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Protein

UPF0606 protein KIAA1549L

Gene

KIAA1549L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0606 protein KIAA1549L
Gene namesi
Name:KIAA1549L
Synonyms:C11orf41, C11orf69
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24836. KIAA1549L.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1180 – 1200HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25758.
OpenTargetsiENSG00000110427.
PharmGKBiPA142672301.

Polymorphism and mutation databases

BioMutaiKIAA1549L.
DMDMi193806328.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002747801 – 1849UPF0606 protein KIAA1549LAdd BLAST1849

Proteomic databases

PaxDbiQ6ZVL6.
PeptideAtlasiQ6ZVL6.
PRIDEiQ6ZVL6.

PTM databases

iPTMnetiQ6ZVL6.
PhosphoSitePlusiQ6ZVL6.

Expressioni

Gene expression databases

BgeeiENSG00000110427.
CleanExiHS_C11orf41.
ExpressionAtlasiQ6ZVL6. baseline and differential.
GenevisibleiQ6ZVL6. HS.

Organism-specific databases

HPAiHPA010132.
HPA051594.

Interactioni

Protein-protein interaction databases

BioGridi117301. 2 interactors.
IntActiQ6ZVL6. 2 interactors.
STRINGi9606.ENSP00000315295.

Structurei

3D structure databases

ProteinModelPortaliQ6ZVL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili958 – 986Sequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 62Poly-Pro6
Compositional biasi1196 – 1200Poly-Ile5
Compositional biasi1638 – 1644Poly-Pro7

Sequence similaritiesi

Belongs to the UPF0606 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVCV. Eukaryota.
ENOG410ZTDZ. LUCA.
GeneTreeiENSGT00530000063472.
HOGENOMiHOG000111726.
HOVERGENiHBG107700.
InParanoidiQ6ZVL6.
OMAiLQQTNYD.
OrthoDBiEOG091G00FE.
PhylomeDBiQ6ZVL6.
TreeFamiTF332690.

