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Q6ZW31

- SYDE1_HUMAN

UniProt

Q6ZW31 - SYDE1_HUMAN

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Protein

Rho GTPase-activating protein SYDE1

Gene

SYDE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

GO - Molecular functioni

  1. Rho GTPase activator activity Source: UniProtKB

GO - Biological processi

  1. activation of Rho GTPase activity Source: UniProtKB
  2. positive regulation of synaptic transmission Source: Ensembl
  3. regulation of small GTPase mediated signal transduction Source: Reactome
  4. small GTPase mediated signal transduction Source: Reactome
  5. synaptic vesicle docking involved in exocytosis Source: Ensembl
  6. synaptonemal complex assembly Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein SYDE1
Alternative name(s):
Synapse defective protein 1 homolog 1
Short name:
Protein syd-1 homolog 1
Gene namesi
Name:SYDE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:25824. SYDE1.

Subcellular locationi

GO - Cellular componenti

  1. cerebellar mossy fiber Source: Ensembl
  2. cytosol Source: Reactome
  3. synaptic membrane Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670851.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Rho GTPase-activating protein SYDE1PRO_0000312158Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei231 – 2311Phosphoserine1 Publication
Modified residuei235 – 2351Phosphoserine1 Publication
Modified residuei244 – 2441Phosphoserine1 Publication
Modified residuei683 – 6831Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6ZW31.
PaxDbiQ6ZW31.
PRIDEiQ6ZW31.

PTM databases

PhosphoSiteiQ6ZW31.

Expressioni

Gene expression databases

BgeeiQ6ZW31.
CleanExiHS_SYDE1.
ExpressionAtlasiQ6ZW31. baseline and differential.
GenevestigatoriQ6ZW31.

Organism-specific databases

HPAiHPA013328.

Interactioni

Protein-protein interaction databases

BioGridi124489. 2 interactions.
STRINGi9606.ENSP00000341489.

Structurei

3D structure databases

ProteinModelPortaliQ6ZW31.
SMRiQ6ZW31. Positions 414-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini398 – 604207Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 162131Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG304605.
GeneTreeiENSGT00760000119098.
HOGENOMiHOG000154469.
HOVERGENiHBG053037.
InParanoidiQ6ZW31.
OMAiDHTFHLE.
OrthoDBiEOG7060Q7.
PhylomeDBiQ6ZW31.
TreeFamiTF323458.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZW31-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEPLLRKTF SRLRGREKLP RKKSDAKERG HPAQRPEPSP PEPEPQAPEG
60 70 80 90 100
SQAGAEGPSS PEASRSPARG AYLQSLEPSS RRWVLGGAKP AEDTSLGPGV
110 120 130 140 150
PGTGEPAGEI WYNPIPEEDP RPPAPEPPGP QPGSAESEGL APQGAAPASP
160 170 180 190 200
PTKASRTKSP GPARRLSIKM KKLPELRRRL SLRGPRAGRE RERAAPAGSV
210 220 230 240 250
ISRYHLDSSV GGPGPAAGPG GTRSPRAGYL SDGDSPERPA GPPSPTSFRP
260 270 280 290 300
YEVGPAARAP PAALWGRLSL HLYGLGGLRP APGATPRDLC CLLQVDGEAR
310 320 330 340 350
ARTGPLRGGP DFLRLDHTFH LELEAARLLR ALVLAWDPGV RRHRPCAQGT
360 370 380 390 400
VLLPTVFRGC QAQQLAVRLE PQGLLYAKLT LSEQQEAPAT AEPRVFGLPL
410 420 430 440 450
PLLVERERPP GQVPLIIQKC VGQIERRGLR VVGLYRLCGS AAVKKELRDA
460 470 480 490 500
FERDSAAVCL SEDLYPDINV ITGILKDYLR ELPTPLITQP LYKVVLEAMA
510 520 530 540 550
RDPPNRVPPT TEGTRGLLSC LPDVERATLT LLLDHLRLVS SFHAYNRMTP
560 570 580 590 600
QNLAVCFGPV LLPARQAPTR PRARSSGPGL ASAVDFKHHI EVLHYLLQSW
610 620 630 640 650
PDPRLPRQSP DVAPYLRPKR QPPLHLPLAD PEVVTRPRGR GGPESPPSNR
660 670 680 690 700
YAGDWSVCGR DFLPCGRDFL SGPDYDHVTG SDSEDEDEEV GEPRVTGDFE
710 720 730
DDFDAPFNPH LNLKDFDALI LDLERELSKQ INVCL
Length:735
Mass (Da):79,793
Last modified:July 5, 2004 - v1
Checksum:i87310623E756EB31
GO
Isoform 2 (identifier: Q6ZW31-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-96: Missing.

