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Q6ZV89

- SH2D5_HUMAN

UniProt

Q6ZV89 - SH2D5_HUMAN

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Protein

SH2 domain-containing protein 5

Gene

SH2D5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 5
Gene namesi
Name:SH2D5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:28819. SH2D5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670927.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423SH2 domain-containing protein 5PRO_0000231581Add
BLAST

Proteomic databases

PaxDbiQ6ZV89.
PRIDEiQ6ZV89.

PTM databases

PhosphoSiteiQ6ZV89.

Expressioni

Gene expression databases

BgeeiQ6ZV89.
CleanExiHS_SH2D5.
ExpressionAtlasiQ6ZV89. baseline and differential.
GenevestigatoriQ6ZV89.

Organism-specific databases

HPAiHPA030182.

Interactioni

Protein-protein interaction databases

BioGridi134738. 2 interactions.
IntActiQ6ZV89. 2 interactions.
MINTiMINT-1496332.
STRINGi9606.ENSP00000408509.

Structurei

3D structure databases

ProteinModelPortaliQ6ZV89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini296 – 39297SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG42660.
GeneTreeiENSGT00510000048936.
HOGENOMiHOG000231648.
HOVERGENiHBG080377.
InParanoidiQ6ZV89.
OMAiEHLPAEF.
OrthoDBiEOG7GXPBD.
PhylomeDBiQ6ZV89.
TreeFamiTF334487.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
[Graphical view]
PfamiPF00640. PID. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZV89-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQKAGAGGRR ASDCGLAPHR PRCITKFAQY VGSFPVDDLD TQESVWLVQQ
60 70 80 90 100
QLWALKDCPR RRAVILKFSL QGLKIYSGEG EVLLMAHALR RILYSTWCPA
110 120 130 140 150
DCQFAFMARN PRSPASKLFC HLFVGSQPGE VQILHLLLCR SFQLAYLLQH
160 170 180 190 200
PEERAQPEPC PGPTGEVPLK PLSSSGGLVR EPFGRDQLSQ NVHALVSFRR
210 220 230 240 250
LPAEGLVGSG KELPESEGRA RHARLGNPYC SPTLVRKKAI RSKVIRSGAY
260 270 280 290 300
RGCTYETQLQ LSAREAFPAA WEAWPRGPGG HSCLVESEGS LTENIWAFAG
310 320 330 340 350
ISRPCALALL RRDVLGAFLL WPELGASGQW CLSVRTQCGV VPHQVFRNHL
360 370 380 390 400
GRYCLEHLPA EFPSLEALVE NHAVTERSLF CPLDMGRLNP TYEEQDCGPP
410 420
GRPPRTLRPL SHAKSEAELQ GLG
Length:423
Mass (Da):46,797
Last modified:December 14, 2011 - v2
Checksum:iBD0C7D55C7FF8FDB
GO
Isoform 2 (identifier: Q6ZV89-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Show »
Length:339
Mass (Da):37,439
Checksum:i23552A7C9CC6F229
GO

Sequence cautioni

The sequence BAC85974.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI23392.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8484Missing in isoform 2. CuratedVSP_045938Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124869 mRNA. Translation: BAC85974.1. Different initiation.
AK296431 mRNA. Translation: BAH12349.1.
AL663074 Genomic DNA. Translation: CAI23391.1.
AL663074 Genomic DNA. Translation: CAI23392.1. Different initiation.
CH471134 Genomic DNA. Translation: EAW94947.1.
CCDSiCCDS41280.1. [Q6ZV89-2]
CCDS44080.1. [Q6ZV89-1]
RefSeqiNP_001096630.1. NM_001103160.1. [Q6ZV89-2]
NP_001096631.1. NM_001103161.1. [Q6ZV89-1]
UniGeneiHs.591522.

Genome annotation databases

EnsembliENST00000375031; ENSP00000364171; ENSG00000189410. [Q6ZV89-2]
ENST00000444387; ENSP00000406026; ENSG00000189410. [Q6ZV89-1]
GeneIDi400745.
KEGGihsa:400745.
UCSCiuc001bdt.1. human. [Q6ZV89-1]

Polymorphism databases

DMDMi363548475.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124869 mRNA. Translation: BAC85974.1 . Different initiation.
AK296431 mRNA. Translation: BAH12349.1 .
AL663074 Genomic DNA. Translation: CAI23391.1 .
AL663074 Genomic DNA. Translation: CAI23392.1 . Different initiation.
CH471134 Genomic DNA. Translation: EAW94947.1 .
CCDSi CCDS41280.1. [Q6ZV89-2 ]
CCDS44080.1. [Q6ZV89-1 ]
RefSeqi NP_001096630.1. NM_001103160.1. [Q6ZV89-2 ]
NP_001096631.1. NM_001103161.1. [Q6ZV89-1 ]
UniGenei Hs.591522.

3D structure databases

ProteinModelPortali Q6ZV89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 134738. 2 interactions.
IntActi Q6ZV89. 2 interactions.
MINTi MINT-1496332.
STRINGi 9606.ENSP00000408509.

PTM databases

PhosphoSitei Q6ZV89.

Polymorphism databases

DMDMi 363548475.

Proteomic databases

PaxDbi Q6ZV89.
PRIDEi Q6ZV89.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375031 ; ENSP00000364171 ; ENSG00000189410 . [Q6ZV89-2 ]
ENST00000444387 ; ENSP00000406026 ; ENSG00000189410 . [Q6ZV89-1 ]
GeneIDi 400745.
KEGGi hsa:400745.
UCSCi uc001bdt.1. human. [Q6ZV89-1 ]

Organism-specific databases

CTDi 400745.
GeneCardsi GC01M021046.
HGNCi HGNC:28819. SH2D5.
HPAi HPA030182.
neXtProti NX_Q6ZV89.
PharmGKBi PA142670927.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42660.
GeneTreei ENSGT00510000048936.
HOGENOMi HOG000231648.
HOVERGENi HBG080377.
InParanoidi Q6ZV89.
OMAi EHLPAEF.
OrthoDBi EOG7GXPBD.
PhylomeDBi Q6ZV89.
TreeFami TF334487.

Miscellaneous databases

GenomeRNAii 400745.
NextBioi 106154.
PROi Q6ZV89.

Gene expression databases

Bgeei Q6ZV89.
CleanExi HS_SH2D5.
ExpressionAtlasi Q6ZV89. baseline and differential.
Genevestigatori Q6ZV89.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
[Graphical view ]
Pfami PF00640. PID. 1 hit.
[Graphical view ]
SMARTi SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hippocampus and Thalamus.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSH2D5_HUMAN
AccessioniPrimary (citable) accession number: Q6ZV89
Secondary accession number(s): B7Z3W3, Q5SSJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 14, 2011
Last modified: October 29, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3