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Q6ZUT1

- CK057_HUMAN

UniProt

Q6ZUT1 - CK057_HUMAN

Protein

Uncharacterized protein C11orf57

Gene

C11orf57

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 2 (06 Feb 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein C11orf57
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:25569. C11orf57.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485352.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Uncharacterized protein C11orf57PRO_0000274244Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6ZUT1.
    PaxDbiQ6ZUT1.
    PRIDEiQ6ZUT1.

    PTM databases

    PhosphoSiteiQ6ZUT1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ZUT1.
    BgeeiQ6ZUT1.
    CleanExiHS_C11orf57.
    GenevestigatoriQ6ZUT1.

    Organism-specific databases

    HPAiHPA039493.
    HPA039892.

    Interactioni

    Protein-protein interaction databases

    BioGridi120512. 4 interactions.
    IntActiQ6ZUT1. 4 interactions.
    STRINGi9606.ENSP00000376767.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZUT1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi134 – 257124Lys-richAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG80585.
    HOGENOMiHOG000264248.
    HOVERGENiHBG057829.
    OMAiSSTHESH.
    PhylomeDBiQ6ZUT1.
    TreeFamiTF332101.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZUT1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRIPLGKVL LRNVIRHTDA HNKIQEESDM WKIRELEKQM EDAYRGTKRK    50
    MLPSSSSRMR SDGFDEESQR YYWRPKNEIS GTLEDDFLKA KSWNKKFYDY 100
    EANMPDRWGH SGYKELYPEE FETDSDQQDI TNGKKTSPQV KSSTHESRKH 150
    KKSKKSHKKK QKKRSHKKQK KSKKEATDIT ADSSSEFSEE TGASGTRKGK 200
    QPHKRKKKSR KKSLKKPALF LEAESNTSHS DDSASSSSEE SEERDTKKTK 250
    RKKREKKAHT SVANNEIQER TNKRTNWKVA TDERSAESSE DD 292
    Length:292
    Mass (Da):34,110
    Last modified:February 6, 2007 - v2
    Checksum:i34053EE777795A10
    GO
    Isoform 2 (identifier: Q6ZUT1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         124-124: D → DS

    Note: Contains a phosphothreonine at position 123. Contains a phosphoserine at position 125. Contains a phosphoserine at position 126.

    Show »
    Length:293
    Mass (Da):34,197
    Checksum:i9A90B24DCDA16DA2
    GO
    Isoform 3 (identifier: Q6ZUT1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-29: Missing.
         124-124: D → DS

    Note: Contains a phosphothreonine at position 94. Contains a phosphoserine at position 96. Contains a phosphoserine at position 97.

    Show »
    Length:264
    Mass (Da):30,844
    Checksum:iA32FBFEF353A069F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321K → E in AAH48133. (PubMed:15489334)Curated
    Sequence conflicti96 – 961K → R in CAD98020. (PubMed:17974005)Curated
    Sequence conflicti124 – 1241D → N in BAC86137. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2929Missing in isoform 3. 1 PublicationVSP_022685Add
    BLAST
    Alternative sequencei124 – 1241D → DS in isoform 2 and isoform 3. 2 PublicationsVSP_022686

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK125340 mRNA. Translation: BAC86137.1.
    BX538107 mRNA. Translation: CAD98020.1.
    BC005403 mRNA. Translation: AAH05403.3.
    BC030546 mRNA. Translation: AAH30546.3.
    BC048133 mRNA. Translation: AAH48133.2.
    BC072455 mRNA. Translation: AAH72455.2.
    CCDSiCCDS41715.1. [Q6ZUT1-1]
    CCDS8356.2. [Q6ZUT1-2]
    RefSeqiNP_001076439.1. NM_001082970.1. [Q6ZUT1-1]
    XP_006718936.1. XM_006718873.1. [Q6ZUT1-1]
    XP_006718939.1. XM_006718876.1. [Q6ZUT1-3]
    UniGeneiHs.195060.

