Q6ZVK8 (NUD18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleoside diphosphate-linked moiety X motif 18
Short name=Nudix motif 18
EC=3.6.1.-

Gene names

Name:

NUDT18

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably mediates the hydrolysis of some nucleoside diphosphate derivatives By similarity.
Cofactor	Magnesium or manganese By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family. Contains 1 nudix hydrolase domain.
Sequence caution	The sequence BAC85853.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	Magnesium Manganese Metal-binding
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
APIP	Q96GX9	3	EBI-740486,EBI-359248
DHPS	P49366	3	EBI-740486,EBI-741925
DUT	P33316	3	EBI-740486,EBI-353224
EVI5L	Q96CN4	3	EBI-740486,EBI-749523
HSD17B14	Q9BPX1	3	EBI-740486,EBI-742664
NT5C2	P49902	3	EBI-740486,EBI-742084
PAICS	P22234	3	EBI-740486,EBI-712261
RAB3IL1	Q8TBN0	3	EBI-740486,EBI-743796
RABAC1	Q9UI14	3	EBI-740486,EBI-712367

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZVK8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZVK8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.
     101-125: EPETLLSVEERGPSWVRFVFLARPT → MSVDSARAALLSTQTLPAPSPTSPP

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 323

323

Nucleoside diphosphate-linked moiety X motif 18

PRO_0000324567

Regions

Domain

37 – 167

131

Nudix hydrolase

Motif

76 – 97

22

Nudix box

Sites

Metal binding

91

1

Magnesium or manganese By similarity

Metal binding

95

1

Magnesium or manganese By similarity

Natural variations

Alternative sequence

1 – 100

100

Missing in isoform 2.

VSP_032276

Alternative sequence

101 – 125

25

EPETL…LARPT → MSVDSARAALLSTQTLPAPS PTSPP in isoform 2.

VSP_032277

Experimental info

Sequence conflict

177

1

L → P in BAB15376. Ref.1

Sequence conflict

224

1

V → M in AAH16902. Ref.2

Secondary structure

1

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323

Helix Strand Turn

Details...

Beta strand

43 – 49

7

Beta strand

55 – 61

7

Helix

84 – 95

12

Beta strand

100 – 110

11

Beta strand

115 – 124

10

Helix

132 – 134

3

Beta strand

136 – 138

3

Beta strand

140 – 146

7

Beta strand

152 – 155

4

Helix

159 – 174

16

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: EA137D5EDF81231C	FASTA	323	35,469
	10 20 30 40 50 60 MASEGLAGAL ASVLAGQGSS VHSCDSAPAG EPPAPVRLRK NVCYVVLAVF LSEQDEVLLI 70 80 90 100 110 120 QEAKRECRGS WYLPAGRMEP GETIVEALQR EVKEEAGLHC EPETLLSVEE RGPSWVRFVF 130 140 150 160 170 180 LARPTGGILK TSKEADAESL QAAWYPRTSL PTPLRAHDIL HLVELAAQYR QQARHPLILP 190 200 210 220 230 240 QELPCDLVCQ RLVATFTSAQ TVWVLVGTVG MPHLPVTACG LDPVEQRGGM KMAVLRLLQE 250 260 270 280 290 300 CLTLHHLVVE IKGLLGLQHL GRDHSDGICL NVLVTVAFRS PGIQDEPPKV RGENFSWWKV 310 320 MEEDLQSQLL QRLQGSSVVP VNR
	Isoform 2 [UniParc]. Checksum: 86EC1E28511B9358	FASTA	223	24,431
	10 20 30 40 50 60 MSVDSARAAL LSTQTLPAPS PTSPPGGILK TSKEADAESL QAAWYPRTSL PTPLRAHDIL 70 80 90 100 110 120 HLVELAAQYR QQARHPLILP QELPCDLVCQ RLVATFTSAQ TVWVLVGTVG MPHLPVTACG 130 140 150 160 170 180 LDPVEQRGGM KMAVLRLLQE CLTLHHLVVE IKGLLGLQHL GRDHSDGICL NVLVTVAFRS 190 200 210 220 PGIQDEPPKV RGENFSWWKV MEEDLQSQLL QRLQGSSVVP VNR

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Cerebellum.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK026147 mRNA. Translation: BAB15376.1.
AK124446 mRNA. Translation: BAC85853.1. Different initiation.
BC016902 mRNA. Translation: AAH16902.1.

IPI

IPI00217911.
IPI00396292.

RefSeq

NP_079091.3. NM_024815.3.

UniGene

Hs.527101.
Hs.729690.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3GG6	X-ray	2.10	A	26-179	[»]

ProteinModelPortal

Q6ZVK8.

SMR

Q6ZVK8. Positions 36-179.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q6ZVK8. 32 interactions.

MINT

MINT-1436358.

STRING

Q6ZVK8.

Polymorphism databases

DMDM

172046172.

Proteomic databases

PRIDE

Q6ZVK8.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000309188; ENSP00000307852; ENSG00000173566.

GeneID

79873.

KEGG

hsa:79873.

UCSC

uc003xaq.1. human.

Organism-specific databases

CTD

79873.

GeneCards

GC08M022021.

HGNC

HGNC:26194. NUDT18.

HPA

HPA028581.

neXtProt

NX_Q6ZVK8.

PharmGKB

PA142671238.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG11591.

GeneTree

ENSGT00390000002931.

HOGENOM

HBG283899.

HOVERGEN

HBG108203.

InParanoid

Q6ZVK8.

OrthoDB

EOG4KKZ2Z.

Gene expression databases

ArrayExpress

Q6ZVK8.

Bgee

Q6ZVK8.

CleanEx

HS_NUDT18.

Genevestigator

Q6ZVK8.

Family and domain databases

InterPro

IPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]

Gene3D

G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.

Pfam

PF00293. NUDIX. 1 hit.
[Graphical view]

PRINTS

PR00502. NUDIXFAMILY.

SUPFAM

SSF55811. NUDIX_hydrolase. 1 hit.

PROSITE

PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

69645.

Entry information

Entry name

NUD18_HUMAN

Accession

Primary (citable) accession number: Q6ZVK8
Secondary accession number(s): Q8IZ75, Q9H687

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	January 25, 2012
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.