Q6ZVD8 (PHLP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PH domain leucine-rich repeat-containing protein phosphatase 2
EC=3.1.3.16

Alternative name(s):
PH domain leucine-rich repeat-containing protein phosphatase-like
Short name=PHLPP-like

Gene names

Name:	PHLPP2
Synonyms:	KIAA0931, PHLPPL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1323 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. Ref.7 Ref.8 Ref.9
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Subunit structure	Interacts with AKT1, AKT3 and PRKCB isoform beta-II. Ref.7 Ref.8
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note: In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus. Ref.7 Ref.9
Tissue specificity	In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level). Ref.9
Sequence similarities	Contains 22 LRR (leucine-rich) repeats. Contains 1 PH domain. Contains 1 PP2C-like domain.
Biophysicochemical properties	Kinetic parameters: KM=4.13 mM for p-nitrophenyl phosphate
Sequence caution	The sequence BAA76775.2 differs from that shown. Reason: Erroneous initiation. The sequence BAA91943.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane Nucleus
Coding sequence diversity	Alternative splicing
Disease	Tumor suppressor
Domain	Leucine-rich repeat Repeat
Ligand	Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein dephosphorylation Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from direct assay. Source: LIFEdb nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell photoreceptor inner segment Inferred from electronic annotation. Source: Compara photoreceptor outer segment membrane Inferred from electronic annotation. Source: Compara
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine phosphatase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZVD8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZVD8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     940-956: DNKVNGVTCCTRMLGCT → NWVLNQKHLQDFPGEDK
     957-1323: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q6ZVD8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     596-662: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1323	1323	PH domain leucine-rich repeat-containing protein phosphatase 2		PRO_0000057784
Regions
	Domain	150 – 248	99	PH
	Repeat	250 – 271	22	LRR 1
	Repeat	273 – 296	24	LRR 2
	Repeat	300 – 321	22	LRR 3
	Repeat	323 – 344	22	LRR 4
	Repeat	346 – 368	23	LRR 5
	Repeat	369 – 390	22	LRR 6
	Repeat	392 – 412	21	LRR 7
	Repeat	416 – 439	24	LRR 8
	Repeat	440 – 460	21	LRR 9
	Repeat	461 – 480	20	LRR 10
	Repeat	481 – 502	22	LRR 11
	Repeat	503 – 524	22	LRR 12
	Repeat	526 – 547	22	LRR 13
	Repeat	549 – 570	22	LRR 14
	Repeat	571 – 592	22	LRR 15
	Repeat	595 – 616	22	LRR 16
	Repeat	621 – 644	24	LRR 17
	Repeat	645 – 666	22	LRR 18
	Repeat	669 – 690	22	LRR 19
	Repeat	692 – 713	22	LRR 20
	Repeat	714 – 735	22	LRR 21
	Repeat	737 – 758	22	LRR 22
	Domain	775 – 1031	257	PP2C-like
	Compositional bias	40 – 49	10	Poly-Thr
	Compositional bias	50 – 60	11	Poly-Ser
	Compositional bias	1071 – 1074	4	Poly-Ser
Sites
	Metal binding	820	1	Manganese 1 By similarity
	Metal binding	820	1	Manganese 2 By similarity
	Metal binding	821	1	Manganese 1; via carbonyl oxygen By similarity
