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Protein

Progestin and adipoQ receptor family member 9

Gene

PAQR9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Progestin and adipoQ receptor family member 9
Alternative name(s):
Progestin and adipoQ receptor family member IX
Gene namesi
Name:PAQR9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30131. PAQR9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8686CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST
Topological domaini108 – 1169ExtracellularSequence Analysis
Transmembranei117 – 13721HelicalSequence AnalysisAdd
BLAST
Topological domaini138 – 16225CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST
Topological domaini184 – 20522ExtracellularSequence AnalysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence AnalysisAdd
BLAST
Topological domaini227 – 24317CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST
Topological domaini265 – 30137ExtracellularSequence AnalysisAdd
BLAST
Transmembranei302 – 32221HelicalSequence AnalysisAdd
BLAST
Topological domaini323 – 34321CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence AnalysisAdd
BLAST
Topological domaini365 – 37713ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880790.

Polymorphism and mutation databases

BioMutaiPAQR9.
DMDMi51701778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Progestin and adipoQ receptor family member 9PRO_0000218852Add
BLAST

Proteomic databases

PaxDbiQ6ZVX9.
PRIDEiQ6ZVX9.

Expressioni

Tissue specificityi

Expression levels vary widely in a range of tissues.1 Publication

Gene expression databases

BgeeiQ6ZVX9.
CleanExiHS_PAQR9.
ExpressionAtlasiQ6ZVX9. baseline and differential.
GenevisibleiQ6ZVX9. HS.

Organism-specific databases

HPAiHPA052798.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341564.

Structurei

3D structure databases

ProteinModelPortaliQ6ZVX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG241923.
GeneTreeiENSGT00530000062965.
HOGENOMiHOG000115439.
HOVERGENiHBG053506.
InParanoidiQ6ZVX9.
OMAiMTPYVQQ.
PhylomeDBiQ6ZVX9.
TreeFamiTF319738.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZVX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRRLQPRGA GTKGPPAPAP AASGAARNSH SAASRDPPAS AKPLLRWDEV
60 70 80 90 100
PDDFVECFIL SGYRRLPCTA QECLASVLKP TNETLNFWTH FIPLLLFLSK
110 120 130 140 150
FCRLFFLSGG DVPFHHPWLL PLWCYASGVL LTFAMSCTAH VFSCLSLRLR
160 170 180 190 200
AAFFYLDYAS ISYYGFGSTV AYYYYLLPGL SLLDARVMTP YLQQRLGWHV
210 220 230 240 250
DCTRLIAAYR ALVLPVAFVL AVACTVACCK SRTDWCTYPF ALRTFVFVMP
260 270 280 290 300
LSMACPIMLE SWLFDLRGEN PTLFVHFYRR YFWLVVAAFF NVSKIPERIQ
310 320 330 340 350
PGLFDIIGHS HQLFHIFTFL SIYDQVYYVE EGLRQFLQAP PAAPTFSGTV
360 370
GYMLLLVVCL GLVIRKFLNS SEFCSKK
Length:377
Mass (Da):42,692
Last modified:July 5, 2004 - v1
Checksum:iC1708C12C5C5A7C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424287 mRNA. Translation: AAR08375.1.
AK123932 mRNA. Translation: BAC85729.1.
BC118666 mRNA. Translation: AAI18667.1.
BC122527 mRNA. Translation: AAI22528.1.
CCDSiCCDS3128.1.
RefSeqiNP_940906.1. NM_198504.2.
UniGeneiHs.408385.
Hs.656111.

Genome annotation databases

EnsembliENST00000340634; ENSP00000341564; ENSG00000188582.
GeneIDi344838.
KEGGihsa:344838.
UCSCiuc003evg.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424287 mRNA. Translation: AAR08375.1.
AK123932 mRNA. Translation: BAC85729.1.
BC118666 mRNA. Translation: AAI18667.1.
BC122527 mRNA. Translation: AAI22528.1.
CCDSiCCDS3128.1.
RefSeqiNP_940906.1. NM_198504.2.
UniGeneiHs.408385.
Hs.656111.

3D structure databases

ProteinModelPortaliQ6ZVX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341564.

Polymorphism and mutation databases

BioMutaiPAQR9.
DMDMi51701778.

Proteomic databases

PaxDbiQ6ZVX9.
PRIDEiQ6ZVX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340634; ENSP00000341564; ENSG00000188582.
GeneIDi344838.
KEGGihsa:344838.
UCSCiuc003evg.3. human.

Organism-specific databases

CTDi344838.
GeneCardsiGC03M142668.
HGNCiHGNC:30131. PAQR9.
HPAiHPA052798.
MIMi614580. gene.
neXtProtiNX_Q6ZVX9.
PharmGKBiPA134880790.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG241923.
GeneTreeiENSGT00530000062965.
HOGENOMiHOG000115439.
HOVERGENiHBG053506.
InParanoidiQ6ZVX9.
OMAiMTPYVQQ.
PhylomeDBiQ6ZVX9.
TreeFamiTF319738.

Miscellaneous databases

GenomeRNAii344838.
NextBioi98775.
PROiQ6ZVX9.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZVX9.
CleanExiHS_PAQR9.
ExpressionAtlasiQ6ZVX9. baseline and differential.
GenevisibleiQ6ZVX9. HS.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
    Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
    J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pericardium.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiPAQR9_HUMAN
AccessioniPrimary (citable) accession number: Q6ZVX9
Secondary accession number(s): Q147T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: June 24, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.