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Q6ZW05

- PTHD4_HUMAN

UniProt

Q6ZW05 - PTHD4_HUMAN

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Protein
Patched domain-containing protein 4
Gene
PTCHD4, C6orf138
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. hedgehog receptor activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Patched domain-containing protein 4
Gene namesi
Name:PTCHD4
Synonyms:C6orf138
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21345. PTCHD4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6121Helical; Reviewed prediction
Add
BLAST
Transmembranei230 – 25021Helical; Reviewed prediction
Add
BLAST
Transmembranei265 – 28521Helical; Reviewed prediction
Add
BLAST
Transmembranei293 – 31321Helical; Reviewed prediction
Add
BLAST
Transmembranei336 – 35621Helical; Reviewed prediction
Add
BLAST
Transmembranei373 – 39321Helical; Reviewed prediction
Add
BLAST
Transmembranei465 – 48521Helical; Reviewed prediction
Add
BLAST
Transmembranei660 – 68021Helical; Reviewed prediction
Add
BLAST
Transmembranei686 – 70621Helical; Reviewed prediction
Add
BLAST
Transmembranei718 – 73821Helical; Reviewed prediction
Add
BLAST
Transmembranei765 – 78521Helical; Reviewed prediction
Add
BLAST
Transmembranei787 – 80721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982541.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 846846Patched domain-containing protein 4
PRO_0000320640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi762 – 7621N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6ZW05.
PRIDEiQ6ZW05.

PTM databases

PhosphoSiteiQ6ZW05.

Expressioni

Gene expression databases

ArrayExpressiQ6ZW05.
BgeeiQ6ZW05.
CleanExiHS_C6orf138.
GenevestigatoriQ6ZW05.

Organism-specific databases

HPAiHPA041276.

Structurei

3D structure databases

ProteinModelPortaliQ6ZW05.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini233 – 392160SSD
Add
BLAST

Sequence similaritiesi

Belongs to the patched family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG242733.
HOGENOMiHOG000049274.
HOVERGENiHBG080559.
InParanoidiQ6ZW05.
OMAiWIWWRML.
OrthoDBiEOG718KCB.
PhylomeDBiQ6ZW05.
TreeFamiTF331806.

Family and domain databases

InterProiIPR003392. Patched.
IPR000731. SSD.
[Graphical view]
PfamiPF02460. Patched. 1 hit.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZW05-1 [UniParc]FASTAAdd to Basket

« Hide

MCFLRRPGAP ASWIWWRMLR QVLRRGLQSF CHRLGLCVSR HPVFFLTVPA    50
VLTITFGLSA LNRFQPEGDL ERLVAPSHSL AKIERSLASS LFPLDQSKSQ 100
LYSDLHTPGR YGRVILLSPT GDNILLQAEG ILQTHRAVLE MKDGRNSFIG 150
HQLGGVVEVP NSKDQRVKSA RAIQITYYLQ TYGSATQDLI GEKWENEFCK 200
LIRKLQEEHQ ELQLYSLASF SLWRDFHKTS ILARSKVLVS LVLILTTATL 250
SSSMKDCLRS KPFLGLLGVL TVCISIITAA GIFFITDGKY NSTLLGIPFF 300
AMGHGTKGVF ELLSGWRRTK ENLPFKDRIA DAYSDVMVTY TMTSSLYFIT 350
FGMGASPFTN IEAVKVFCQN MCVSILLNYF YIFSFFGSCL VFAGQLEQNR 400
YHSIFCCKIP SAEYLDRKPV WFQTVMSDGH QQTSHHETNP YQHHFIQHFL 450
REHYNEWITN IYVKPFVVIL YLIYASFSFM GCLQISDGAN IINLLASDSP 500
SVSYAMVQQK YFSNYSPVIG FYVYEPLEYW NSSVQDDLRR LCSGFTAVSW 550
VEQYYQFLKV SNVSANNKSD FISVLQSSFL KKPEFQHFRN DIIFSKAGDE 600
SNIIASRLYL VARTSRDKQK EITEVLEKLR PLSLSKSIRF IVFNPSFVFM 650
DHYSLSVTVP VLIAGFGVLL VLILTFFLVI HPLGNFWLIL SVTSIELGVL 700
GLMTLWNVDM DCISILCLIY TLNFAIDHCA PLLFTFVLAT EHTRTQCIKS 750
SLQDHGTAIL QNVTSFLIGL VPLLFVPSNL TFTLFKCLLL TGGCTLLHCF 800
VILPVFLTFF PPSKKHHKKK KRAKRKEREE IECIEIQENP DHVTTV 846
Length:846
Mass (Da):96,371
Last modified:November 24, 2009 - v3
Checksum:i2B82D1EB3519F0C6
GO

