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Q6ZVD8

- PHLP2_HUMAN

UniProt

Q6ZVD8 - PHLP2_HUMAN

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Protein

PH domain leucine-rich repeat-containing protein phosphatase 2

Gene
PHLPP2, KIAA0931, PHLPPL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.3 Publications

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Kineticsi

  1. KM=4.13 mM for p-nitrophenyl phosphate

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi820 – 8201Manganese 1 By similarity
Metal bindingi820 – 8201Manganese 2 By similarity
Metal bindingi821 – 8211Manganese 1; via carbonyl oxygen By similarity
Metal bindingi985 – 9851Manganese 2 By similarity
Metal bindingi1024 – 10241Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: Ensembl

GO - Biological processi

  1. epidermal growth factor receptor signaling pathway Source: Reactome
  2. Fc-epsilon receptor signaling pathway Source: Reactome
  3. fibroblast growth factor receptor signaling pathway Source: Reactome
  4. innate immune response Source: Reactome
  5. neurotrophin TRK receptor signaling pathway Source: Reactome
  6. phosphatidylinositol-mediated signaling Source: Reactome
  7. protein dephosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_12447. Negative regulation of the PI3K/AKT network.

Names & Taxonomyi

Protein namesi
Recommended name:
PH domain leucine-rich repeat-containing protein phosphatase 2 (EC:3.1.3.16)
Alternative name(s):
PH domain leucine-rich repeat-containing protein phosphatase-like
Short name:
PHLPP-like
Gene namesi
Name:PHLPP2
Synonyms:KIAA0931, PHLPPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:29149. PHLPP2.

Subcellular locationi

Cytoplasm. Membrane; Peripheral membrane protein. Nucleus
Note: In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus.2 Publications

GO - Cellular componenti

  1. cytoplasm Source: LIFEdb
  2. cytosol Source: Reactome
  3. nucleus Source: UniProtKB-SubCell
  4. photoreceptor inner segment Source: Ensembl
  5. photoreceptor outer segment membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA165450496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13231323PH domain leucine-rich repeat-containing protein phosphatase 2PRO_0000057784Add
BLAST

Proteomic databases

MaxQBiQ6ZVD8.
PaxDbiQ6ZVD8.
PRIDEiQ6ZVD8.

PTM databases

PhosphoSiteiQ6ZVD8.

Expressioni

Tissue specificityi

In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ6ZVD8.
BgeeiQ6ZVD8.
CleanExiHS_PHLPPL.
GenevestigatoriQ6ZVD8.

Organism-specific databases

HPAiHPA048598.

Interactioni

Subunit structurei

Interacts with AKT1, AKT3 and PRKCB isoform beta-II.2 Publications

Protein-protein interaction databases

BioGridi116674. 13 interactions.
IntActiQ6ZVD8. 14 interactions.
MINTiMINT-4781843.
STRINGi9606.ENSP00000348611.

Structurei

3D structure databases

ProteinModelPortaliQ6ZVD8.
SMRiQ6ZVD8. Positions 251-773, 797-1033.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini150 – 24899PHAdd
BLAST
Repeati250 – 27122LRR 1Add
BLAST
Repeati273 – 29624LRR 2Add
BLAST
Repeati300 – 32122LRR 3Add
BLAST
Repeati323 – 34422LRR 4Add
BLAST
Repeati346 – 36823LRR 5Add
BLAST
Repeati369 – 39022LRR 6Add
BLAST
Repeati392 – 41221LRR 7Add
BLAST
Repeati416 – 43924LRR 8Add
BLAST
Repeati440 – 46021LRR 9Add
BLAST
Repeati461 – 48020LRR 10Add
BLAST
Repeati481 – 50222LRR 11Add
BLAST
Repeati503 – 52422LRR 12Add
BLAST
Repeati526 – 54722LRR 13Add
BLAST
Repeati549 – 57022LRR 14Add
BLAST
Repeati571 – 59222LRR 15Add
BLAST
Repeati595 – 61622LRR 16Add
BLAST
Repeati621 – 64424LRR 17Add
BLAST
Repeati645 – 66622LRR 18Add
BLAST
Repeati669 – 69022LRR 19Add
BLAST
Repeati692 – 71322LRR 20Add
BLAST
Repeati714 – 73522LRR 21Add
BLAST
Repeati737 – 75822LRR 22Add
BLAST
Domaini775 – 1031257PP2C-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi40 – 4910Poly-Thr
Compositional biasi50 – 6011Poly-SerAdd
BLAST
Compositional biasi1071 – 10744Poly-Ser

Sequence similaritiesi

Contains 1 PH domain.
Contains 1 PP2C-like domain.

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000115529.
InParanoidiQ6ZVD8.
KOiK16340.
PhylomeDBiQ6ZVD8.
TreeFamiTF315993.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001932. PP2C-like_dom.
[Graphical view]
PfamiPF00560. LRR_1. 2 hits.
PF13855. LRR_8. 2 hits.
PF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS51450. LRR. 18 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZVD8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKRNGSRNCL NRRSRFGSRE RDWLREDVKR GCVYLYGADT TTATTTTTTS     50
SSSSSSSSSS DLHLVLCTVE TPASEICAGE GRESLYLQLH GDLVRRLEPT 100
ERPLQIVYDY LSRLGFDDPV RIQEEATNPD LGCMIRFYGE KPCHMDRLDR 150
ILLSGIYNVR KGKTQLHKWA ERLVVLCGTC LIVSSVKDCQ TGKMHILPLV 200
GGKIEEVKRR QYSLAFSSAG AQAQTYHVSF ETLAEYQRWQ RQASKVVSQR 250
ISTVDLSCYS LEEVPEHLFY SQDITYLNLR HNFMQLERPG GLDTLYKFSQ 300
LKGLNLSHNK LGLFPILLCE ISTLTELNLS CNGFHDLPSQ IGNLLNLQTL 350
CLDGNFLTTL PEELGNLQQL SSLGISFNNF SQIPEVYEKL TMLDRVVMAG 400
NCLEVLNLGV LNRMNHIKHV DLRMNHLKTM VIENLEGNKH ITHVDLRDNR 450
LTDLDLSSLC SLEQLHCGRN QLRELTLSGF SLRTLYASSN RLTAVNVYPV 500
PSLLTFLDLS RNLLECVPDW ACEAKKIEVL DVSYNLLTEV PVRILSSLSL 550
RKLMLGHNHV QNLPTLVEHI PLEVLDLQHN ALTRLPDTLF SKALNLRYLN 600
ASANSLESLP SACTGEESLS MLQLLYLTNN LLTDQCIPVL VGHLHLRILH 650
LANNQLQTFP ASKLNKLEQL EELNLSGNKL KTIPTTIANC KRLHTLVAHS 700
NNISIFPEIL QLPQIQFVDL SCNDLTEILI PEALPATLQD LDLTGNTNLV 750
LEHKTLDIFS HITTLKIDQK PLPTTDSTVT STFWSHGLAE MAGQRNKLCV 800
SALAMDSFAE GVGAVYGMFD GDRNEELPRL LQCTMADVLL EEVQQSTNDT 850
VFMANTFLVS HRKLGMAGQK LGSSALLCYI RPDTADPASS FSLTVANVGT 900
CQAVLCRGGK PVPLSKVFSL EQDPEEAQRV KDQKAIITED NKVNGVTCCT 950
RMLGCTYLYP WILPKPHISS TPLTIQDELL ILGNKALWEH LSYTEAVNAV 1000
RHVQDPLAAA KKLCTLAQSY GCQDNVGAMV VYLNIGEEGC TCEMNGLTLP 1050
GPVGFASTTT IKDAPKPATP SSSSGIASEF SSEMSTSEVS SEVGSTASDE 1100
HNAGGLDTAL LPRPERRCSL HPTPTSGLFQ RQPSSATFSS NQSDNGLDSD 1150
DDQPVEGVIT NGSKVEVEVD IHCCRGRDLE NSPPLIESSP TLCSEEHARG 1200
SCFGIRRQNS VNSGMLLPMS KDRMELQKSP STSCLYGKKL SNGSIVPLED 1250
SLNLIEVATE VPKRKTGYFA APTQMEPEDQ FVVPHDLEEE VKEQMKQHQD 1300
SRLEPEPHEE DRTEPPEEFD TAL 1323
Length:1,323
Mass (Da):146,751
Last modified:October 17, 2006 - v3
Checksum:i04FC8550C2E22A6D
GO
Isoform 2 (identifier: Q6ZVD8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     940-956: DNKVNGVTCCTRMLGCT → NWVLNQKHLQDFPGEDK
     957-1323: Missing.

Note: No experimental confirmation available.

Show »
Length:956
Mass (Da):107,079
Checksum:iD639027D022AFED9
GO
Isoform 3 (identifier: Q6ZVD8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     596-662: Missing.

Show »
Length:1,256
Mass (Da):139,394
Checksum:iDC706C3744570432
GO

Sequence cautioni

The sequence BAA76775.2 differs from that shown. Reason: Erroneous initiation.
The sequence BAA91943.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei596 – 66267Missing in isoform 3. VSP_017265Add
BLAST
Alternative sequencei940 – 95617DNKVN…MLGCT → NWVLNQKHLQDFPGEDK in isoform 2. VSP_014056Add
BLAST
Alternative sequencei957 – 1323367Missing in isoform 2. VSP_014057Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti147 – 1471R → C in BX647823. 1 Publication
Sequence conflicti542 – 5421V → L1 Publication
Sequence conflicti766 – 7661K → E in BX647823. 1 Publication
Sequence conflicti896 – 8961A → G in BAA91943. 1 Publication
Sequence conflicti978 – 9781E → G in BX647823. 1 Publication
Sequence conflicti1016 – 10161L → S in BX647823. 1 Publication
Sequence conflicti1312 – 13121R → Q in AAI29928. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023148 mRNA. Translation: BAA76775.2. Different initiation.
BX647823 mRNA. No translation available.
AC009097 Genomic DNA. No translation available.
BC129927 mRNA. Translation: AAI29928.1.
AK001854 mRNA. Translation: BAA91943.1. Different initiation.
AK124678 mRNA. Translation: BAC85924.1.
CCDSiCCDS32479.1. [Q6ZVD8-1]
RefSeqiNP_001275932.1. NM_001289003.1. [Q6ZVD8-3]
NP_055835.2. NM_015020.3. [Q6ZVD8-1]
UniGeneiHs.709458.

Genome annotation databases

EnsembliENST00000356272; ENSP00000348611; ENSG00000040199. [Q6ZVD8-1]
ENST00000360429; ENSP00000353610; ENSG00000040199. [Q6ZVD8-2]
ENST00000393524; ENSP00000377159; ENSG00000040199. [Q6ZVD8-3]
ENST00000568954; ENSP00000457991; ENSG00000040199. [Q6ZVD8-1]
GeneIDi23035.
KEGGihsa:23035.
UCSCiuc002fax.3. human. [Q6ZVD8-1]
uc010cgf.3. human. [Q6ZVD8-3]

Polymorphism databases

DMDMi116242711.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023148 mRNA. Translation: BAA76775.2 . Different initiation.
BX647823 mRNA. No translation available.
AC009097 Genomic DNA. No translation available.
BC129927 mRNA. Translation: AAI29928.1 .
AK001854 mRNA. Translation: BAA91943.1 . Different initiation.
AK124678 mRNA. Translation: BAC85924.1 .
CCDSi CCDS32479.1. [Q6ZVD8-1 ]
RefSeqi NP_001275932.1. NM_001289003.1. [Q6ZVD8-3 ]
NP_055835.2. NM_015020.3. [Q6ZVD8-1 ]
UniGenei Hs.709458.

3D structure databases

ProteinModelPortali Q6ZVD8.
SMRi Q6ZVD8. Positions 251-773, 797-1033.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116674. 13 interactions.
IntActi Q6ZVD8. 14 interactions.
MINTi MINT-4781843.
STRINGi 9606.ENSP00000348611.

Chemistry

BindingDBi Q6ZVD8.
ChEMBLi CHEMBL1275209.

PTM databases

PhosphoSitei Q6ZVD8.

Polymorphism databases

DMDMi 116242711.

Proteomic databases

MaxQBi Q6ZVD8.
PaxDbi Q6ZVD8.
PRIDEi Q6ZVD8.

Protocols and materials databases

DNASUi 23035.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356272 ; ENSP00000348611 ; ENSG00000040199 . [Q6ZVD8-1 ]
ENST00000360429 ; ENSP00000353610 ; ENSG00000040199 . [Q6ZVD8-2 ]
ENST00000393524 ; ENSP00000377159 ; ENSG00000040199 . [Q6ZVD8-3 ]
ENST00000568954 ; ENSP00000457991 ; ENSG00000040199 . [Q6ZVD8-1 ]
GeneIDi 23035.
KEGGi hsa:23035.
UCSCi uc002fax.3. human. [Q6ZVD8-1 ]
uc010cgf.3. human. [Q6ZVD8-3 ]

Organism-specific databases

CTDi 23035.
GeneCardsi GC16M071674.
H-InvDB HIX0013215.
HIX0173315.
HGNCi HGNC:29149. PHLPP2.
HPAi HPA048598.
MIMi 611066. gene.
neXtProti NX_Q6ZVD8.
PharmGKBi PA165450496.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
HOGENOMi HOG000115529.
InParanoidi Q6ZVD8.
KOi K16340.
PhylomeDBi Q6ZVD8.
TreeFami TF315993.

Enzyme and pathway databases

Reactomei REACT_12447. Negative regulation of the PI3K/AKT network.

Miscellaneous databases

GeneWikii PHLPPL.
GenomeRNAii 23035.
NextBioi 44034.
PROi Q6ZVD8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6ZVD8.
Bgeei Q6ZVD8.
CleanExi HS_PHLPPL.
Genevestigatori Q6ZVD8.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001932. PP2C-like_dom.
[Graphical view ]
Pfami PF00560. LRR_1. 2 hits.
PF13855. LRR_8. 2 hits.
PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS51450. LRR. 18 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  2. Ohara O., Nagase T., Kikuno R.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Retina.
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-423 (ISOFORMS 1/2/3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 639-1323 (ISOFORM 2).
    Tissue: Amygdala and Placenta.
  7. "PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms."
    Brognard J., Sierecki E., Gao T., Newton A.C.
    Mol. Cell 25:917-931(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH AKT1 AND AKT3.
  8. "The phosphatase PHLPP controls the cellular levels of protein kinase C."
    Gao T., Brognard J., Newton A.C.
    J. Biol. Chem. 283:6300-6311(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PRKCB.
  9. "Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis."
    Liu J., Weiss H.L., Rychahou P., Jackson L.N., Evers B.M., Gao T.
    Oncogene 28:994-1004(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiPHLP2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZVD8
Secondary accession number(s): A1L374, Q9NV17, Q9Y2E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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