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Protein

FYVE, RhoGEF and PH domain-containing protein 6

Gene

FGD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1222 – 128160FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
FYVE, RhoGEF and PH domain-containing protein 6
Alternative name(s):
Zinc finger FYVE domain-containing protein 24
Gene namesi
Name:FGD6
Synonyms:KIAA1362, ZFYVE24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:21740. FGD6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134967436.

Polymorphism and mutation databases

BioMutaiFGD6.
DMDMi61213484.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14301430FYVE, RhoGEF and PH domain-containing protein 6PRO_0000080952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei231 – 2311PhosphoserineCombined sources
Modified residuei515 – 5151PhosphoserineCombined sources
Modified residuei554 – 5541PhosphoserineCombined sources
Modified residuei605 – 6051PhosphoserineBy similarity
Modified residuei692 – 6921PhosphoserineCombined sources
Modified residuei721 – 7211PhosphoserineCombined sources
Modified residuei1197 – 11971PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZV73.
MaxQBiQ6ZV73.
PaxDbiQ6ZV73.
PeptideAtlasiQ6ZV73.
PRIDEiQ6ZV73.

PTM databases

iPTMnetiQ6ZV73.
PhosphoSiteiQ6ZV73.

Expressioni

Gene expression databases

BgeeiENSG00000180263.
CleanExiHS_FGD6.
ExpressionAtlasiQ6ZV73. baseline and differential.
GenevisibleiQ6ZV73. HS.

Organism-specific databases

HPAiHPA007974.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120899. 14 interactions.
IntActiQ6ZV73. 11 interactions.
STRINGi9606.ENSP00000344446.

Structurei

3D structure databases

ProteinModelPortaliQ6ZV73.
SMRiQ6ZV73. Positions 1339-1429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini871 – 1060190DHPROSITE-ProRule annotationAdd
BLAST
Domaini1089 – 118395PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini1333 – 142997PH 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi344 – 3496Poly-Ser

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1222 – 128160FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IUBB. Eukaryota.
ENOG410XRXV. LUCA.
GeneTreeiENSGT00750000117280.
HOGENOMiHOG000112571.
HOVERGENiHBG051610.
InParanoidiQ6ZV73.
KOiK05724.
OMAiKRITFCP.
OrthoDBiEOG091G00IK.
PhylomeDBiQ6ZV73.
TreeFamiTF316247.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF00169. PH. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZV73-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSAAEIKKP PVAPKPKFVV ANNKPAPPPI APKPDIVISS VPQSTKKMKP
60 70 80 90 100
AIAPKPKVLK TSPVREIGQS PSRKIMLNLE GHKQELAEST DNFNCKYEGN
110 120 130 140 150
QSNDYISPMC SCSSECIHKL GHRENLCVKQ LVLEPLEMNE NLENSKIDET
160 170 180 190 200
LTIKTRSKCD LYGEKAKNQG GVVLKASVLE EELKDALIHQ MPPFISAQKH
210 220 230 240 250
RPTDSPEMNG GCNSNGQFRI EFADLSPSPS SFEKVPDHHS CHLQLPSDEC
260 270 280 290 300
EHFETCQDDS EKSNNCFQSS ELEALENGKR STLISSDGVS KKSEVKDLGP
310 320 330 340 350
LEIHLVPYTP KFPTPKPRKT RTARLLRQKC VDTPSESTEE PGNSDSSSSC
360 370 380 390 400
LTENSLKINK ISVLHQNVLC KQEQVDKMKL GNKSELNMES NSDAQDLVNS
410 420 430 440 450
QKAMCNETTS FEKMAPSFDK DSNLSSDSTT VDGSSMSLAV DEGTGFIRCT
460 470 480 490 500
VSMSLPKQLK LTCNEHLQSG RNLGVSAPQM QKESVIKEEN SLRIVPKKPQ
510 520 530 540 550
RHSLPATGVL KKAASEELLE KSSYPSSEEK SSEKSLERNH LQHLCAQNRG
560 570 580 590 600
VSSSFDMPKR ASEKPVWKLP HPILPFSGNP EFLKSVTVSS NSEPSTALTK
610 620 630 640 650
PRAKSLSAMD VEKCTKPCKD STKKNSFKKL LSMKLSICFM KSDFQKFWSK
660 670 680 690 700
SSQLGDTTTG HLSSGEQKGI ESDWQGLLVG EEKRSKPIKA YSTENYSLES
710 720 730 740 750
QKKRKKSRGQ TSAANGLRAE SLDDQMLSRE SSSQAPYKSV TSLCAPEYEN
760 770 780 790 800
IRHYEEIPEY ENLPFIMAIR KTQELEWQNS SSMEDADANV YEVEEPYEAP
810 820 830 840 850
DGQLQLGPRH QHSSSGASQE EQNDLGLGDL PSDEEEIINS SDEDDVSSES
860 870 880 890 900
SKGEPDPLED KQDEDNGMKS KVHHIAKEIM SSEKVFVDVL KLLHIDFRDA
910 920 930 940 950
VAHASRQLGK PVIEDRILNQ ILYYLPQLYE LNRDLLKELE ERMLHWTEQQ
960 970 980 990 1000
RIADIFVKKG PYLKMYSTYI KEFDKNIALL DEQCKKNPGF AAVVREFEMS
1010 1020 1030 1040 1050
PRCANLALKH YLLKPVQRIP QYRLLLTDYL KNLIEDAGDY RDTQDALAVV
1060 1070 1080 1090 1100
IEVANHANDT MKQGDNFQKL MQIQYSLNGH HEIVQPGRVF LKEGILMKLS
1110 1120 1130 1140 1150
RKVMQPRMFF LFNDALLYTT PVQSGMYKLN NMLSLAGMKV RKPTQEAYQN
1160 1170 1180 1190 1200
ELKIESVERS FILSASSATE RDEWLEAISR AIEEYAKKRI TFCPSRSLDE
1210 1220 1230 1240 1250
ADSENKEEVS PLGSKAPIWI PDTRATMCMI CTSEFTLTWR RHHCRACGKI
1260 1270 1280 1290 1300
VCQACSSNKY GLDYLKNQPA RVCEHCFQEL QKLDHQHSPR IGSPGNHKSP
1310 1320 1330 1340 1350
SSALSSVLHS IPSGRKQKKI PAALKEVSAN TEDSSMSGYL YRSKGNKKPW
1360 1370 1380 1390 1400
KHFWFVIKNK VLYTYAASED VAALESQPLL GFTVIQVKDE NSESKVFQLL
1410 1420 1430
HKNMLFYVFK AEDAHSAQKW IEAFQEGTIL
Length:1,430
Mass (Da):160,816
Last modified:March 15, 2005 - v2
Checksum:i705D1D4DFB50D8FF
GO
Isoform 2 (identifier: Q6ZV73-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1370-1374: DVAAL → VRSEI
     1375-1430: Missing.

Note: No experimental confirmation available.
Show »
Length:1,374
Mass (Da):154,465
Checksum:iFA017AC35B18B7D1
GO

Sequence cautioni

The sequence BAA92052 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA92600 differs from that shown. Reason: Frameshift at position 1365. Curated
The sequence BAC87464 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAD98096 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti832 – 8321S → P in CAD98096 (PubMed:17974005).Curated
Sequence conflicti848 – 8481S → F in CAD98096 (PubMed:17974005).Curated
Sequence conflicti949 – 9491Q → H in BAC85990 (PubMed:14702039).Curated
Sequence conflicti966 – 9661Y → D in AAH13319 (PubMed:15489334).Curated
Sequence conflicti992 – 9921A → T in AAH13319 (PubMed:15489334).Curated
Sequence conflicti1002 – 10021R → C in BAA92600 (PubMed:10718198).Curated
Sequence conflicti1051 – 10511I → V in AAH13319 (PubMed:15489334).Curated
Sequence conflicti1115 – 11151A → V in CAD98096 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti257 – 2571Q → R.
Corresponds to variant rs10507047 [ dbSNP | Ensembl ].
VAR_024286
Natural varianti1393 – 13931E → K.
Corresponds to variant rs3794255 [ dbSNP | Ensembl ].
VAR_051985

