNP_938167.1. NM_198353.2.
UniGeneiHs.479644.

3D structure databases

ProteinModelPortaliQ6ZWB6.
SMRiQ6ZWB6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132113. 2 interactors.
IntActiQ6ZWB6. 2 interactors.
STRINGi9606.ENSP00000353129.

PTM databases

iPTMnetiQ6ZWB6.
PhosphoSitePlusiQ6ZWB6.

Polymorphism and mutation databases

BioMutaiKCTD8.
DMDMi74749707.

Proteomic databases

MaxQBiQ6ZWB6.
PaxDbiQ6ZWB6.
PeptideAtlasiQ6ZWB6.
PRIDEiQ6ZWB6.

Protocols and materials databases

DNASUi386617.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360029; ENSP00000353129; ENSG00000183783.
GeneIDi386617.
KEGGihsa:386617.
UCSCiuc003gwu.4. human.

Organism-specific databases

CTDi386617.
GeneCardsiKCTD8.
HGNCiHGNC:22394. KCTD8.
HPAiHPA031562.
neXtProtiNX_Q6ZWB6.
OpenTargetsiENSG00000183783.
PharmGKBiPA134909779.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000041197.
HOVERGENiHBG052218.
InParanoidiQ6ZWB6.
OMAiDHEERKH.
OrthoDBiEOG091G0P3F.
PhylomeDBiQ6ZWB6.
TreeFamiTF315332.

Enzyme and pathway databases

BioCyciZFISH:G66-33341-MONOMER.

Miscellaneous databases

ChiTaRSiKCTD8. human.
GenomeRNAii386617.
PROiQ6ZWB6.

Gene expression databases

BgeeiENSG00000183783.
CleanExiHS_KCTD8.
ExpressionAtlasiQ6ZWB6. baseline and differential.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCTD8_HUMAN
AccessioniPrimary (citable) accession number: Q6ZWB6
Secondary accession number(s): A2RU39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.