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Protein

MICAL C-terminal-like protein

Gene

MICALCL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
MICAL C-terminal-like protein
Alternative name(s):
ERK2-binding testicular protein 1
Ebitein-1
Gene namesi
Name:MICALCL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25933. MICALCL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi84953.
OpenTargetsiENSG00000133808.
PharmGKBiPA142671455.

Polymorphism and mutation databases

BioMutaiMICALCL.
DMDMi296439303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002841231 – 695MICAL C-terminal-like proteinAdd BLAST695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei426PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6ZW33.
PeptideAtlasiQ6ZW33.
PRIDEiQ6ZW33.

PTM databases

iPTMnetiQ6ZW33.
PhosphoSitePlusiQ6ZW33.

Expressioni

Gene expression databases

BgeeiENSG00000133808.
CleanExiHS_MICALCL.
ExpressionAtlasiQ6ZW33. baseline and differential.
GenevisibleiQ6ZW33. HS.

Organism-specific databases

HPAiHPA039895.
HPA040438.

Interactioni

Subunit structurei

Interacts with MAPK1/ERK2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000256186.

Structurei

Secondary structure

1695
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi534 – 572Combined sources39
Helixi583 – 632Combined sources50
Helixi635 – 637Combined sources3
Helixi640 – 677Combined sources38

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5SZHX-ray2.30A534-683[»]
5SZIX-ray2.85B534-683[»]
5SZJX-ray2.66B534-683[»]
5SZKX-ray2.80A534-683[»]
ProteinModelPortaliQ6ZW33.
SMRiQ6ZW33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 101Interaction with MAPK1By similarityAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili513 – 674Sequence analysisAdd BLAST162

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 54Ser-richAdd BLAST47
Compositional biasi457 – 470Poly-ProAdd BLAST14
Compositional biasi490 – 500Poly-SerAdd BLAST11

Sequence similaritiesi

Belongs to the ebitein family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJMF. Eukaryota.
ENOG410YJPN. LUCA.
GeneTreeiENSGT00760000118856.
HOGENOMiHOG000113587.
HOVERGENiHBG108134.
InParanoidiQ6ZW33.
OMAiNRPSKVF.
OrthoDBiEOG091G0256.
PhylomeDBiQ6ZW33.
TreeFamiTF336446.

Family and domain databases

InterProiIPR022735. DUF3585.
IPR016103. ProQ/FinO.
[Graphical view]
PfamiPF12130. DUF3585. 1 hit.
[Graphical view]
SMARTiSM00945. ProQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZW33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPPKDPSPS LPLPSSSSHS SSPPSSSSTS VSGNAPDGSS PPQMTASEPL
60 70 80 90 100
SQVSRGHPSP PTPNFRRRAV AQGAPREIPL YLPHHPKPEW AEYCLVSPGE
110 120 130 140 150
DGLSDPAEMT SDECQPAEAP LGDIGSNHRD PHPIWGKDRS WTGQELSPLA
160 170 180 190 200
GEDREKGSTG ARKEEEGGPV LVKEKLGLKK LVLTQEQKTM LLDWNDSIPE
210 220 230 240 250
SVHLKAGERI SQKSAENGRG GRVLKPVRPL LLPRAAGEPL PTQRGAQEKM
260 270 280 290 300
GTPAEQAQGE RNVPPPKSPL RLIANAIRRS LEPLLSNSEG GKKAWAKQES
310 320 330 340 350
KTLPAQACTR SFSLRKTNSN KDGDQHSPGR NQSSAFSPPD PALRTHSLPN
360 370 380 390 400
RPSKVFPALR SPPCSKIEDV PTLLEKVSLQ ENFPDASKPP KKRISLFSSL
410 420 430 440 450
RLKDKSFESF LQESRQRKDI RDLFGSPKRK VLPEDSAQAL EKLLQPFKST
460 470 480 490 500
SLRQAAPPPP PPPPPPPPPP TAGGADSKNF PLRAQVTEAS SSASSTSSSS
510 520 530 540 550
ADEEFDPQLS LQLKEKKTLR RRKKLEKAMK QLVKQEELKR LYKAQAIQRQ
560 570 580 590 600
LEEVEERQRA SEIQGVRLEK ALRGEADSGT QDEAQLLQEW FKLVLEKNKL
610 620 630 640 650
MRYESELLIM AQELELEDHQ SRLEQKLREK MLKEESQKDE KDLNEEQEVF
660 670 680 690
TELMQVIEQR DKLVDSLEEQ RIREKAEDQH FESFVFSRGC QLSRT
Length:695
Mass (Da):77,277
Last modified:May 18, 2010 - v3
Checksum:iF032CA8CB0783A41
GO

