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Protein

F-box only protein 50

Gene

NCCRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Promotes cell proliferation.1 Publication

GO - Biological processi

  • positive regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31570-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 50
Alternative name(s):
NCC receptor protein 1 homolog
Short name:
NCCRP-1
Non-specific cytotoxic cell receptor protein 1 homolog
Gene namesi
Name:NCCRP1
Synonyms:FBXO50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:33739. NCCRP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188505.
PharmGKBiPA164723566.

Polymorphism and mutation databases

BioMutaiNCCRP1.
DMDMi74738333.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003260281 – 275F-box only protein 50Add BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineBy similarity1
Modified residuei37PhosphoserineBy similarity1
Modified residuei49PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZVX7.
MaxQBiQ6ZVX7.
PaxDbiQ6ZVX7.
PeptideAtlasiQ6ZVX7.
PRIDEiQ6ZVX7.

PTM databases

iPTMnetiQ6ZVX7.
PhosphoSitePlusiQ6ZVX7.

Expressioni

Tissue specificityi

Expressed in the esophagus, oral cavity, skin, tongue and reproductive organs.1 Publication

Gene expression databases

BgeeiENSG00000188505.
CleanExiHS_NCCRP1.

Organism-specific databases

HPAiHPA052812.

Interactioni

Protein-protein interaction databases

BioGridi131204. 22 interactors.
IntActiQ6ZVX7. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ6ZVX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 273FBAPROSITE-ProRule annotationAdd BLAST179

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi26 – 64Pro-richAdd BLAST39

Sequence similaritiesi

Contains 1 FBA (F-box associated) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IXB8. Eukaryota.
ENOG4111KW8. LUCA.
GeneTreeiENSGT00390000003865.
HOGENOMiHOG000113747.
HOVERGENiHBG099012.
InParanoidiQ6ZVX7.
OMAiLPQRLTW.
OrthoDBiEOG091G0G3L.
PhylomeDBiQ6ZVX7.
TreeFamiTF320527.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM01198. FBA. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZVX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEVREGHAL GGGMEADGPA SLQELPPSPR SPSPPPSPPP LPSPPSLPSP
60 70 80 90 100
AAPEAPELPE PAQPSEAHAR QLLLEEWGPL SGGLELPQRL TWKLLLLRRP
110 120 130 140 150
LYRNLLRSPN PEGINIYEPA PPTGPTQRPL ETLGNFRGWY IRTEKLQQNQ
160 170 180 190 200
SWTVKQQCVD LLAEGLWEEL LDDEQPAITV MDWFEDSRLD ACVYELHVWL
210 220 230 240 250
LAADRRTVIA QHHVAPRTSG RGPPGRWVQV SHVFRHYGPG VRFIHFLHKA
260 270
KNRMEPGGLR RTRVTDSSVS VQLRE
Length:275
Mass (Da):30,847
Last modified:July 5, 2004 - v1
Checksum:iFB9C700E1799E50E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123941 mRNA. Translation: BAC85732.1.
AC011443 Genomic DNA. No translation available.
BC067874 mRNA. Translation: AAH67874.2.
BC092493 mRNA. Translation: AAH92493.1.
CCDSiCCDS12529.1.
RefSeqiNP_001001414.1. NM_001001414.1.
UniGeneiHs.726934.

Genome annotation databases

EnsembliENST00000339852; ENSP00000342137; ENSG00000188505.
GeneIDi342897.
KEGGihsa:342897.
UCSCiuc002okq.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123941 mRNA. Translation: BAC85732.1.
AC011443 Genomic DNA. No translation available.
BC067874 mRNA. Translation: AAH67874.2.
BC092493 mRNA. Translation: AAH92493.1.
CCDSiCCDS12529.1.
RefSeqiNP_001001414.1. NM_001001414.1.
UniGeneiHs.726934.

3D structure databases

ProteinModelPortaliQ6ZVX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131204. 22 interactors.
IntActiQ6ZVX7. 2 interactors.

PTM databases

iPTMnetiQ6ZVX7.
PhosphoSitePlusiQ6ZVX7.

Polymorphism and mutation databases

BioMutaiNCCRP1.
DMDMi74738333.

Proteomic databases

EPDiQ6ZVX7.
MaxQBiQ6ZVX7.
PaxDbiQ6ZVX7.
PeptideAtlasiQ6ZVX7.
PRIDEiQ6ZVX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339852; ENSP00000342137; ENSG00000188505.
GeneIDi342897.
KEGGihsa:342897.
UCSCiuc002okq.2. human.

Organism-specific databases

CTDi342897.
GeneCardsiNCCRP1.
HGNCiHGNC:33739. NCCRP1.
HPAiHPA052812.
MIMi615901. gene.
neXtProtiNX_Q6ZVX7.
OpenTargetsiENSG00000188505.
PharmGKBiPA164723566.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXB8. Eukaryota.
ENOG4111KW8. LUCA.
GeneTreeiENSGT00390000003865.
HOGENOMiHOG000113747.
HOVERGENiHBG099012.
InParanoidiQ6ZVX7.
OMAiLPQRLTW.
OrthoDBiEOG091G0G3L.
PhylomeDBiQ6ZVX7.
TreeFamiTF320527.

Enzyme and pathway databases

BioCyciZFISH:G66-31570-MONOMER.

Miscellaneous databases

ChiTaRSiNCCRP1. human.
GenomeRNAii342897.
PROiQ6ZVX7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188505.
CleanExiHS_NCCRP1.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM01198. FBA. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX50_HUMAN
AccessioniPrimary (citable) accession number: Q6ZVX7
Secondary accession number(s): Q6NVV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.