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Protein

Inactive polyglycylase TTLL10

Gene

TTLL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inactive polyglycylase.1 Publication

Caution

In human, the presence of a Lys-467 instead of a Thr as well as the presence of a variant at position 448 inactivates the polyglycylase activity. It explains the absence of polyglycylation in human sperm (PubMed:19524510).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei375ATPBy similarity1
Binding sitei377ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi362 – 365ATP bindingBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8955332 Carboxyterminal post-translational modifications of tubulin

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive polyglycylase TTLL10
Alternative name(s):
Tubulin--tyrosine ligase-like protein 10
Gene namesi
Name:TTLL10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162571.13
HGNCiHGNC:26693 TTLL10
neXtProtiNX_Q6ZVT0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi448S → N: Recovers polyglycylase activity; when associated with T-467. 1 Publication1
Mutagenesisi467K → T: Recovers polyglycylase activity; when associated with N-448. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000162571
PharmGKBiPA142670679

Polymorphism and mutation databases

BioMutaiTTLL10
DMDMi172046174

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245201 – 673Inactive polyglycylase TTLL10Add BLAST673

Proteomic databases

PaxDbiQ6ZVT0
PeptideAtlasiQ6ZVT0
PRIDEiQ6ZVT0
ProteomicsDBi68439
68440 [Q6ZVT0-2]
68441 [Q6ZVT0-3]

PTM databases

iPTMnetiQ6ZVT0
PhosphoSitePlusiQ6ZVT0

Expressioni

Gene expression databases

BgeeiENSG00000162571
CleanExiHS_TTLL10
ExpressionAtlasiQ6ZVT0 baseline and differential
GenevisibleiQ6ZVT0 HS

Organism-specific databases

HPAiHPA042712

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi129020, 10 interactors
IntActiQ6ZVT0, 17 interactors
MINTiQ6ZVT0
STRINGi9606.ENSP00000368591

Structurei

3D structure databases

ProteinModelPortaliQ6ZVT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 552TTLPROSITE-ProRule annotationAdd BLAST398

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi586 – 627Pro-richAdd BLAST42

Phylogenomic databases

eggNOGiKOG2157 Eukaryota
ENOG410XQDM LUCA
GeneTreeiENSGT00760000118951
HOGENOMiHOG000049156
HOVERGENiHBG108614
InParanoidiQ6ZVT0
OMAiEHLNRYI
OrthoDBiEOG091G0F6S
PhylomeDBiQ6ZVT0
TreeFamiTF329363

Family and domain databases

InterProiView protein in InterPro
IPR004344 TTL/TTLL_fam
IPR027752 TTLL10
PANTHERiPTHR12241:SF72 PTHR12241:SF72, 1 hit
PfamiView protein in Pfam
PF03133 TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221 TTL, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZVT0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDHSCTRFIH RRGPPTRTRA GFKRGKRPRI QQRPRARVSG TIPASRLHPA
60 70 80 90 100
PASQPGPCPA PGHCPVGPAH ERPMGSSQEE GLRCQPSQPD HDADGHCGPD
110 120 130 140 150
LEGAERASAT PGPPGLLNSH RPADSDDTNA AGPSAALLEG LLLGGGKPSP
160 170 180 190 200
HSTRPGPFFY IGGSNGATII SSYCKSKGWQ RIHDSRRDDY TLKWCEVKSR
210 220 230 240 250
DSYGSFREGE QLLYQLPNNK LLTTKIGLLS TLRGRARAMS KASKVPGGVQ
260 270 280 290 300
ARLEKDAAAP ALEDLPWTSP GYLRPQRVLR MEEFFPETYR LDLKHEREAF
310 320 330 340 350
FTLFDETQIW ICKPTASNQG KGIFLLRNQE EVAALQAKTR SMEDDPIHHK
360 370 380 390 400
TPFRGPQARV VQRYIQNPLL VDGRKFDVRS YLLIACTTPY MIFFGHGYAR
410 420 430 440 450
LTLSLYDPHS SDLGGHLTNQ FMQKKSPLYM LLKEHTVWSM EHLNRYISDT
460 470 480 490 500
FWKARGLAKD WVFTTLKKRM QQIMAHCFLA AKPKLDCKLG YFDLIGCDFL
510 520 530 540 550
IDDNFKVWLL EMNSNPALHT NCEVLKEVIP GVVIETLDLV LETFRKSLRG
560 570 580 590 600
QKMLPLLSQR RFVLLHNGEA DPRPHLGGSC SLRRWPPLPT RQAKSSGPPM
610 620 630 640 650
PHAPDQPGAR RPAPPPLVPQ RPRPPGPDLD SAHDGEPQAP GTEQSGTGNR
660 670
HPAQEPSPGT AKEEREEPEN ARP
Length:673
Mass (Da):75,042
Last modified:March 18, 2008 - v2
Checksum:iAF81F9215D73A446
GO
Isoform 2 (identifier: Q6ZVT0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Show »
Length:600
Mass (Da):67,045
Checksum:iCBD7710C8CFFAFEA
GO
Isoform 3 (identifier: Q6ZVT0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.
     468-477: KRMQQIMAHC → VRPLCPPVWE
     478-673: Missing.

Show »
Length:404
Mass (Da):45,434
Checksum:i2C8EA3EDFE7C0222
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti214Y → D in BAC85781 (PubMed:14702039).Curated1
Sequence conflicti241K → R in BAC04164 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039806130A → T in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs139755178Ensembl.1
Natural variantiVAR_039807249V → A. Corresponds to variant dbSNP:rs13374146Ensembl.1
Natural variantiVAR_039808448S → N. Corresponds to variant dbSNP:rs1320571Ensembl.1
Natural variantiVAR_058480578G → D. Corresponds to variant dbSNP:rs2274791Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0322621 – 73Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_032263468 – 477KRMQQIMAHC → VRPLCPPVWE in isoform 3. 2 Publications10
Alternative sequenceiVSP_032264478 – 673Missing in isoform 3. 2 PublicationsAdd BLAST196

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093438 mRNA Translation: BAC04164.1
AK124125 mRNA Translation: BAC85781.1
AL162741 Genomic DNA No translation available.
AL390719 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56285.1
BC126152 mRNA Translation: AAI26153.1
BC126154 mRNA Translation: AAI26155.1
CCDSiCCDS44036.1 [Q6ZVT0-1]
CCDS8.1 [Q6ZVT0-3]
RefSeqiNP_001123517.1, NM_001130045.1 [Q6ZVT0-1]
NP_694986.2, NM_153254.2 [Q6ZVT0-3]
XP_005244795.1, XM_005244738.1 [Q6ZVT0-2]
XP_011539479.1, XM_011541177.2 [Q6ZVT0-1]
XP_016856401.1, XM_017000912.1 [Q6ZVT0-1]
UniGeneiHs.454835

Genome annotation databases

EnsembliENST00000379288; ENSP00000368590; ENSG00000162571 [Q6ZVT0-3]
ENST00000379289; ENSP00000368591; ENSG00000162571 [Q6ZVT0-1]
ENST00000379290; ENSP00000368592; ENSG00000162571 [Q6ZVT0-1]
GeneIDi254173
KEGGihsa:254173
UCSCiuc001acy.2 human [Q6ZVT0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTTL10_HUMAN
AccessioniPrimary (citable) accession number: Q6ZVT0
Secondary accession number(s): B1AMF6
, Q5T2W4, Q5T2W5, Q8N9X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: June 20, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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