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Q6ZV89

- SH2D5_HUMAN

UniProt

Q6ZV89 - SH2D5_HUMAN

Protein

SH2 domain-containing protein 5

Gene

SH2D5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (14 Dec 2011)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH2 domain-containing protein 5
    Gene namesi
    Name:SH2D5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:28819. SH2D5.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670927.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423SH2 domain-containing protein 5PRO_0000231581Add
    BLAST

    Proteomic databases

    PaxDbiQ6ZV89.
    PRIDEiQ6ZV89.

    PTM databases

    PhosphoSiteiQ6ZV89.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ZV89.
    BgeeiQ6ZV89.
    CleanExiHS_SH2D5.
    GenevestigatoriQ6ZV89.

    Organism-specific databases

    HPAiHPA030182.

    Interactioni

    Protein-protein interaction databases

    BioGridi134738. 2 interactions.
    IntActiQ6ZV89. 2 interactions.
    MINTiMINT-1496332.
    STRINGi9606.ENSP00000408509.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZV89.
    SMRiQ6ZV89. Positions 290-386.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini296 – 39297SH2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG42660.
    HOGENOMiHOG000231648.
    HOVERGENiHBG080377.
    InParanoidiQ6ZV89.
    OMAiEHLPAEF.
    OrthoDBiEOG7GXPBD.
    PhylomeDBiQ6ZV89.
    TreeFamiTF334487.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    IPR000980. SH2.
    [Graphical view]
    PfamiPF00640. PID. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZV89-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQKAGAGGRR ASDCGLAPHR PRCITKFAQY VGSFPVDDLD TQESVWLVQQ    50
    QLWALKDCPR RRAVILKFSL QGLKIYSGEG EVLLMAHALR RILYSTWCPA 100
    DCQFAFMARN PRSPASKLFC HLFVGSQPGE VQILHLLLCR SFQLAYLLQH 150
    PEERAQPEPC PGPTGEVPLK PLSSSGGLVR EPFGRDQLSQ NVHALVSFRR 200
    LPAEGLVGSG KELPESEGRA RHARLGNPYC SPTLVRKKAI RSKVIRSGAY 250
    RGCTYETQLQ LSAREAFPAA WEAWPRGPGG HSCLVESEGS LTENIWAFAG 300
    ISRPCALALL RRDVLGAFLL WPELGASGQW CLSVRTQCGV VPHQVFRNHL 350
    GRYCLEHLPA EFPSLEALVE NHAVTERSLF CPLDMGRLNP TYEEQDCGPP 400
    GRPPRTLRPL SHAKSEAELQ GLG 423
    Length:423
    Mass (Da):46,797
    Last modified:December 14, 2011 - v2
    Checksum:iBD0C7D55C7FF8FDB
    GO
    Isoform 2 (identifier: Q6ZV89-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-84: Missing.

    Show »
    Length:339
    Mass (Da):37,439
    Checksum:i23552A7C9CC6F229
    GO

    Sequence cautioni

    The sequence BAC85974.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAI23392.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8484Missing in isoform 2. CuratedVSP_045938Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK124869 mRNA. Translation: BAC85974.1. Different initiation.
    AK296431 mRNA. Translation: BAH12349.1.
    AL663074 Genomic DNA. Translation: CAI23391.1.
    AL663074 Genomic DNA. Translation: CAI23392.1. Different initiation.
    CH471134 Genomic DNA. Translation: EAW94947.1.
    CCDSiCCDS41280.1. [Q6ZV89-2]
    CCDS44080.1. [Q6ZV89-1]
    RefSeqiNP_001096630.1. NM_001103160.1. [Q6ZV89-2]
    NP_001096631.1. NM_001103161.1. [Q6ZV89-1]
    UniGeneiHs.591522.

    Genome annotation databases

    EnsembliENST00000375031; ENSP00000364171; ENSG00000189410. [Q6ZV89-2]
    ENST00000444387; ENSP00000406026; ENSG00000189410. [Q6ZV89-1]
    GeneIDi400745.
    KEGGihsa:400745.
    UCSCiuc001bdt.1. human. [Q6ZV89-1]

    Polymorphism databases

    DMDMi363548475.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK124869 mRNA. Translation: BAC85974.1 . Different initiation.
    AK296431 mRNA. Translation: BAH12349.1 .
    AL663074 Genomic DNA. Translation: CAI23391.1 .
    AL663074 Genomic DNA. Translation: CAI23392.1 . Different initiation.
    CH471134 Genomic DNA. Translation: EAW94947.1 .
    CCDSi CCDS41280.1. [Q6ZV89-2 ]
    CCDS44080.1. [Q6ZV89-1 ]
    RefSeqi NP_001096630.1. NM_001103160.1. [Q6ZV89-2 ]
    NP_001096631.1. NM_001103161.1. [Q6ZV89-1 ]
    UniGenei Hs.591522.

    3D structure databases

    ProteinModelPortali Q6ZV89.
    SMRi Q6ZV89. Positions 290-386.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 134738. 2 interactions.
    IntActi Q6ZV89. 2 interactions.
    MINTi MINT-1496332.
    STRINGi 9606.ENSP00000408509.

    PTM databases

    PhosphoSitei Q6ZV89.

    Polymorphism databases

    DMDMi 363548475.

    Proteomic databases

    PaxDbi Q6ZV89.
    PRIDEi Q6ZV89.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375031 ; ENSP00000364171 ; ENSG00000189410 . [Q6ZV89-2 ]
    ENST00000444387 ; ENSP00000406026 ; ENSG00000189410 . [Q6ZV89-1 ]
    GeneIDi 400745.
    KEGGi hsa:400745.
    UCSCi uc001bdt.1. human. [Q6ZV89-1 ]

    Organism-specific databases

    CTDi 400745.
    GeneCardsi GC01M021046.
    HGNCi HGNC:28819. SH2D5.
    HPAi HPA030182.
    neXtProti NX_Q6ZV89.
    PharmGKBi PA142670927.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42660.
    HOGENOMi HOG000231648.
    HOVERGENi HBG080377.
    InParanoidi Q6ZV89.
    OMAi EHLPAEF.
    OrthoDBi EOG7GXPBD.
    PhylomeDBi Q6ZV89.
    TreeFami TF334487.

    Miscellaneous databases

    GenomeRNAii 400745.
    NextBioi 106154.
    PROi Q6ZV89.

    Gene expression databases

    ArrayExpressi Q6ZV89.
    Bgeei Q6ZV89.
    CleanExi HS_SH2D5.
    Genevestigatori Q6ZV89.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    IPR000980. SH2.
    [Graphical view ]
    Pfami PF00640. PID. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Hippocampus and Thalamus.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSH2D5_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZV89
    Secondary accession number(s): B7Z3W3, Q5SSJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3