Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

MICAL C-terminal-like protein

Gene

MICALCL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
MICAL C-terminal-like protein
Alternative name(s):
ERK2-binding testicular protein 1
Ebitein-1
Gene namesi
Name:MICALCL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25933. MICALCL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671455.

Polymorphism and mutation databases

BioMutaiMICALCL.
DMDMi296439303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695MICAL C-terminal-like proteinPRO_0000284123Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei426 – 4261PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZW33.
PaxDbiQ6ZW33.
PeptideAtlasiQ6ZW33.
PRIDEiQ6ZW33.

PTM databases

iPTMnetiQ6ZW33.
PhosphoSiteiQ6ZW33.

Expressioni

Gene expression databases

BgeeiQ6ZW33.
CleanExiHS_MICALCL.
ExpressionAtlasiQ6ZW33. baseline and differential.
GenevisibleiQ6ZW33. HS.

Organism-specific databases

HPAiHPA039895.
HPA040438.

Interactioni

Subunit structurei

Interacts with MAPK1/ERK2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000256186.

Structurei

3D structure databases

ProteinModelPortaliQ6ZW33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 10140Interaction with MAPK1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili513 – 674162Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi8 – 5447Ser-richAdd
BLAST
Compositional biasi457 – 47014Poly-ProAdd
BLAST
Compositional biasi490 – 50011Poly-SerAdd
BLAST

Sequence similaritiesi

Belongs to the ebitein family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJMF. Eukaryota.
ENOG410YJPN. LUCA.
GeneTreeiENSGT00760000118856.
HOGENOMiHOG000113587.
HOVERGENiHBG108134.
InParanoidiQ6ZW33.
OMAiNRPSKVF.
OrthoDBiEOG7S21XV.
PhylomeDBiQ6ZW33.
TreeFamiTF336446.

Family and domain databases

InterProiIPR022735. DUF3585.
IPR016103. ProQ/FinO.
[Graphical view]
PfamiPF12130. DUF3585. 1 hit.
[Graphical view]
SMARTiSM00945. ProQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZW33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPPKDPSPS LPLPSSSSHS SSPPSSSSTS VSGNAPDGSS PPQMTASEPL
60 70 80 90 100
SQVSRGHPSP PTPNFRRRAV AQGAPREIPL YLPHHPKPEW AEYCLVSPGE
110 120 130 140 150
DGLSDPAEMT SDECQPAEAP LGDIGSNHRD PHPIWGKDRS WTGQELSPLA
160 170 180 190 200
GEDREKGSTG ARKEEEGGPV LVKEKLGLKK LVLTQEQKTM LLDWNDSIPE
210 220 230 240 250
SVHLKAGERI SQKSAENGRG GRVLKPVRPL LLPRAAGEPL PTQRGAQEKM
260 270 280 290 300
GTPAEQAQGE RNVPPPKSPL RLIANAIRRS LEPLLSNSEG GKKAWAKQES
310 320 330 340 350
KTLPAQACTR SFSLRKTNSN KDGDQHSPGR NQSSAFSPPD PALRTHSLPN
360 370 380 390 400
RPSKVFPALR SPPCSKIEDV PTLLEKVSLQ ENFPDASKPP KKRISLFSSL
410 420 430 440 450
RLKDKSFESF LQESRQRKDI RDLFGSPKRK VLPEDSAQAL EKLLQPFKST
460 470 480 490 500
SLRQAAPPPP PPPPPPPPPP TAGGADSKNF PLRAQVTEAS SSASSTSSSS
510 520 530 540 550
ADEEFDPQLS LQLKEKKTLR RRKKLEKAMK QLVKQEELKR LYKAQAIQRQ
560 570 580 590 600
LEEVEERQRA SEIQGVRLEK ALRGEADSGT QDEAQLLQEW FKLVLEKNKL
610 620 630 640 650
MRYESELLIM AQELELEDHQ SRLEQKLREK MLKEESQKDE KDLNEEQEVF
660 670 680 690
TELMQVIEQR DKLVDSLEEQ RIREKAEDQH FESFVFSRGC QLSRT
Length:695
Mass (Da):77,277
Last modified:May 18, 2010 - v3
Checksum:iF032CA8CB0783A41
GO

