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Protein

Storkhead-box protein 1

Gene

STOX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity).By similarity1 Publication
Isoform A: Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed:22253775). Induces phosphorylation of MAPT/tau (PubMed:22995177).2 Publications

GO - Molecular functioni

  • RNA polymerase II regulatory region sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cellular response to nitrosative stress Source: UniProtKB
  • inner ear development Source: Ensembl
  • mitotic nuclear division Source: UniProtKB-KW
  • negative regulation of gene expression Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of cyclin-dependent protein kinase activity Source: UniProtKB
  • positive regulation of epithelial cell proliferation Source: Ensembl
  • positive regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of otic vesicle morphogenesis Source: Ensembl
  • positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
  • positive regulation of peptidyl-threonine phosphorylation Source: UniProtKB
  • positive regulation of protein kinase B signaling Source: Ensembl
  • regulation of gene expression Source: UniProtKB
  • regulation of mitochondrial DNA metabolic process Source: UniProtKB
  • regulation of mitochondrial membrane potential Source: UniProtKB
  • regulation of mitochondrion organization Source: UniProtKB
  • regulation of response to oxidative stress Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Storkhead-box protein 1
Alternative name(s):
Winged-helix domain-containing protein
Gene namesi
Name:STOX1
Synonyms:C10orf24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23508. STOX1.

Subcellular locationi

Isoform A :

GO - Cellular componenti

  • cell cortex Source: Ensembl
  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

Pre-eclampsia/eclampsia 4 (PEE4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide.
See also OMIM:609404
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181R → P in PEE4. 1 Publication
VAR_023784
Natural varianti153 – 1531Y → H in PEE4. 2 Publications
Corresponds to variant rs1341667 [ dbSNP | Ensembl ].
VAR_023785
Natural varianti825 – 8251N → I in PEE4. 1 Publication
Corresponds to variant rs41278532 [ dbSNP | Ensembl ].
VAR_023787

Keywords - Diseasei

Disease mutation

Organism-specific databases

MalaCardsiSTOX1.
MIMi609404. phenotype.
Orphaneti275555. Preeclampsia.
PharmGKBiPA134883643.

Polymorphism and mutation databases

BioMutaiSTOX1.
DMDMi82592525.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 989989Storkhead-box protein 1PRO_0000072281Add
BLAST

Proteomic databases

PaxDbiQ6ZVD7.
PRIDEiQ6ZVD7.

PTM databases

iPTMnetiQ6ZVD7.
PhosphoSiteiQ6ZVD7.

Expressioni

Tissue specificityi

Expressed in placenta, including the invasive extravillus trophoblast cells.1 Publication

Gene expression databases

BgeeiQ6ZVD7.
GenevisibleiQ6ZVD7. HS.

Organism-specific databases

HPAiHPA037844.
HPA037845.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GORASP2Q9H8Y83EBI-3923644,EBI-739467

Protein-protein interaction databases

BioGridi128569. 4 interactions.
IntActiQ6ZVD7. 2 interactions.
STRINGi9606.ENSP00000298596.

Structurei

3D structure databases

ProteinModelPortaliQ6ZVD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3897. Eukaryota.
ENOG410ZJ97. LUCA.
GeneTreeiENSGT00520000055589.
HOVERGENiHBG080004.
InParanoidiQ6ZVD7.
OMAiYPGIAIP.
OrthoDBiEOG7FFMQW.
PhylomeDBiQ6ZVD7.
TreeFamiTF337253.

Family and domain databases

InterProiIPR019391. Storkhead-box_winged-helix.
[Graphical view]
PfamiPF10264. Stork_head. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q6ZVD7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARPVQLAPG SLALVLCRLE AQKAAGAAEE PGGRAVFRAF RRANARCFWN
60 70 80 90 100
ARLARAASRL AFQGWLRRGV LLVRAPPACL QVLRDAWRRR ALRPPRGFRI
110 120 130 140 150
RAVGDVFPVQ MNPITQSQFV PLGEVLCCAI SDMNTAQIVV TQESLLERLM
160 170 180 190 200
KHYPGIAIPS EDILYTTLGT LIKERKIYHT GEGYFIVTPQ TYFITNTTTQ
210 220 230 240 250
ENKRMLPSDE SRLMPASMTY LVSMESCAES AQENAAPISH CQSCQCFRDM
260 270 280 290 300
HTQDVQEAPV AAEVTRKSHR GLGESVSWVQ NGAVSVSAEH HICESTKPLP
310 320 330 340 350
YTRDKEKGKK FGFSLLWRSL SRKEKPKTEH SSFSAQFPPE EWPVRDEDDL
360 370 380 390 400
DNIPRDVEHE IIKRINPILT VDNLIKHTVL MQKYEEQKKY NSQGTSTDML
410 420 430 440 450
TIGHKYPSKE GVKKRQGLSA KPQGQGHSRR DRHKARNQGS EFQPGSIRLE
460 470 480 490 500
KHPKLPATQP IPRIKSPNEM VGQKPLGEIT TVLGSHLIYK KRISNPFQGL
510 520 530 540 550
SHRGSTISKG HKIQKTSDLK PSQTGPKEKP FQKPRSLDSS RIFDGKAKEP
560 570 580 590 600
YAEQPNDKME AESIYINDPT VKPINDDFRG HLFSHPQQSM LQNDGKCCPF
610 620 630 640 650
MESMLRYEVY GGENEVIPEV LRKSHSHFDK LGETKQTPHS LPSRGASFSD
660 670 680 690 700
RTPSACRLVD NTIHQFQNLG LLDYPVGVNP LRQAARQDKD SEELLRKGFV
710 720 730 740 750
QDAETTSLEN EQLSNDDQAL YQNEVEDDDG ACSSLYLEED DISENDDLRQ
760 770 780 790 800
MLPGHSQYSF TGGSQGNHLG KQKVIERSLT EYNSTMERVE SQVLKRNECY
810 820 830 840 850
KPTGLHATPG ESQEPNLSAE SCGLNSGAQF GFNYEEEPSV AKCVQASAPA
860 870 880 890 900
DERIFDYYSA RKASFEAEVI QDTIGDTGKK PASWSQSPQN QEMRKHFPQK
910 920 930 940 950
FQLFNTSHMP VLAQDVQYEH SHLEGTENHS MAGDSGIDSP RTQSLGSNNS
960 970 980
VILDGLKRRQ NFLQNVEGTK SSQPLTSNSL LPLTPVINV
Length:989
Mass (Da):110,962
Last modified:November 22, 2005 - v2
Checksum:i5F1E70504F081AC7
GO
Isoform B (identifier: Q6ZVD7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-227: VSMESC → DTESGI
     228-989: Missing.

Show »
Length:227
Mass (Da):25,421
Checksum:iDF3237D2ECA7649C
GO
Isoform C (identifier: Q6ZVD7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-169: IAIPSEDILYTTLG → HRVWDLIIQSFWMD
     170-989: Missing.

Show »
Length:169
Mass (Da):19,059
Checksum:iA0C1D44F90B50E7F
GO

Sequence cautioni

The sequence AAH63627.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB71600.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB71607.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC85925.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC87173.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181R → P in PEE4. 1 Publication
VAR_023784
Natural varianti153 – 1531Y → H in PEE4. 2 Publications
Corresponds to variant rs1341667 [ dbSNP | Ensembl ].
VAR_023785
Natural varianti608 – 6081E → D.2 Publications
Corresponds to variant rs10509305 [ dbSNP | Ensembl ].
VAR_023786
Natural varianti825 – 8251N → I in PEE4. 1 Publication
Corresponds to variant rs41278532 [ dbSNP | Ensembl ].
VAR_023787
Natural varianti863 – 8631A → T.
Corresponds to variant rs7904300 [ dbSNP | Ensembl ].
VAR_051388

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei156 – 16914IAIPS…YTTLG → HRVWDLIIQSFWMD in isoform C. 1 PublicationVSP_016226Add
BLAST
Alternative sequencei170 – 989820Missing in isoform C. 1 PublicationVSP_016227Add
BLAST
Alternative sequencei222 – 2276VSMESC → DTESGI in isoform B. 2 PublicationsVSP_016228
Alternative sequencei228 – 989762Missing in isoform B. 2 PublicationsVSP_016229Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY842014 mRNA. Translation: AAW48524.1.
AY842015 mRNA. Translation: AAW48525.1.
AY842016 mRNA. Translation: AAW48526.1.
AY842017 mRNA. Translation: AAW48527.1.
AL359844, AL391539 Genomic DNA. Translation: CAQ07951.1.
AL359844, AL391539 Genomic DNA. Translation: CAQ07952.1.
AL359844, AL391539 Genomic DNA. Translation: CAQ07953.1.
AL391539, AL359844 Genomic DNA. Translation: CAQ08406.1.
AL391539, AL359844 Genomic DNA. Translation: CAQ08407.1.
AL391539, AL359844 Genomic DNA. Translation: CAQ08408.1.
BC063627 mRNA. Translation: AAH63627.1. Different initiation.
BC140011 mRNA. Translation: AAI40012.1.
DQ099680 Genomic DNA. Translation: AAZ07992.1.
AK057864 mRNA. Translation: BAB71600.1. Different initiation.
AK057891 mRNA. Translation: BAB71607.1. Different initiation.
AK124681 mRNA. Translation: BAC85925.1. Different initiation.
AK127878 mRNA. Translation: BAC87173.1. Different initiation.
CCDSiCCDS41535.1. [Q6ZVD7-1]
CCDS44416.1. [Q6ZVD7-3]
CCDS44417.1. [Q6ZVD7-2]
RefSeqiNP_001123631.1. NM_001130159.2. [Q6ZVD7-2]
NP_001123632.1. NM_001130160.2. [Q6ZVD7-3]
NP_001123633.1. NM_001130161.2. [Q6ZVD7-1]
NP_689922.3. NM_152709.4. [Q6ZVD7-1]
UniGeneiHs.37636.

Genome annotation databases

EnsembliENST00000298596; ENSP00000298596; ENSG00000165730. [Q6ZVD7-1]
ENST00000399162; ENSP00000382115; ENSG00000165730. [Q6ZVD7-3]
ENST00000399165; ENSP00000382118; ENSG00000165730. [Q6ZVD7-2]
ENST00000399169; ENSP00000382121; ENSG00000165730. [Q6ZVD7-1]
GeneIDi219736.
KEGGihsa:219736.
UCSCiuc001joq.5. human. [Q6ZVD7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY842014 mRNA. Translation: AAW48524.1.
AY842015 mRNA. Translation: AAW48525.1.
AY842016 mRNA. Translation: AAW48526.1.
AY842017 mRNA. Translation: AAW48527.1.
AL359844, AL391539 Genomic DNA. Translation: CAQ07951.1.
AL359844, AL391539 Genomic DNA. Translation: CAQ07952.1.
AL359844, AL391539 Genomic DNA. Translation: CAQ07953.1.
AL391539, AL359844 Genomic DNA. Translation: CAQ08406.1.
AL391539, AL359844 Genomic DNA. Translation: CAQ08407.1.
AL391539, AL359844 Genomic DNA. Translation: CAQ08408.1.
BC063627 mRNA. Translation: AAH63627.1. Different initiation.
BC140011 mRNA. Translation: AAI40012.1.
DQ099680 Genomic DNA. Translation: AAZ07992.1.
AK057864 mRNA. Translation: BAB71600.1. Different initiation.
AK057891 mRNA. Translation: BAB71607.1. Different initiation.
AK124681 mRNA. Translation: BAC85925.1. Different initiation.
AK127878 mRNA. Translation: BAC87173.1. Different initiation.
CCDSiCCDS41535.1. [Q6ZVD7-1]
CCDS44416.1. [Q6ZVD7-3]
CCDS44417.1. [Q6ZVD7-2]
RefSeqiNP_001123631.1. NM_001130159.2. [Q6ZVD7-2]
NP_001123632.1. NM_001130160.2. [Q6ZVD7-3]
NP_001123633.1. NM_001130161.2. [Q6ZVD7-1]
NP_689922.3. NM_152709.4. [Q6ZVD7-1]
UniGeneiHs.37636.

3D structure databases

ProteinModelPortaliQ6ZVD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128569. 4 interactions.
IntActiQ6ZVD7. 2 interactions.
STRINGi9606.ENSP00000298596.

PTM databases

iPTMnetiQ6ZVD7.
PhosphoSiteiQ6ZVD7.

Polymorphism and mutation databases

BioMutaiSTOX1.
DMDMi82592525.

Proteomic databases

PaxDbiQ6ZVD7.
PRIDEiQ6ZVD7.

Protocols and materials databases

DNASUi219736.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298596; ENSP00000298596; ENSG00000165730. [Q6ZVD7-1]
ENST00000399162; ENSP00000382115; ENSG00000165730. [Q6ZVD7-3]
ENST00000399165; ENSP00000382118; ENSG00000165730. [Q6ZVD7-2]
ENST00000399169; ENSP00000382121; ENSG00000165730. [Q6ZVD7-1]
GeneIDi219736.
KEGGihsa:219736.
UCSCiuc001joq.5. human. [Q6ZVD7-1]

Organism-specific databases

CTDi219736.
GeneCardsiSTOX1.
HGNCiHGNC:23508. STOX1.
HPAiHPA037844.
HPA037845.
MalaCardsiSTOX1.
MIMi609397. gene.
609404. phenotype.
neXtProtiNX_Q6ZVD7.
Orphaneti275555. Preeclampsia.
PharmGKBiPA134883643.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3897. Eukaryota.
ENOG410ZJ97. LUCA.
GeneTreeiENSGT00520000055589.
HOVERGENiHBG080004.
InParanoidiQ6ZVD7.
OMAiYPGIAIP.
OrthoDBiEOG7FFMQW.
PhylomeDBiQ6ZVD7.
TreeFamiTF337253.

Miscellaneous databases

GenomeRNAii219736.
NextBioi90726.
PROiQ6ZVD7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZVD7.
GenevisibleiQ6ZVD7. HS.

Family and domain databases

InterProiIPR019391. Storkhead-box_winged-helix.
[Graphical view]
PfamiPF10264. Stork_head. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family."
    van Dijk M., Mulders J., Poutsma A., Koenst A.A.M., Lachmeijer A.M.A., Dekker G.A., Blankenstein M.A., Oudejans C.B.M.
    Nat. Genet. 37:514-519(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C), ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS PEE4 PRO-18; HIS-153 AND ILE-825, VARIANT ASP-608.
    Tissue: Placenta.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 512-989 (ISOFORM A), VARIANT HIS-153.
    Tissue: Pancreas.
  4. van Dijk M., Oudejans C.B.M., Mol A.J.M.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-104.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 74-989 (ISOFORM A), VARIANT ASP-608.
    Tissue: Amygdala, Brain and Prostate.
  6. "STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease."
    van Abel D., Abdulhamid O., Scheper W., van Dijk M., Oudejans C.B.
    Neurosci. Lett. 528:104-109(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Transcription factor STOX1A promotes mitotic entry by binding to the CCNB1 promotor."
    Abel D.V., Abdul-Hamid O., Dijk M.V., Oudejans C.B.
    PLoS ONE 7:E29769-E29769(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  8. "Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene."
    Doridot L., Chatre L., Ducat A., Vilotte J.L., Lombes A., Mehats C., Barbaux S., Calicchio R., Ricchetti M., Vaiman D.
    Antioxid. Redox Signal. 21:819-834(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSTOX1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZVD7
Secondary accession number(s): A2A3Q9
, A5D6Y7, B0QZA4, B0QZA5, B0QZA6, Q4F8Q6, Q5I946, Q5I947, Q5I948, Q5VX38, Q5VX39, Q6ZRY3, Q96LR3, Q96LS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: November 22, 2005
Last modified: March 16, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.