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Q6ZVX9 (PAQR9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Progestin and adipoQ receptor family member 9
Alternative name(s):
Progestin and adipoQ receptor family member IX
Gene names
Name:PAQR9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expression levels vary widely in a range of tissues. Ref.1

Sequence similarities

Belongs to the ADIPOR family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionReceptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionreceptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Progestin and adipoQ receptor family member 9
PRO_0000218852

Regions

Topological domain1 – 8686Cytoplasmic Potential
Transmembrane87 – 10721Helical; Potential
Topological domain108 – 1169Extracellular Potential
Transmembrane117 – 13721Helical; Potential
Topological domain138 – 16225Cytoplasmic Potential
Transmembrane163 – 18321Helical; Potential
Topological domain184 – 20522Extracellular Potential
Transmembrane206 – 22621Helical; Potential
Topological domain227 – 24317Cytoplasmic Potential
Transmembrane244 – 26421Helical; Potential
Topological domain265 – 30137Extracellular Potential
Transmembrane302 – 32221Helical; Potential
Topological domain323 – 34321Cytoplasmic Potential
Transmembrane344 – 36421Helical; Potential
Topological domain365 – 37713Extracellular Potential

Sequences

Sequence LengthMass (Da)Tools
Q6ZVX9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C1708C12C5C5A7C5

FASTA37742,692
        10         20         30         40         50         60 
MPRRLQPRGA GTKGPPAPAP AASGAARNSH SAASRDPPAS AKPLLRWDEV PDDFVECFIL 

        70         80         90        100        110        120 
SGYRRLPCTA QECLASVLKP TNETLNFWTH FIPLLLFLSK FCRLFFLSGG DVPFHHPWLL 

       130        140        150        160        170        180 
PLWCYASGVL LTFAMSCTAH VFSCLSLRLR AAFFYLDYAS ISYYGFGSTV AYYYYLLPGL 

       190        200        210        220        230        240 
SLLDARVMTP YLQQRLGWHV DCTRLIAAYR ALVLPVAFVL AVACTVACCK SRTDWCTYPF 

       250        260        270        280        290        300 
ALRTFVFVMP LSMACPIMLE SWLFDLRGEN PTLFVHFYRR YFWLVVAAFF NVSKIPERIQ 

       310        320        330        340        350        360 
PGLFDIIGHS HQLFHIFTFL SIYDQVYYVE EGLRQFLQAP PAAPTFSGTV GYMLLLVVCL 

       370 
GLVIRKFLNS SEFCSKK 

« Hide

References

« Hide 'large scale' references
[1]"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pericardium.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY424287 mRNA. Translation: AAR08375.1.
AK123932 mRNA. Translation: BAC85729.1.
BC118666 mRNA. Translation: AAI18667.1.
BC122527 mRNA. Translation: AAI22528.1.
CCDSCCDS3128.1.
RefSeqNP_940906.1. NM_198504.2.
UniGeneHs.408385.
Hs.656111.

3D structure databases

ProteinModelPortalQ6ZVX9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000341564.

Polymorphism databases

DMDM51701778.

Proteomic databases

PaxDbQ6ZVX9.
PRIDEQ6ZVX9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000340634; ENSP00000341564; ENSG00000188582.
GeneID344838.
KEGGhsa:344838.
UCSCuc003evg.3. human.

Organism-specific databases

CTD344838.
GeneCardsGC03M142668.
HGNCHGNC:30131. PAQR9.
HPAHPA052798.
MIM614580. gene.
neXtProtNX_Q6ZVX9.
PharmGKBPA134880790.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG241923.
HOGENOMHOG000115439.
HOVERGENHBG053506.
InParanoidQ6ZVX9.
OMAMTPYVQQ.
PhylomeDBQ6ZVX9.
TreeFamTF319738.

Gene expression databases

ArrayExpressQ6ZVX9.
BgeeQ6ZVX9.
CleanExHS_PAQR9.
GenevestigatorQ6ZVX9.

Family and domain databases

InterProIPR004254. HlyIII-related.
[Graphical view]
PANTHERPTHR20855. PTHR20855. 1 hit.
PfamPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi344838.
NextBio98775.
PROQ6ZVX9.
SOURCESearch...

Entry information

Entry namePAQR9_HUMAN
AccessionPrimary (citable) accession number: Q6ZVX9
Secondary accession number(s): Q147T6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM