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Protein

Vesicle transport protein GOT1A

Gene

GOLT1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in fusion of ER-derived transport vesicles with the Golgi complex.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport protein GOT1A
Alternative name(s):
Golgi transport 1 homolog A
hGOT1b
Gene namesi
Name:GOLT1AImported
Synonyms:GOT1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24766. GOLT1A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence analysis
Transmembranei10 – 3021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini31 – 311LumenalSequence analysis
Transmembranei32 – 5221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini53 – 6816CytoplasmicSequence analysisAdd
BLAST
Transmembranei69 – 8921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini90 – 10011LumenalSequence analysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini122 – 13211CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134874119.

Polymorphism and mutation databases

BioMutaiGOLT1A.
DMDMi74749697.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132Vesicle transport protein GOT1APRO_0000237607Add
BLAST

Proteomic databases

PaxDbiQ6ZVE7.
PRIDEiQ6ZVE7.

Expressioni

Gene expression databases

BgeeiQ6ZVE7.
CleanExiHS_GOLT1A.
GenevisibleiQ6ZVE7. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308535.

Structurei

3D structure databases

ProteinModelPortaliQ6ZVE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GOT1 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1743. Eukaryota.
COG5120. LUCA.
GeneTreeiENSGT00390000014507.
HOGENOMiHOG000035939.
HOVERGENiHBG009362.
InParanoidiQ6ZVE7.
OMAiWFFFQRH.
OrthoDBiEOG7J9VRZ.
PhylomeDBiQ6ZVE7.
TreeFamiTF300267.

Family and domain databases

InterProiIPR007305. Vesicle_transpt_Got1/SFT2.
[Graphical view]
PfamiPF04178. Got1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZVE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISITEWQKI GVGITGFGIF FILFGTLLYF DSVLLAFGNL LFLTGLSLII
60 70 80 90 100
GLRKTFWFFF QRHKLKGTSF LLGGVVIVLL RWPLLGMFLE TYGFFSLFKG
110 120 130
FFPVAFGFLG NVCNIPFLGA LFRRLQGTSS MV
Length:132
Mass (Da):14,887
Last modified:July 5, 2004 - v1
Checksum:i74FA90D30D372FC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124645 mRNA. Translation: BAC85915.1.
AL592114 Genomic DNA. Translation: CAH71227.1.
BC058832 mRNA. Translation: AAH58832.1.
CCDSiCCDS1443.1.
RefSeqiNP_940849.1. NM_198447.1.
UniGeneiHs.532401.

Genome annotation databases

EnsembliENST00000308302; ENSP00000308535; ENSG00000174567.
GeneIDi127845.
KEGGihsa:127845.
UCSCiuc001has.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124645 mRNA. Translation: BAC85915.1.
AL592114 Genomic DNA. Translation: CAH71227.1.
BC058832 mRNA. Translation: AAH58832.1.
CCDSiCCDS1443.1.
RefSeqiNP_940849.1. NM_198447.1.
UniGeneiHs.532401.

3D structure databases

ProteinModelPortaliQ6ZVE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308535.

Polymorphism and mutation databases

BioMutaiGOLT1A.
DMDMi74749697.

Proteomic databases

PaxDbiQ6ZVE7.
PRIDEiQ6ZVE7.

Protocols and materials databases

DNASUi127845.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308302; ENSP00000308535; ENSG00000174567.
GeneIDi127845.
KEGGihsa:127845.
UCSCiuc001has.1. human.

Organism-specific databases

CTDi127845.
GeneCardsiGOLT1A.
HGNCiHGNC:24766. GOLT1A.
neXtProtiNX_Q6ZVE7.
PharmGKBiPA134874119.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1743. Eukaryota.
COG5120. LUCA.
GeneTreeiENSGT00390000014507.
HOGENOMiHOG000035939.
HOVERGENiHBG009362.
InParanoidiQ6ZVE7.
OMAiWFFFQRH.
OrthoDBiEOG7J9VRZ.
PhylomeDBiQ6ZVE7.
TreeFamiTF300267.

Miscellaneous databases

ChiTaRSiGOLT1A. human.
GenomeRNAii127845.
NextBioi82200.
PROiQ6ZVE7.

Gene expression databases

BgeeiQ6ZVE7.
CleanExiHS_GOLT1A.
GenevisibleiQ6ZVE7. HS.

Family and domain databases

InterProiIPR007305. Vesicle_transpt_Got1/SFT2.
[Graphical view]
PfamiPF04178. Got1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: CerebellumImported.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex."
    Conchon S., Cao X., Barlowe C., Pelham H.R.
    EMBO J. 18:3934-3946(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PUTATIVE FUNCTION.

Entry informationi

Entry nameiGOT1A_HUMAN
AccessioniPrimary (citable) accession number: Q6ZVE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: February 17, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.