Q6ZUT3 (FRMD7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FERM domain-containing protein 7

Gene names

Name:

FRMD7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	714 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in neurite development By similarity. May play a specific role in the control of eye movement and gaze stability.
Subcellular location	Cell projection By similarity. Cell projection › growth cone By similarity. Note: In undifferentiated neurons, located in the actin-rich regions of the cell body. In differentiated neurons, located in the actin-rich regions of the cell body and primary neurite processes but is almost absent from secondary extensions arising from the primary neurite. Also found at the actin-rich distal end of growth cones By similarity.
Tissue specificity	Expressed in liver, kidney, pancreas and at low levels in brain and heart. Expressed in embryonic brain and developing neural retina. Ref.6
Developmental stage	In 37 day post-ovulation (dpo) embryos, expression is found in the mid- and hindbrain, regions known to be involved in motor control of eye movement, and in the ventricular zone of the forebrain. In 56 dpo embryos, expressed in the ventricular layer of the forebrain, midbrain, cerebellar primordium, spinal cord and the developing neural retina. In later development, highly expressed in postmitotic cells within the developing subplate and cortical plate. Ref.5 Ref.6
Involvement in disease	Nystagmus congenital X-linked 1 (NYS1) [MIM:310700]: A condition defined as conjugated, spontaneous and involuntary ocular oscillations that appear at birth or during the first three months of life. Other associated features may include mildly decreased visual acuity, strabismus, astigmatism, and occasionally head nodding. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12
Sequence similarities	Contains 1 FERM domain.

Ontologies

Keywords
Biological process	Neurogenesis
Cellular component	Cell projection
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of neuron projection development Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoskeleton Inferred from electronic annotation. Source: InterPro growth cone Inferred from sequence or structural similarity. Source: UniProtKB neuronal cell body Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZUT3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZUT3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     69-84: NPKEIVFKFMVKFFPV → M

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 714	714	FERM domain-containing protein 7		PRO_0000259532
Regions
	Domain	2 – 282	281	FERM
	Coiled coil	537 – 558	22	Potential
Natural variations
	Alternative sequence	69 – 84	16	NPKEI…KFFPV → M in isoform 2.		VSP_038722
	Natural variant	14	1	Missing in NYS1. Ref.8		VAR_062650
	Natural variant	24	1	G → E in NYS1. Ref.6		VAR_028951
	Natural variant	24	1	G → R in NYS1. Ref.6 Ref.8		VAR_028952
	Natural variant	24	1	G → W in NYS1. Ref.12		VAR_062651
	Natural variant	142	1	L → R in NYS1. Ref.6		VAR_028953
	Natural variant	146	1	R → W in NYS1. Ref.8		VAR_062652
	Natural variant	221	1	N → D in NYS1. Ref.6		VAR_028954
	Natural variant	225	1	W → G in NYS1. Ref.7		VAR_062653
	Natural variant	226	1	A → T in NYS1. Ref.6		VAR_028955
	Natural variant	229	1	R → C in NYS1. Ref.8		VAR_062654
	Natural variant	229	1	R → G in NYS1. Ref.10		VAR_062655
	Natural variant	231	1	L → V in NYS1. Ref.6		VAR_028956
	Natural variant	261	1	R → G in NYS1. Ref.9		VAR_062656
	Natural variant	261	1	R → Q in NYS1. Ref.12		VAR_062657
	Natural variant	266	1	A → P in NYS1. Ref.6		VAR_028957
	Natural variant	271	1	C → F in NYS1. Ref.11 Ref.12		VAR_062658
	Natural variant	271	1	C → Y in NYS1. Ref.6		VAR_028958
	Natural variant	275	1	H → P in NYS1. Ref.7		VAR_062659
	Natural variant	281	1	S → L. Corresponds to variant rs5977625 [ dbSNP | Ensembl ].		VAR_028959
	Natural variant	296	1	G → R in NYS1. Ref.9		VAR_062660
	Natural variant	301	1	Y → C in NYS1. Ref.6		VAR_028960
	Natural variant	340	1	S → L in NYS1. Ref.6		VAR_028961
	Natural variant	468	1	R → H. Corresponds to variant rs6637934 [ dbSNP | Ensembl ].		VAR_028962

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 7AD1D96FD4585217	FASTA	714	81,614
	10 20 30 40 50 60 MLHLKVQFLD DSQKIFVVDQ KSSGKALFNL SCSHLNLAEK EYFGLEFCSH SGNNVWLELL 70 80 90 100 110 120 KPITKQVKNP KEIVFKFMVK FFPVDPGHLR EELTRYLFTL QIKKDLALGR LPCSDNCTAL 130 140 150 160 170 180 MVSHILQSEL GDFHEETDRK HLAQTRYLPN QDCLEGKIMH FHQKHIGRSP AESDILLLDI 190 200 210 220 230 240 ARKLDMYGIR PHPASDGEGM QIHLAVAHMG VLVLRGNTKI NTFNWAKIRK LSFKRKHFLI 250 260 270 280 290 300 KLHANILVLC KDTLEFTMAS RDACKAFWKT CVEYHAFFRL SEEPKSKPKT LLCSKGSSFR 310 320 330 340 350 360 YSGRTQRQLL EYGRKGRLKS LPFERKHYPS QYHERQCRSS PDLLSDVSKQ VEDLRLAYGG 370 380 390 400 410 420 GYYQNVNGVH ASEPVLESRR RNSALEVTFA TELEHSKPEA DPTLLHQSQS SSSFPFIYMD 430 440 450 460 470 480 PVFNTEPNPN PDPRDIFSER SSLSSFQTSC KFSGNHMSIY SGLTSKVRPA KQLTYTDVPY 490 500 510 520 530 540 IPCTGQQVGI MPPQVFFYVD KPPQVPRWSP IRAEERTSPH SYVEPTAMKP AERSPRNIRM 550 560 570 580 590 600 KSFQQDLQVL QEAIARTSGR SNINVGLEEE DPNLEDAFVC NIQEQTPKRS QSQSDMKTIR 610 620 630 640 650 660 FPFGSEFRPL GPCPALSHKA DLFTDMFAEQ ELPAVLMDQS TAERYVASES SDSESEILKP 670 680 690 700 710 DYYALYGKEI RSPMARIRLS SGSLQLDEED EDAYFNTPTA EDRTSLKPCN YFLA
	Isoform 2 [UniParc]. Checksum: A6441806524D27FD	FASTA	699	79,793
	10 20 30 40 50 60 MLHLKVQFLD DSQKIFVVDQ KSSGKALFNL SCSHLNLAEK EYFGLEFCSH SGNNVWLELL 70 80 90 100 110 120 KPITKQVKMD PGHLREELTR YLFTLQIKKD LALGRLPCSD NCTALMVSHI LQSELGDFHE 130 140 150 160 170 180 ETDRKHLAQT RYLPNQDCLE GKIMHFHQKH IGRSPAESDI LLLDIARKLD MYGIRPHPAS 190 200 210 220 230 240 DGEGMQIHLA VAHMGVLVLR GNTKINTFNW AKIRKLSFKR KHFLIKLHAN ILVLCKDTLE 250 260 270 280 290 300 FTMASRDACK AFWKTCVEYH AFFRLSEEPK SKPKTLLCSK GSSFRYSGRT QRQLLEYGRK 310 320 330 340 350 360 GRLKSLPFER KHYPSQYHER QCRSSPDLLS DVSKQVEDLR LAYGGGYYQN VNGVHASEPV 370 380 390 400 410 420 LESRRRNSAL EVTFATELEH SKPEADPTLL HQSQSSSSFP FIYMDPVFNT EPNPNPDPRD 430 440 450 460 470 480 IFSERSSLSS FQTSCKFSGN HMSIYSGLTS KVRPAKQLTY TDVPYIPCTG QQVGIMPPQV 490 500 510 520 530 540 FFYVDKPPQV PRWSPIRAEE RTSPHSYVEP TAMKPAERSP RNIRMKSFQQ DLQVLQEAIA 550 560 570 580 590 600 RTSGRSNINV GLEEEDPNLE DAFVCNIQEQ TPKRSQSQSD MKTIRFPFGS EFRPLGPCPA 610 620 630 640 650 660 LSHKADLFTD MFAEQELPAV LMDQSTAERY VASESSDSES EILKPDYYAL YGKEIRSPMA 670 680 690 RIRLSSGSLQ LDEEDEDAYF NTPTAEDRTS LKPCNYFLA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and identification of a novel splice variant of human FRMD7." Zhang B., Xu S., Liu Z. Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and development." Betts-Henderson J., Bartesaghi S., Crosier M., Lindsay S., Chen H.L., Salomoni P., Gottlob I., Nicotera P. Hum. Mol. Genet. 19:342-351(2010) [PubMed] [Europe PMC] [Abstract] Cited for: DEVELOPMENTAL STAGE.
[6]	"Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus." Tarpey P., Thomas S., Sarvananthan N., Mallya U., Lisgo S., Talbot C.J., Roberts E.O., Awan M., Surendran M., McLean R.J., Reinecke R.D., Langmann A., Lindner S., Koch M., Jain S., Woodruff G., Gale R.P., Degg C. , Droutsas K., Asproudis I., Zubcov A.A., Pieh C., Veal C.D., Machado R.D., Backhouse O.C., Baumber L., Constantinescu C.S., Brodsky M.C., Hunter D.G., Hertle R.W., Read R.J., Edkins S., O'meara S., Parker A., Stevens C., Teague J., Wooster R., Futreal P.A., Trembath R.C., Stratton M.R., Raymond F.L., Gottlob I. Nat. Genet. 38:1242-1244(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS NYS1 ARG-24; GLU-24; ARG-142; ASP-221; THR-226; VAL-231; PRO-266; TYR-271; CYS-301 AND LEU-340, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[7]	"Novel mutations in FRMD7 in X-linked congenital nystagmus." Schorderet D.F., Tiab L., Gaillard M.C., Lorenz B., Klainguti G., Kerrison J.B., Traboulsi E.I., Munier F.L. Hum. Mutat. 28:525-525(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS NYS1 GLY-225 AND PRO-275.
[8]	"FRMD7 mutations in Chinese families with X-linked congenital motor nystagmus." Zhang Q., Xiao X., Li S., Guo X. Mol. Vis. 13:1375-1378(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS NYS1 LYS-14 DEL; ARG-24; TRP-146 AND CYS-229.
[9]	"Novel mutations of the FRMD7 gene in X-linked congenital motor nystagmus." Zhang B., Liu Z., Zhao G., Xie X., Yin X., Hu Z., Xu S., Li Q., Song F., Tian J., Luo W., Ding M., Yin J., Xia K., Xia J. Mol. Vis. 13:1674-1679(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS NYS1 GLY-261 AND ARG-296.
[10]	"Skewed X inactivation in an X linked nystagmus family resulted from a novel, p.R229G, missense mutation in the FRMD7 gene." Kaplan Y., Vargel I., Kansu T., Akin B., Rohmann E., Kamaci S., Uz E., Ozcelik T., Wollnik B., Akarsu N.A. Br. J. Ophthalmol. 92:135-141(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT NYS1 GLY-229.
[11]	"A novel mutation in FRMD7 causing X-linked idiopathic congenital nystagmus in a large family." He X., Gu F., Wang Y., Yan J., Zhang M., Huang S., Ma X. Mol. Vis. 14:56-60(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT NYS1 PHE-271.
[12]	"Five novel mutations of the FRMD7 gene in Chinese families with X-linked infantile nystagmus." Li N., Wang L., Cui L., Zhang L., Dai S., Li H., Chen X., Zhu L., Hejtmancik J.F., Zhao K. Mol. Vis. 14:733-738(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS NYS1 TRP-24; GLN-261 AND PHE-271.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FJ717411 mRNA. Translation: ACN56448.1. AK125336 mRNA. Translation: BAC86135.1. AL049792 Genomic DNA. No translation available. AL109749 Genomic DNA. Translation: CAI42080.1. Sequence problems. BC114371 mRNA. Translation: AAI14372.1.
IPI	IPI00375566. IPI00946784.
RefSeq	NP_919253.1. NM_194277.2.
UniGene	Hs.170776.
3D structure databases
HSSP	HSSP built from PDB template 1GG3 based on UniProtKB P11171.
ProteinModelPortal	Q6ZUT3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000298542.
PTM databases
PhosphoSite	Q6ZUT3.
Polymorphism databases
DMDM	74749680.
Proteomic databases
PaxDb	Q6ZUT3.
PRIDE	Q6ZUT3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298542; ENSP00000298542; ENSG00000165694. ENST00000370879; ENSP00000359916; ENSG00000165694. ENST00000464296; ENSP00000417996; ENSG00000165694.
GeneID	90167.
KEGG	hsa:90167.
UCSC	uc004ewn.3. human. uc011muy.2. human.
Organism-specific databases
CTD	90167.
GeneCards	GC0XM131211.
HGNC	HGNC:8079. FRMD7.
HPA	HPA000886.
MIM	300628. gene. 310700. phenotype.
neXtProt	NX_Q6ZUT3.
Orphanet	651. Congenital idiopathic nystagmus.
PharmGKB	PA162388934.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG282099.
HOGENOM	HOG000231290.
HOVERGEN	HBG080212.
InParanoid	Q6ZUT3.
OMA	FPFGSEF.
PhylomeDB	Q6ZUT3.
Gene expression databases
Bgee	Q6ZUT3.
CleanEx	HS_FRMD7.
Genevestigator	Q6ZUT3.
GermOnline	ENSG00000165694. Homo sapiens.
Family and domain databases
Gene3D	1.20.80.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR019749. Band_41_domain. IPR019750. Band_41_fam. IPR014847. FERM-adjacent. IPR014352. FERM/acyl-CoA-bd_prot_3-hlx. IPR019748. FERM_central. IPR019747. FERM_CS. IPR000299. FERM_domain. IPR018979. FERM_N. IPR018980. FERM_PH-like_C. IPR011993. PH_like_dom. [Graphical view]
Pfam	PF08736. FA. 1 hit. PF09380. FERM_C. 1 hit. PF00373. FERM_M. 1 hit. PF09379. FERM_N. 1 hit. [Graphical view]
PRINTS	PR00935. BAND41.
SMART	SM00295. B41. 1 hit. [Graphical view]
SUPFAM	SSF47031. FERM_3-hlx. 1 hit.
PROSITE	PS00660. FERM_1. 1 hit. PS00661. FERM_2. False negative. PS50057. FERM_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	90167.
NextBio	76567.
SOURCE	Search...

Entry information

Entry name

FRMD7_HUMAN

Accession

Primary (citable) accession number: Q6ZUT3
Secondary accession number(s): C0LLJ3, Q5JX99

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.