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Protein

Rho GTPase-activating protein SYDE1

Gene

SYDE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein SYDE1
Alternative name(s):
Synapse defective protein 1 homolog 1
Short name:
Protein syd-1 homolog 1
Gene namesi
Name:SYDE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25824. SYDE1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670851.

Polymorphism and mutation databases

BioMutaiSYDE1.
DMDMi74723056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Rho GTPase-activating protein SYDE1PRO_0000312158Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei231 – 2311Phosphoserine1 Publication
Modified residuei235 – 2351Phosphoserine1 Publication
Modified residuei244 – 2441Phosphoserine1 Publication
Modified residuei683 – 6831Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6ZW31.
PaxDbiQ6ZW31.
PRIDEiQ6ZW31.

PTM databases

PhosphoSiteiQ6ZW31.

Expressioni

Gene expression databases

BgeeiQ6ZW31.
CleanExiHS_SYDE1.
ExpressionAtlasiQ6ZW31. baseline and differential.
GenevisibleiQ6ZW31. HS.

Organism-specific databases

HPAiHPA013328.

Interactioni

Protein-protein interaction databases

BioGridi124489. 9 interactions.
STRINGi9606.ENSP00000341489.

Structurei

3D structure databases

ProteinModelPortaliQ6ZW31.
SMRiQ6ZW31. Positions 414-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini398 – 604207Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 162131Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG304605.
GeneTreeiENSGT00800000124037.
HOGENOMiHOG000154469.
HOVERGENiHBG053037.
InParanoidiQ6ZW31.
OMAiDHTFHLE.
OrthoDBiEOG7060Q7.
PhylomeDBiQ6ZW31.
TreeFamiTF323458.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZW31-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEPLLRKTF SRLRGREKLP RKKSDAKERG HPAQRPEPSP PEPEPQAPEG
60 70 80 90 100
SQAGAEGPSS PEASRSPARG AYLQSLEPSS RRWVLGGAKP AEDTSLGPGV
110 120 130 140 150
PGTGEPAGEI WYNPIPEEDP RPPAPEPPGP QPGSAESEGL APQGAAPASP
160 170 180 190 200
PTKASRTKSP GPARRLSIKM KKLPELRRRL SLRGPRAGRE RERAAPAGSV
210 220 230 240 250
ISRYHLDSSV GGPGPAAGPG GTRSPRAGYL SDGDSPERPA GPPSPTSFRP
260 270 280 290 300
YEVGPAARAP PAALWGRLSL HLYGLGGLRP APGATPRDLC CLLQVDGEAR
310 320 330 340 350
ARTGPLRGGP DFLRLDHTFH LELEAARLLR ALVLAWDPGV RRHRPCAQGT
360 370 380 390 400
VLLPTVFRGC QAQQLAVRLE PQGLLYAKLT LSEQQEAPAT AEPRVFGLPL
410 420 430 440 450
PLLVERERPP GQVPLIIQKC VGQIERRGLR VVGLYRLCGS AAVKKELRDA
460 470 480 490 500
FERDSAAVCL SEDLYPDINV ITGILKDYLR ELPTPLITQP LYKVVLEAMA
510 520 530 540 550
RDPPNRVPPT TEGTRGLLSC LPDVERATLT LLLDHLRLVS SFHAYNRMTP
560 570 580 590 600
QNLAVCFGPV LLPARQAPTR PRARSSGPGL ASAVDFKHHI EVLHYLLQSW
610 620 630 640 650
PDPRLPRQSP DVAPYLRPKR QPPLHLPLAD PEVVTRPRGR GGPESPPSNR
660 670 680 690 700
YAGDWSVCGR DFLPCGRDFL SGPDYDHVTG SDSEDEDEEV GEPRVTGDFE
710 720 730
DDFDAPFNPH LNLKDFDALI LDLERELSKQ INVCL
Length:735
Mass (Da):79,793
Last modified:July 5, 2004 - v1
Checksum:i87310623E756EB31
GO
Isoform 2 (identifier: Q6ZW31-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-96: Missing.

