ID   SEML_HUMAN              Reviewed;         128 AA.
AC   Q6ZVN7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   24-JAN-2024, entry version 109.
DE   RecName: Full=Putative protein SEM1, isoform 2 {ECO:0000312|HGNC:HGNC:10845};
GN   Name=SEM1 {ECO:0000312|HGNC:HGNC:10845}; Synonyms=C7orf76;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative promoter usage; Named isoforms=2;
CC       Name=2;
CC         IsoId=Q6ZVN7-1; Sequence=Displayed;
CC       Name=1;
CC         IsoId=P60896-1; Sequence=External;
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DR   EMBL; AK124274; BAC85824.1; -; mRNA.
DR   EMBL; AC092031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001188379.1; NM_001201450.1.
DR   RefSeq; NP_001188380.1; NM_001201451.1.
DR   AlphaFoldDB; Q6ZVN7; -.
DR   BioGRID; 135063; 58.
DR   STRING; 9606.ENSP00000481021; -.
DR   BioMuta; SEM1; -.
DR   PaxDb; 9606-ENSP00000481021; -.
DR   Antibodypedia; 30181; 182 antibodies from 28 providers.
DR   Ensembl; ENST00000356686.2; ENSP00000349114.1; ENSG00000127922.10. [Q6ZVN7-1]
DR   UCSC; uc064fom.1; human. [Q6ZVN7-1]
DR   AGR; HGNC:10845; -.
DR   GeneCards; SEM1; -.
DR   HGNC; HGNC:10845; SEM1.
DR   HPA; ENSG00000127922; Low tissue specificity.
DR   MalaCards; SEM1; -.
DR   neXtProt; NX_Q6ZVN7; -.
DR   OpenTargets; ENSG00000127922; -.
DR   VEuPathDB; HostDB:ENSG00000127922; -.
DR   eggNOG; ENOG502TE1I; Eukaryota.
DR   GeneTree; ENSGT00940000162732; -.
DR   HOGENOM; CLU_2009139_0_0_1; -.
DR   InParanoid; Q6ZVN7; -.
DR   PhylomeDB; Q6ZVN7; -.
DR   PathwayCommons; Q6ZVN7; -.
DR   SignaLink; Q6ZVN7; -.
DR   BioGRID-ORCS; 7979; 692 hits in 1156 CRISPR screens.
DR   ChiTaRS; SHFM1; human.
DR   GenomeRNAi; 7979; -.
DR   Pharos; Q6ZVN7; Tbio.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q6ZVN7; Protein.
DR   Bgee; ENSG00000127922; Expressed in calcaneal tendon and 204 other cell types or tissues.
DR   ExpressionAtlas; Q6ZVN7; baseline and differential.
DR   GO; GO:0000502; C:proteasome complex; IBA:GO_Central.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   InterPro; IPR041319; DUF5543.
DR   Pfam; PF17697; DUF5543; 1.
PE   2: Evidence at transcript level;
KW   Alternative promoter usage; Reference proteome.
FT   CHAIN           1..128
FT                   /note="Putative protein SEM1, isoform 2"
FT                   /id="PRO_0000319035"
FT   REGION          22..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        86
FT                   /note="R -> G (in Ref. 1; BAC85824)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   128 AA;  14085 MW;  168AB7945F5ADAB8 CRC64;
     MYCQDSNICA VFAVQGGKVG RKHGIKRGRR PSIRSPAQRA RGPWIHESKH PAFAKQQINL
     EMPNSRATTE LAWVCSSTSR KKKWARSLTL STAPLSPPPS LVHCEDCSCL PGCHSGDLYN
     LAPAERTC
//