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Protein

Membrane progestin receptor epsilon

Gene

PAQR9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).1 Publication1 Publication

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane progestin receptor epsilon1 Publication
Short name:
mPR epsilon1 Publication
Alternative name(s):
Membrane progesterone P4 receptor epsilon1 Publication
Membrane progesterone receptor epsilon1 Publication
Progesterone and adipoQ receptor family member 9
Progestin and adipoQ receptor family member 9
Progestin and adipoQ receptor family member IX
Gene namesi
Name:PAQR9Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000188582.8.
HGNCiHGNC:30131. PAQR9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 86CytoplasmicSequence analysisAdd BLAST86
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 116ExtracellularSequence analysis9
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 162CytoplasmicSequence analysisAdd BLAST25
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 205ExtracellularSequence analysisAdd BLAST22
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 243CytoplasmicSequence analysisAdd BLAST17
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 301ExtracellularSequence analysisAdd BLAST37
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Topological domaini323 – 343CytoplasmicSequence analysisAdd BLAST21
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 377ExtracellularSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi344838.
OpenTargetsiENSG00000188582.
PharmGKBiPA134880790.

Polymorphism and mutation databases

BioMutaiPAQR9.
DMDMi51701778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188521 – 377Membrane progestin receptor epsilonAdd BLAST377

Proteomic databases

PaxDbiQ6ZVX9.
PeptideAtlasiQ6ZVX9.
PRIDEiQ6ZVX9.

PTM databases

iPTMnetiQ6ZVX9.
PhosphoSitePlusiQ6ZVX9.

Expressioni

Tissue specificityi

Expression levels vary widely in a range of tissues (PubMed:16044242). Expressed in the brain, at high level in the pituitary gland and also in hypothalamus, limbic system, caudate nucleus accumens, pons and olfactory bulb (PubMed:23161870).2 Publications

Gene expression databases

BgeeiENSG00000188582.
CleanExiHS_PAQR9.
ExpressionAtlasiQ6ZVX9. baseline and differential.
GenevisibleiQ6ZVX9. HS.

Organism-specific databases

HPAiHPA052798.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000341564.

Structurei

3D structure databases

ProteinModelPortaliQ6ZVX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0748. Eukaryota.
COG1272. LUCA.
GeneTreeiENSGT00530000062965.
HOGENOMiHOG000115439.
HOVERGENiHBG053506.
InParanoidiQ6ZVX9.
OMAiVMTPYVQ.
OrthoDBiEOG091G0949.
PhylomeDBiQ6ZVX9.
TreeFamiTF319738.

Family and domain databases

InterProiView protein in InterPro
IPR004254. AdipoR/HlyIII-related.
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiView protein in Pfam
PF03006. HlyIII. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ZVX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRRLQPRGA GTKGPPAPAP AASGAARNSH SAASRDPPAS AKPLLRWDEV
60 70 80 90 100
PDDFVECFIL SGYRRLPCTA QECLASVLKP TNETLNFWTH FIPLLLFLSK
110 120 130 140 150
FCRLFFLSGG DVPFHHPWLL PLWCYASGVL LTFAMSCTAH VFSCLSLRLR
160 170 180 190 200
AAFFYLDYAS ISYYGFGSTV AYYYYLLPGL SLLDARVMTP YLQQRLGWHV
210 220 230 240 250
DCTRLIAAYR ALVLPVAFVL AVACTVACCK SRTDWCTYPF ALRTFVFVMP
260 270 280 290 300
LSMACPIMLE SWLFDLRGEN PTLFVHFYRR YFWLVVAAFF NVSKIPERIQ
310 320 330 340 350
PGLFDIIGHS HQLFHIFTFL SIYDQVYYVE EGLRQFLQAP PAAPTFSGTV
360 370
GYMLLLVVCL GLVIRKFLNS SEFCSKK
Length:377
Mass (Da):42,692
Last modified:July 5, 2004 - v1
Checksum:iC1708C12C5C5A7C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424287 mRNA. Translation: AAR08375.1.
AK123932 mRNA. Translation: BAC85729.1.
BC118666 mRNA. Translation: AAI18667.1.
BC122527 mRNA. Translation: AAI22528.1.
CCDSiCCDS3128.1.
RefSeqiNP_940906.1. NM_198504.2.
UniGeneiHs.408385.
Hs.656111.

Genome annotation databases

EnsembliENST00000340634; ENSP00000341564; ENSG00000188582.
GeneIDi344838.
KEGGihsa:344838.
UCSCiuc003evg.5. human.

Similar proteinsi

Entry informationi

Entry nameiPAQR9_HUMAN
AccessioniPrimary (citable) accession number: Q6ZVX9
Secondary accession number(s): Q147T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families