Q6ZVX9 (PAQR9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Progestin and adipoQ receptor family member 9

Alternative name(s):
Progestin and adipoQ receptor family member IX

Gene names

Name:

PAQR9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expression levels vary widely in a range of tissues. Ref.1
Sequence similarities	Belongs to the ADIPOR family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 377	377	Progestin and adipoQ receptor family member 9		PRO_0000218852
Regions
	Topological domain	1 – 86	86	Cytoplasmic Potential
	Transmembrane	87 – 107	21	Helical; Potential
	Topological domain	108 – 116	9	Extracellular Potential
	Transmembrane	117 – 137	21	Helical; Potential
	Topological domain	138 – 162	25	Cytoplasmic Potential
	Transmembrane	163 – 183	21	Helical; Potential
	Topological domain	184 – 205	22	Extracellular Potential
	Transmembrane	206 – 226	21	Helical; Potential
	Topological domain	227 – 243	17	Cytoplasmic Potential
	Transmembrane	244 – 264	21	Helical; Potential
	Topological domain	265 – 301	37	Extracellular Potential
	Transmembrane	302 – 322	21	Helical; Potential
	Topological domain	323 – 343	21	Cytoplasmic Potential
	Transmembrane	344 – 364	21	Helical; Potential
	Topological domain	365 – 377	13	Extracellular Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6ZVX9 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: C1708C12C5C5A7C5	FASTA	377	42,692
	10 20 30 40 50 60 MPRRLQPRGA GTKGPPAPAP AASGAARNSH SAASRDPPAS AKPLLRWDEV PDDFVECFIL 70 80 90 100 110 120 SGYRRLPCTA QECLASVLKP TNETLNFWTH FIPLLLFLSK FCRLFFLSGG DVPFHHPWLL 130 140 150 160 170 180 PLWCYASGVL LTFAMSCTAH VFSCLSLRLR AAFFYLDYAS ISYYGFGSTV AYYYYLLPGL 190 200 210 220 230 240 SLLDARVMTP YLQQRLGWHV DCTRLIAAYR ALVLPVAFVL AVACTVACCK SRTDWCTYPF 250 260 270 280 290 300 ALRTFVFVMP LSMACPIMLE SWLFDLRGEN PTLFVHFYRR YFWLVVAAFF NVSKIPERIQ 310 320 330 340 350 360 PGLFDIIGHS HQLFHIFTFL SIYDQVYYVE EGLRQFLQAP PAAPTFSGTV GYMLLLVVCL 370 GLVIRKFLNS SEFCSKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif." Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D. J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pericardium.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY424287 mRNA. Translation: AAR08375.1. AK123932 mRNA. Translation: BAC85729.1. BC118666 mRNA. Translation: AAI18667.1. BC122527 mRNA. Translation: AAI22528.1.
IPI	IPI00394849.
RefSeq	NP_940906.1. NM_198504.2.
UniGene	Hs.408385. Hs.656111.
3D structure databases
ProteinModelPortal	Q6ZVX9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000341564.
Polymorphism databases
DMDM	51701778.
Proteomic databases
PaxDb	Q6ZVX9.
PRIDE	Q6ZVX9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340634; ENSP00000341564; ENSG00000188582.
GeneID	344838.
KEGG	hsa:344838.
UCSC	uc003evg.3. human.
Organism-specific databases
CTD	344838.
GeneCards	GC03M142668.
HGNC	HGNC:30131. PAQR9.
HPA	HPA052798.
MIM	614580. gene.
neXtProt	NX_Q6ZVX9.
PharmGKB	PA134880790.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG241923.
HOGENOM	HOG000115439.
HOVERGEN	HBG053506.
InParanoid	Q6ZVX9.
OMA	SYPFALR.
OrthoDB	EOG4K3KWD.
PhylomeDB	Q6ZVX9.
Gene expression databases
ArrayExpress	Q6ZVX9.
Bgee	Q6ZVX9.
CleanEx	HS_PAQR9.
Genevestigator	Q6ZVX9.
GermOnline	ENSG00000188582. Homo sapiens.
Family and domain databases
InterPro	IPR004254. HlyIII-related. [Graphical view]
PANTHER	PTHR20855. PTHR20855. 1 hit.
Pfam	PF03006. HlyIII. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	344838.
NextBio	98775.
SOURCE	Search...

Entry information

Entry name

PAQR9_HUMAN

Accession

Primary (citable) accession number: Q6ZVX9
Secondary accession number(s): Q147T6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.