Q6ZV56 (CV034_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C22orf34

Gene names

Name:

C22orf34

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	151 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence caution

The sequence BAC86548.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZV56-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZV56-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MCTVDVEGFDDVGETLSD → MIVFPETSQPRFLYSLQNY
     123-151: VSTRSITVPSPQRSAPRASLCPPHKGKSP → ENLHDASRRV...ARHRKTNTTF

Isoform 3 (identifier: Q6ZV56-3)

The sequence of this isoform differs from the canonical sequence as follows:
     126-126: R → PSITVPSPQRSAALSITVPSPQRSAAP
     149-151: KSP → QHPEHHCALP...SLCLSLSHCV

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 151	151	Uncharacterized protein C22orf34		PRO_0000296771
Regions
	Compositional bias	79 – 98	20	Cys-rich
Natural variations
	Alternative sequence	1 – 18	18	MCTVD…ETLSD → MIVFPETSQPRFLYSLQNY in isoform 2.		VSP_027255
	Alternative sequence	123 – 151	29	VSTRS…KGKSP → ENLHDASRRVHRGRGEENVE WTGDLHPAQLGRGGRPEICH SLEAIALVTKARHRKTNTTF in isoform 2.		VSP_027256
	Alternative sequence	126	1	R → PSITVPSPQRSAALSITVPS PQRSAAP in isoform 3.		VSP_027257
	Alternative sequence	149 – 151	3	KSP → QHPEHHCALPPKGQHPEHHC ALPTKVSTPSITVPSPQRSP QMSLSSAARGSNTDVAGLSV GEWPGWQLWGEGQDGAQQRP HLPSGGSGAGVAPQRLPKSR ACILCSRHGAQGPWVTGRSV SHSHCPIQGLLDLQRPDLGT DWGRTRPLCTPQDLCGGRPL PSTWGVTMHLIHCLSVSLSL CLSLSHCV in isoform 3.		VSP_027258

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 25BDB9AAA5A2F90B	FASTA	151	16,313
	10 20 30 40 50 60 MCTVDVEGFD DVGETLSDAV RDGLGTILRG GAEEGSYDNW PHTRKSWGPL SPGHQRELWT 70 80 90 100 110 120 QPDPWTEVLS GHKGDAGACG CCCFCSQFIN ARCAHPLCLA RGLDRRASEE MPILQALCLL 130 140 150 PKVSTRSITV PSPQRSAPRA SLCPPHKGKS P
	Isoform 2 [UniParc]. Checksum: DFCDD031B55DCD6F	FASTA	183	20,454
	10 20 30 40 50 60 MIVFPETSQP RFLYSLQNYA VRDGLGTILR GGAEEGSYDN WPHTRKSWGP LSPGHQRELW 70 80 90 100 110 120 TQPDPWTEVL SGHKGDAGAC GCCCFCSQFI NARCAHPLCL ARGLDRRASE EMPILQALCL 130 140 150 160 170 180 LPKENLHDAS RRVHRGRGEE NVEWTGDLHP AQLGRGGRPE ICHSLEAIAL VTKARHRKTN TTF
	Isoform 3 [UniParc]. Checksum: A5E79A760EE4A346	FASTA	362	38,521
	10 20 30 40 50 60 MCTVDVEGFD DVGETLSDAV RDGLGTILRG GAEEGSYDNW PHTRKSWGPL SPGHQRELWT 70 80 90 100 110 120 QPDPWTEVLS GHKGDAGACG CCCFCSQFIN ARCAHPLCLA RGLDRRASEE MPILQALCLL 130 140 150 160 170 180 PKVSTPSITV PSPQRSAALS ITVPSPQRSA APSITVPSPQ RSAPRASLCP PHKGQHPEHH 190 200 210 220 230 240 CALPPKGQHP EHHCALPTKV STPSITVPSP QRSPQMSLSS AARGSNTDVA GLSVGEWPGW 250 260 270 280 290 300 QLWGEGQDGA QQRPHLPSGG SGAGVAPQRL PKSRACILCS RHGAQGPWVT GRSVSHSHCP 310 320 330 340 350 360 IQGLLDLQRP DLGTDWGRTR PLCTPQDLCG GRPLPSTWGV TMHLIHCLSV SLSLCLSLSH CV

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-151 (ISOFORM 3). Tissue: Subthalamic nucleus and Uterus.
[2]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK124962 mRNA. No translation available. AK126430 mRNA. Translation: BAC86548.1. Different initiation. Z97192 Genomic DNA. Translation: CAI20086.1. BC048207 mRNA. No translation available.
IPI	IPI00394842. IPI00445897. IPI00744248.
UniGene	Hs.133159.
3D structure databases
ModBase	Search...
Polymorphism databases
DMDM	74712163.
Proteomic databases
PRIDE	Q6ZV56.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380974; ENSP00000370361; ENSG00000188511.
Organism-specific databases
GeneCards	GC22M049808.
HGNC	HGNC:28010. C22orf34.
neXtProt	NX_Q6ZV56.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000001122.
HOVERGEN	HBG099544.
OMA	ENLHDAS.
Gene expression databases
ArrayExpress	Q6ZV56.
CleanEx	HS_C22orf34.
Genevestigator	Q6ZV56.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CV034_HUMAN

Accession

Primary (citable) accession number: Q6ZV56
Secondary accession number(s): Q147Y0, Q5R3D1, Q6ZTN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.