	Metal binding	985	1	Manganese 2 By similarity
	Metal binding	1024	1	Manganese 2 By similarity
Natural variations
	Alternative sequence	596 – 662	67	Missing in isoform 3.		VSP_017265
	Alternative sequence	940 – 956	17	DNKVN…MLGCT → NWVLNQKHLQDFPGEDK in isoform 2.		VSP_014056
	Alternative sequence	957 – 1323	367	Missing in isoform 2.		VSP_014057
Experimental info
	Sequence conflict	147	1	R → C in BX647823. Ref.3
	Sequence conflict	542	1	V → L Ref.4
	Sequence conflict	766	1	K → E in BX647823. Ref.3
	Sequence conflict	896	1	A → G in BAA91943. Ref.6
	Sequence conflict	978	1	E → G in BX647823. Ref.3
	Sequence conflict	1016	1	L → S in BX647823. Ref.3
	Sequence conflict	1312	1	R → Q in AAI29928. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 3. Checksum: 04FC8550C2E22A6D	FASTA	1,323	146,751
	10 20 30 40 50 60 MKRNGSRNCL NRRSRFGSRE RDWLREDVKR GCVYLYGADT TTATTTTTTS SSSSSSSSSS 70 80 90 100 110 120 DLHLVLCTVE TPASEICAGE GRESLYLQLH GDLVRRLEPT ERPLQIVYDY LSRLGFDDPV 130 140 150 160 170 180 RIQEEATNPD LGCMIRFYGE KPCHMDRLDR ILLSGIYNVR KGKTQLHKWA ERLVVLCGTC 190 200 210 220 230 240 LIVSSVKDCQ TGKMHILPLV GGKIEEVKRR QYSLAFSSAG AQAQTYHVSF ETLAEYQRWQ 250 260 270 280 290 300 RQASKVVSQR ISTVDLSCYS LEEVPEHLFY SQDITYLNLR HNFMQLERPG GLDTLYKFSQ 310 320 330 340 350 360 LKGLNLSHNK LGLFPILLCE ISTLTELNLS CNGFHDLPSQ IGNLLNLQTL CLDGNFLTTL 370 380 390 400 410 420 PEELGNLQQL SSLGISFNNF SQIPEVYEKL TMLDRVVMAG NCLEVLNLGV LNRMNHIKHV 430 440 450 460 470 480 DLRMNHLKTM VIENLEGNKH ITHVDLRDNR LTDLDLSSLC SLEQLHCGRN QLRELTLSGF 490 500 510 520 530 540 SLRTLYASSN RLTAVNVYPV PSLLTFLDLS RNLLECVPDW ACEAKKIEVL DVSYNLLTEV 550 560 570 580 590 600 PVRILSSLSL RKLMLGHNHV QNLPTLVEHI PLEVLDLQHN ALTRLPDTLF SKALNLRYLN 610 620 630 640 650 660 ASANSLESLP SACTGEESLS MLQLLYLTNN LLTDQCIPVL VGHLHLRILH LANNQLQTFP 670 680 690 700 710 720 ASKLNKLEQL EELNLSGNKL KTIPTTIANC KRLHTLVAHS NNISIFPEIL QLPQIQFVDL 730 740 750 760 770 780 SCNDLTEILI PEALPATLQD LDLTGNTNLV LEHKTLDIFS HITTLKIDQK PLPTTDSTVT 790 800 810 820 830 840 STFWSHGLAE MAGQRNKLCV SALAMDSFAE GVGAVYGMFD GDRNEELPRL LQCTMADVLL 850 860 870 880 890 900 EEVQQSTNDT VFMANTFLVS HRKLGMAGQK LGSSALLCYI RPDTADPASS FSLTVANVGT 910 920 930 940 950 960 CQAVLCRGGK PVPLSKVFSL EQDPEEAQRV KDQKAIITED NKVNGVTCCT RMLGCTYLYP 970 980 990 1000 1010 1020 WILPKPHISS TPLTIQDELL ILGNKALWEH LSYTEAVNAV RHVQDPLAAA KKLCTLAQSY 1030 1040 1050 1060 1070 1080 GCQDNVGAMV VYLNIGEEGC TCEMNGLTLP GPVGFASTTT IKDAPKPATP SSSSGIASEF 1090 1100 1110 1120 1130 1140 SSEMSTSEVS SEVGSTASDE HNAGGLDTAL LPRPERRCSL HPTPTSGLFQ RQPSSATFSS 1150 1160 1170 1180 1190 1200 NQSDNGLDSD DDQPVEGVIT NGSKVEVEVD IHCCRGRDLE NSPPLIESSP TLCSEEHARG 1210 1220 1230 1240 1250 1260 SCFGIRRQNS VNSGMLLPMS KDRMELQKSP STSCLYGKKL SNGSIVPLED SLNLIEVATE 1270 1280 1290 1300 1310 1320 VPKRKTGYFA APTQMEPEDQ FVVPHDLEEE VKEQMKQHQD SRLEPEPHEE DRTEPPEEFD TAL
	Isoform 2 [UniParc]. Checksum: D639027D022AFED9	FASTA	956	107,079
