Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uncharacterized protein NKAPD1

Gene

NKAPD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein NKAPD1
Alternative name(s):
NKAP domain containing protein 1Imported
Gene namesi
Name:NKAPD1Imported
Synonyms:C11orf57
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000150776.17
HGNCiHGNC:25569 NKAPD1
neXtProtiNX_Q6ZUT1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150776
PharmGKBiPA143485352

Polymorphism and mutation databases

BioMutaiC11orf57
DMDMi125863638

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002742441 – 292Uncharacterized protein NKAPD1Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki76Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 3 (identifier: Q6ZUT1-3)
Modified residuei94PhosphothreonineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Isoform 2 (identifier: Q6ZUT1-2)
Modified residuei123PhosphothreonineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei126PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ6ZUT1
PaxDbiQ6ZUT1
PeptideAtlasiQ6ZUT1
PRIDEiQ6ZUT1

PTM databases

iPTMnetiQ6ZUT1
PhosphoSitePlusiQ6ZUT1

Expressioni

Gene expression databases

BgeeiENSG00000150776
CleanExiHS_C11orf57
ExpressionAtlasiQ6ZUT1 baseline and differential
GenevisibleiQ6ZUT1 HS

Organism-specific databases

HPAiHPA039493
HPA039892

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120512, 91 interactors
IntActiQ6ZUT1, 37 interactors
MINTiQ6ZUT1
STRINGi9606.ENSP00000376767

Structurei

3D structure databases

ProteinModelPortaliQ6ZUT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi134 – 257Lys-richAdd BLAST124

Phylogenomic databases

eggNOGiENOG410IGQD Eukaryota
ENOG41126TE LUCA
GeneTreeiENSGT00510000048628
HOGENOMiHOG000264248
HOVERGENiHBG057829
InParanoidiQ6ZUT1
OMAiSSTHESH
PhylomeDBiQ6ZUT1
TreeFamiTF332101

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZUT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRIPLGKVL LRNVIRHTDA HNKIQEESDM WKIRELEKQM EDAYRGTKRK
60 70 80 90 100
MLPSSSSRMR SDGFDEESQR YYWRPKNEIS GTLEDDFLKA KSWNKKFYDY
110 120 130 140 150
EANMPDRWGH SGYKELYPEE FETDSDQQDI TNGKKTSPQV KSSTHESRKH
160 170 180 190 200
KKSKKSHKKK QKKRSHKKQK KSKKEATDIT ADSSSEFSEE TGASGTRKGK
210 220 230 240 250
QPHKRKKKSR KKSLKKPALF LEAESNTSHS DDSASSSSEE SEERDTKKTK
260 270 280 290
RKKREKKAHT SVANNEIQER TNKRTNWKVA TDERSAESSE DD
Length:292
Mass (Da):34,110
Last modified:February 6, 2007 - v2
Checksum:i34053EE777795A10
GO
Isoform 2 (identifier: Q6ZUT1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-124: D → DS

Show »
Length:293
Mass (Da):34,197
Checksum:i9A90B24DCDA16DA2
GO
Isoform 3 (identifier: Q6ZUT1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     124-124: D → DS

Show »
Length:264
Mass (Da):30,844
Checksum:iA32FBFEF353A069F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32K → E in AAH48133 (PubMed:15489334).Curated1
Sequence conflicti96K → R in CAD98020 (PubMed:17974005).Curated1
Sequence conflicti124D → N in BAC86137 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0226851 – 29Missing in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_022686124D → DS in isoform 2 and isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125340 mRNA Translation: BAC86137.1
BX538107 mRNA Translation: CAD98020.1
BC005403 mRNA Translation: AAH05403.3
BC030546 mRNA Translation: AAH30546.3
BC048133 mRNA Translation: AAH48133.2
BC072455 mRNA Translation: AAH72455.2
CCDSiCCDS41715.1 [Q6ZUT1-1]
CCDS73383.1 [Q6ZUT1-3]
CCDS8356.2 [Q6ZUT1-2]
RefSeqiNP_001076439.1, NM_001082970.1 [Q6ZUT1-1]
NP_001287946.1, NM_001301017.1 [Q6ZUT1-1]
NP_001287948.1, NM_001301019.1 [Q6ZUT1-3]
NP_001287950.1, NM_001301021.1
UniGeneiHs.195060

Genome annotation databases

EnsembliENST00000280352; ENSP00000339076; ENSG00000150776 [Q6ZUT1-1]
ENST00000393047; ENSP00000376767; ENSG00000150776 [Q6ZUT1-2]
ENST00000420986; ENSP00000402208; ENSG00000150776 [Q6ZUT1-1]
ENST00000532163; ENSP00000432188; ENSG00000150776 [Q6ZUT1-3]
GeneIDi55216
KEGGihsa:55216
UCSCiuc001pmr.5 human [Q6ZUT1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNKAP1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZUT1
Secondary accession number(s): Q5RL41
, Q6IN53, Q7Z357, Q8N2T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health