Sequence cautioni

The sequence BAB55422 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05693670V → I.1 PublicationCorresponds to variant rs10741578dbSNPEnsembl.1
Natural variantiVAR_05693793Y → S.Corresponds to variant rs12574273dbSNPEnsembl.1
Natural variantiVAR_056938305A → T.1 PublicationCorresponds to variant rs1493953dbSNPEnsembl.1
Natural variantiVAR_056939313S → G.1 PublicationCorresponds to variant rs1493954dbSNPEnsembl.1
Natural variantiVAR_056940369D → E.1 PublicationCorresponds to variant rs3812753dbSNPEnsembl.1
Natural variantiVAR_061684471T → P.Corresponds to variant rs3812754dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027872 mRNA. Translation: BAB55422.1. Different initiation.
AK123671 mRNA. Translation: BAC85674.1.
AC025300 Genomic DNA. No translation available.
BK000463 mRNA. Translation: DAA01342.1.
CCDSiCCDS41620.1.
RefSeqiNP_116256.2. NM_032867.2.
UniGeneiHs.128196.

Genome annotation databases

EnsembliENST00000256186; ENSP00000256186; ENSG00000133808.
GeneIDi84953.
KEGGihsa:84953.
UCSCiuc001mkg.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027872 mRNA. Translation: BAB55422.1. Different initiation.
AK123671 mRNA. Translation: BAC85674.1.
AC025300 Genomic DNA. No translation available.
BK000463 mRNA. Translation: DAA01342.1.
CCDSiCCDS41620.1.
RefSeqiNP_116256.2. NM_032867.2.
UniGeneiHs.128196.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5SZHX-ray2.30A534-683[»]
5SZIX-ray2.85B534-683[»]
5SZJX-ray2.66B534-683[»]
5SZKX-ray2.80A534-683[»]
ProteinModelPortaliQ6ZW33.
SMRiQ6ZW33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000256186.

PTM databases

iPTMnetiQ6ZW33.
PhosphoSitePlusiQ6ZW33.

Polymorphism and mutation databases

BioMutaiMICALCL.
DMDMi296439303.

Proteomic databases

PaxDbiQ6ZW33.
PeptideAtlasiQ6ZW33.
PRIDEiQ6ZW33.

Protocols and materials databases

DNASUi84953.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256186; ENSP00000256186; ENSG00000133808.
GeneIDi84953.
KEGGihsa:84953.
UCSCiuc001mkg.1. human.

Organism-specific databases

CTDi84953.
DisGeNETi84953.
GeneCardsiMICALCL.
H-InvDBHIX0009454.
HGNCiHGNC:25933. MICALCL.
HPAiHPA039895.
HPA040438.
MIMi612355. gene.
neXtProtiNX_Q6ZW33.
OpenTargetsiENSG00000133808.
PharmGKBiPA142671455.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJMF. Eukaryota.
ENOG410YJPN. LUCA.
GeneTreeiENSGT00760000118856.
HOGENOMiHOG000113587.
HOVERGENiHBG108134.
InParanoidiQ6ZW33.
OMAiNRPSKVF.
OrthoDBiEOG091G0256.
PhylomeDBiQ6ZW33.
TreeFamiTF336446.

Miscellaneous databases

GenomeRNAii84953.
PROiQ6ZW33.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133808.
CleanExiHS_MICALCL.
ExpressionAtlasiQ6ZW33. baseline and differential.
GenevisibleiQ6ZW33. HS.

Family and domain databases

InterProiIPR022735. DUF3585.
IPR016103. ProQ/FinO.
[Graphical view]
PfamiPF12130. DUF3585. 1 hit.
[Graphical view]
SMARTiSM00945. ProQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMICLK_HUMAN
AccessioniPrimary (citable) accession number: Q6ZW33
Secondary accession number(s): Q7RTP7, Q96JU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.