Family and domain databases

InterProiIPR024606. DUF3827.
[Graphical view]
PANTHERiPTHR21590. PTHR21590. 1 hit.
PfamiPF12877. DUF3827. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZVL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDHTASQNAQ DLIGIPHLGV SGSSTKWHSE LSPTEGPHSA GSSTPGFLSP
60 70 80 90 100
MAELSHPSPP PPALGSLLQL PDGSPSWSML EVASGPASTQ QIKAGVPGRV
110 120 130 140 150
HNGVSLPTFK NTETATHEAE PPLFQTAESG AIEMTSRKLA SATANDSANP
160 170 180 190 200
LHLSAAPENS RGPALSAEHT SSLVPSLHIT TLGQEQAILS GAVPASPSTG
210 220 230 240 250
TADFPSILTF LQPTENHASP SPVPEMPTLP AEGSDGSPPA TRDLLLSSKV
260 270 280 290 300
PNLLSTSWTF PRWKKDSVTA ILGKNEEANV TIPLQAFPRK EVLSLHTVNG
310 320 330 340 350
FVSDFSTGSV SSPIITAPRT NPLPSGPPLP SILSIQATQT VFPSLGFSST
360 370 380 390 400
KPEAYAAAVD HSGLPASASK QVRASPSSMD VYDSLTIGDM KKPATTDVFW
410 420 430 440 450
SSLSAETGSL STESIISGLQ QQTNYDLNGH TISTTSWETH LAPTAPPNGL
460 470 480 490 500
TSAADAIKSQ DFKDTAGHSV TAEGFSIQDL VLGTSIEQPV QQSDMTMVGS
510 520 530 540 550
HIDLWPTSNN NHSRDFQTAE VAYYSPTTRH SVSHPQLQLP NQPAHPLLLT
560 570 580 590 600
SPGPTSTGSL QEMLSDGTDT GSEISSDINS SPERNASTPF QNILGYHSAA
610 620 630 640 650
ESSISTSVFP RTSSRVLRAS QHPKKWTADT VSSKVQPTAA AAVTLFLRKS
660 670 680 690 700
SPPALSAALV AKGTSSSPLA VASGPAKSSS MTTLAKNVTN KAASGPKRTP
710 720 730 740 750
GAVHTAFPFT PTYMYARTGH TTSTHTAMQG NMDTASGLLS TTYLPRKPQA
760 770 780 790 800
MHTGLPNPTN LEMPRASTPR PLTVTAALTS ITASVKATRL PPLRAENTDA
810 820 830 840 850
VLPAASAAVV TTGKMASNLE CQMSSKLLVK TVLFLTQRRV QISESLKFSI
860 870 880 890 900
AKGLTQALRK AFHQNDVSAH VDILEYSHNV TVGYYATKGK LVYLPAVVIE
910 920 930 940 950
MLGVYGVSNV TADLKQHTPH LQSVAVLASP WNPQPAGYFQ LKTVLQFVSQ
960 970 980 990 1000
ADNIQSCKFA QTMEQRLQKA FQDAERKVLN TKSNLTIQIV STSNASQAVT
1010 1020 1030 1040 1050
LVYVVGNQST FLNGTVASSL LSQLSAELVG FYLTYPPLTI AEPLEYPNLD
1060 1070 1080 1090 1100
ISETTRDYWV ITVLQGVDNS LVGLHNQSFA RVMEQRLAQL FMMSQQQGRR
1110 1120 1130 1140 1150
FKRATTLGSY TVQMVKMQRV PGPKDPAELT YYTLYNGKPL LGTAAAKILS
1160 1170 1180 1190 1200
TIDSQRMALT LHHVVLLQAD PVVKNPPNNL WIIAAVLAPI AVVTVIIIII
1210 1220 1230 1240 1250
TAVLCRKNKN DFKPDTMINL PQRAKPVQGF DYAKQHLGQQ GADEEVIPVT
1260 1270 1280 1290 1300
QETVVLPLPI RDAPQERDVA QDGSTIKTAK STETRKSRSP SENGSVISNE
1310 1320 1330 1340 1350
SGKPSSGRRS PQNVMAQQKV TKEEARKRNV PASDEEEGAV LFDNSSKVAA
1360 1370 1380 1390 1400
EPFDTSSGSV QLIAIKPTAL PMVPPTSDRS QESSAVLNGE VNKALKQKSD
1410 1420 1430 1440 1450
IEHYRNKLRL KAKRKGYYDF PAVETSKGLT ERKKMYEKAP KEMEHVLDPD
1460 1470 1480 1490 1500
SELCAPFTES KNRQQMKNSV YRSRQSLNSP SPGETEMDLL VTRERPRRGI
1510 1520 1530 1540 1550
RNSGYDTEPE IIEETNIDRV PEPRGYSRSR QVKGHSETST LSSQPSIDEV
1560 1570 1580 1590 1600
RQQMHMLLEE AFSLASAGHA GQSRHQEAYG SAQHLPYSEV VTSAPGTMTR
1610 1620 1630 1640 1650
PRAGVQWVPT YRPEMYQYSL PRPAYRFSQL PEMVMGSPPP PVPPRTGPVA
1660 1670 1680 1690 1700
VASLRRSTSD IGSKTRMAES TGPEPAQLHD SASFTQMSRG PVSVTQLDQS
1710 1720 1730 1740 1750
ALNYSGNTVP AVFAIPAANR PGFTGYFIPT PPSSYRNQAW MSYAGENELP
1760 1770 1780 1790 1800
SQWADSVPLP GYIEAYPRSR YPQSSPSRLP RQYSQPANLH PSLEQAPAPS
1810 1820 1830 1840
TAASQQSLAE NDPSDAPLTN ISTAALVKAI REEVAKLAKK QTDMFEFQV
Length:1,849
Mass (Da):198,999
Last modified:July 1, 2008 - v2
Checksum:iC0FE96132DF8CE8F
GO
Isoform 2 (identifier: Q6ZVL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     627-627: T → TGAATNA
     1226-1229: PVQG → QVAQ
     1230-1849: Missing.

Note: No experimental confirmation available.
Show »
Length:1,235
Mass (Da):131,202
Checksum:iC850776973AE8E7F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034445627T → TGAATNA in isoform 2. 1 Publication1
Alternative sequenceiVSP_0344461226 – 1229PVQG → QVAQ in isoform 2. 1 Publication4
Alternative sequenceiVSP_0344471230 – 1849Missing in isoform 2. 1 PublicationAdd BLAST620

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124395 mRNA. Translation: BAC85845.1.
AL049629, AL049575 Genomic DNA. Translation: CAQ07672.1.
AL049575, AL049629 Genomic DNA. Translation: CAQ10890.1.
CCDSiCCDS44565.2. [Q6ZVL6-1]
RefSeqiNP_036326.2. NM_012194.2. [Q6ZVL6-1]
XP_011518271.1. XM_011519969.2. [Q6ZVL6-2]
UniGeneiHs.502266.

Genome annotation databases

EnsembliENST00000265654; ENSP00000265654; ENSG00000110427. [Q6ZVL6-2]
ENST00000321505; ENSP00000315295; ENSG00000110427. [Q6ZVL6-1]
GeneIDi25758.
KEGGihsa:25758.
UCSCiuc001mun.1. human. [Q6ZVL6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124395 mRNA. Translation: BAC85845.1.
AL049629, AL049575 Genomic DNA. Translation: CAQ07672.1.
AL049575, AL049629 Genomic DNA. Translation: CAQ10890.1.
CCDSiCCDS44565.2. [Q6ZVL6-1]
RefSeqiNP_036326.2. NM_012194.2. [Q6ZVL6-1]
XP_011518271.1. XM_011519969.2. [Q6ZVL6-2]
UniGeneiHs.502266.

3D structure databases

ProteinModelPortaliQ6ZVL6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117301. 2 interactors.
IntActiQ6ZVL6. 2 interactors.
STRINGi9606.ENSP00000315295.

PTM databases

iPTMnetiQ6ZVL6.
PhosphoSitePlusiQ6ZVL6.

Polymorphism and mutation databases

BioMutaiKIAA1549L.
DMDMi193806328.

Proteomic databases

PaxDbiQ6ZVL6.
PeptideAtlasiQ6ZVL6.
PRIDEiQ6ZVL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265654; ENSP00000265654; ENSG00000110427. [Q6ZVL6-2]
ENST00000321505; ENSP00000315295; ENSG00000110427. [Q6ZVL6-1]
GeneIDi25758.
KEGGihsa:25758.
UCSCiuc001mun.1. human. [Q6ZVL6-1]

Organism-specific databases

CTDi25758.
DisGeNETi25758.
GeneCardsiKIAA1549L.
HGNCiHGNC:24836. KIAA1549L.
HPAiHPA010132.
HPA051594.
MIMi612297. gene.
neXtProtiNX_Q6ZVL6.
OpenTargetsiENSG00000110427.
PharmGKBiPA142672301.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVCV. Eukaryota.
ENOG410ZTDZ. LUCA.
GeneTreeiENSGT00530000063472.
HOGENOMiHOG000111726.
HOVERGENiHBG107700.
InParanoidiQ6ZVL6.
OMAiLQQTNYD.
OrthoDBiEOG091G00FE.
PhylomeDBiQ6ZVL6.
TreeFamiTF332690.

Miscellaneous databases

ChiTaRSiKIAA1549L. human.
GenomeRNAii25758.
PROiQ6ZVL6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110427.
CleanExiHS_C11orf41.
ExpressionAtlasiQ6ZVL6. baseline and differential.
GenevisibleiQ6ZVL6. HS.

Family and domain databases

InterProiIPR024606. DUF3827.
[Graphical view]
PANTHERiPTHR21590. PTHR21590. 1 hit.
PfamiPF12877. DUF3827. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK154L_HUMAN
AccessioniPrimary (citable) accession number: Q6ZVL6
Secondary accession number(s): B0QYU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 1, 2008
Last modified: November 2, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.