    Genome annotation databases

    EnsembliENST00000280352; ENSP00000339076; ENSG00000150776. [Q6ZUT1-1]
    ENST00000393047; ENSP00000376767; ENSG00000150776. [Q6ZUT1-2]
    ENST00000420986; ENSP00000402208; ENSG00000150776. [Q6ZUT1-1]
    ENST00000532163; ENSP00000432188; ENSG00000150776. [Q6ZUT1-3]
    GeneIDi55216.
    KEGGihsa:55216.
    UCSCiuc001pmr.4. human. [Q6ZUT1-1]
    uc001pms.4. human. [Q6ZUT1-3]
    uc001pmt.4. human. [Q6ZUT1-2]

    Polymorphism databases

    DMDMi125863638.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK125340 mRNA. Translation: BAC86137.1 .
    BX538107 mRNA. Translation: CAD98020.1 .
    BC005403 mRNA. Translation: AAH05403.3 .
    BC030546 mRNA. Translation: AAH30546.3 .
    BC048133 mRNA. Translation: AAH48133.2 .
    BC072455 mRNA. Translation: AAH72455.2 .
    CCDSi CCDS41715.1. [Q6ZUT1-1 ]
    CCDS8356.2. [Q6ZUT1-2 ]
    RefSeqi NP_001076439.1. NM_001082970.1. [Q6ZUT1-1 ]
    XP_006718936.1. XM_006718873.1. [Q6ZUT1-1 ]
    XP_006718939.1. XM_006718876.1. [Q6ZUT1-3 ]
    UniGenei Hs.195060.

    3D structure databases

    ProteinModelPortali Q6ZUT1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120512. 4 interactions.
    IntActi Q6ZUT1. 4 interactions.
    STRINGi 9606.ENSP00000376767.

    PTM databases

    PhosphoSitei Q6ZUT1.

    Polymorphism databases

    DMDMi 125863638.

    Proteomic databases

    MaxQBi Q6ZUT1.
    PaxDbi Q6ZUT1.
    PRIDEi Q6ZUT1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000280352 ; ENSP00000339076 ; ENSG00000150776 . [Q6ZUT1-1 ]
    ENST00000393047 ; ENSP00000376767 ; ENSG00000150776 . [Q6ZUT1-2 ]
    ENST00000420986 ; ENSP00000402208 ; ENSG00000150776 . [Q6ZUT1-1 ]
    ENST00000532163 ; ENSP00000432188 ; ENSG00000150776 . [Q6ZUT1-3 ]
    GeneIDi 55216.
    KEGGi hsa:55216.
    UCSCi uc001pmr.4. human. [Q6ZUT1-1 ]
    uc001pms.4. human. [Q6ZUT1-3 ]
    uc001pmt.4. human. [Q6ZUT1-2 ]

    Organism-specific databases

    CTDi 55216.
    GeneCardsi GC11P111944.
    H-InvDB HIX0010120.
    HGNCi HGNC:25569. C11orf57.
    HPAi HPA039493.
    HPA039892.
    neXtProti NX_Q6ZUT1.
    PharmGKBi PA143485352.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG80585.
    HOGENOMi HOG000264248.
    HOVERGENi HBG057829.
    OMAi SSTHESH.
    PhylomeDBi Q6ZUT1.
    TreeFami TF332101.

    Miscellaneous databases

    GenomeRNAii 55216.
    NextBioi 59176.

    Gene expression databases

    ArrayExpressi Q6ZUT1.
    Bgeei Q6ZUT1.
    CleanExi HS_C11orf57.
    Genevestigatori Q6ZUT1.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Teratocarcinoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Colon endothelium.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain, Cervix and PNS.
    4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-123; SER-125 AND SER-126 (ISOFORM 2), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-94; SER-96 AND SER-97 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCK057_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZUT1
    Secondary accession number(s): Q5RL41
    , Q6IN53, Q7Z357, Q8N2T3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 71 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM

    External Data

    Dasty 3