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Protein

Inactive polyglycylase TTLL10

Gene

TTLL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inactive polyglycylase.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei375ATPBy similarity1
Binding sitei377ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi362 – 365ATP bindingBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive polyglycylase TTLL10
Alternative name(s):
Tubulin--tyrosine ligase-like protein 10
Gene namesi
Name:TTLL10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26693. TTLL10.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi448S → N: Recovers polyglycylase activity; when associated with T-467. 1 Publication1
Mutagenesisi467K → T: Recovers polyglycylase activity; when associated with N-448. 1 Publication1

Organism-specific databases

DisGeNETi254173.
OpenTargetsiENSG00000162571.
PharmGKBiPA142670679.

Polymorphism and mutation databases

BioMutaiTTLL10.
DMDMi172046174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245201 – 673Inactive polyglycylase TTLL10Add BLAST673

Proteomic databases

PaxDbiQ6ZVT0.
PeptideAtlasiQ6ZVT0.
PRIDEiQ6ZVT0.

PTM databases

iPTMnetiQ6ZVT0.
PhosphoSitePlusiQ6ZVT0.

Expressioni

Gene expression databases

BgeeiENSG00000162571.
CleanExiHS_TTLL10.
ExpressionAtlasiQ6ZVT0. baseline and differential.
GenevisibleiQ6ZVT0. HS.

Organism-specific databases

HPAiHPA042712.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi129020. 10 interactors.
IntActiQ6ZVT0. 17 interactors.
MINTiMINT-6493200.
STRINGi9606.ENSP00000368591.

Structurei

3D structure databases

ProteinModelPortaliQ6ZVT0.
SMRiQ6ZVT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 552TTLPROSITE-ProRule annotationAdd BLAST398

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi586 – 627Pro-richAdd BLAST42

Phylogenomic databases

eggNOGiKOG2157. Eukaryota.
ENOG410XQDM. LUCA.
GeneTreeiENSGT00760000118951.
HOGENOMiHOG000049156.
HOVERGENiHBG108614.
InParanoidiQ6ZVT0.
OMAiLEDLPWT.
OrthoDBiEOG091G0F6S.
PhylomeDBiQ6ZVT0.
TreeFamiTF329363.

Family and domain databases

InterProiView protein in InterPro
IPR004344. TTL/TTLL_fam.
IPR027752. TTLL10.
PANTHERiPTHR12241:SF117. PTHR12241:SF117. 1 hit.
PfamiView protein in Pfam
PF03133. TTL. 1 hit.
PROSITEiView protein in PROSITE
PS51221. TTL. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZVT0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDHSCTRFIH RRGPPTRTRA GFKRGKRPRI QQRPRARVSG TIPASRLHPA
60 70 80 90 100
PASQPGPCPA PGHCPVGPAH ERPMGSSQEE GLRCQPSQPD HDADGHCGPD
110 120 130 140 150
LEGAERASAT PGPPGLLNSH RPADSDDTNA AGPSAALLEG LLLGGGKPSP
160 170 180 190 200
HSTRPGPFFY IGGSNGATII SSYCKSKGWQ RIHDSRRDDY TLKWCEVKSR
210 220 230 240 250
DSYGSFREGE QLLYQLPNNK LLTTKIGLLS TLRGRARAMS KASKVPGGVQ
260 270 280 290 300
ARLEKDAAAP ALEDLPWTSP GYLRPQRVLR MEEFFPETYR LDLKHEREAF
310 320 330 340 350
FTLFDETQIW ICKPTASNQG KGIFLLRNQE EVAALQAKTR SMEDDPIHHK
360 370 380 390 400
TPFRGPQARV VQRYIQNPLL VDGRKFDVRS YLLIACTTPY MIFFGHGYAR
410 420 430 440 450
LTLSLYDPHS SDLGGHLTNQ FMQKKSPLYM LLKEHTVWSM EHLNRYISDT
460 470 480 490 500
FWKARGLAKD WVFTTLKKRM QQIMAHCFLA AKPKLDCKLG YFDLIGCDFL
510 520 530 540 550
IDDNFKVWLL EMNSNPALHT NCEVLKEVIP GVVIETLDLV LETFRKSLRG
560 570 580 590 600
QKMLPLLSQR RFVLLHNGEA DPRPHLGGSC SLRRWPPLPT RQAKSSGPPM
610 620 630 640 650
PHAPDQPGAR RPAPPPLVPQ RPRPPGPDLD SAHDGEPQAP GTEQSGTGNR
660 670
HPAQEPSPGT AKEEREEPEN ARP
Length:673
Mass (Da):75,042
Last modified:March 18, 2008 - v2
Checksum:iAF81F9215D73A446
GO
Isoform 2 (identifier: Q6ZVT0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Show »
Length:600
Mass (Da):67,045
Checksum:iCBD7710C8CFFAFEA
GO
Isoform 3 (identifier: Q6ZVT0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.
     468-477: KRMQQIMAHC → VRPLCPPVWE
     478-673: Missing.

Show »
Length:404
Mass (Da):45,434
Checksum:i2C8EA3EDFE7C0222
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti214Y → D in BAC85781 (PubMed:14702039).Curated1
Sequence conflicti241K → R in BAC04164 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039806130A → T in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs139755178Ensembl.1
Natural variantiVAR_039807249V → A. Corresponds to variant dbSNP:rs13374146Ensembl.1
Natural variantiVAR_039808448S → N. Corresponds to variant dbSNP:rs1320571Ensembl.1
Natural variantiVAR_058480578G → D. Corresponds to variant dbSNP:rs2274791Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0322621 – 73Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_032263468 – 477KRMQQIMAHC → VRPLCPPVWE in isoform 3. 2 Publications10
Alternative sequenceiVSP_032264478 – 673Missing in isoform 3. 2 PublicationsAdd BLAST196

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093438 mRNA. Translation: BAC04164.1.
AK124125 mRNA. Translation: BAC85781.1.
AL390719, AL162741 Genomic DNA. Translation: CAI14321.1.
AL390719 Genomic DNA. Translation: CAI14322.1.
AL162741, AL390719 Genomic DNA. Translation: CAI23266.1.
CH471183 Genomic DNA. Translation: EAW56285.1.
BC126152 mRNA. Translation: AAI26153.1.
BC126154 mRNA. Translation: AAI26155.1.
CCDSiCCDS44036.1. [Q6ZVT0-1]
CCDS8.1. [Q6ZVT0-3]
RefSeqiNP_001123517.1. NM_001130045.1. [Q6ZVT0-1]
NP_694986.2. NM_153254.2. [Q6ZVT0-3]
XP_005244795.1. XM_005244738.1. [Q6ZVT0-2]
XP_011539479.1. XM_011541177.2. [Q6ZVT0-1]
XP_016856401.1. XM_017000912.1. [Q6ZVT0-1]
UniGeneiHs.454835.

Genome annotation databases

EnsembliENST00000379288; ENSP00000368590; ENSG00000162571. [Q6ZVT0-3]
ENST00000379289; ENSP00000368591; ENSG00000162571. [Q6ZVT0-1]
ENST00000379290; ENSP00000368592; ENSG00000162571. [Q6ZVT0-1]
GeneIDi254173.
KEGGihsa:254173.
UCSCiuc001acy.2. human. [Q6ZVT0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093438 mRNA. Translation: BAC04164.1.
AK124125 mRNA. Translation: BAC85781.1.
AL390719, AL162741 Genomic DNA. Translation: CAI14321.1.
AL390719 Genomic DNA. Translation: CAI14322.1.
AL162741, AL390719 Genomic DNA. Translation: CAI23266.1.
CH471183 Genomic DNA. Translation: EAW56285.1.
BC126152 mRNA. Translation: AAI26153.1.
BC126154 mRNA. Translation: AAI26155.1.
CCDSiCCDS44036.1. [Q6ZVT0-1]
CCDS8.1. [Q6ZVT0-3]
RefSeqiNP_001123517.1. NM_001130045.1. [Q6ZVT0-1]
NP_694986.2. NM_153254.2. [Q6ZVT0-3]
XP_005244795.1. XM_005244738.1. [Q6ZVT0-2]
XP_011539479.1. XM_011541177.2. [Q6ZVT0-1]
XP_016856401.1. XM_017000912.1. [Q6ZVT0-1]
UniGeneiHs.454835.

3D structure databases

ProteinModelPortaliQ6ZVT0.
SMRiQ6ZVT0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129020. 10 interactors.
IntActiQ6ZVT0. 17 interactors.
MINTiMINT-6493200.
STRINGi9606.ENSP00000368591.

PTM databases

iPTMnetiQ6ZVT0.
PhosphoSitePlusiQ6ZVT0.

Polymorphism and mutation databases

BioMutaiTTLL10.
DMDMi172046174.

Proteomic databases

PaxDbiQ6ZVT0.
PeptideAtlasiQ6ZVT0.
PRIDEiQ6ZVT0.

Protocols and materials databases

DNASUi254173.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379288; ENSP00000368590; ENSG00000162571. [Q6ZVT0-3]
ENST00000379289; ENSP00000368591; ENSG00000162571. [Q6ZVT0-1]
ENST00000379290; ENSP00000368592; ENSG00000162571. [Q6ZVT0-1]
GeneIDi254173.
KEGGihsa:254173.
UCSCiuc001acy.2. human. [Q6ZVT0-1]

Organism-specific databases

CTDi254173.
DisGeNETi254173.
GeneCardsiTTLL10.
H-InvDBHIX0000014.
HGNCiHGNC:26693. TTLL10.
HPAiHPA042712.
neXtProtiNX_Q6ZVT0.
OpenTargetsiENSG00000162571.
PharmGKBiPA142670679.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2157. Eukaryota.
ENOG410XQDM. LUCA.
GeneTreeiENSGT00760000118951.
HOGENOMiHOG000049156.
HOVERGENiHBG108614.
InParanoidiQ6ZVT0.
OMAiLEDLPWT.
OrthoDBiEOG091G0F6S.
PhylomeDBiQ6ZVT0.
TreeFamiTF329363.

Miscellaneous databases

GenomeRNAii254173.
PROiQ6ZVT0.

Gene expression databases

BgeeiENSG00000162571.
CleanExiHS_TTLL10.
ExpressionAtlasiQ6ZVT0. baseline and differential.
GenevisibleiQ6ZVT0. HS.

Family and domain databases

InterProiView protein in InterPro
IPR004344. TTL/TTLL_fam.
IPR027752. TTLL10.
PANTHERiPTHR12241:SF117. PTHR12241:SF117. 1 hit.
PfamiView protein in Pfam
PF03133. TTL. 1 hit.
PROSITEiView protein in PROSITE
PS51221. TTL. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTTL10_HUMAN
AccessioniPrimary (citable) accession number: Q6ZVT0
Secondary accession number(s): B1AMF6
, Q5T2W4, Q5T2W5, Q8N9X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: March 15, 2017
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

In human, the presence of a Lys-467 instead of a Thr as well as the presence of a variant at position 448 inactivates the polyglycylase activity. It explains the absence of polyglycylation in human sperm (PubMed:19524510).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.