Show »
Length:668
Mass (Da):72,911
Checksum:iABAFE07FDAF5CDCA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti408 – 4081R → Q in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_062661

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei30 – 9667Missing in isoform 2. 1 PublicationVSP_029717Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK023573 mRNA. Translation: BAB14612.1.
AK123686 mRNA. Translation: BAC85676.1.
CH471106 Genomic DNA. Translation: EAW84462.1.
CH471106 Genomic DNA. Translation: EAW84463.1.
BC018942 mRNA. Translation: AAH18942.2.
BC029926 mRNA. Translation: AAH29926.1.
CCDSiCCDS12324.1. [Q6ZW31-1]
CCDS74299.1. [Q6ZW31-2]
RefSeqiNP_149014.3. NM_033025.5. [Q6ZW31-1]
UniGeneiHs.528701.
Hs.706845.

Genome annotation databases

EnsembliENST00000342784; ENSP00000341489; ENSG00000105137. [Q6ZW31-1]
ENST00000600440; ENSP00000470733; ENSG00000105137. [Q6ZW31-2]
GeneIDi85360.
KEGGihsa:85360.
UCSCiuc002nah.1. human. [Q6ZW31-1]
uc002nai.1. human. [Q6ZW31-2]

Polymorphism databases

DMDMi74723056.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK023573 mRNA. Translation: BAB14612.1 .
AK123686 mRNA. Translation: BAC85676.1 .
CH471106 Genomic DNA. Translation: EAW84462.1 .
CH471106 Genomic DNA. Translation: EAW84463.1 .
BC018942 mRNA. Translation: AAH18942.2 .
BC029926 mRNA. Translation: AAH29926.1 .
CCDSi CCDS12324.1. [Q6ZW31-1 ]
CCDS74299.1. [Q6ZW31-2 ]
RefSeqi NP_149014.3. NM_033025.5. [Q6ZW31-1 ]
UniGenei Hs.528701.
Hs.706845.

3D structure databases

ProteinModelPortali Q6ZW31.
SMRi Q6ZW31. Positions 414-599.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124489. 2 interactions.
STRINGi 9606.ENSP00000341489.

PTM databases

PhosphoSitei Q6ZW31.

Polymorphism databases

DMDMi 74723056.

Proteomic databases

MaxQBi Q6ZW31.
PaxDbi Q6ZW31.
PRIDEi Q6ZW31.

Protocols and materials databases

DNASUi 85360.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342784 ; ENSP00000341489 ; ENSG00000105137 . [Q6ZW31-1 ]
ENST00000600440 ; ENSP00000470733 ; ENSG00000105137 . [Q6ZW31-2 ]
GeneIDi 85360.
KEGGi hsa:85360.
UCSCi uc002nah.1. human. [Q6ZW31-1 ]
uc002nai.1. human. [Q6ZW31-2 ]

Organism-specific databases

CTDi 85360.
GeneCardsi GC19P015218.
H-InvDB HIX0014846.
HGNCi HGNC:25824. SYDE1.
HPAi HPA013328.
neXtProti NX_Q6ZW31.
PharmGKBi PA142670851.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG304605.
GeneTreei ENSGT00760000119098.
HOGENOMi HOG000154469.
HOVERGENi HBG053037.
InParanoidi Q6ZW31.
OMAi DHTFHLE.
OrthoDBi EOG7060Q7.
PhylomeDBi Q6ZW31.
TreeFami TF323458.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.

Miscellaneous databases

GenomeRNAii 85360.
NextBioi 75879.
PROi Q6ZW31.

Gene expression databases

Bgeei Q6ZW31.
CleanExi HS_SYDE1.
ExpressionAtlasi Q6ZW31. baseline and differential.
Genevestigatori Q6ZW31.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
InterProi IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view ]
Pfami PF00620. RhoGAP. 1 hit.
[Graphical view ]
SMARTi SM00324. RhoGAP. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
PROSITEi PS50238. RHOGAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cervix and Muscle.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231; SER-235; SER-244 AND SER-683, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-408.

Entry informationi

Entry nameiSYDE1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZW31
Secondary accession number(s): Q7L2I8, Q8N6J2, Q9H8K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3