Sequence cautioni

The sequence BAC85703.1 differs from that shown. Reason: Frameshift at several positions.
The sequence BAC85703.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAI20456.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAX04325.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL161622 Genomic DNA. Translation: CAI20456.1. Sequence problems.
AL139336 Genomic DNA. No translation available.
AL121973 Genomic DNA. No translation available.
AL353138 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX04325.1. Sequence problems.
AK123835 mRNA. Translation: BAC85703.1. Sequence problems.
AK299301 mRNA. Translation: BAG61315.1.
CCDSiCCDS34473.2.
RefSeqiNP_001013754.3. NM_001013732.3.
NP_997382.2. NM_207499.2.
UniGeneiHs.659409.

Genome annotation databases

EnsembliENST00000339488; ENSP00000341914; ENSG00000244694.
GeneIDi442213.
KEGGihsa:442213.
UCSCiuc011dwm.2. human.

Polymorphism databases

DMDMi269849699.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL161622 Genomic DNA. Translation: CAI20456.1 . Sequence problems.
AL139336 Genomic DNA. No translation available.
AL121973 Genomic DNA. No translation available.
AL353138 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX04325.1 . Sequence problems.
AK123835 mRNA. Translation: BAC85703.1 . Sequence problems.
AK299301 mRNA. Translation: BAG61315.1 .
CCDSi CCDS34473.2.
RefSeqi NP_001013754.3. NM_001013732.3.
NP_997382.2. NM_207499.2.
UniGenei Hs.659409.

3D structure databases

ProteinModelPortali Q6ZW05.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6ZW05.

Polymorphism databases

DMDMi 269849699.

Proteomic databases

PaxDbi Q6ZW05.
PRIDEi Q6ZW05.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339488 ; ENSP00000341914 ; ENSG00000244694 .
GeneIDi 442213.
KEGGi hsa:442213.
UCSCi uc011dwm.2. human.

Organism-specific databases

CTDi 442213.
GeneCardsi GC06M047845.
HGNCi HGNC:21345. PTCHD4.
HPAi HPA041276.
neXtProti NX_Q6ZW05.
PharmGKBi PA134982541.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG242733.
HOGENOMi HOG000049274.
HOVERGENi HBG080559.
InParanoidi Q6ZW05.
OMAi WIWWRML.
OrthoDBi EOG718KCB.
PhylomeDBi Q6ZW05.
TreeFami TF331806.

Miscellaneous databases

GenomeRNAii 442213.
NextBioi 110853.
PROi Q6ZW05.

Gene expression databases

ArrayExpressi Q6ZW05.
Bgeei Q6ZW05.
CleanExi HS_C6orf138.
Genevestigatori Q6ZW05.

Family and domain databases

InterProi IPR003392. Patched.
IPR000731. SSD.
[Graphical view ]
Pfami PF02460. Patched. 1 hit.
[Graphical view ]
PROSITEi PS50156. SSD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiPTHD4_HUMAN
AccessioniPrimary (citable) accession number: Q6ZW05
Secondary accession number(s): B4DRK3, Q5T884
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 24, 2009
Last modified: July 9, 2014
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi