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Protein
Submitted name:

Potassium channel subfamily K member 2

Gene

KCNK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel subfamily K member 2Imported
Submitted name:
cDNA FLJ41415 fis, clone BRHIP2001805, moderately similar to Homo sapiens TREK-1 potassium channel (KCNK2) mRNAImported
Gene namesi
Name:KCNK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6277. KCNK2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei60 – 7920HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30059.

Expressioni

Gene expression databases

ExpressionAtlasiQ6ZW95. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ6ZW95.
SMRiQ6ZW95. Positions 49-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00760000118858.
HOGENOMiHOG000069932.
HOVERGENiHBG065673.
KOiK04913.
OrthoDBiEOG7QK0F0.

Family and domain databases

InterProiIPR003976. 2pore_dom_K_chnl_TREK.
[Graphical view]
PRINTSiPR01499. TREKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q6ZW95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNPRAKRDF YLAAPDLLDP KSAAQNSKPR LSFSTKPTVL ASRVESDTTI
60 70 80 90 100
NVMKWKTVST IFLVVVLYLI IGATVFKALE QPHEISQRTT IVIQKQTFIS
110 120 130 140 150
QHSCVNSTEL DELIQDLETS HHAQKAAKYS VSSMPYWEFP SLVFSWLELE

IS
Length:152
Mass (Da):17,248
Last modified:July 5, 2004 - v1
Checksum:iDC9BF5C52AC672AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092804 Genomic DNA. No translation available.
AC099675 Genomic DNA. No translation available.
AL583830 Genomic DNA. No translation available.
AK123409 mRNA. Translation: BAC85609.1.
RefSeqiNP_001017424.1. NM_001017424.2.
NP_001017425.2. NM_001017425.2.
NP_055032.1. NM_014217.3.
UniGeneiHs.497745.

Genome annotation databases

EnsembliENST00000486921; ENSP00000418706; ENSG00000082482.
GeneIDi3776.
KEGGihsa:3776.
UCSCiuc057pkk.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092804 Genomic DNA. No translation available.
AC099675 Genomic DNA. No translation available.
AL583830 Genomic DNA. No translation available.
AK123409 mRNA. Translation: BAC85609.1.
RefSeqiNP_001017424.1. NM_001017424.2.
NP_001017425.2. NM_001017425.2.
NP_055032.1. NM_014217.3.
UniGeneiHs.497745.

3D structure databases

ProteinModelPortaliQ6ZW95.
SMRiQ6ZW95. Positions 49-144.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000486921; ENSP00000418706; ENSG00000082482.
GeneIDi3776.
KEGGihsa:3776.
UCSCiuc057pkk.1. human.

Organism-specific databases

CTDi3776.
HGNCiHGNC:6277. KCNK2.
PharmGKBiPA30059.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118858.
HOGENOMiHOG000069932.
HOVERGENiHBG065673.
KOiK04913.
OrthoDBiEOG7QK0F0.

Miscellaneous databases

ChiTaRSiKCNK2. human.
GenomeRNAii3776.
NextBioi14811.

Gene expression databases

ExpressionAtlasiQ6ZW95. baseline and differential.

Family and domain databases

InterProiIPR003976. 2pore_dom_K_chnl_TREK.
[Graphical view]
PRINTSiPR01499. TREKCHANNEL.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HippocampusImported.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., Porter K.M., Prigmore E.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ6ZW95_HUMAN
AccessioniPrimary (citable) accession number: Q6ZW95
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.