Q6ZWB6 (KCTD8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BTB/POZ domain-containing protein KCTD8

Gene names

Name:

KCTD8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization By similarity.
Subunit structure	Interacts as a tetramer with GABRB1 and GABRB2 By similarity.
Subcellular location	Cell junction › synapse › presynaptic cell membrane By similarity. Cell junction › synapse › postsynaptic cell membrane By similarity.
Sequence similarities	Contains 1 BTB (POZ) domain.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro regulation of G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell presynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell receptor complex Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	BTB/POZ domain-containing protein KCTD8		PRO_0000251481
Regions
	Domain	44 – 122	79	BTB
	Compositional bias	21 – 25	5	Poly-Ser
	Compositional bias	194 – 200	7	Poly-Gly
Natural variations
	Natural variant	329	1	P → L. Corresponds to variant rs13115990 [ dbSNP | Ensembl ].		VAR_027692

Sequences

	Sequence		Length	Mass (Da)
	Q6ZWB6 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: D5AA3F75716D3715	FASTA	473	52,440
	10 20 30 40 50 60 MALKDTGSGG STILPISEMV SSSSSPGASA AAAPGPCAPS PFPEVVELNV GGQVYVTKHS 70 80 90 100 110 120 TLLSVPDSTL ASMFSPSSPR GGARRRGELP RDSRARFFID RDGFLFRYVL DYLRDKQLAL 130 140 150 160 170 180 PEHFPEKERL LREAEYFQLT DLVKLLSPKV TKQNSLNDEG CQSDLEDNVS QGSSDALLLR 190 200 210 220 230 240 GAAAAVPSGP GAHGGGGGGG AQDKRSGFLT LGYRGSYTTV RDNQADAKFR RVARIMVCGR 250 260 270 280 290 300 IALAKEVFGD TLNESRDPDR QPEKYTSRFY LKFTYLEQAF DRLSEAGFHM VACNSSGTAA 310 320 330 340 350 360 FVNQYRDDKI WSSYTEYIFF RPPQKIVSPK QEHEDRKHDK VTDKGSESGT SCNELSTSSC 370 380 390 400 410 420 DSHSEASTPQ DNPSSAQQAT AHQPNTLTLD RPSKKAPVQW IPPPDKRRNS ELFQTLISKS 430 440 450 460 470 RETNLSKKKV CEKLSVEEEM KKCIQDFKKI HIPDYFPERK RQWQSELLQK YGL

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK123347 mRNA. Translation: BAC85588.1. BC132743 mRNA. Translation: AAI32744.1. BC136793 mRNA. Translation: AAI36794.1.
IPI	IPI00383585.
RefSeq	NP_938167.1. NM_198353.2.
UniGene	Hs.479644.
3D structure databases
HSSP	HSSP built from PDB template 1S1G based on UniProtKB Q9UK17.
ProteinModelPortal	Q6ZWB6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6ZWB6. 1 interaction.
STRING	9606.ENSP00000353129.
PTM databases
PhosphoSite	Q6ZWB6.
Polymorphism databases
DMDM	74749707.
Proteomic databases
PaxDb	Q6ZWB6.
PRIDE	Q6ZWB6.
Protocols and materials databases
DNASU	386617.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360029; ENSP00000353129; ENSG00000183783.
GeneID	386617.
KEGG	hsa:386617.
UCSC	uc003gwu.3. human.
Organism-specific databases
CTD	386617.
GeneCards	GC04M044091.
HGNC	HGNC:22394. KCTD8.
HPA	HPA031562.
neXtProt	NX_Q6ZWB6.
PharmGKB	PA134909779.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG295576.
HOGENOM	HOG000041197.
HOVERGEN	HBG052218.
InParanoid	Q6ZWB6.
OMA	FINQYRD.
OrthoDB	EOG4MKNGT.
PhylomeDB	Q6ZWB6.
Gene expression databases
ArrayExpress	Q6ZWB6.
Bgee	Q6ZWB6.
CleanEx	HS_KCTD8.
Genevestigator	Q6ZWB6.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR003131. T1-type_BTB. [Graphical view]
Pfam	PF02214. K_tetra. 1 hit. [Graphical view]
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	386617.
NextBio	100945.

Entry information

Entry name

KCTD8_HUMAN

Accession

Primary (citable) accession number: Q6ZWB6
Secondary accession number(s): A2RU39

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.