Sequence cautioni

The sequence BAB55422.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701V → I.1 Publication
Corresponds to variant rs10741578 [ dbSNP | Ensembl ].
VAR_056936
Natural varianti93 – 931Y → S.
Corresponds to variant rs12574273 [ dbSNP | Ensembl ].
VAR_056937
Natural varianti305 – 3051A → T.1 Publication
Corresponds to variant rs1493953 [ dbSNP | Ensembl ].
VAR_056938
Natural varianti313 – 3131S → G.1 Publication
Corresponds to variant rs1493954 [ dbSNP | Ensembl ].
VAR_056939
Natural varianti369 – 3691D → E.1 Publication
Corresponds to variant rs3812753 [ dbSNP | Ensembl ].
VAR_056940
Natural varianti471 – 4711T → P.
Corresponds to variant rs3812754 [ dbSNP | Ensembl ].
VAR_061684

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027872 mRNA. Translation: BAB55422.1. Different initiation.
AK123671 mRNA. Translation: BAC85674.1.
AC025300 Genomic DNA. No translation available.
BK000463 mRNA. Translation: DAA01342.1.
CCDSiCCDS41620.1.
RefSeqiNP_116256.2. NM_032867.2.
UniGeneiHs.128196.

Genome annotation databases

EnsembliENST00000256186; ENSP00000256186; ENSG00000133808.
GeneIDi84953.
KEGGihsa:84953.
UCSCiuc001mkg.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027872 mRNA. Translation: BAB55422.1. Different initiation.
AK123671 mRNA. Translation: BAC85674.1.
AC025300 Genomic DNA. No translation available.
BK000463 mRNA. Translation: DAA01342.1.
CCDSiCCDS41620.1.
RefSeqiNP_116256.2. NM_032867.2.
UniGeneiHs.128196.

3D structure databases

ProteinModelPortaliQ6ZW33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000256186.

PTM databases

iPTMnetiQ6ZW33.
PhosphoSiteiQ6ZW33.

Polymorphism and mutation databases

BioMutaiMICALCL.
DMDMi296439303.

Proteomic databases

EPDiQ6ZW33.
PaxDbiQ6ZW33.
PeptideAtlasiQ6ZW33.
PRIDEiQ6ZW33.

Protocols and materials databases

DNASUi84953.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256186; ENSP00000256186; ENSG00000133808.
GeneIDi84953.
KEGGihsa:84953.
UCSCiuc001mkg.1. human.

Organism-specific databases

CTDi84953.
GeneCardsiMICALCL.
H-InvDBHIX0009454.
HGNCiHGNC:25933. MICALCL.
HPAiHPA039895.
HPA040438.
MIMi612355. gene.
neXtProtiNX_Q6ZW33.
PharmGKBiPA142671455.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJMF. Eukaryota.
ENOG410YJPN. LUCA.
GeneTreeiENSGT00760000118856.
HOGENOMiHOG000113587.
HOVERGENiHBG108134.
InParanoidiQ6ZW33.
OMAiNRPSKVF.
OrthoDBiEOG7S21XV.
PhylomeDBiQ6ZW33.
TreeFamiTF336446.

Miscellaneous databases

GenomeRNAii84953.
PROiQ6ZW33.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZW33.
CleanExiHS_MICALCL.
ExpressionAtlasiQ6ZW33. baseline and differential.
GenevisibleiQ6ZW33. HS.

Family and domain databases

InterProiIPR022735. DUF3585.
IPR016103. ProQ/FinO.
[Graphical view]
PfamiPF12130. DUF3585. 1 hit.
[Graphical view]
SMARTiSM00945. ProQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-70; THR-305; GLY-313 AND GLU-369.
    Tissue: Thyroid.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion."
    Terman J.R., Mao T., Pasterkamp R.J., Yu H.-H., Kolodkin A.L.
    Cell 109:887-900(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE STRUCTURE.

Entry informationi

Entry nameiMICLK_HUMAN
AccessioniPrimary (citable) accession number: Q6ZW33
Secondary accession number(s): Q7RTP7, Q96JU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.