Show »
Length:668
Mass (Da):72,911
Checksum:iABAFE07FDAF5CDCA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti408 – 4081R → Q in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_062661

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei30 – 9667Missing in isoform 2. 1 PublicationVSP_029717Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023573 mRNA. Translation: BAB14612.1.
AK123686 mRNA. Translation: BAC85676.1.
CH471106 Genomic DNA. Translation: EAW84462.1.
CH471106 Genomic DNA. Translation: EAW84463.1.
BC018942 mRNA. Translation: AAH18942.2.
BC029926 mRNA. Translation: AAH29926.1.
CCDSiCCDS12324.1. [Q6ZW31-1]
CCDS74299.1. [Q6ZW31-2]
RefSeqiNP_001287839.1. NM_001300910.1. [Q6ZW31-2]
NP_149014.3. NM_033025.5. [Q6ZW31-1]
UniGeneiHs.528701.
Hs.706845.

Genome annotation databases

EnsembliENST00000342784; ENSP00000341489; ENSG00000105137.
ENST00000600440; ENSP00000470733; ENSG00000105137. [Q6ZW31-2]
GeneIDi85360.
KEGGihsa:85360.
UCSCiuc002nah.1. human. [Q6ZW31-1]
uc002nai.1. human. [Q6ZW31-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023573 mRNA. Translation: BAB14612.1.
AK123686 mRNA. Translation: BAC85676.1.
CH471106 Genomic DNA. Translation: EAW84462.1.
CH471106 Genomic DNA. Translation: EAW84463.1.
BC018942 mRNA. Translation: AAH18942.2.
BC029926 mRNA. Translation: AAH29926.1.
CCDSiCCDS12324.1. [Q6ZW31-1]
CCDS74299.1. [Q6ZW31-2]
RefSeqiNP_001287839.1. NM_001300910.1. [Q6ZW31-2]
NP_149014.3. NM_033025.5. [Q6ZW31-1]
UniGeneiHs.528701.
Hs.706845.

3D structure databases

ProteinModelPortaliQ6ZW31.
SMRiQ6ZW31. Positions 414-599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124489. 9 interactions.
STRINGi9606.ENSP00000341489.

PTM databases

PhosphoSiteiQ6ZW31.

Polymorphism and mutation databases

BioMutaiSYDE1.
DMDMi74723056.

Proteomic databases

MaxQBiQ6ZW31.
PaxDbiQ6ZW31.
PRIDEiQ6ZW31.

Protocols and materials databases

DNASUi85360.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342784; ENSP00000341489; ENSG00000105137.
ENST00000600440; ENSP00000470733; ENSG00000105137. [Q6ZW31-2]
GeneIDi85360.
KEGGihsa:85360.
UCSCiuc002nah.1. human. [Q6ZW31-1]
uc002nai.1. human. [Q6ZW31-2]

Organism-specific databases

CTDi85360.
GeneCardsiGC19P015218.
H-InvDBHIX0014846.
HGNCiHGNC:25824. SYDE1.
HPAiHPA013328.
neXtProtiNX_Q6ZW31.
PharmGKBiPA142670851.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG304605.
GeneTreeiENSGT00800000124037.
HOGENOMiHOG000154469.
HOVERGENiHBG053037.
InParanoidiQ6ZW31.
OMAiDHTFHLE.
OrthoDBiEOG7060Q7.
PhylomeDBiQ6ZW31.
TreeFamiTF323458.

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Miscellaneous databases

GenomeRNAii85360.
NextBioi75879.
PROiQ6ZW31.

Gene expression databases

BgeeiQ6ZW31.
CleanExiHS_SYDE1.
ExpressionAtlasiQ6ZW31. baseline and differential.
GenevisibleiQ6ZW31. HS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cervix and Muscle.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231; SER-235; SER-244 AND SER-683, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-683, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-408.

Entry informationi

Entry nameiSYDE1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZW31
Secondary accession number(s): Q7L2I8, Q8N6J2, Q9H8K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.