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Protein

SH2 domain-containing protein 5

Gene

SH2D5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 5
Gene namesi
Name:SH2D5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:28819. SH2D5.

Subcellular locationi

Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. postsynaptic density Source: UniProtKB
  3. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670927.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423SH2 domain-containing protein 5PRO_0000231581Add
BLAST

Proteomic databases

PaxDbiQ6ZV89.
PRIDEiQ6ZV89.

PTM databases

PhosphoSiteiQ6ZV89.

Expressioni

Gene expression databases

BgeeiQ6ZV89.
CleanExiHS_SH2D5.
ExpressionAtlasiQ6ZV89. baseline and differential.
GenevestigatoriQ6ZV89.

Organism-specific databases

HPAiHPA030182.

Interactioni

Subunit structurei

Interacts with BCR.1 Publication

Protein-protein interaction databases

BioGridi134738. 2 interactions.
IntActiQ6ZV89. 2 interactions.
MINTiMINT-1496332.
STRINGi9606.ENSP00000408509.

Structurei

3D structure databases

ProteinModelPortaliQ6ZV89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini296 – 39297SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG42660.
GeneTreeiENSGT00510000048936.
HOGENOMiHOG000231648.
HOVERGENiHBG080377.
InParanoidiQ6ZV89.
OMAiDCPRRRA.
OrthoDBiEOG7GXPBD.
PhylomeDBiQ6ZV89.
TreeFamiTF334487.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
[Graphical view]
PfamiPF00640. PID. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZV89-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQKAGAGGRR ASDCGLAPHR PRCITKFAQY VGSFPVDDLD TQESVWLVQQ
60 70 80 90 100
QLWALKDCPR RRAVILKFSL QGLKIYSGEG EVLLMAHALR RILYSTWCPA
110 120 130 140 150
DCQFAFMARN PRSPASKLFC HLFVGSQPGE VQILHLLLCR SFQLAYLLQH
160 170 180 190 200
PEERAQPEPC PGPTGEVPLK PLSSSGGLVR EPFGRDQLSQ NVHALVSFRR
210 220 230 240 250
LPAEGLVGSG KELPESEGRA RHARLGNPYC SPTLVRKKAI RSKVIRSGAY
260 270 280 290 300
RGCTYETQLQ LSAREAFPAA WEAWPRGPGG HSCLVESEGS LTENIWAFAG
310 320 330 340 350
ISRPCALALL RRDVLGAFLL WPELGASGQW CLSVRTQCGV VPHQVFRNHL
360 370 380 390 400
GRYCLEHLPA EFPSLEALVE NHAVTERSLF CPLDMGRLNP TYEEQDCGPP
410 420
GRPPRTLRPL SHAKSEAELQ GLG
Length:423
Mass (Da):46,797
Last modified:December 14, 2011 - v2
Checksum:iBD0C7D55C7FF8FDB
GO
Isoform 2 (identifier: Q6ZV89-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Show »
Length:339
Mass (Da):37,439
Checksum:i23552A7C9CC6F229
GO

Sequence cautioni

The sequence BAC85974.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI23392.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8484Missing in isoform 2. CuratedVSP_045938Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124869 mRNA. Translation: BAC85974.1. Different initiation.
AK296431 mRNA. Translation: BAH12349.1.
AL663074 Genomic DNA. Translation: CAI23391.1.
AL663074 Genomic DNA. Translation: CAI23392.1. Different initiation.
CH471134 Genomic DNA. Translation: EAW94947.1.
CCDSiCCDS41280.1. [Q6ZV89-2]
CCDS44080.1. [Q6ZV89-1]
RefSeqiNP_001096630.1. NM_001103160.1. [Q6ZV89-2]
NP_001096631.1. NM_001103161.1. [Q6ZV89-1]
UniGeneiHs.591522.

Genome annotation databases

EnsembliENST00000375031; ENSP00000364171; ENSG00000189410. [Q6ZV89-2]
ENST00000444387; ENSP00000406026; ENSG00000189410. [Q6ZV89-1]
GeneIDi400745.
KEGGihsa:400745.
UCSCiuc001bdt.1. human. [Q6ZV89-1]

Polymorphism databases

DMDMi363548475.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124869 mRNA. Translation: BAC85974.1. Different initiation.
AK296431 mRNA. Translation: BAH12349.1.
AL663074 Genomic DNA. Translation: CAI23391.1.
AL663074 Genomic DNA. Translation: CAI23392.1. Different initiation.
CH471134 Genomic DNA. Translation: EAW94947.1.
CCDSiCCDS41280.1. [Q6ZV89-2]
CCDS44080.1. [Q6ZV89-1]
RefSeqiNP_001096630.1. NM_001103160.1. [Q6ZV89-2]
NP_001096631.1. NM_001103161.1. [Q6ZV89-1]
UniGeneiHs.591522.

3D structure databases

ProteinModelPortaliQ6ZV89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134738. 2 interactions.
IntActiQ6ZV89. 2 interactions.
MINTiMINT-1496332.
STRINGi9606.ENSP00000408509.

PTM databases

PhosphoSiteiQ6ZV89.

Polymorphism databases

DMDMi363548475.

Proteomic databases

PaxDbiQ6ZV89.
PRIDEiQ6ZV89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375031; ENSP00000364171; ENSG00000189410. [Q6ZV89-2]
ENST00000444387; ENSP00000406026; ENSG00000189410. [Q6ZV89-1]
GeneIDi400745.
KEGGihsa:400745.
UCSCiuc001bdt.1. human. [Q6ZV89-1]

Organism-specific databases

CTDi400745.
GeneCardsiGC01M021046.
HGNCiHGNC:28819. SH2D5.
HPAiHPA030182.
neXtProtiNX_Q6ZV89.
PharmGKBiPA142670927.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG42660.
GeneTreeiENSGT00510000048936.
HOGENOMiHOG000231648.
HOVERGENiHBG080377.
InParanoidiQ6ZV89.
OMAiDCPRRRA.
OrthoDBiEOG7GXPBD.
PhylomeDBiQ6ZV89.
TreeFamiTF334487.

Miscellaneous databases

GenomeRNAii400745.
NextBioi106154.
PROiQ6ZV89.

Gene expression databases

BgeeiQ6ZV89.
CleanExiHS_SH2D5.
ExpressionAtlasiQ6ZV89. baseline and differential.
GenevestigatoriQ6ZV89.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
[Graphical view]
PfamiPF00640. PID. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hippocampus and Thalamus.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "src homology 2 domain containing protein 5 (sh2d5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP."
    Gray E.J., Petsalaki E., James D.A., Bagshaw R.D., Stacey M.M., Rocks O., Gingras A.C., Pawson T.
    J. Biol. Chem. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BCR.

Entry informationi

Entry nameiSH2D5_HUMAN
AccessioniPrimary (citable) accession number: Q6ZV89
Secondary accession number(s): B7Z3W3, Q5SSJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 14, 2011
Last modified: March 4, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.