Q6ZVK8 (NUD18_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 63.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Nucleoside diphosphate-linked moiety X motif 18 Short name=Nudix motif 18 EC=3.6.1.- | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 323 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Probably mediates the hydrolysis of some nucleoside diphosphate derivatives By similarity. |
| Cofactor | Magnesium or manganese By similarity. |
| Sequence similarities | Belongs to the Nudix hydrolase family. Contains 1 nudix hydrolase domain. |
| Sequence caution | The sequence BAC85853.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Ligand | Magnesium Manganese Metal-binding |
| Molecular function | Hydrolase |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Molecular function | hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| APIP | Q96GX9 | 3 | EBI-740486,EBI-359248 | |
| DHPS | P49366 | 3 | EBI-740486,EBI-741925 | |
| DUT | P33316 | 3 | EBI-740486,EBI-353224 | |
| EVI5L | Q96CN4 | 3 | EBI-740486,EBI-749523 | |
| HSD17B14 | Q9BPX1 | 3 | EBI-740486,EBI-742664 | |
| NT5C2 | P49902 | 3 | EBI-740486,EBI-742084 | |
| PAICS | P22234 | 3 | EBI-740486,EBI-712261 | |
| RAB3IL1 | Q8TBN0 | 3 | EBI-740486,EBI-743796 | |
| RABAC1 | Q9UI14 | 3 | EBI-740486,EBI-712367 |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q6ZVK8-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q6ZVK8-2) The sequence of this isoform differs from the canonical sequence as follows: 1-100: Missing. 101-125: EPETLLSVEERGPSWVRFVFLARPT → MSVDSARAALLSTQTLPAPSPTSPP | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 323 | 323 | Nucleoside diphosphate-linked moiety X motif 18 | PRO_0000324567 | |||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||
| Domain | 37 – 167 | 131 | Nudix hydrolase | ||||||||||||||||||||||||||
| Motif | 76 – 97 | 22 | Nudix box | ||||||||||||||||||||||||||
Sites | |||||||||||||||||||||||||||||
| Metal binding | 91 | 1 | Magnesium or manganese By similarity | ||||||||||||||||||||||||||
| Metal binding | 95 | 1 | Magnesium or manganese By similarity | ||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||
| Alternative sequence | 1 – 100 | 100 | Missing in isoform 2. | VSP_032276 | |||||||||||||||||||||||||
| Alternative sequence | 101 – 125 | 25 | EPETL…LARPT → MSVDSARAALLSTQTLPAPS PTSPP in isoform 2. | VSP_032277 | |||||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||||
| Sequence conflict | 177 | 1 | L → P in BAB15376. Ref.1 | ||||||||||||||||||||||||||
| Sequence conflict | 224 | 1 | V → M in AAH16902. Ref.2 | ||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||
| Beta strand | 43 – 49 | 7 | |||||||||||||||||||||||||||
| Beta strand | 55 – 61 | 7 | |||||||||||||||||||||||||||
| Helix | 84 – 95 | 12 | |||||||||||||||||||||||||||
| Beta strand | 100 – 110 | 11 | |||||||||||||||||||||||||||
| Beta strand | 115 – 124 | 10 | |||||||||||||||||||||||||||
| Helix | 132 – 134 | 3 | |||||||||||||||||||||||||||
| Beta strand | 136 – 138 | 3 | |||||||||||||||||||||||||||
| Beta strand | 140 – 146 | 7 | |||||||||||||||||||||||||||
| Beta strand | 152 – 155 | 4 | |||||||||||||||||||||||||||
| Helix | 159 – 174 | 16 | |||||||||||||||||||||||||||
Sequences
| ||||||||||||||||||||||||
References
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Cerebellum. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Uterus. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AK026147 mRNA. Translation: BAB15376.1. AK124446 mRNA. Translation: BAC85853.1. Different initiation. BC016902 mRNA. Translation: AAH16902.1. | ||||||||||||
| IPI | IPI00217911. IPI00396292. | ||||||||||||
| RefSeq | NP_079091.3. NM_024815.3. | ||||||||||||
| UniGene | Hs.527101. Hs.729690. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | Q6ZVK8. | ||||||||||||
| SMR | Q6ZVK8. Positions 36-179. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q6ZVK8. 32 interactions. | ||||||||||||
| MINT | MINT-1436358. | ||||||||||||
| STRING | Q6ZVK8. | ||||||||||||
Polymorphism databases | |||||||||||||
| DMDM | 172046172. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q6ZVK8. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000309188; ENSP00000307852; ENSG00000173566. | ||||||||||||
| GeneID | 79873. | ||||||||||||
| KEGG | hsa:79873. | ||||||||||||
| UCSC | uc003xaq.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 79873. | ||||||||||||
| GeneCards | GC08M022021. | ||||||||||||
| HGNC | HGNC:26194. NUDT18. | ||||||||||||
| HPA | HPA028581. | ||||||||||||
| neXtProt | NX_Q6ZVK8. | ||||||||||||
| PharmGKB | PA142671238. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG11591. | ||||||||||||
| GeneTree | ENSGT00390000002931. | ||||||||||||
| HOGENOM | HBG283899. | ||||||||||||
| HOVERGEN | HBG108203. | ||||||||||||
| InParanoid | Q6ZVK8. | ||||||||||||
| OrthoDB | EOG4KKZ2Z. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q6ZVK8. | ||||||||||||
| Bgee | Q6ZVK8. | ||||||||||||
| CleanEx | HS_NUDT18. | ||||||||||||
| Genevestigator | Q6ZVK8. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR020476. Nudix_hydrolase. IPR020084. NUDIX_hydrolase_CS. IPR000086. NUDIX_hydrolase_dom. IPR015797. NUDIX_hydrolase_dom-like. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit. | ||||||||||||
| Pfam | PF00293. NUDIX. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00502. NUDIXFAMILY. | ||||||||||||
| SUPFAM | SSF55811. NUDIX_hydrolase. 1 hit. | ||||||||||||
| PROSITE | PS51462. NUDIX. 1 hit. PS00893. NUDIX_BOX. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| NextBio | 69645. | ||||||||||||
Entry information
| Entry name | NUD18_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q6ZVK8 Secondary accession number(s): Q8IZ75, Q9H687 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 8 Human chromosome 8: entries, gene names and cross-references to MIM |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with