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Q6ZWB6 (KCTD8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BTB/POZ domain-containing protein KCTD8
Gene names
Name:KCTD8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization By similarity.

Subunit structure

Interacts as a tetramer with GABRB1 and GABRB2 By similarity.

Subcellular location

Cell junctionsynapsepresynaptic cell membrane By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity.

Sequence similarities

Contains 1 BTB (POZ) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 473473BTB/POZ domain-containing protein KCTD8
PRO_0000251481

Regions

Domain44 – 12279BTB
Compositional bias21 – 255Poly-Ser
Compositional bias194 – 2007Poly-Gly

Natural variations

Natural variant3291P → L.
Corresponds to variant rs13115990 [ dbSNP | Ensembl ].
VAR_027692

Sequences

Sequence LengthMass (Da)Tools
Q6ZWB6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: D5AA3F75716D3715

FASTA47352,440
        10         20         30         40         50         60 
MALKDTGSGG STILPISEMV SSSSSPGASA AAAPGPCAPS PFPEVVELNV GGQVYVTKHS 

        70         80         90        100        110        120 
TLLSVPDSTL ASMFSPSSPR GGARRRGELP RDSRARFFID RDGFLFRYVL DYLRDKQLAL 

       130        140        150        160        170        180 
PEHFPEKERL LREAEYFQLT DLVKLLSPKV TKQNSLNDEG CQSDLEDNVS QGSSDALLLR 

       190        200        210        220        230        240 
GAAAAVPSGP GAHGGGGGGG AQDKRSGFLT LGYRGSYTTV RDNQADAKFR RVARIMVCGR 

       250        260        270        280        290        300 
IALAKEVFGD TLNESRDPDR QPEKYTSRFY LKFTYLEQAF DRLSEAGFHM VACNSSGTAA 

       310        320        330        340        350        360 
FVNQYRDDKI WSSYTEYIFF RPPQKIVSPK QEHEDRKHDK VTDKGSESGT SCNELSTSSC 

       370        380        390        400        410        420 
DSHSEASTPQ DNPSSAQQAT AHQPNTLTLD RPSKKAPVQW IPPPDKRRNS ELFQTLISKS 

       430        440        450        460        470 
RETNLSKKKV CEKLSVEEEM KKCIQDFKKI HIPDYFPERK RQWQSELLQK YGL 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK123347 mRNA. Translation: BAC85588.1.
BC132743 mRNA. Translation: AAI32744.1.
BC136793 mRNA. Translation: AAI36794.1.
CCDSCCDS3467.1.
RefSeqNP_938167.1. NM_198353.2.
UniGeneHs.479644.

3D structure databases

ProteinModelPortalQ6ZWB6.
SMRQ6ZWB6. Positions 44-146.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid132113. 1 interaction.
IntActQ6ZWB6. 1 interaction.
STRING9606.ENSP00000353129.

PTM databases

PhosphoSiteQ6ZWB6.

Polymorphism databases

DMDM74749707.

Proteomic databases

PaxDbQ6ZWB6.
PRIDEQ6ZWB6.

Protocols and materials databases

DNASU386617.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360029; ENSP00000353129; ENSG00000183783.
GeneID386617.
KEGGhsa:386617.
UCSCuc003gwu.3. human.

Organism-specific databases

CTD386617.
GeneCardsGC04M044091.
HGNCHGNC:22394. KCTD8.
HPAHPA031562.
neXtProtNX_Q6ZWB6.
PharmGKBPA134909779.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG295576.
HOGENOMHOG000041197.
HOVERGENHBG052218.
InParanoidQ6ZWB6.
OMADSTLATM.
OrthoDBEOG7K3TM1.
PhylomeDBQ6ZWB6.
TreeFamTF315332.

Gene expression databases

BgeeQ6ZWB6.
CleanExHS_KCTD8.
GenevestigatorQ6ZWB6.

Family and domain databases

Gene3D3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view]
PfamPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi386617.
NextBio100945.
PROQ6ZWB6.

Entry information

Entry nameKCTD8_HUMAN
AccessionPrimary (citable) accession number: Q6ZWB6
Secondary accession number(s): A2RU39
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM