Q6ZV29 (PLPL7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Patatin-like phospholipase domain-containing protein 7
EC=3.1.1.-

Gene names

Name:	PNPLA7
Synonyms:	C9orf111

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1317 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy By similarity.
Subcellular location	Membrane; Single-pass membrane protein Potential. Nucleus membrane; Single-pass membrane protein By similarity. Mitochondrion membrane; Single-pass membrane protein By similarity. Lysosome membrane; Single-pass membrane protein By similarity. Microsome membrane; Single-pass membrane protein By similarity. Note: Found in the nuclear, mitochondrial, lysosomal, and microsomal fractions By similarity.
Sequence similarities	Belongs to the NTE family. Contains 3 cyclic nucleotide-binding domains. Contains 1 patatin domain.
Sequence caution	The sequence BAB71033.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAI14579.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Lysosome Membrane Microsome Mitochondrion Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Molecular function	Hydrolase
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW lysosomal membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZV29-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZV29-2)

The sequence of this isoform differs from the canonical sequence as follows:
     10-10: Q → QADFCLGTALHSWGLWFTEEGSPSTM
     384-433: GGPGSATSDL...VAEIPSTVSQ → ARVLCLLPQC...GHKPHVTVDT
     434-1317: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q6ZV29-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1191-1255: EVGYQHGRTVFDIWGRSGVLEKMLRDQQGPSKKPASAVLTCPNASFTDLAEIVSRIEPAKPAMVD → VP

Note: No experimental confirmation available.

Isoform 4 (identifier: Q6ZV29-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1256-1268: DESDYQTEYEEEL → GEWRRKTKPWRRA
     1269-1317: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q6ZV29-5)

The sequence of this isoform differs from the canonical sequence as follows:
     10-10: Q → QADFCLGTALHSWGLWFTEEGSPSTM

