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Protein

Lipoma HMGIC fusion partner-like 2 protein

Gene

LHFPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoma HMGIC fusion partner-like 2 protein
Gene namesi
Name:LHFPL2
Synonyms:KIAA0206
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6588. LHFPL2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence analysisAdd
BLAST
Transmembranei102 – 12221HelicalSequence analysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence analysisAdd
BLAST
Transmembranei181 – 20121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30360.

Polymorphism and mutation databases

BioMutaiLHFPL2.
DMDMi116242618.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Lipoma HMGIC fusion partner-like 2 proteinPRO_0000244763Add
BLAST

Proteomic databases

EPDiQ6ZUX7.
MaxQBiQ6ZUX7.
PaxDbiQ6ZUX7.
PeptideAtlasiQ6ZUX7.
PRIDEiQ6ZUX7.

PTM databases

iPTMnetiQ6ZUX7.
PhosphoSiteiQ6ZUX7.
SwissPalmiQ6ZUX7.

Expressioni

Tissue specificityi

Expressed in all tissues and cell lines examined except brain and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000145685.
CleanExiHS_LHFPL2.
ExpressionAtlasiQ6ZUX7. baseline and differential.
GenevisibleiQ6ZUX7. HS.

Organism-specific databases

HPAiHPA042402.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369702.

Structurei

3D structure databases

ProteinModelPortaliQ6ZUX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LHFP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4026. Eukaryota.
ENOG410XSUB. LUCA.
GeneTreeiENSGT00550000074479.
HOGENOMiHOG000285972.
HOVERGENiHBG054430.
InParanoidiQ6ZUX7.
OMAiVYPGEWK.
OrthoDBiEOG091G0J9C.
PhylomeDBiQ6ZUX7.
TreeFamiTF321143.

Family and domain databases

InterProiIPR019372. Lipome_HGMIC_fus_partner-like.
[Graphical view]
PfamiPF10242. L_HMGIC_fpl. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZUX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHVIVTCRS MLWTLLSIVV AFAELIAFMS ADWLIGKARS RGGVEPAGPG
60 70 80 90 100
GGSPEPYHPT LGIYARCIRN PGVQHFQRDT LCGPYAESFG EIASGFWQAT
110 120 130 140 150
AIFLAVGIFI LCMVALVSVF TMCVQSIMKK SIFNVCGLLQ GIAGLFLILG
160 170 180 190 200
LILYPAGWGC QKAIDYCGHY ASAYKPGDCS LGWAFYTAIG GTVLTFICAV
210 220
FSAQAEIATS SDKVQEEIEE GKNLICLL
Length:228
Mass (Da):24,486
Last modified:October 17, 2006 - v2
Checksum:iC8FD766FFD9D0D31
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351I → T in BAC86089 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021I → V.
Corresponds to variant rs2303654 [ dbSNP | Ensembl ].
VAR_026913

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125227 mRNA. Translation: BAC86089.1.
AY309920 mRNA. Translation: AAP74733.1.
CH471084 Genomic DNA. Translation: EAW95818.1.
BC136335 mRNA. Translation: AAI36336.1.
BC136336 mRNA. Translation: AAI36337.1.
D86961 mRNA. Translation: BAA13197.1.
CCDSiCCDS4042.1.
RefSeqiNP_005770.1. NM_005779.2.
XP_006714578.1. XM_006714515.1.
UniGeneiHs.670094.
Hs.79299.

Genome annotation databases

EnsembliENST00000380345; ENSP00000369702; ENSG00000145685.
ENST00000515007; ENSP00000425906; ENSG00000145685.
GeneIDi10184.
KEGGihsa:10184.
UCSCiuc003kfo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125227 mRNA. Translation: BAC86089.1.
AY309920 mRNA. Translation: AAP74733.1.
CH471084 Genomic DNA. Translation: EAW95818.1.
BC136335 mRNA. Translation: AAI36336.1.
BC136336 mRNA. Translation: AAI36337.1.
D86961 mRNA. Translation: BAA13197.1.
CCDSiCCDS4042.1.
RefSeqiNP_005770.1. NM_005779.2.
XP_006714578.1. XM_006714515.1.
UniGeneiHs.670094.
Hs.79299.

3D structure databases

ProteinModelPortaliQ6ZUX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369702.

PTM databases

iPTMnetiQ6ZUX7.
PhosphoSiteiQ6ZUX7.
SwissPalmiQ6ZUX7.

Polymorphism and mutation databases

BioMutaiLHFPL2.
DMDMi116242618.

Proteomic databases

EPDiQ6ZUX7.
MaxQBiQ6ZUX7.
PaxDbiQ6ZUX7.
PeptideAtlasiQ6ZUX7.
PRIDEiQ6ZUX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380345; ENSP00000369702; ENSG00000145685.
ENST00000515007; ENSP00000425906; ENSG00000145685.
GeneIDi10184.
KEGGihsa:10184.
UCSCiuc003kfo.4. human.

Organism-specific databases

CTDi10184.
GeneCardsiLHFPL2.
HGNCiHGNC:6588. LHFPL2.
HPAiHPA042402.
MIMi609718. gene.
neXtProtiNX_Q6ZUX7.
PharmGKBiPA30360.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4026. Eukaryota.
ENOG410XSUB. LUCA.
GeneTreeiENSGT00550000074479.
HOGENOMiHOG000285972.
HOVERGENiHBG054430.
InParanoidiQ6ZUX7.
OMAiVYPGEWK.
OrthoDBiEOG091G0J9C.
PhylomeDBiQ6ZUX7.
TreeFamiTF321143.

Miscellaneous databases

ChiTaRSiLHFPL2. human.
GeneWikiiLHFPL2.
GenomeRNAii10184.
PROiQ6ZUX7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145685.
CleanExiHS_LHFPL2.
ExpressionAtlasiQ6ZUX7. baseline and differential.
GenevisibleiQ6ZUX7. HS.

Family and domain databases

InterProiIPR019372. Lipome_HGMIC_fus_partner-like.
[Graphical view]
PfamiPF10242. L_HMGIC_fpl. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLHPL2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZUX7
Secondary accession number(s): B2RMQ6, Q7Z5P0, Q92605
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.