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Protein

Rho GTPase-activating protein SYDE1

Gene

SYDE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469).1 Publication

GO - Molecular functioni

GO - Biological processi

  • activation of GTPase activity Source: UniProtKB
  • positive regulation of trophoblast cell migration Source: UniProtKB
  • regulation of cytoskeleton organization Source: UniProtKB
  • regulation of GTPase activity Source: GO_Central
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • signal transduction Source: InterPro

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein SYDE1
Alternative name(s):
Synapse defective protein 1 homolog 1
Short name:
Protein syd-1 homolog 1
Gene namesi
Name:SYDE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25824. SYDE1.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105137.
PharmGKBiPA142670851.

Polymorphism and mutation databases

BioMutaiSYDE1.
DMDMi74723056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003121581 – 735Rho GTPase-activating protein SYDE1Add BLAST735

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei224PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei235PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei681PhosphoserineBy similarity1
Modified residuei683PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZW31.
MaxQBiQ6ZW31.
PaxDbiQ6ZW31.
PeptideAtlasiQ6ZW31.
PRIDEiQ6ZW31.

PTM databases

iPTMnetiQ6ZW31.
PhosphoSitePlusiQ6ZW31.

Expressioni

Tissue specificityi

Expressed in trophoblast cells of placental villi.1 Publication

Gene expression databases

BgeeiENSG00000105137.
CleanExiHS_SYDE1.
ExpressionAtlasiQ6ZW31. baseline and differential.
GenevisibleiQ6ZW31. HS.

Organism-specific databases

HPAiHPA013328.

Interactioni

Protein-protein interaction databases

BioGridi124489. 10 interactors.
IntActiQ6ZW31. 1 interactor.
STRINGi9606.ENSP00000341489.

Structurei

3D structure databases

ProteinModelPortaliQ6ZW31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini398 – 604Rho-GAPPROSITE-ProRule annotationAdd BLAST207

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 162Pro-richAdd BLAST131

Phylogenomic databases

eggNOGiKOG1452. Eukaryota.
ENOG410XYAD. LUCA.
GeneTreeiENSGT00860000133689.
HOGENOMiHOG000154469.
HOVERGENiHBG053037.
InParanoidiQ6ZW31.
KOiK20655.
OMAiDHTFHLE.
OrthoDBiEOG091G01HK.
PhylomeDBiQ6ZW31.
TreeFamiTF323458.

Family and domain databases

InterProiView protein in InterPro
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
PfamiView protein in Pfam
PF00620. RhoGAP. 1 hit.
SMARTiView protein in SMART
SM00324. RhoGAP. 1 hit.
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiView protein in PROSITE
PS50238. RHOGAP. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZW31-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEPLLRKTF SRLRGREKLP RKKSDAKERG HPAQRPEPSP PEPEPQAPEG
60 70 80 90 100
SQAGAEGPSS PEASRSPARG AYLQSLEPSS RRWVLGGAKP AEDTSLGPGV
110 120 130 140 150
PGTGEPAGEI WYNPIPEEDP RPPAPEPPGP QPGSAESEGL APQGAAPASP
160 170 180 190 200
PTKASRTKSP GPARRLSIKM KKLPELRRRL SLRGPRAGRE RERAAPAGSV
210 220 230 240 250
ISRYHLDSSV GGPGPAAGPG GTRSPRAGYL SDGDSPERPA GPPSPTSFRP
260 270 280 290 300
YEVGPAARAP PAALWGRLSL HLYGLGGLRP APGATPRDLC CLLQVDGEAR
310 320 330 340 350
ARTGPLRGGP DFLRLDHTFH LELEAARLLR ALVLAWDPGV RRHRPCAQGT
360 370 380 390 400
VLLPTVFRGC QAQQLAVRLE PQGLLYAKLT LSEQQEAPAT AEPRVFGLPL
410 420 430 440 450
PLLVERERPP GQVPLIIQKC VGQIERRGLR VVGLYRLCGS AAVKKELRDA
460 470 480 490 500
FERDSAAVCL SEDLYPDINV ITGILKDYLR ELPTPLITQP LYKVVLEAMA
510 520 530 540 550
RDPPNRVPPT TEGTRGLLSC LPDVERATLT LLLDHLRLVS SFHAYNRMTP
560 570 580 590 600
QNLAVCFGPV LLPARQAPTR PRARSSGPGL ASAVDFKHHI EVLHYLLQSW
610 620 630 640 650
PDPRLPRQSP DVAPYLRPKR QPPLHLPLAD PEVVTRPRGR GGPESPPSNR
660 670 680 690 700
YAGDWSVCGR DFLPCGRDFL SGPDYDHVTG SDSEDEDEEV GEPRVTGDFE
710 720 730
DDFDAPFNPH LNLKDFDALI LDLERELSKQ INVCL
Length:735
Mass (Da):79,793
Last modified:July 5, 2004 - v1
Checksum:i87310623E756EB31
GO
Isoform 2 (identifier: Q6ZW31-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-96: Missing.

Show »
Length:668
Mass (Da):72,911
Checksum:iABAFE07FDAF5CDCA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062661408R → Q in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs772906202Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02971730 – 96Missing in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023573 mRNA. Translation: BAB14612.1.
AK123686 mRNA. Translation: BAC85676.1.
CH471106 Genomic DNA. Translation: EAW84462.1.
CH471106 Genomic DNA. Translation: EAW84463.1.
BC018942 mRNA. Translation: AAH18942.2.
BC029926 mRNA. Translation: AAH29926.1.
CCDSiCCDS12324.1. [Q6ZW31-1]
CCDS74299.1. [Q6ZW31-2]
RefSeqiNP_001287839.1. NM_001300910.1. [Q6ZW31-2]
NP_149014.3. NM_033025.5. [Q6ZW31-1]
UniGeneiHs.528701.
Hs.706845.

Genome annotation databases

EnsembliENST00000342784; ENSP00000341489; ENSG00000105137. [Q6ZW31-1]
ENST00000600440; ENSP00000470733; ENSG00000105137. [Q6ZW31-2]
GeneIDi85360.
KEGGihsa:85360.
UCSCiuc002nah.2. human. [Q6ZW31-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSYDE1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZW31
Secondary accession number(s): Q7L2I8, Q8N6J2, Q9H8K4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot