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Protein

Inactive polyglycylase TTLL10

Gene

TTLL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inactive polyglycylase.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei375 – 3751ATPBy similarity
Binding sitei377 – 3771ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi362 – 3654ATP bindingBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive polyglycylase TTLL10
Alternative name(s):
Tubulin--tyrosine ligase-like protein 10
Gene namesi
Name:TTLL10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26693. TTLL10.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi448 – 4481S → N: Recovers polyglycylase activity; when associated with T-467. 1 Publication
Mutagenesisi467 – 4671K → T: Recovers polyglycylase activity; when associated with N-448. 1 Publication

Organism-specific databases

PharmGKBiPA142670679.

Polymorphism and mutation databases

BioMutaiTTLL10.
DMDMi172046174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 673673Inactive polyglycylase TTLL10PRO_0000324520Add
BLAST

Proteomic databases

PaxDbiQ6ZVT0.
PRIDEiQ6ZVT0.

PTM databases

PhosphoSiteiQ6ZVT0.

Expressioni

Gene expression databases

BgeeiQ6ZVT0.
CleanExiHS_TTLL10.
ExpressionAtlasiQ6ZVT0. baseline and differential.
GenevisibleiQ6ZVT0. HS.

Organism-specific databases

HPAiHPA042712.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CADPSA2RRN73EBI-7844656,EBI-10179719
CEP70Q8NHQ13EBI-7844656,EBI-739624
FHL3Q136433EBI-7844656,EBI-741101
KRT40Q6A1623EBI-7844656,EBI-10171697
MDFIQ997503EBI-7844656,EBI-724076
NAP1L1P552095EBI-7844656,EBI-356392
PNMA2Q9UL423EBI-7844656,EBI-302355
RBPMSQ930623EBI-7844656,EBI-740322
THAP1Q9NVV93EBI-7844656,EBI-741515
TRIM27P143733EBI-7844656,EBI-719493
TRIP6Q156543EBI-7844656,EBI-742327

Protein-protein interaction databases

BioGridi129020. 10 interactions.
IntActiQ6ZVT0. 11 interactions.
MINTiMINT-6493200.
STRINGi9606.ENSP00000368591.

Structurei

3D structure databases

ProteinModelPortaliQ6ZVT0.
SMRiQ6ZVT0. Positions 284-517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini155 – 552398TTLPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi586 – 62742Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 TTL domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2157. Eukaryota.
ENOG410XQDM. LUCA.
GeneTreeiENSGT00760000118951.
HOGENOMiHOG000049156.
HOVERGENiHBG108614.
InParanoidiQ6ZVT0.
OMAiHCFLAAK.
OrthoDBiEOG7XDBF8.
PhylomeDBiQ6ZVT0.
TreeFamiTF329363.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
IPR027752. TTLL10.
[Graphical view]
PANTHERiPTHR12241:SF110. PTHR12241:SF110. 2 hits.
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZVT0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDHSCTRFIH RRGPPTRTRA GFKRGKRPRI QQRPRARVSG TIPASRLHPA
60 70 80 90 100
PASQPGPCPA PGHCPVGPAH ERPMGSSQEE GLRCQPSQPD HDADGHCGPD
110 120 130 140 150
LEGAERASAT PGPPGLLNSH RPADSDDTNA AGPSAALLEG LLLGGGKPSP
160 170 180 190 200
HSTRPGPFFY IGGSNGATII SSYCKSKGWQ RIHDSRRDDY TLKWCEVKSR
210 220 230 240 250
DSYGSFREGE QLLYQLPNNK LLTTKIGLLS TLRGRARAMS KASKVPGGVQ
260 270 280 290 300
ARLEKDAAAP ALEDLPWTSP GYLRPQRVLR MEEFFPETYR LDLKHEREAF
310 320 330 340 350
FTLFDETQIW ICKPTASNQG KGIFLLRNQE EVAALQAKTR SMEDDPIHHK
360 370 380 390 400
TPFRGPQARV VQRYIQNPLL VDGRKFDVRS YLLIACTTPY MIFFGHGYAR
410 420 430 440 450
LTLSLYDPHS SDLGGHLTNQ FMQKKSPLYM LLKEHTVWSM EHLNRYISDT
460 470 480 490 500
FWKARGLAKD WVFTTLKKRM QQIMAHCFLA AKPKLDCKLG YFDLIGCDFL
510 520 530 540 550
IDDNFKVWLL EMNSNPALHT NCEVLKEVIP GVVIETLDLV LETFRKSLRG
560 570 580 590 600
QKMLPLLSQR RFVLLHNGEA DPRPHLGGSC SLRRWPPLPT RQAKSSGPPM
610 620 630 640 650
PHAPDQPGAR RPAPPPLVPQ RPRPPGPDLD SAHDGEPQAP GTEQSGTGNR
660 670
HPAQEPSPGT AKEEREEPEN ARP
Length:673
Mass (Da):75,042
Last modified:March 18, 2008 - v2
Checksum:iAF81F9215D73A446
GO
Isoform 2 (identifier: Q6ZVT0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Show »
Length:600
Mass (Da):67,045
Checksum:iCBD7710C8CFFAFEA
GO
Isoform 3 (identifier: Q6ZVT0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.
     468-477: KRMQQIMAHC → VRPLCPPVWE
     478-673: Missing.

Show »
Length:404
Mass (Da):45,434
Checksum:i2C8EA3EDFE7C0222
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti214 – 2141Y → D in BAC85781 (PubMed:14702039).Curated
Sequence conflicti241 – 2411K → R in BAC04164 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti130 – 1301A → T in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_039806
Natural varianti249 – 2491V → A.
Corresponds to variant rs13374146 [ dbSNP | Ensembl ].
VAR_039807
Natural varianti448 – 4481S → N.
Corresponds to variant rs1320571 [ dbSNP | Ensembl ].
VAR_039808
Natural varianti578 – 5781G → D.
Corresponds to variant rs2274791 [ dbSNP | Ensembl ].
VAR_058480

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7373Missing in isoform 2 and isoform 3. 2 PublicationsVSP_032262Add
BLAST
Alternative sequencei468 – 47710KRMQQIMAHC → VRPLCPPVWE in isoform 3. 2 PublicationsVSP_032263
Alternative sequencei478 – 673196Missing in isoform 3. 2 PublicationsVSP_032264Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093438 mRNA. Translation: BAC04164.1.
AK124125 mRNA. Translation: BAC85781.1.
AL390719, AL162741 Genomic DNA. Translation: CAI14321.1.
AL390719 Genomic DNA. Translation: CAI14322.1.
AL162741, AL390719 Genomic DNA. Translation: CAI23266.1.
CH471183 Genomic DNA. Translation: EAW56285.1.
BC126152 mRNA. Translation: AAI26153.1.
BC126154 mRNA. Translation: AAI26155.1.
CCDSiCCDS44036.1. [Q6ZVT0-1]
CCDS8.1. [Q6ZVT0-3]
RefSeqiNP_001123517.1. NM_001130045.1. [Q6ZVT0-1]
NP_694986.2. NM_153254.2. [Q6ZVT0-3]
XP_005244795.1. XM_005244738.1. [Q6ZVT0-2]
XP_011539479.1. XM_011541177.1. [Q6ZVT0-1]
UniGeneiHs.454835.

Genome annotation databases

EnsembliENST00000379288; ENSP00000368590; ENSG00000162571. [Q6ZVT0-3]
ENST00000379289; ENSP00000368591; ENSG00000162571. [Q6ZVT0-1]
ENST00000379290; ENSP00000368592; ENSG00000162571. [Q6ZVT0-1]
GeneIDi254173.
KEGGihsa:254173.
UCSCiuc001acy.2. human. [Q6ZVT0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093438 mRNA. Translation: BAC04164.1.
AK124125 mRNA. Translation: BAC85781.1.
AL390719, AL162741 Genomic DNA. Translation: CAI14321.1.
AL390719 Genomic DNA. Translation: CAI14322.1.
AL162741, AL390719 Genomic DNA. Translation: CAI23266.1.
CH471183 Genomic DNA. Translation: EAW56285.1.
BC126152 mRNA. Translation: AAI26153.1.
BC126154 mRNA. Translation: AAI26155.1.
CCDSiCCDS44036.1. [Q6ZVT0-1]
CCDS8.1. [Q6ZVT0-3]
RefSeqiNP_001123517.1. NM_001130045.1. [Q6ZVT0-1]
NP_694986.2. NM_153254.2. [Q6ZVT0-3]
XP_005244795.1. XM_005244738.1. [Q6ZVT0-2]
XP_011539479.1. XM_011541177.1. [Q6ZVT0-1]
UniGeneiHs.454835.

3D structure databases

ProteinModelPortaliQ6ZVT0.
SMRiQ6ZVT0. Positions 284-517.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129020. 10 interactions.
IntActiQ6ZVT0. 11 interactions.
MINTiMINT-6493200.
STRINGi9606.ENSP00000368591.

PTM databases

PhosphoSiteiQ6ZVT0.

Polymorphism and mutation databases

BioMutaiTTLL10.
DMDMi172046174.

Proteomic databases

PaxDbiQ6ZVT0.
PRIDEiQ6ZVT0.

Protocols and materials databases

DNASUi254173.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379288; ENSP00000368590; ENSG00000162571. [Q6ZVT0-3]
ENST00000379289; ENSP00000368591; ENSG00000162571. [Q6ZVT0-1]
ENST00000379290; ENSP00000368592; ENSG00000162571. [Q6ZVT0-1]
GeneIDi254173.
KEGGihsa:254173.
UCSCiuc001acy.2. human. [Q6ZVT0-1]

Organism-specific databases

CTDi254173.
GeneCardsiTTLL10.
H-InvDBHIX0000014.
HGNCiHGNC:26693. TTLL10.
HPAiHPA042712.
neXtProtiNX_Q6ZVT0.
PharmGKBiPA142670679.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2157. Eukaryota.
ENOG410XQDM. LUCA.
GeneTreeiENSGT00760000118951.
HOGENOMiHOG000049156.
HOVERGENiHBG108614.
InParanoidiQ6ZVT0.
OMAiHCFLAAK.
OrthoDBiEOG7XDBF8.
PhylomeDBiQ6ZVT0.
TreeFamiTF329363.

Miscellaneous databases

GenomeRNAii254173.
NextBioi92279.
PROiQ6ZVT0.

Gene expression databases

BgeeiQ6ZVT0.
CleanExiHS_TTLL10.
ExpressionAtlasiQ6ZVT0. baseline and differential.
GenevisibleiQ6ZVT0. HS.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
IPR027752. TTLL10.
[Graphical view]
PANTHERiPTHR12241:SF110. PTHR12241:SF110. 2 hits.
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  5. "Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation."
    Rogowski K., Juge F., van Dijk J., Wloga D., Strub J.-M., Levilliers N., Thomas D., Bre M.-H., Van Dorsselaer A., Gaertig J., Janke C.
    Cell 137:1076-1087(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF SER-448 AND LYS-467.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-130.

Entry informationi

Entry nameiTTL10_HUMAN
AccessioniPrimary (citable) accession number: Q6ZVT0
Secondary accession number(s): B1AMF6
, Q5T2W4, Q5T2W5, Q8N9X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: March 16, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

In human, the presence of a Lys-467 instead of a Thr as well as the presence of a variant at position 448 inactivates the polyglycylase activity. It explains the absence of polyglycylation in human sperm (PubMed:19524510).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.