Q6ZW31 (SYDE1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho GTPase-activating protein SYDE1

Alternative name(s):
Synapse defective protein 1 homolog 1
Short name=Protein syd-1 homolog 1

Gene names

Name:

SYDE1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	735 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state By similarity.
Sequence similarities	Contains 1 Rho-GAP domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	GTPase activation
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of Rho GTPase activity Inferred from sequence or structural similarity. Source: UniProtKB small GTPase mediated signal transduction Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome
Molecular_function	Rho GTPase activator activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZW31-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZW31-2)

The sequence of this isoform differs from the canonical sequence as follows:
     30-96: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 735	735	Rho GTPase-activating protein SYDE1		PRO_0000312158
Regions
	Domain	398 – 604	207	Rho-GAP
	Compositional bias	32 – 162	131	Pro-rich
Amino acid modifications
	Modified residue	231	1	Phosphoserine Ref.4
	Modified residue	235	1	Phosphoserine Ref.4
	Modified residue	244	1	Phosphoserine Ref.4
	Modified residue	683	1	Phosphoserine Ref.4
Natural variations
	Alternative sequence	30 – 96	67	Missing in isoform 2.		VSP_029717
	Natural variant	408	1	R → Q in a pancreatic ductal adenocarcinoma sample; somatic mutation. Ref.5		VAR_062661

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 87310623E756EB31	FASTA	735	79,793
	10 20 30 40 50 60 MAEPLLRKTF SRLRGREKLP RKKSDAKERG HPAQRPEPSP PEPEPQAPEG SQAGAEGPSS 70 80 90 100 110 120 PEASRSPARG AYLQSLEPSS RRWVLGGAKP AEDTSLGPGV PGTGEPAGEI WYNPIPEEDP 130 140 150 160 170 180 RPPAPEPPGP QPGSAESEGL APQGAAPASP PTKASRTKSP GPARRLSIKM KKLPELRRRL 190 200 210 220 230 240 SLRGPRAGRE RERAAPAGSV ISRYHLDSSV GGPGPAAGPG GTRSPRAGYL SDGDSPERPA 250 260 270 280 290 300 GPPSPTSFRP YEVGPAARAP PAALWGRLSL HLYGLGGLRP APGATPRDLC CLLQVDGEAR 310 320 330 340 350 360 ARTGPLRGGP DFLRLDHTFH LELEAARLLR ALVLAWDPGV RRHRPCAQGT VLLPTVFRGC 370 380 390 400 410 420 QAQQLAVRLE PQGLLYAKLT LSEQQEAPAT AEPRVFGLPL PLLVERERPP GQVPLIIQKC 430 440 450 460 470 480 VGQIERRGLR VVGLYRLCGS AAVKKELRDA FERDSAAVCL SEDLYPDINV ITGILKDYLR 490 500 510 520 530 540 ELPTPLITQP LYKVVLEAMA RDPPNRVPPT TEGTRGLLSC LPDVERATLT LLLDHLRLVS 550 560 570 580 590 600 SFHAYNRMTP QNLAVCFGPV LLPARQAPTR PRARSSGPGL ASAVDFKHHI EVLHYLLQSW 610 620 630 640 650 660 PDPRLPRQSP DVAPYLRPKR QPPLHLPLAD PEVVTRPRGR GGPESPPSNR YAGDWSVCGR 670 680 690 700 710 720 DFLPCGRDFL SGPDYDHVTG SDSEDEDEEV GEPRVTGDFE DDFDAPFNPH LNLKDFDALI 730 LDLERELSKQ INVCL
	Isoform 2 [UniParc]. Checksum: ABAFE07FDAF5CDCA	FASTA	668	72,911
	10 20 30 40 50 60 MAEPLLRKTF SRLRGREKLP RKKSDAKERG PGVPGTGEPA GEIWYNPIPE EDPRPPAPEP 70 80 90 100 110 120 PGPQPGSAES EGLAPQGAAP ASPPTKASRT KSPGPARRLS IKMKKLPELR RRLSLRGPRA 130 140 150 160 170 180 GRERERAAPA GSVISRYHLD SSVGGPGPAA GPGGTRSPRA GYLSDGDSPE RPAGPPSPTS 190 200 210 220 230 240 FRPYEVGPAA RAPPAALWGR LSLHLYGLGG LRPAPGATPR DLCCLLQVDG EARARTGPLR 250 260 270 280 290 300 GGPDFLRLDH TFHLELEAAR LLRALVLAWD PGVRRHRPCA QGTVLLPTVF RGCQAQQLAV 310 320 330 340 350 360 RLEPQGLLYA KLTLSEQQEA PATAEPRVFG LPLPLLVERE RPPGQVPLII QKCVGQIERR 370 380 390 400 410 420 GLRVVGLYRL CGSAAVKKEL RDAFERDSAA VCLSEDLYPD INVITGILKD YLRELPTPLI 430 440 450 460 470 480 TQPLYKVVLE AMARDPPNRV PPTTEGTRGL LSCLPDVERA TLTLLLDHLR LVSSFHAYNR 490 500 510 520 530 540 MTPQNLAVCF GPVLLPARQA PTRPRARSSG PGLASAVDFK HHIEVLHYLL QSWPDPRLPR 550 560 570 580 590 600 QSPDVAPYLR PKRQPPLHLP LADPEVVTRP RGRGGPESPP SNRYAGDWSV CGRDFLPCGR 610 620 630 640 650 660 DFLSGPDYDH VTGSDSEDED EEVGEPRVTG DFEDDFDAPF NPHLNLKDFD ALILDLEREL SKQINVCL

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Cervix and Muscle.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231; SER-235; SER-244 AND SER-683, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Core signaling pathways in human pancreatic cancers revealed by global genomic analyses." Jones S., Zhang X., Parsons D.W., Lin J.C., Leary R.J., Angenendt P., Mankoo P., Carter H., Kamiyama H., Jimeno A., Hong S.M., Fu B., Lin M.T., Calhoun E.S., Kamiyama M., Walter K., Nikolskaya T., Nikolsky Y. , Hartigan J., Smith D.R., Hidalgo M., Leach S.D., Klein A.P., Jaffee E.M., Goggins M., Maitra A., Iacobuzio-Donahue C., Eshleman J.R., Kern S.E., Hruban R.H., Karchin R., Papadopoulos N., Parmigiani G., Vogelstein B., Velculescu V.E., Kinzler K.W. Science 321:1801-1806(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-408.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK023573 mRNA. Translation: BAB14612.1. AK123686 mRNA. Translation: BAC85676.1. CH471106 Genomic DNA. Translation: EAW84462.1. CH471106 Genomic DNA. Translation: EAW84463.1. BC018942 mRNA. Translation: AAH18942.2. BC029926 mRNA. Translation: AAH29926.1.
IPI	IPI00171137. IPI00793111.
RefSeq	NP_149014.3. NM_033025.4.
UniGene	Hs.528701. Hs.706845.
3D structure databases
HSSP	HSSP built from PDB template 1TX4 based on UniProtKB Q07960.
ProteinModelPortal	Q6ZW31.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000341489.
PTM databases
PhosphoSite	Q6ZW31.
Polymorphism databases
DMDM	74723056.
Proteomic databases
PaxDb	Q6ZW31.
PRIDE	Q6ZW31.
Protocols and materials databases
DNASU	85360.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000342784; ENSP00000341489; ENSG00000105137. ENST00000600440; ENSP00000470733; ENSG00000105137.
GeneID	85360.
KEGG	hsa:85360.
UCSC	uc002nah.1. human. uc002nai.1. human.
Organism-specific databases
CTD	85360.
GeneCards	GC19P015218.
H-InvDB	HIX0014846.
HGNC	HGNC:25824. SYDE1.
HPA	HPA013328.
neXtProt	NX_Q6ZW31.
PharmGKB	PA142670851.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG304605.
HOGENOM	HOG000154469.
HOVERGEN	HBG053037.
InParanoid	Q6ZW31.
OMA	DHTFHLE.
OrthoDB	EOG48WC1M.
PhylomeDB	Q6ZW31.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q6ZW31.
CleanEx	HS_SYDE1.
Genevestigator	Q6ZW31.
Family and domain databases
Gene3D	1.10.555.10. 1 hit.
InterPro	IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP_dom. [Graphical view]
Pfam	PF00620. RhoGAP. 1 hit. [Graphical view]
SMART	SM00324. RhoGAP. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit. SSF48350. Rho_GAP. 1 hit.
PROSITE	PS50238. RHOGAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	85360.
NextBio	75879.

Entry information

Entry name

SYDE1_HUMAN

Accession

Primary (citable) accession number: Q6ZW31
Secondary accession number(s): Q7L2I8, Q8N6J2, Q9H8K4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.