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Protein

F-box only protein 50

Gene

NCCRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Promotes cell proliferation.1 Publication

GO - Biological processi

  • positive regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 50
Alternative name(s):
NCC receptor protein 1 homolog
Short name:
NCCRP-1
Non-specific cytotoxic cell receptor protein 1 homolog
Gene namesi
Name:NCCRP1
Synonyms:FBXO50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:33739. NCCRP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164723566.

Polymorphism and mutation databases

BioMutaiNCCRP1.
DMDMi74738333.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275F-box only protein 50PRO_0000326028Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 311PhosphoserineBy similarity
Modified residuei37 – 371PhosphoserineBy similarity
Modified residuei49 – 491PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZVX7.
MaxQBiQ6ZVX7.
PaxDbiQ6ZVX7.
PeptideAtlasiQ6ZVX7.
PRIDEiQ6ZVX7.

PTM databases

iPTMnetiQ6ZVX7.
PhosphoSiteiQ6ZVX7.

Expressioni

Tissue specificityi

Expressed in the esophagus, oral cavity, skin, tongue and reproductive organs.1 Publication

Gene expression databases

BgeeiQ6ZVX7.
CleanExiHS_NCCRP1.

Organism-specific databases

HPAiHPA052812.

Interactioni

Protein-protein interaction databases

BioGridi131204. 22 interactions.
IntActiQ6ZVX7. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6ZVX7.
SMRiQ6ZVX7. Positions 103-272.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini95 – 273179FBAPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi26 – 6439Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 FBA (F-box associated) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IXB8. Eukaryota.
ENOG4111KW8. LUCA.
GeneTreeiENSGT00390000003865.
HOGENOMiHOG000113747.
HOVERGENiHBG099012.
InParanoidiQ6ZVX7.
OMAiLPQRLTW.
OrthoDBiEOG7DRJ3R.
PhylomeDBiQ6ZVX7.
TreeFamiTF320527.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM01198. FBA. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZVX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEVREGHAL GGGMEADGPA SLQELPPSPR SPSPPPSPPP LPSPPSLPSP
60 70 80 90 100
AAPEAPELPE PAQPSEAHAR QLLLEEWGPL SGGLELPQRL TWKLLLLRRP
110 120 130 140 150
LYRNLLRSPN PEGINIYEPA PPTGPTQRPL ETLGNFRGWY IRTEKLQQNQ
160 170 180 190 200
SWTVKQQCVD LLAEGLWEEL LDDEQPAITV MDWFEDSRLD ACVYELHVWL
210 220 230 240 250
LAADRRTVIA QHHVAPRTSG RGPPGRWVQV SHVFRHYGPG VRFIHFLHKA
260 270
KNRMEPGGLR RTRVTDSSVS VQLRE
Length:275
Mass (Da):30,847
Last modified:July 5, 2004 - v1
Checksum:iFB9C700E1799E50E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123941 mRNA. Translation: BAC85732.1.
AC011443 Genomic DNA. No translation available.
BC067874 mRNA. Translation: AAH67874.2.
BC092493 mRNA. Translation: AAH92493.1.
CCDSiCCDS12529.1.
RefSeqiNP_001001414.1. NM_001001414.1.
UniGeneiHs.726934.

Genome annotation databases

EnsembliENST00000339852; ENSP00000342137; ENSG00000188505.
GeneIDi342897.
KEGGihsa:342897.
UCSCiuc002okq.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123941 mRNA. Translation: BAC85732.1.
AC011443 Genomic DNA. No translation available.
BC067874 mRNA. Translation: AAH67874.2.
BC092493 mRNA. Translation: AAH92493.1.
CCDSiCCDS12529.1.
RefSeqiNP_001001414.1. NM_001001414.1.
UniGeneiHs.726934.

3D structure databases

ProteinModelPortaliQ6ZVX7.
SMRiQ6ZVX7. Positions 103-272.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131204. 22 interactions.
IntActiQ6ZVX7. 2 interactions.

PTM databases

iPTMnetiQ6ZVX7.
PhosphoSiteiQ6ZVX7.

Polymorphism and mutation databases

BioMutaiNCCRP1.
DMDMi74738333.

Proteomic databases

EPDiQ6ZVX7.
MaxQBiQ6ZVX7.
PaxDbiQ6ZVX7.
PeptideAtlasiQ6ZVX7.
PRIDEiQ6ZVX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339852; ENSP00000342137; ENSG00000188505.
GeneIDi342897.
KEGGihsa:342897.
UCSCiuc002okq.2. human.

Organism-specific databases

CTDi342897.
GeneCardsiNCCRP1.
HGNCiHGNC:33739. NCCRP1.
HPAiHPA052812.
MIMi615901. gene.
neXtProtiNX_Q6ZVX7.
PharmGKBiPA164723566.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXB8. Eukaryota.
ENOG4111KW8. LUCA.
GeneTreeiENSGT00390000003865.
HOGENOMiHOG000113747.
HOVERGENiHBG099012.
InParanoidiQ6ZVX7.
OMAiLPQRLTW.
OrthoDBiEOG7DRJ3R.
PhylomeDBiQ6ZVX7.
TreeFamiTF320527.

Miscellaneous databases

ChiTaRSiNCCRP1. human.
GenomeRNAii342897.
PROiQ6ZVX7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZVX7.
CleanExiHS_NCCRP1.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM01198. FBA. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "Characterization of non-specific cytotoxic cell receptor protein 1: a new member of the lectin-type subfamily of F-box proteins."
    Kallio H., Tolvanen M., Janis J., Pan P.W., Laurila E., Kallioniemi A., Kilpinen S., Tuominen V.J., Isola J., Valjakka J., Pastorekova S., Pastorek J., Parkkila S.
    PLoS ONE 6:E27152-E27152(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiFBX50_HUMAN
AccessioniPrimary (citable) accession number: Q6ZVX7
Secondary accession number(s): Q6NVV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.