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1370 – 13745DVAAL → VRSEI in isoform 2. 1 PublicationVSP_013091
Alternative sequencei1375 – 143056Missing in isoform 2. 1 PublicationVSP_013092Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002045 mRNA. Translation: BAA92052.1. Different initiation.
AK124904 mRNA. Translation: BAC85990.1.
AK128492 mRNA. Translation: BAC87464.1. Different initiation.
BC013319 mRNA. Translation: AAH13319.2.
BX538322 mRNA. Translation: CAD98096.1. Sequence problems.
AB037783 mRNA. Translation: BAA92600.1. Frameshift.
CCDSiCCDS31878.1. [Q6ZV73-1]
RefSeqiNP_060821.3. NM_018351.3. [Q6ZV73-1]
UniGeneiHs.506381.

Genome annotation databases

EnsembliENST00000343958; ENSP00000344446; ENSG00000180263. [Q6ZV73-1]
ENST00000546711; ENSP00000450342; ENSG00000180263. [Q6ZV73-2]
GeneIDi55785.
KEGGihsa:55785.
UCSCiuc001tdp.4. human. [Q6ZV73-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002045 mRNA. Translation: BAA92052.1. Different initiation.
AK124904 mRNA. Translation: BAC85990.1.
AK128492 mRNA. Translation: BAC87464.1. Different initiation.
BC013319 mRNA. Translation: AAH13319.2.
BX538322 mRNA. Translation: CAD98096.1. Sequence problems.
AB037783 mRNA. Translation: BAA92600.1. Frameshift.
CCDSiCCDS31878.1. [Q6ZV73-1]
RefSeqiNP_060821.3. NM_018351.3. [Q6ZV73-1]
UniGeneiHs.506381.

3D structure databases

ProteinModelPortaliQ6ZV73.
SMRiQ6ZV73. Positions 1339-1429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120899. 14 interactions.
IntActiQ6ZV73. 11 interactions.
STRINGi9606.ENSP00000344446.

PTM databases

iPTMnetiQ6ZV73.
PhosphoSiteiQ6ZV73.

Polymorphism and mutation databases

BioMutaiFGD6.
DMDMi61213484.

Proteomic databases

EPDiQ6ZV73.
MaxQBiQ6ZV73.
PaxDbiQ6ZV73.
PeptideAtlasiQ6ZV73.
PRIDEiQ6ZV73.

Protocols and materials databases

DNASUi55785.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343958; ENSP00000344446; ENSG00000180263. [Q6ZV73-1]
ENST00000546711; ENSP00000450342; ENSG00000180263. [Q6ZV73-2]
GeneIDi55785.
KEGGihsa:55785.
UCSCiuc001tdp.4. human. [Q6ZV73-1]

Organism-specific databases

CTDi55785.
GeneCardsiFGD6.
H-InvDBHIX0020465.
HGNCiHGNC:21740. FGD6.
HPAiHPA007974.
MIMi613520. gene.
neXtProtiNX_Q6ZV73.
PharmGKBiPA134967436.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUBB. Eukaryota.
ENOG410XRXV. LUCA.
GeneTreeiENSGT00750000117280.
HOGENOMiHOG000112571.
HOVERGENiHBG051610.
InParanoidiQ6ZV73.
KOiK05724.
OMAiKRITFCP.
OrthoDBiEOG091G00IK.
PhylomeDBiQ6ZV73.
TreeFamiTF316247.

Miscellaneous databases

ChiTaRSiFGD6. human.
GenomeRNAii55785.
PROiQ6ZV73.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180263.
CleanExiHS_FGD6.
ExpressionAtlasiQ6ZV73. baseline and differential.
GenevisibleiQ6ZV73. HS.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF00169. PH. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGD6_HUMAN
AccessioniPrimary (citable) accession number: Q6ZV73
Secondary accession number(s): Q6ZR53
, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: September 7, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.