	10 20 30 40 50 60 MKRNGSRNCL NRRSRFGSRE RDWLREDVKR GCVYLYGADT TTATTTTTTS SSSSSSSSSS 70 80 90 100 110 120 DLHLVLCTVE TPASEICAGE GRESLYLQLH GDLVRRLEPT ERPLQIVYDY LSRLGFDDPV 130 140 150 160 170 180 RIQEEATNPD LGCMIRFYGE KPCHMDRLDR ILLSGIYNVR KGKTQLHKWA ERLVVLCGTC 190 200 210 220 230 240 LIVSSVKDCQ TGKMHILPLV GGKIEEVKRR QYSLAFSSAG AQAQTYHVSF ETLAEYQRWQ 250 260 270 280 290 300 RQASKVVSQR ISTVDLSCYS LEEVPEHLFY SQDITYLNLR HNFMQLERPG GLDTLYKFSQ 310 320 330 340 350 360 LKGLNLSHNK LGLFPILLCE ISTLTELNLS CNGFHDLPSQ IGNLLNLQTL CLDGNFLTTL 370 380 390 400 410 420 PEELGNLQQL SSLGISFNNF SQIPEVYEKL TMLDRVVMAG NCLEVLNLGV LNRMNHIKHV 430 440 450 460 470 480 DLRMNHLKTM VIENLEGNKH ITHVDLRDNR LTDLDLSSLC SLEQLHCGRN QLRELTLSGF 490 500 510 520 530 540 SLRTLYASSN RLTAVNVYPV PSLLTFLDLS RNLLECVPDW ACEAKKIEVL DVSYNLLTEV 550 560 570 580 590 600 PVRILSSLSL RKLMLGHNHV QNLPTLVEHI PLEVLDLQHN ALTRLPDTLF SKALNLRYLN 610 620 630 640 650 660 ASANSLESLP SACTGEESLS MLQLLYLTNN LLTDQCIPVL VGHLHLRILH LANNQLQTFP 670 680 690 700 710 720 ASKLNKLEQL EELNLSGNKL KTIPTTIANC KRLHTLVAHS NNISIFPEIL QLPQIQFVDL 730 740 750 760 770 780 SCNDLTEILI PEALPATLQD LDLTGNTNLV LEHKTLDIFS HITTLKIDQK PLPTTDSTVT 790 800 810 820 830 840 STFWSHGLAE MAGQRNKLCV SALAMDSFAE GVGAVYGMFD GDRNEELPRL LQCTMADVLL 850 860 870 880 890 900 EEVQQSTNDT VFMANTFLVS HRKLGMAGQK LGSSALLCYI RPDTADPASS FSLTVANVGT 910 920 930 940 950 CQAVLCRGGK PVPLSKVFSL EQDPEEAQRV KDQKAIITEN WVLNQKHLQD FPGEDK
	Isoform 3 [UniParc]. Checksum: DC706C3744570432	FASTA	1,256	139,394
	10 20 30 40 50 60 MKRNGSRNCL NRRSRFGSRE RDWLREDVKR GCVYLYGADT TTATTTTTTS SSSSSSSSSS 70 80 90 100 110 120 DLHLVLCTVE TPASEICAGE GRESLYLQLH GDLVRRLEPT ERPLQIVYDY LSRLGFDDPV 130 140 150 160 170 180 RIQEEATNPD LGCMIRFYGE KPCHMDRLDR ILLSGIYNVR KGKTQLHKWA ERLVVLCGTC 190 200 210 220 230 240 LIVSSVKDCQ TGKMHILPLV GGKIEEVKRR QYSLAFSSAG AQAQTYHVSF ETLAEYQRWQ 250 260 270 280 290 300 RQASKVVSQR ISTVDLSCYS LEEVPEHLFY SQDITYLNLR HNFMQLERPG GLDTLYKFSQ 310 320 330 340 350 360 LKGLNLSHNK LGLFPILLCE ISTLTELNLS CNGFHDLPSQ IGNLLNLQTL CLDGNFLTTL 370 380 390 400 410 420 PEELGNLQQL SSLGISFNNF SQIPEVYEKL TMLDRVVMAG NCLEVLNLGV LNRMNHIKHV 430 440 450 460 470 480 DLRMNHLKTM VIENLEGNKH ITHVDLRDNR LTDLDLSSLC SLEQLHCGRN QLRELTLSGF 490 500 510 520 530 540 SLRTLYASSN RLTAVNVYPV PSLLTFLDLS RNLLECVPDW ACEAKKIEVL DVSYNLLTEV 550 560 570 580 590 600 PVRILSSLSL RKLMLGHNHV QNLPTLVEHI PLEVLDLQHN ALTRLPDTLF SKALNKLNKL 610 620 630 640 650 660 EQLEELNLSG NKLKTIPTTI ANCKRLHTLV AHSNNISIFP EILQLPQIQF VDLSCNDLTE 670 680 690 700 710 720 ILIPEALPAT LQDLDLTGNT NLVLEHKTLD IFSHITTLKI DQKPLPTTDS TVTSTFWSHG 730 740 750 760 770 780 LAEMAGQRNK LCVSALAMDS FAEGVGAVYG MFDGDRNEEL PRLLQCTMAD VLLEEVQQST 790 800 810 820 830 840 NDTVFMANTF LVSHRKLGMA GQKLGSSALL CYIRPDTADP ASSFSLTVAN VGTCQAVLCR 850 860 870 880 890 900 GGKPVPLSKV FSLEQDPEEA QRVKDQKAII TEDNKVNGVT CCTRMLGCTY LYPWILPKPH 910 920 930 940 950 960 ISSTPLTIQD ELLILGNKAL WEHLSYTEAV NAVRHVQDPL AAAKKLCTLA QSYGCQDNVG 970 980 990 1000 1010 1020 AMVVYLNIGE EGCTCEMNGL TLPGPVGFAS TTTIKDAPKP ATPSSSSGIA SEFSSEMSTS 1030 1040 1050 1060 1070 1080 EVSSEVGSTA SDEHNAGGLD TALLPRPERR CSLHPTPTSG LFQRQPSSAT FSSNQSDNGL 1090 1100 1110 1120 1130 1140 DSDDDQPVEG VITNGSKVEV EVDIHCCRGR DLENSPPLIE SSPTLCSEEH ARGSCFGIRR 1150 1160 1170 1180 1190 1200 QNSVNSGMLL PMSKDRMELQ KSPSTSCLYG KKLSNGSIVP LEDSLNLIEV ATEVPKRKTG 1210 1220 1230 1240 1250 YFAAPTQMEP EDQFVVPHDL EEEVKEQMKQ HQDSRLEPEP HEEDRTEPPE EFDTAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[2]	Ohara O., Nagase T., Kikuno R. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Retina.
[4]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-423 (ISOFORMS 1/2/3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 639-1323 (ISOFORM 2). Tissue: Amygdala and Placenta.
[7]	"PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms." Brognard J., Sierecki E., Gao T., Newton A.C. Mol. Cell 25:917-931(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH AKT1 AND AKT3.
[8]	"The phosphatase PHLPP controls the cellular levels of protein kinase C." Gao T., Brognard J., Newton A.C. J. Biol. Chem. 283:6300-6311(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH PRKCB.
[9]	"Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis." Liu J., Weiss H.L., Rychahou P., Jackson L.N., Evers B.M., Gao T. Oncogene 28:994-1004(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB023148 mRNA. Translation: BAA76775.2. Different initiation. BX647823 mRNA. No translation available. AC009097 Genomic DNA. No translation available. BC129927 mRNA. Translation: AAI29928.1. AK001854 mRNA. Translation: BAA91943.1. Different initiation. AK124678 mRNA. Translation: BAC85924.1.
IPI	IPI00176709. IPI00477369. IPI00718931.
RefSeq	NP_055835.2. NM_015020.2.
UniGene	Hs.709458.
3D structure databases
ProteinModelPortal	Q6ZVD8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6ZVD8. 12 interactions.
STRING	9606.ENSP00000348611.
PTM databases
PhosphoSite	Q6ZVD8.
Polymorphism databases
DMDM	116242711.
Proteomic databases
PaxDb	Q6ZVD8.
PRIDE	Q6ZVD8.
Protocols and materials databases
DNASU	23035.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356272; ENSP00000348611; ENSG00000040199. ENST00000360429; ENSP00000353610; ENSG00000040199. ENST00000393524; ENSP00000377159; ENSG00000040199. ENST00000568954; ENSP00000457991; ENSG00000040199.
GeneID	23035.
KEGG	hsa:23035.
UCSC	uc002fax.3. human. uc010cgf.3. human.
Organism-specific databases
CTD	23035.
GeneCards	GC16M071674.
H-InvDB	HIX0013215. HIX0173315.
HGNC	HGNC:29149. PHLPP2.
HPA	HPA048598.
MIM	611066. gene.
neXtProt	NX_Q6ZVD8.
PharmGKB	PA165450496.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4886.
HOGENOM	HOG000115529.
InParanoid	Q6ZVD8.
KO	K16340.
OMA	DLSCYSL.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_116125. Disease. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q6ZVD8.
Bgee	Q6ZVD8.
CleanEx	HS_PHLPPL.
Genevestigator	Q6ZVD8.
GermOnline	ENSG00000040199. Homo sapiens.
Family and domain databases
Gene3D	3.60.40.10. 1 hit.
InterPro	IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR001932. PP2C-like. [Graphical view]
Pfam	PF00560. LRR_1. 2 hits. PF00481. PP2C. 1 hit. [Graphical view]
SMART	SM00369. LRR_TYP. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view]
SUPFAM	SSF81606. PP2C-related. 1 hit.
PROSITE	PS51450. LRR. 18 hits. PS50003. PH_DOMAIN. False negative. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q6ZVD8.
ChEMBL	CHEMBL1275209.
GenomeRNAi	23035.
NextBio	44034.
SOURCE	Search...

Entry information

Entry name

PHLP2_HUMAN

Accession

Primary (citable) accession number: Q6ZVD8
Secondary accession number(s): A1L374, Q9NV17, Q9Y2E3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 94 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.