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Q6ZW31

- SYDE1_HUMAN

UniProt

Q6ZW31 - SYDE1_HUMAN

Protein

Rho GTPase-activating protein SYDE1

Gene

SYDE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

    GO - Molecular functioni

    1. Rho GTPase activator activity Source: UniProtKB

    GO - Biological processi

    1. activation of Rho GTPase activity Source: UniProtKB
    2. regulation of small GTPase mediated signal transduction Source: Reactome
    3. small GTPase mediated signal transduction Source: Reactome

    Keywords - Molecular functioni

    GTPase activation

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho GTPase-activating protein SYDE1
    Alternative name(s):
    Synapse defective protein 1 homolog 1
    Short name:
    Protein syd-1 homolog 1
    Gene namesi
    Name:SYDE1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:25824. SYDE1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670851.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 735735Rho GTPase-activating protein SYDE1PRO_0000312158Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei231 – 2311Phosphoserine1 Publication
    Modified residuei235 – 2351Phosphoserine1 Publication
    Modified residuei244 – 2441Phosphoserine1 Publication
    Modified residuei683 – 6831Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6ZW31.
    PaxDbiQ6ZW31.
    PRIDEiQ6ZW31.

    PTM databases

    PhosphoSiteiQ6ZW31.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ZW31.
    BgeeiQ6ZW31.
    CleanExiHS_SYDE1.
    GenevestigatoriQ6ZW31.

    Organism-specific databases

    HPAiHPA013328.

    Interactioni

    Protein-protein interaction databases

    BioGridi124489. 2 interactions.
    STRINGi9606.ENSP00000341489.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZW31.
    SMRiQ6ZW31. Positions 414-599.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini398 – 604207Rho-GAPPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi32 – 162131Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG304605.
    HOGENOMiHOG000154469.
    HOVERGENiHBG053037.
    InParanoidiQ6ZW31.
    OMAiDHTFHLE.
    OrthoDBiEOG7060Q7.
    PhylomeDBiQ6ZW31.
    TreeFamiTF323458.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    InterProiIPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view]
    PfamiPF00620. RhoGAP. 1 hit.
    [Graphical view]
    SMARTiSM00324. RhoGAP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    PROSITEiPS50238. RHOGAP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZW31-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEPLLRKTF SRLRGREKLP RKKSDAKERG HPAQRPEPSP PEPEPQAPEG    50
    SQAGAEGPSS PEASRSPARG AYLQSLEPSS RRWVLGGAKP AEDTSLGPGV 100
    PGTGEPAGEI WYNPIPEEDP RPPAPEPPGP QPGSAESEGL APQGAAPASP 150
    PTKASRTKSP GPARRLSIKM KKLPELRRRL SLRGPRAGRE RERAAPAGSV 200
    ISRYHLDSSV GGPGPAAGPG GTRSPRAGYL SDGDSPERPA GPPSPTSFRP 250
    YEVGPAARAP PAALWGRLSL HLYGLGGLRP APGATPRDLC CLLQVDGEAR 300
    ARTGPLRGGP DFLRLDHTFH LELEAARLLR ALVLAWDPGV RRHRPCAQGT 350
    VLLPTVFRGC QAQQLAVRLE PQGLLYAKLT LSEQQEAPAT AEPRVFGLPL 400
    PLLVERERPP GQVPLIIQKC VGQIERRGLR VVGLYRLCGS AAVKKELRDA 450
    FERDSAAVCL SEDLYPDINV ITGILKDYLR ELPTPLITQP LYKVVLEAMA 500
    RDPPNRVPPT TEGTRGLLSC LPDVERATLT LLLDHLRLVS SFHAYNRMTP 550
    QNLAVCFGPV LLPARQAPTR PRARSSGPGL ASAVDFKHHI EVLHYLLQSW 600
    PDPRLPRQSP DVAPYLRPKR QPPLHLPLAD PEVVTRPRGR GGPESPPSNR 650
    YAGDWSVCGR DFLPCGRDFL SGPDYDHVTG SDSEDEDEEV GEPRVTGDFE 700
    DDFDAPFNPH LNLKDFDALI LDLERELSKQ INVCL 735
    Length:735
    Mass (Da):79,793
    Last modified:July 5, 2004 - v1
    Checksum:i87310623E756EB31
    GO
    Isoform 2 (identifier: Q6ZW31-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         30-96: Missing.

    Show »
    Length:668
    Mass (Da):72,911
    Checksum:iABAFE07FDAF5CDCA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti408 – 4081R → Q in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_062661

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei30 – 9667Missing in isoform 2. 1 PublicationVSP_029717Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023573 mRNA. Translation: BAB14612.1.
    AK123686 mRNA. Translation: BAC85676.1.
    CH471106 Genomic DNA. Translation: EAW84462.1.
    CH471106 Genomic DNA. Translation: EAW84463.1.
    BC018942 mRNA. Translation: AAH18942.2.
    BC029926 mRNA. Translation: AAH29926.1.
    CCDSiCCDS12324.1. [Q6ZW31-1]
    RefSeqiNP_149014.3. NM_033025.4. [Q6ZW31-1]
    XP_005260183.1. XM_005260126.2. [Q6ZW31-2]
    UniGeneiHs.528701.
    Hs.706845.

    Genome annotation databases

    EnsembliENST00000342784; ENSP00000341489; ENSG00000105137. [Q6ZW31-1]
    ENST00000600440; ENSP00000470733; ENSG00000105137. [Q6ZW31-2]
    GeneIDi85360.
    KEGGihsa:85360.
    UCSCiuc002nah.1. human. [Q6ZW31-1]
    uc002nai.1. human. [Q6ZW31-2]

    Polymorphism databases

    DMDMi74723056.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023573 mRNA. Translation: BAB14612.1 .
    AK123686 mRNA. Translation: BAC85676.1 .
    CH471106 Genomic DNA. Translation: EAW84462.1 .
    CH471106 Genomic DNA. Translation: EAW84463.1 .
    BC018942 mRNA. Translation: AAH18942.2 .
    BC029926 mRNA. Translation: AAH29926.1 .
    CCDSi CCDS12324.1. [Q6ZW31-1 ]
    RefSeqi NP_149014.3. NM_033025.4. [Q6ZW31-1 ]
    XP_005260183.1. XM_005260126.2. [Q6ZW31-2 ]
    UniGenei Hs.528701.
    Hs.706845.

    3D structure databases

    ProteinModelPortali Q6ZW31.
    SMRi Q6ZW31. Positions 414-599.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124489. 2 interactions.
    STRINGi 9606.ENSP00000341489.

    PTM databases

    PhosphoSitei Q6ZW31.

    Polymorphism databases

    DMDMi 74723056.

    Proteomic databases

    MaxQBi Q6ZW31.
    PaxDbi Q6ZW31.
    PRIDEi Q6ZW31.

    Protocols and materials databases

    DNASUi 85360.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342784 ; ENSP00000341489 ; ENSG00000105137 . [Q6ZW31-1 ]
    ENST00000600440 ; ENSP00000470733 ; ENSG00000105137 . [Q6ZW31-2 ]
    GeneIDi 85360.
    KEGGi hsa:85360.
    UCSCi uc002nah.1. human. [Q6ZW31-1 ]
    uc002nai.1. human. [Q6ZW31-2 ]

    Organism-specific databases

    CTDi 85360.
    GeneCardsi GC19P015218.
    H-InvDB HIX0014846.
    HGNCi HGNC:25824. SYDE1.
    HPAi HPA013328.
    neXtProti NX_Q6ZW31.
    PharmGKBi PA142670851.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG304605.
    HOGENOMi HOG000154469.
    HOVERGENi HBG053037.
    InParanoidi Q6ZW31.
    OMAi DHTFHLE.
    OrthoDBi EOG7060Q7.
    PhylomeDBi Q6ZW31.
    TreeFami TF323458.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.

    Miscellaneous databases

    GenomeRNAii 85360.
    NextBioi 75879.
    PROi Q6ZW31.

    Gene expression databases

    ArrayExpressi Q6ZW31.
    Bgeei Q6ZW31.
    CleanExi HS_SYDE1.
    Genevestigatori Q6ZW31.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    InterProi IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view ]
    Pfami PF00620. RhoGAP. 1 hit.
    [Graphical view ]
    SMARTi SM00324. RhoGAP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    PROSITEi PS50238. RHOGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Cervix and Muscle.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231; SER-235; SER-244 AND SER-683, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-408.

    Entry informationi

    Entry nameiSYDE1_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZW31
    Secondary accession number(s): Q7L2I8, Q8N6J2, Q9H8K4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3