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Protein

Putative cytosolic acyl coenzyme A thioester hydrolase-like

Gene

ACOT7L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH.By similarity

Catalytic activityi

Palmitoyl-CoA + H2O = CoA + palmitate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

ReactomeiR-HSA-77289. Mitochondrial Fatty Acid Beta-Oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cytosolic acyl coenzyme A thioester hydrolase-like (EC:3.1.2.2)
Alternative name(s):
Acyl-CoA thioesterase 7-like
Gene namesi
Name:ACOT7L
Synonyms:BACHL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

A functional variant in the transcriptional regulatory region of in ACOT7L cosegregates with disease phenotype in family affected by nasopharyngeal carcinoma. The variant creates an AP1-binding site that significantly enhances binding of AP1 to the promoter, resulting in up-regulation.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003470581 – 252Putative cytosolic acyl coenzyme A thioester hydrolase-likeAdd BLAST252

Proteomic databases

MaxQBiQ6ZUV0.
PeptideAtlasiQ6ZUV0.
PRIDEiQ6ZUV0.

Expressioni

Tissue specificityi

Expressed in all tissues examined. Up-regulated in nasopharyngeal carcinoma (at protein level).1 Publication

Interactioni

Subunit structurei

Homodimer.Curated

Structurei

3D structure databases

ProteinModelPortaliQ6ZUV0.
SMRiQ6ZUV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 90HotDog ACOT-type 1PROSITE-ProRule annotationAdd BLAST90
Domaini146 – 252HotDog ACOT-type 2PROSITE-ProRule annotationAdd BLAST107

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG036928.
InParanoidiQ6ZUV0.
PhylomeDBiQ6ZUV0.

Family and domain databases

InterProiView protein in InterPro
IPR033120. HOTDOG_ACOT.
IPR029069. HotDog_dom.
IPR006683. Thioestr_dom.
PfamiView protein in Pfam
PF03061. 4HBT. 1 hit.
SUPFAMiSSF54637. SSF54637. 2 hits.
PROSITEiView protein in PROSITE
PS51770. HOTDOG_ACOT. 2 hits.

Sequencei

Sequence statusi: Complete.

Q6ZUV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKEAGAIIS TRHCNPQNGD RCVAALARVE CTHFLWPMCI GEVAHVSAEI
60 70 80 90 100
TYTSKHSVEV QVNMMSENIL TGAKKLTNKA TLWYAPLSLT NVDKVLEEPP
110 120 130 140 150
VVYFRQEQEE EGQKRYKTQK LERMETNWRN GDIVQPVLNP EPNTVSYSQS
160 170 180 190 200
SLIHLVGPSD CTLHSFVHEG VTMKVMDEVA GILAARHCKT NLVTASMEAI
210 220 230 240 250
NFDNKIRKGC IKTISGRMTF TSNKSVEIEV LVDADCVVDS SQKRYRAASV

FT
Length:252
Mass (Da):28,164
Last modified:July 5, 2004 - v1
Checksum:iE9C4DF4A82B87717
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125299 mRNA. Translation: BAC86118.1.
UniGeneiHs.534633.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBACHL_HUMAN
AccessioniPrimary (citable) accession number: Q6ZUV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 5, 2004
Last modified: July 5, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. The peptide used to produce antibodies against ACOT7L matches at 85% with ACOT7 and the antibodies may not be specific to ACOT7L.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot