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Q6ZV89 (SH2D5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SH2 domain-containing protein 5
Gene names
Name:SH2D5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 SH2 domain.

Sequence caution

The sequence BAC85974.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAI23392.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainSH2 domain
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZV89-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZV89-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 423423SH2 domain-containing protein 5
PRO_0000231581

Regions

Domain296 – 39297SH2

Natural variations

Alternative sequence1 – 8484Missing in isoform 2.
VSP_045938

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 14, 2011. Version 2.
Checksum: BD0C7D55C7FF8FDB

FASTA42346,797
        10         20         30         40         50         60 
MQKAGAGGRR ASDCGLAPHR PRCITKFAQY VGSFPVDDLD TQESVWLVQQ QLWALKDCPR 

        70         80         90        100        110        120 
RRAVILKFSL QGLKIYSGEG EVLLMAHALR RILYSTWCPA DCQFAFMARN PRSPASKLFC 

       130        140        150        160        170        180 
HLFVGSQPGE VQILHLLLCR SFQLAYLLQH PEERAQPEPC PGPTGEVPLK PLSSSGGLVR 

       190        200        210        220        230        240 
EPFGRDQLSQ NVHALVSFRR LPAEGLVGSG KELPESEGRA RHARLGNPYC SPTLVRKKAI 

       250        260        270        280        290        300 
RSKVIRSGAY RGCTYETQLQ LSAREAFPAA WEAWPRGPGG HSCLVESEGS LTENIWAFAG 

       310        320        330        340        350        360 
ISRPCALALL RRDVLGAFLL WPELGASGQW CLSVRTQCGV VPHQVFRNHL GRYCLEHLPA 

       370        380        390        400        410        420 
EFPSLEALVE NHAVTERSLF CPLDMGRLNP TYEEQDCGPP GRPPRTLRPL SHAKSEAELQ 


GLG 

« Hide

Isoform 2 [UniParc].

Checksum: 23552A7C9CC6F229
Show »

FASTA33937,439

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Hippocampus and Thalamus.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK124869 mRNA. Translation: BAC85974.1. Different initiation.
AK296431 mRNA. Translation: BAH12349.1.
AL663074 Genomic DNA. Translation: CAI23391.1.
AL663074 Genomic DNA. Translation: CAI23392.1. Different initiation.
CH471134 Genomic DNA. Translation: EAW94947.1.
CCDSCCDS41280.1. [Q6ZV89-2]
CCDS44080.1. [Q6ZV89-1]
RefSeqNP_001096630.1. NM_001103160.1. [Q6ZV89-2]
NP_001096631.1. NM_001103161.1. [Q6ZV89-1]
UniGeneHs.591522.

3D structure databases

ProteinModelPortalQ6ZV89.
SMRQ6ZV89. Positions 290-386.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid134738. 2 interactions.
IntActQ6ZV89. 2 interactions.
MINTMINT-1496332.
STRING9606.ENSP00000408509.

PTM databases

PhosphoSiteQ6ZV89.

Polymorphism databases

DMDM363548475.

Proteomic databases

PaxDbQ6ZV89.
PRIDEQ6ZV89.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000375031; ENSP00000364171; ENSG00000189410. [Q6ZV89-2]
ENST00000444387; ENSP00000406026; ENSG00000189410. [Q6ZV89-1]
GeneID400745.
KEGGhsa:400745.
UCSCuc001bdt.1. human. [Q6ZV89-1]

Organism-specific databases

CTD400745.
GeneCardsGC01M021046.
HGNCHGNC:28819. SH2D5.
HPAHPA030182.
neXtProtNX_Q6ZV89.
PharmGKBPA142670927.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42660.
HOGENOMHOG000231648.
HOVERGENHBG080377.
InParanoidQ6ZV89.
OMAEHLPAEF.
OrthoDBEOG7GXPBD.
PhylomeDBQ6ZV89.
TreeFamTF334487.

Gene expression databases

ArrayExpressQ6ZV89.
BgeeQ6ZV89.
CleanExHS_SH2D5.
GenevestigatorQ6ZV89.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
[Graphical view]
PfamPF00640. PID. 1 hit.
[Graphical view]
SMARTSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi400745.
NextBio106154.
PROQ6ZV89.

Entry information

Entry nameSH2D5_HUMAN
AccessionPrimary (citable) accession number: Q6ZV89
Secondary accession number(s): B7Z3W3, Q5SSJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 14, 2011
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM