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Protein

Ankyrin repeat and SOCS box protein 18

Gene

ASB18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:G66-31312-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 18
Short name:
ASB-18
Gene namesi
Name:ASB18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:19770. ASB18.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182177.
PharmGKBiPA134950797.

Polymorphism and mutation databases

BioMutaiASB18.
DMDMi162416260.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003118751 – 466Ankyrin repeat and SOCS box protein 18Add BLAST466

Proteomic databases

PaxDbiQ6ZVZ8.
PRIDEiQ6ZVZ8.

PTM databases

iPTMnetiQ6ZVZ8.
PhosphoSitePlusiQ6ZVZ8.

Expressioni

Gene expression databases

BgeeiENSG00000182177.
CleanExiHS_ASB18.
ExpressionAtlasiQ6ZVZ8. baseline and differential.

Organism-specific databases

HPAiHPA068447.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi134882. 23 interactors.
STRINGi9606.ENSP00000386532.

Structurei

3D structure databases

ProteinModelPortaliQ6ZVZ8.
SMRiQ6ZVZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati119 – 148ANK 1Add BLAST30
Repeati151 – 180ANK 2Add BLAST30
Repeati184 – 213ANK 3Add BLAST30
Repeati218 – 247ANK 4Add BLAST30
Repeati251 – 288ANK 5Add BLAST38
Repeati292 – 321ANK 6Add BLAST30
Domaini405 – 463SOCS boxPROSITE-ProRule annotationAdd BLAST59

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000011960.
HOGENOMiHOG000232066.
HOVERGENiHBG073573.
InParanoidiQ6ZVZ8.
KOiK10340.
OMAiWMKEPSA.
OrthoDBiEOG091G0543.
PhylomeDBiQ6ZVZ8.
TreeFamiTF323921.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF13606. Ank_3. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZVZ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNSDYLPDY PLNSDLVKRL KSALDAKDEE RVRDLICTEI TPVDAVIELA
60 70 80 90 100
NDDWMKDPSA QLPTGMLLGD LDHLKPLMDQ FFQDANVVFE INKDEMEWQV
110 120 130 140 150
KSPATFGLSG LWTLEYKREL TTPLCIAAAH GHTACVRHLL GRGADPDASP
160 170 180 190 200
GGRGALHEAC LGGHTACVRL LLQHRADPDL LSAEGLAPLH LCRTAASLGC
210 220 230 240 250
AQALLEHGAS VQRVGGTGRD TPLHVAAQRG LDEHARLYLG RGAHVDARNG
260 270 280 290 300
RGETALSAAC GAARRPDEHG RCLRLCALLL RRGAEADARD EDERSPLHKA
310 320 330 340 350
CGHASHSLAR LLLRHGADAG ALDYGGASPL GRVLQTASCA LQASPQRTVQ
360 370 380 390 400
ALLNHGSPTV WPDAFPKVLK TCASVPAVIE VLFNSYPQLC LSESWKEVIP
410 420 430 440 450
EEVFQMHKPF YQSLFALALT PRCLQHLCRC ALRRLFGKRC FDLIPLLPLP
460
KPLQNYLLLE PQGVLH
Length:466
Mass (Da):50,803
Last modified:December 4, 2007 - v2
Checksum:i80AA94D1846D4D85
GO
Isoform 2 (identifier: Q6ZVZ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: MSNSDYLPDY...SAQLPTGMLL → MERQPGPVRG...VQEYHTALVA

Note: No experimental confirmation available.
Show »
Length:437
Mass (Da):47,516
Checksum:i6DDE5787E9745D35
GO

Sequence cautioni

The sequence BAC85710 differs from that shown. Unlikely isoform. Aberrant splice sites.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048289104A → T.Corresponds to variant rs6756597dbSNPEnsembl.1
Natural variantiVAR_037331127A → P.Corresponds to variant rs7588748dbSNPEnsembl.1
Natural variantiVAR_059128261G → S.Corresponds to variant rs6431437dbSNPEnsembl.1
Natural variantiVAR_048290407H → N.Corresponds to variant rs10177957dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0296211 – 68MSNSD…TGMLL → MERQPGPVRGKLQIFQKTEK DPQARAGSPVQEYHTALVA in isoform 2. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123854 mRNA. Translation: BAC85710.1. Sequence problems.
AC019068 Genomic DNA. No translation available.
AC079135 Genomic DNA. No translation available.
CCDSiCCDS46548.1. [Q6ZVZ8-1]
RefSeqiNP_997721.2. NM_212556.2. [Q6ZVZ8-1]
UniGeneiHs.639909.

Genome annotation databases

EnsembliENST00000409749; ENSP00000386532; ENSG00000182177. [Q6ZVZ8-1]
GeneIDi401036.
KEGGihsa:401036.
UCSCiuc010znh.2. human. [Q6ZVZ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123854 mRNA. Translation: BAC85710.1. Sequence problems.
AC019068 Genomic DNA. No translation available.
AC079135 Genomic DNA. No translation available.
CCDSiCCDS46548.1. [Q6ZVZ8-1]
RefSeqiNP_997721.2. NM_212556.2. [Q6ZVZ8-1]
UniGeneiHs.639909.

3D structure databases

ProteinModelPortaliQ6ZVZ8.
SMRiQ6ZVZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134882. 23 interactors.
STRINGi9606.ENSP00000386532.

PTM databases

iPTMnetiQ6ZVZ8.
PhosphoSitePlusiQ6ZVZ8.

Polymorphism and mutation databases

BioMutaiASB18.
DMDMi162416260.

Proteomic databases

PaxDbiQ6ZVZ8.
PRIDEiQ6ZVZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409749; ENSP00000386532; ENSG00000182177. [Q6ZVZ8-1]
GeneIDi401036.
KEGGihsa:401036.
UCSCiuc010znh.2. human. [Q6ZVZ8-1]

Organism-specific databases

CTDi401036.
GeneCardsiASB18.
HGNCiHGNC:19770. ASB18.
HPAiHPA068447.
neXtProtiNX_Q6ZVZ8.
OpenTargetsiENSG00000182177.
PharmGKBiPA134950797.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000011960.
HOGENOMiHOG000232066.
HOVERGENiHBG073573.
InParanoidiQ6ZVZ8.
KOiK10340.
OMAiWMKEPSA.
OrthoDBiEOG091G0543.
PhylomeDBiQ6ZVZ8.
TreeFamiTF323921.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:G66-31312-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii401036.
PROiQ6ZVZ8.

Gene expression databases

BgeeiENSG00000182177.
CleanExiHS_ASB18.
ExpressionAtlasiQ6ZVZ8. baseline and differential.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF13606. Ank_3. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASB18_HUMAN
AccessioniPrimary (citable) accession number: Q6ZVZ8
Secondary accession number(s): B6ZDL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.