Reviewed, UniProtKB/Swiss-Prot Q6ZUV0 (BACHL_HUMAN)

Names and origin

Protein names

Recommended name:
    Cytosolic acyl coenzyme A thioester hydrolase-like
    EC=3.1.2.2
Alternative name(s):
    Acyl-CoA thioesterase 7-like

Gene names

Name:	ACOT7L
Synonyms:	BACHL

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH By similarity.
Catalytic activity	Palmitoyl-CoA + H2O = CoA + palmitate.
Subunit structure	Homodimer Probable.
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Expressed in all tissues examined. Up-regulated in nasopharyngeal carcinoma (at protein level). Ref.2
Involvement in disease	Genetic variations in ACOT7L may be a cause of susceptibility to nasopharyngeal carcinoma type 1 (NPCA1) [MIM:607107]. A variant located in the regulatory region of the gene creates an AP1-binding site that significantly enhances binding of AP1 to the promoter, resulting in up-regulation in nasopharyngeal carcinoma. Ref.2
Sequence similarities	Contains 2 acyl coenzyme A hydrolase domains.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Repeat
Molecular function	Hydrolase Serine esterase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carboxylesterase activity Inferred from electronic annotation. Source: UniProtKB-KW palmitoyl-CoA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	Cytosolic acyl coenzyme A thioester hydrolase-like		PRO_0000347058
Regions
	Domain	4 – 73	70	Acyl coenzyme A hydrolase 1
	Domain	164 – 241	78	Acyl coenzyme A hydrolase 2

Sequences

	Sequence		Length	Mass (Da)
	Q6ZUV0-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: E9C4DF4A82B87717	FASTA	252	28,164
	10 20 30 40 50 60 MIKEAGAIIS TRHCNPQNGD RCVAALARVE CTHFLWPMCI GEVAHVSAEI TYTSKHSVEV 70 80 90 100 110 120 QVNMMSENIL TGAKKLTNKA TLWYAPLSLT NVDKVLEEPP VVYFRQEQEE EGQKRYKTQK 130 140 150 160 170 180 LERMETNWRN GDIVQPVLNP EPNTVSYSQS SLIHLVGPSD CTLHSFVHEG VTMKVMDEVA 190 200 210 220 230 240 GILAARHCKT NLVTASMEAI NFDNKIRKGC IKTISGRMTF TSNKSVEIEV LVDADCVVDS 250 SQKRYRAASV FT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"A functional variant in the transcriptional regulatory region of gene LOC344967 cosegregates with disease phenotype in familial nasopharyngeal carcinoma." Jiang R.-C., Qin H.-D., Zeng M.-S., Huang W., Feng B.-J., Zhang F., Chen H.-K., Jia W.-H., Chen L.-Z., Feng Q.-S., Zhang R.-H., Yu X.-J., Zheng M.-Z., Zeng Y.-X. Cancer Res. 66:693-700(2006) [PubMed: 16423998] [Abstract] Cited for: TISSUE SPECIFICITY, INVOLVEMENT IN NPCA1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK125299 mRNA. Translation: BAC86118.1.
IPI	IPI00445888.
UniGene	Hs.534633
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q6ZUV0.
Genome annotation databases
Ensembl	ENST00000381811; ENSP00000371232; ENSG00000205794; Homo sapiens. [Genome view]
Organism-specific databases
GeneCards	GC04M039720.
MIM	607107. phenotype. 611963. gene.
Phylogenomic databases
HOGENOM	Q6ZUV0.
HOVERGEN	Q6ZUV0.
OMA	LERMETN.
Gene expression databases
Bgee	Q6ZUV0.
Genevestigator	Q6ZUV0.
Family and domain databases
InterPro	IPR006683. Thioestr_supf. [Graphical view]
Pfam	PF03061. 4HBT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

BACHL_HUMAN

Accession

Primary (citable) accession number: Q6ZUV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.