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1317	1317	Patatin-like phospholipase domain-containing protein 7		PRO_0000293489
Regions
	Transmembrane	13 – 33	21	Helical; Potential
	Domain	928 – 1094	167	Patatin
	Nucleotide binding	145 – 272	128	cNMP 1
	Nucleotide binding	458 – 580	123	cNMP 2
	Nucleotide binding	576 – 696	121	cNMP 3
	Motif	959 – 963	5	GXSXG
Sites
	Active site	961	1	By similarity
Amino acid modifications
	Modified residue	355	1	Phosphoserine By similarity
	Glycosylation	728	1	N-linked (GlcNAc...) Potential
	Glycosylation	975	1	N-linked (GlcNAc...) Potential
	Glycosylation	1014	1	N-linked (GlcNAc...) Potential
	Glycosylation	1233	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	10	1	Q → QADFCLGTALHSWGLWFTEE GSPSTM in isoform 2 and isoform 5.		VSP_026500
	Alternative sequence	384 – 433	50	GGPGS…STVSQ → ARVLCLLPQCLGGLPPTDTS VYSSASSDCCGCSMPVLCIM GHKPHVTVDT in isoform 2.		VSP_026501
	Alternative sequence	434 – 1317	884	Missing in isoform 2.		VSP_026502
	Alternative sequence	1191 – 1255	65	EVGYQ…PAMVD → VP in isoform 3.		VSP_026503
	Alternative sequence	1256 – 1268	13	DESDY…YEEEL → GEWRRKTKPWRRA in isoform 4.		VSP_026504
	Alternative sequence	1269 – 1317	49	Missing in isoform 4.		VSP_026505
	Natural variant	236	1	R → H. Corresponds to variant rs12788 [ dbSNP | Ensembl ].		VAR_061139
	Natural variant	286	1	G → S. Corresponds to variant rs2298171 [ dbSNP | Ensembl ].		VAR_055696
	Natural variant	323	1	R → Q. Corresponds to variant rs11137410 [ dbSNP | Ensembl ].		VAR_033060
	Natural variant	364	1	Q → E. Corresponds to variant rs3750378 [ dbSNP | Ensembl ].		VAR_033061
	Natural variant	368	1	E → D. Corresponds to variant rs3750379 [ dbSNP | Ensembl ].		VAR_033062
	Natural variant	387	1	G → S. Corresponds to variant rs11791683 [ dbSNP | Ensembl ].		VAR_060409
	Natural variant	803	1	V → A. Ref.1 Ref.3 Ref.4 Corresponds to variant rs1891630 [ dbSNP | Ensembl ].		VAR_033063
	Natural variant	824	1	V → M. Corresponds to variant rs34938599 [ dbSNP | Ensembl ].		VAR_033064
	Natural variant	908	1	P → L. Ref.3 Corresponds to variant rs3812499 [ dbSNP | Ensembl ].		VAR_033065
	Natural variant	993	1	L → M. Corresponds to variant rs35177111 [ dbSNP | Ensembl ].		VAR_033066
	Natural variant	1050	1	D → N. Ref.1 Corresponds to variant rs4962237 [ dbSNP | Ensembl ].		VAR_055697
Experimental info
	Sequence conflict	173	1	F → L in BAC86509. Ref.1
	Sequence conflict	326	1	K → M in BAC86036. Ref.1
