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Protein

Vesicle transport protein GOT1A

Gene

GOLT1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in fusion of ER-derived transport vesicles with the Golgi complex.1 Publication

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport protein GOT1A
Alternative name(s):
Golgi transport 1 homolog A
hGOT1b
Gene namesi
Name:GOLT1AImported
Synonyms:GOT1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000174567.7.
HGNCiHGNC:24766. GOLT1A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31LumenalSequence analysis1
Transmembranei32 – 52Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini53 – 68CytoplasmicSequence analysisAdd BLAST16
Transmembranei69 – 89Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini90 – 100LumenalSequence analysisAdd BLAST11
Transmembranei101 – 121Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini122 – 132CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi127845.
OpenTargetsiENSG00000174567.
PharmGKBiPA134874119.

Polymorphism and mutation databases

BioMutaiGOLT1A.
DMDMi74749697.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002376071 – 132Vesicle transport protein GOT1AAdd BLAST132

Proteomic databases

EPDiQ6ZVE7.
PaxDbiQ6ZVE7.
PeptideAtlasiQ6ZVE7.
PRIDEiQ6ZVE7.

Expressioni

Gene expression databases

BgeeiENSG00000174567.
CleanExiHS_GOLT1A.
GenevisibleiQ6ZVE7. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308535.

Structurei

3D structure databases

ProteinModelPortaliQ6ZVE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GOT1 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1743. Eukaryota.
COG5120. LUCA.
GeneTreeiENSGT00390000014507.
HOGENOMiHOG000035939.
HOVERGENiHBG009362.
InParanoidiQ6ZVE7.
OMAiKTFWFFF.
OrthoDBiEOG091G10MS.
PhylomeDBiQ6ZVE7.
TreeFamiTF300267.

Family and domain databases

InterProiView protein in InterPro
IPR007305. Vesicle_transpt_Got1/SFT2.
PfamiView protein in Pfam
PF04178. Got1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ZVE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISITEWQKI GVGITGFGIF FILFGTLLYF DSVLLAFGNL LFLTGLSLII
60 70 80 90 100
GLRKTFWFFF QRHKLKGTSF LLGGVVIVLL RWPLLGMFLE TYGFFSLFKG
110 120 130
FFPVAFGFLG NVCNIPFLGA LFRRLQGTSS MV
Length:132
Mass (Da):14,887
Last modified:July 5, 2004 - v1
Checksum:i74FA90D30D372FC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124645 mRNA. Translation: BAC85915.1.
AL592114 Genomic DNA. No translation available.
BC058832 mRNA. Translation: AAH58832.1.
CCDSiCCDS1443.1.
RefSeqiNP_940849.1. NM_198447.1.
UniGeneiHs.532401.

Genome annotation databases

EnsembliENST00000308302; ENSP00000308535; ENSG00000174567.
GeneIDi127845.
KEGGihsa:127845.
UCSCiuc001has.1. human.

Similar proteinsi

Entry informationi

Entry nameiGOT1A_HUMAN
AccessioniPrimary (citable) accession number: Q6ZVE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families