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Protein

SH2 domain-containing protein 5

Gene

SH2D5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 5Imported
Gene namesi
Name:SH2D5Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000189410.11
HGNCiHGNC:28819 SH2D5
neXtProtiNX_Q6ZV89

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi400745
OpenTargetsiENSG00000189410
PharmGKBiPA142670927

Polymorphism and mutation databases

BioMutaiSH2D5
DMDMi363548475

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002315811 – 423SH2 domain-containing protein 5Add BLAST423

Proteomic databases

PaxDbiQ6ZV89
PeptideAtlasiQ6ZV89
PRIDEiQ6ZV89

PTM databases

iPTMnetiQ6ZV89
PhosphoSitePlusiQ6ZV89

Expressioni

Gene expression databases

BgeeiENSG00000189410
CleanExiHS_SH2D5
ExpressionAtlasiQ6ZV89 baseline and differential
GenevisibleiQ6ZV89 HS

Organism-specific databases

HPAiHPA030182

Interactioni

Subunit structurei

Interacts with BCR.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCRP112742EBI-15101685,EBI-712838

Protein-protein interaction databases

BioGridi134738, 3 interactors
IntActiQ6ZV89, 4 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6ZV89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini296 – 392SH2PROSITE-ProRule annotationAdd BLAST97

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IHFV Eukaryota
ENOG4111IJH LUCA
GeneTreeiENSGT00510000048936
HOGENOMiHOG000231648
HOVERGENiHBG080377
InParanoidiQ6ZV89
OMAiQVFRNHL
OrthoDBiEOG091G081S
PhylomeDBiQ6ZV89
TreeFamiTF334487

Family and domain databases

Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZV89-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQKAGAGGRR ASDCGLAPHR PRCITKFAQY VGSFPVDDLD TQESVWLVQQ
60 70 80 90 100
QLWALKDCPR RRAVILKFSL QGLKIYSGEG EVLLMAHALR RILYSTWCPA
110 120 130 140 150
DCQFAFMARN PRSPASKLFC HLFVGSQPGE VQILHLLLCR SFQLAYLLQH
160 170 180 190 200
PEERAQPEPC PGPTGEVPLK PLSSSGGLVR EPFGRDQLSQ NVHALVSFRR
210 220 230 240 250
LPAEGLVGSG KELPESEGRA RHARLGNPYC SPTLVRKKAI RSKVIRSGAY
260 270 280 290 300
RGCTYETQLQ LSAREAFPAA WEAWPRGPGG HSCLVESEGS LTENIWAFAG
310 320 330 340 350
ISRPCALALL RRDVLGAFLL WPELGASGQW CLSVRTQCGV VPHQVFRNHL
360 370 380 390 400
GRYCLEHLPA EFPSLEALVE NHAVTERSLF CPLDMGRLNP TYEEQDCGPP
410 420
GRPPRTLRPL SHAKSEAELQ GLG
Length:423
Mass (Da):46,797
Last modified:December 14, 2011 - v2
Checksum:iBD0C7D55C7FF8FDB
GO
Isoform 2 (identifier: Q6ZV89-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Show »
Length:339
Mass (Da):37,439
Checksum:i23552A7C9CC6F229
GO

Sequence cautioni

The sequence BAC85974 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI23392 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0459381 – 84Missing in isoform 2. CuratedAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124869 mRNA Translation: BAC85974.1 Different initiation.
AK296431 mRNA Translation: BAH12349.1
AL663074 Genomic DNA Translation: CAI23391.1
AL663074 Genomic DNA Translation: CAI23392.1 Different initiation.
CH471134 Genomic DNA Translation: EAW94947.1
CCDSiCCDS41280.1 [Q6ZV89-2]
CCDS44080.1 [Q6ZV89-1]
RefSeqiNP_001096630.1, NM_001103160.1 [Q6ZV89-2]
NP_001096631.1, NM_001103161.1 [Q6ZV89-1]
XP_011539761.1, XM_011541459.1 [Q6ZV89-1]
XP_011539762.1, XM_011541460.1 [Q6ZV89-1]
XP_011539763.1, XM_011541461.2 [Q6ZV89-1]
UniGeneiHs.591522

Genome annotation databases

EnsembliENST00000375031; ENSP00000364171; ENSG00000189410 [Q6ZV89-2]
ENST00000444387; ENSP00000406026; ENSG00000189410 [Q6ZV89-1]
GeneIDi400745
KEGGihsa:400745
UCSCiuc001bdt.1 human [Q6ZV89-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSH2D5_HUMAN
AccessioniPrimary (citable) accession number: Q6ZV89
Secondary accession number(s): B7Z3W3, Q5SSJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 14, 2011
Last modified: March 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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