	Sequence conflict	384 – 399	16	Missing in BAC86509. Ref.1
	Sequence conflict	403 – 473	71	FLHSD…SLLDG → LCLLPQCLGGLPPTDTSVYS SASSDCCGCSMPVLCIMGHK PHVTVDT in BAC86509. Ref.1
	Sequence conflict	409	1	H → D in BAC86036. Ref.1
	Sequence conflict	874	1	W → S in BAB71033. Ref.1
	Sequence conflict	892 – 896	5	SLPKL → RLLPQ in BAC56931. Ref.1
	Sequence conflict	1016 – 1027	12	SIFSV…DQQIE → WERAHLSPVRPQ in BAB15733. Ref.1
	Sequence conflict	1027	1	E → EQ in CAH56483. Ref.4
	Sequence conflict	1055	1	W → R in BAB15733. Ref.1
	Sequence conflict	1055	1	W → R in BAB71033. Ref.1
	Sequence conflict	1055	1	W → R in BAC56931. Ref.1
	Sequence conflict	1055	1	W → R in BAC86036. Ref.1
	Sequence conflict	1055	1	W → R in AAH25663. Ref.3
	Sequence conflict	1055	1	W → R in CAH56322. Ref.4
	Sequence conflict	1055	1	W → R in CAH56483. Ref.4
	Sequence conflict	1140	1	V → VV in CAH56483. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 3C0DF9776006F349	FASTA	1,317	145,733
	10 20 30 40 50 60 MEEEKDDSPQ LTGIAVGALL ALALVGVLIL FMFRRLRQFR QAQPTPQYRF RKRDKVMFYG 70 80 90 100 110 120 RKIMRKVTTL PNTLVENTAL PRQRARKRTK VLSLAKRILR FKKEYPALQP KEPPPSLLEA 130 140 150 160 170 180 DLTEFDVKNS HLPSEVLYML KNVRVLGHFE KPLFLELCKH IVFVQLQEGE HVFQPREPDP 190 200 210 220 230 240 SICVVQDGRL EVCIQDTDGT EVVVKEVLAG DSVHSLLSIL DIITGHAAPY KTVSVRAAIP 250 260 270 280 290 300 STILRLPAAA FHGVFEKYPE TLVRVVQIIM VRLQRVTFLA LHNYLGLTTE LFNAESQAIP 310 320 330 340 350 360 LVSVASVAAG KAKKQVFYGE EERLKKPPRL QESCDSDHGG GRPAAAGPLL KRSHSVPAPS 370 380 390 400 410 420 IRKQILEELE KPGAGDPDPS APQGGPGSAT SDLGMACDRA RVFLHSDEHP GSSVASKSRK 430 440 450 460 470 480 SVMVAEIPST VSQHSESHTD ETLASRKSDA IFRAAKKDLL TLMKLEDSSL LDGRVALLHV 490 500 510 520 530 540 PAGTVVSRQG DQDASILFVV SGLLHVYQRK IGSQEDTCLF LTRPGEMVGQ LAVLTGEPLI 550 560 570 580 590 600 FTVKANRDCS FLSISKAHFY EIMRKQPTVV LGVAHTVVKR MSSFVRQIDF ALDWVEVEAG 610 620 630 640 650 660 RAIYRQGDKS DCTYIMLSGR LRSVIRKDDG KKRLAGEYGR GDLVGVVETL THQARATTVH 670 680 690 700 710 720 AVRDSELAKL PAGALTSIKR RYPQVVTRLI HLLGEKILGS LQQGPVTGHQ LGLPTEGSKW 730 740 750 760 770 780 DLGNPAVNLS TVAVMPVSEE VPLTAFALEL EHALSAIGPT LLLTSDNIKR RLGSAALDSV 790 800 810 820 830 840 HEYRLSSWLG QQEDTHRIVL YQVDGTLTPW TQRCVRQADC ILIVGLGDQE PTVGELERML 850 860 870 880 890 900 ESTAVRAQKQ LILLHREEGP APARTVEWLN MRSWCSGHLH LCCPRRVFSR RSLPKLVEMY 910 920 930 940 950 960 KHVFQRPPDR HSDFSRLARV LTGNAIALVL GGGGARGCAQ VGVLKALAEC GIPVDMVGGT 970 980 990 1000 1010 1020 SIGAFVGALY SEERNYSQMR IRAKQWAEGM TSLMKAALDL TYPITSMFSG AGFNSSIFSV 1030 1040 1050 1060 1070 1080 FKDQQIEDLW IPYFAITTDI TASAMRVHTD GSLWWYVRAS MSLSGYMPPL CDPKDGHLLM 1090 1100 1110 1120 1130 1140 DGGYINNLPA DVARSMGAKV VIAIDVGSRD ETDLTNYGDA LSGWWLLWKR WNPLATKVKV 1150 1160 1170 1180 1190 1200 LNMAEIQTRL AYVCCVRQLE VVKSSDYCEY LRPPIDSYST LDFGKFNEIC EVGYQHGRTV 1210 1220 1230 1240 1250 1260 FDIWGRSGVL EKMLRDQQGP SKKPASAVLT CPNASFTDLA EIVSRIEPAK PAMVDDESDY 1270 1280 1290 1300 1310 QTEYEEELLD VPRDAYADFQ STSAQQGSDL EDESSLRHRH PSLAFPKLSE GSSDQDG
	Isoform 2 [UniParc]. Checksum: 125B513AF8FA5CAC	FASTA	458	50,719
	10 20 30 40 50 60 MEEEKDDSPQ ADFCLGTALH SWGLWFTEEG SPSTMLTGIA VGALLALALV GVLILFMFRR 70 80 90 100 110 120 LRQFRQAQPT PQYRFRKRDK VMFYGRKIMR KVTTLPNTLV ENTALPRQRA RKRTKVLSLA 130 140 150 160 170 180 KRILRFKKEY PALQPKEPPP SLLEADLTEF DVKNSHLPSE VLYMLKNVRV LGHFEKPLFL 190 200 210 220 230 240 ELCKHIVFVQ LQEGEHVFQP REPDPSICVV QDGRLEVCIQ DTDGTEVVVK EVLAGDSVHS 250 260 270 280 290 300 LLSILDIITG HAAPYKTVSV RAAIPSTILR LPAAAFHGVF EKYPETLVRV VQIIMVRLQR 310 320 330 340 350 360 VTFLALHNYL GLTTELFNAE SQAIPLVSVA SVAAGKAKKQ VFYGEEERLK KPPRLQESCD 370 380 390 400 410 420 SDHGGGRPAA AGPLLKRSHS VPAPSIRKQI LEELEKPGAG DPDPSAPQAR VLCLLPQCLG 430 440 450 GLPPTDTSVY SSASSDCCGC SMPVLCIMGH KPHVTVDT
	Isoform 3 [UniParc]. Checksum: 2A60F69C46051181	FASTA	1,254	138,848
	10 20 30 40 50 60 MEEEKDDSPQ LTGIAVGALL ALALVGVLIL FMFRRLRQFR QAQPTPQYRF RKRDKVMFYG 70 80 90 100 110 120 RKIMRKVTTL PNTLVENTAL PRQRARKRTK VLSLAKRILR FKKEYPALQP KEPPPSLLEA 130 140 150 160 170 180 DLTEFDVKNS HLPSEVLYML KNVRVLGHFE KPLFLELCKH IVFVQLQEGE HVFQPREPDP 190 200 210 220 230 240 SICVVQDGRL EVCIQDTDGT EVVVKEVLAG DSVHSLLSIL DIITGHAAPY KTVSVRAAIP 250 260 270 280 290 300 STILRLPAAA FHGVFEKYPE TLVRVVQIIM VRLQRVTFLA LHNYLGLTTE LFNAESQAIP 310 320 330 340 350 360 LVSVASVAAG KAKKQVFYGE EERLKKPPRL QESCDSDHGG GRPAAAGPLL KRSHSVPAPS 370 380 390 400 410 420 IRKQILEELE KPGAGDPDPS APQGGPGSAT SDLGMACDRA RVFLHSDEHP GSSVASKSRK 430 440 450 460 470 480 SVMVAEIPST VSQHSESHTD ETLASRKSDA IFRAAKKDLL TLMKLEDSSL LDGRVALLHV 490 500 510 520 530 540 PAGTVVSRQG DQDASILFVV SGLLHVYQRK IGSQEDTCLF LTRPGEMVGQ LAVLTGEPLI 550 560 570 580 590 600 FTVKANRDCS FLSISKAHFY EIMRKQPTVV LGVAHTVVKR MSSFVRQIDF ALDWVEVEAG 610 620 630 640 650 660 RAIYRQGDKS DCTYIMLSGR LRSVIRKDDG KKRLAGEYGR GDLVGVVETL THQARATTVH 670 680 690 700 710 720 AVRDSELAKL PAGALTSIKR RYPQVVTRLI HLLGEKILGS LQQGPVTGHQ LGLPTEGSKW 730 740 750 760 770 780 DLGNPAVNLS TVAVMPVSEE VPLTAFALEL EHALSAIGPT LLLTSDNIKR RLGSAALDSV 790 800 810 820 830 840 HEYRLSSWLG QQEDTHRIVL YQVDGTLTPW TQRCVRQADC ILIVGLGDQE PTVGELERML 850 860 870 880 890 900 ESTAVRAQKQ LILLHREEGP APARTVEWLN MRSWCSGHLH LCCPRRVFSR RSLPKLVEMY 910 920 930 940 950 960 KHVFQRPPDR HSDFSRLARV LTGNAIALVL GGGGARGCAQ VGVLKALAEC GIPVDMVGGT 970 980 990 1000 1010 1020 SIGAFVGALY SEERNYSQMR IRAKQWAEGM TSLMKAALDL TYPITSMFSG AGFNSSIFSV 1030 1040 1050 1060 1070 1080 FKDQQIEDLW IPYFAITTDI TASAMRVHTD GSLWWYVRAS MSLSGYMPPL CDPKDGHLLM 1090 1100 1110 1120 1130 1140 DGGYINNLPA DVARSMGAKV VIAIDVGSRD ETDLTNYGDA LSGWWLLWKR WNPLATKVKV 1150 1160 1170 1180 1190 1200 LNMAEIQTRL AYVCCVRQLE VVKSSDYCEY LRPPIDSYST LDFGKFNEIC VPDESDYQTE 1210 1220 1230 1240 1250 YEEELLDVPR DAYADFQSTS AQQGSDLEDE SSLRHRHPSL AFPKLSEGSS DQDG
	Isoform 4 [UniParc]. Checksum: 1E4158DB3AC3BD63	FASTA	1,268	140,480
	10 20 30 40 50 60 MEEEKDDSPQ LTGIAVGALL ALALVGVLIL FMFRRLRQFR QAQPTPQYRF RKRDKVMFYG 70 80 90 100 110 120 RKIMRKVTTL PNTLVENTAL PRQRARKRTK VLSLAKRILR FKKEYPALQP KEPPPSLLEA 130 140 150 160 170 180 DLTEFDVKNS HLPSEVLYML KNVRVLGHFE KPLFLELCKH IVFVQLQEGE HVFQPREPDP 190 200 210 220 230 240 SICVVQDGRL EVCIQDTDGT EVVVKEVLAG DSVHSLLSIL DIITGHAAPY KTVSVRAAIP 250 260 270 280 290 300 STILRLPAAA FHGVFEKYPE TLVRVVQIIM VRLQRVTFLA LHNYLGLTTE LFNAESQAIP 310 320 330 340 350 360 LVSVASVAAG KAKKQVFYGE EERLKKPPRL QESCDSDHGG GRPAAAGPLL KRSHSVPAPS 370 380 390 400 410 420 IRKQILEELE KPGAGDPDPS APQGGPGSAT SDLGMACDRA RVFLHSDEHP GSSVASKSRK 430 440 450 460 470 480 SVMVAEIPST VSQHSESHTD ETLASRKSDA IFRAAKKDLL TLMKLEDSSL LDGRVALLHV 490 500 510 520 530 540 PAGTVVSRQG DQDASILFVV SGLLHVYQRK IGSQEDTCLF LTRPGEMVGQ LAVLTGEPLI 550 560 570 580 590 600 FTVKANRDCS FLSISKAHFY EIMRKQPTVV LGVAHTVVKR MSSFVRQIDF ALDWVEVEAG 610 620 630 640 650 660 RAIYRQGDKS DCTYIMLSGR LRSVIRKDDG KKRLAGEYGR GDLVGVVETL THQARATTVH 670 680 690 700 710 720 AVRDSELAKL PAGALTSIKR RYPQVVTRLI HLLGEKILGS LQQGPVTGHQ LGLPTEGSKW 730 740 750 760 770 780 DLGNPAVNLS TVAVMPVSEE VPLTAFALEL EHALSAIGPT LLLTSDNIKR RLGSAALDSV 790 800 810 820 830 840 HEYRLSSWLG QQEDTHRIVL YQVDGTLTPW TQRCVRQADC ILIVGLGDQE PTVGELERML 850 860 870 880 890 900 ESTAVRAQKQ LILLHREEGP APARTVEWLN MRSWCSGHLH LCCPRRVFSR RSLPKLVEMY 910 920 930 940 950 960 KHVFQRPPDR HSDFSRLARV LTGNAIALVL GGGGARGCAQ VGVLKALAEC GIPVDMVGGT 970 980 990 1000 1010 1020 SIGAFVGALY SEERNYSQMR IRAKQWAEGM TSLMKAALDL TYPITSMFSG AGFNSSIFSV 1030 1040 1050 1060 1070 1080 FKDQQIEDLW IPYFAITTDI TASAMRVHTD GSLWWYVRAS MSLSGYMPPL CDPKDGHLLM 1090 1100 1110 1120 1130 1140 DGGYINNLPA DVARSMGAKV VIAIDVGSRD ETDLTNYGDA LSGWWLLWKR WNPLATKVKV 1150 1160 1170 1180 1190 1200 LNMAEIQTRL AYVCCVRQLE VVKSSDYCEY LRPPIDSYST LDFGKFNEIC EVGYQHGRTV 1210 1220 1230 1240 1250 1260 FDIWGRSGVL EKMLRDQQGP SKKPASAVLT CPNASFTDLA EIVSRIEPAK PAMVDGEWRR KTKPWRRA
	Isoform 5 [UniParc]. Checksum: E56D9FD160C30BC1	FASTA	1,342	148,459
	10 20 30 40 50 60 MEEEKDDSPQ ADFCLGTALH SWGLWFTEEG SPSTMLTGIA VGALLALALV GVLILFMFRR 70 80 90 100 110 120 LRQFRQAQPT PQYRFRKRDK VMFYGRKIMR KVTTLPNTLV ENTALPRQRA RKRTKVLSLA 130 140 150 160 170 180 KRILRFKKEY PALQPKEPPP SLLEADLTEF DVKNSHLPSE VLYMLKNVRV LGHFEKPLFL 190 200 210 220 230 240 ELCKHIVFVQ LQEGEHVFQP REPDPSICVV QDGRLEVCIQ DTDGTEVVVK EVLAGDSVHS 250 260 270 280 290 300 LLSILDIITG HAAPYKTVSV RAAIPSTILR LPAAAFHGVF EKYPETLVRV VQIIMVRLQR 310 320 330 340 350 360 VTFLALHNYL GLTTELFNAE SQAIPLVSVA SVAAGKAKKQ VFYGEEERLK KPPRLQESCD 370 380 390 400 410 420 SDHGGGRPAA AGPLLKRSHS VPAPSIRKQI LEELEKPGAG DPDPSAPQGG PGSATSDLGM 430 440 450 460 470 480 ACDRARVFLH SDEHPGSSVA SKSRKSVMVA EIPSTVSQHS ESHTDETLAS RKSDAIFRAA 490 500 510 520 530 540 KKDLLTLMKL EDSSLLDGRV ALLHVPAGTV VSRQGDQDAS ILFVVSGLLH VYQRKIGSQE 550 560 570 580 590 600 DTCLFLTRPG EMVGQLAVLT GEPLIFTVKA NRDCSFLSIS KAHFYEIMRK QPTVVLGVAH 610 620 630 640 650 660 TVVKRMSSFV RQIDFALDWV EVEAGRAIYR QGDKSDCTYI MLSGRLRSVI RKDDGKKRLA 670 680 690 700 710 720 GEYGRGDLVG VVETLTHQAR ATTVHAVRDS ELAKLPAGAL TSIKRRYPQV VTRLIHLLGE 730 740 750 760 770 780 KILGSLQQGP VTGHQLGLPT EGSKWDLGNP AVNLSTVAVM PVSEEVPLTA FALELEHALS 790 800 810 820 830 840 AIGPTLLLTS DNIKRRLGSA ALDSVHEYRL SSWLGQQEDT HRIVLYQVDG TLTPWTQRCV 850 860 870 880 890 900 RQADCILIVG LGDQEPTVGE LERMLESTAV RAQKQLILLH REEGPAPART VEWLNMRSWC 910 920 930 940 950 960 SGHLHLCCPR RVFSRRSLPK LVEMYKHVFQ RPPDRHSDFS RLARVLTGNA IALVLGGGGA 970 980 990 1000 1010 1020 RGCAQVGVLK ALAECGIPVD MVGGTSIGAF VGALYSEERN YSQMRIRAKQ WAEGMTSLMK 1030 1040 1050 1060 1070 1080 AALDLTYPIT SMFSGAGFNS SIFSVFKDQQ IEDLWIPYFA ITTDITASAM RVHTDGSLWW 1090 1100 1110 1120 1130 1140 YVRASMSLSG YMPPLCDPKD GHLLMDGGYI NNLPADVARS MGAKVVIAID VGSRDETDLT 1150 1160 1170 1180 1190 1200 NYGDALSGWW LLWKRWNPLA TKVKVLNMAE IQTRLAYVCC VRQLEVVKSS DYCEYLRPPI 1210 1220 1230 1240 1250 1260 DSYSTLDFGK FNEICEVGYQ HGRTVFDIWG RSGVLEKMLR DQQGPSKKPA SAVLTCPNAS 1270 1280 1290 1300 1310 1320 FTDLAEIVSR IEPAKPAMVD DESDYQTEYE EELLDVPRDA YADFQSTSAQ QGSDLEDESS 1330 1340 LRHRHPSLAF PKLSEGSSDQ DG

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1016-1268 (ISOFORM 4), VARIANTS ALA-803 AND ASN-1050. Tissue: Liver, Spleen, Thalamus and Trachea.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 688-1317 (ISOFORM 1), VARIANTS ALA-803 AND LEU-908. Tissue: Brain.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 721-1317 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 897-1317 (ISOFORM 3), VARIANT ALA-803. Tissue: Lymph node and Stomach.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK024443 mRNA. Translation: BAB15733.1. AK055880 mRNA. Translation: BAB71033.1. Different initiation. AK122590 mRNA. Translation: BAC56931.1. AK125060 mRNA. Translation: BAC86036.1. AK126267 mRNA. Translation: BAC86509.1. AL365502 Genomic DNA. Translation: CAI14579.1. Sequence problems. BC025663 mRNA. Translation: AAH25663.1. AL832944 mRNA. Translation: CAH56322.1. AL832856 mRNA. Translation: CAH56483.1.
IPI	IPI00394981. IPI00445250. IPI00470404. IPI00796247. IPI00852921.
RefSeq	NP_001092007.1. NM_001098537.1. NP_689499.3. NM_152286.3.
UniGene	Hs.294147.
3D structure databases
ProteinModelPortal	Q6ZV29.
SMR	Q6ZV29. Positions 410-661.
ModBase	Search...
PTM databases
PhosphoSite	Q6ZV29.
Polymorphism databases
DMDM	296452996.
Proteomic databases
PaxDb	Q6ZV29.
PRIDE	Q6ZV29.
Protocols and materials databases
DNASU	375775.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000277531; ENSP00000277531; ENSG00000130653. ENST00000371457; ENSP00000360512; ENSG00000130653. ENST00000406427; ENSP00000384610; ENSG00000130653.
GeneID	375775.
KEGG	hsa:375775.
UCSC	uc004cnf.2. human. uc010ncj.1. human.
Organism-specific databases
CTD	375775.
GeneCards	GC09M140354.
H-InvDB	HIX0201358.
HGNC	HGNC:24768. PNPLA7.
HPA	HPA009130.
MIM	612122. gene.
neXtProt	NX_Q6ZV29.
PharmGKB	PA134935962.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0664.
HOVERGEN	HBG053067.
InParanoid	Q6ZV29.
KO	K14676.
OMA	MACDRAR.
PhylomeDB	Q6ZV29.
Gene expression databases
ArrayExpress	Q6ZV29.
Bgee	Q6ZV29.
Genevestigator	Q6ZV29.
Family and domain databases
Gene3D	2.60.120.10. 3 hits.
InterPro	IPR016035. Acyl_Trfase/lysoPLipase. IPR018490. cNMP-bd-like. IPR000595. cNMP-bd_dom. IPR002641. Patatin/PLipase_A2-rel. IPR014710. RmlC-like_jellyroll. [Graphical view]
Pfam	PF00027. cNMP_binding. 3 hits. PF01734. Patatin. 1 hit. [Graphical view]
SMART	SM00100. cNMP. 3 hits. [Graphical view]
SUPFAM	SSF52151. Acyl_Trfase/lysoPlipase. 1 hit. SSF51206. cNMP_binding. 3 hits.
PROSITE	PS00888. CNMP_BINDING_1. False negative. PS00889. CNMP_BINDING_2. False negative. PS50042. CNMP_BINDING_3. 3 hits. PS01237. UPF0028. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PNPLA7. human.
GenomeRNAi	375775.
NextBio	100611.
SOURCE	Search...

Entry information

Entry name

PLPL7_HUMAN

Accession

Primary (citable) accession number: Q6ZV29
Secondary accession number(s): B5MDD3 , Q5T364, Q658X0, Q658Y3, Q6ZTS1, Q86YU8, Q8TAY5, Q96N75, Q9H7N5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 83 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.