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Q6ZUT1

- CK057_HUMAN

UniProt

Q6ZUT1 - CK057_HUMAN

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Protein

Uncharacterized protein C11orf57

Gene

C11orf57

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C11orf57
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:25569. C11orf57.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485352.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Uncharacterized protein C11orf57PRO_0000274244Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6ZUT1.
PaxDbiQ6ZUT1.
PRIDEiQ6ZUT1.

PTM databases

PhosphoSiteiQ6ZUT1.

Expressioni

Gene expression databases

BgeeiQ6ZUT1.
CleanExiHS_C11orf57.
ExpressionAtlasiQ6ZUT1. baseline and differential.
GenevestigatoriQ6ZUT1.

Organism-specific databases

HPAiHPA039493.
HPA039892.

Interactioni

Protein-protein interaction databases

BioGridi120512. 9 interactions.
IntActiQ6ZUT1. 5 interactions.
STRINGi9606.ENSP00000376767.

Structurei

3D structure databases

ProteinModelPortaliQ6ZUT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi134 – 257124Lys-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG80585.
GeneTreeiENSGT00510000048628.
HOGENOMiHOG000264248.
HOVERGENiHBG057829.
InParanoidiQ6ZUT1.
OMAiSSTHESH.
PhylomeDBiQ6ZUT1.
TreeFamiTF332101.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZUT1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRIPLGKVL LRNVIRHTDA HNKIQEESDM WKIRELEKQM EDAYRGTKRK
60 70 80 90 100
MLPSSSSRMR SDGFDEESQR YYWRPKNEIS GTLEDDFLKA KSWNKKFYDY
110 120 130 140 150
EANMPDRWGH SGYKELYPEE FETDSDQQDI TNGKKTSPQV KSSTHESRKH
160 170 180 190 200
KKSKKSHKKK QKKRSHKKQK KSKKEATDIT ADSSSEFSEE TGASGTRKGK
210 220 230 240 250
QPHKRKKKSR KKSLKKPALF LEAESNTSHS DDSASSSSEE SEERDTKKTK
260 270 280 290
RKKREKKAHT SVANNEIQER TNKRTNWKVA TDERSAESSE DD
Length:292
Mass (Da):34,110
Last modified:February 6, 2007 - v2
Checksum:i34053EE777795A10
GO
Isoform 2 (identifier: Q6ZUT1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-124: D → DS

Note: Contains a phosphothreonine at position 123. Contains a phosphoserine at position 125. Contains a phosphoserine at position 126.

Show »
Length:293
Mass (Da):34,197
Checksum:i9A90B24DCDA16DA2
GO
Isoform 3 (identifier: Q6ZUT1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     124-124: D → DS

Note: Contains a phosphothreonine at position 94. Contains a phosphoserine at position 96. Contains a phosphoserine at position 97.

Show »
Length:264
Mass (Da):30,844
Checksum:iA32FBFEF353A069F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321K → E in AAH48133. (PubMed:15489334)Curated
Sequence conflicti96 – 961K → R in CAD98020. (PubMed:17974005)Curated
Sequence conflicti124 – 1241D → N in BAC86137. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2929Missing in isoform 3. 1 PublicationVSP_022685Add
BLAST
Alternative sequencei124 – 1241D → DS in isoform 2 and isoform 3. 2 PublicationsVSP_022686

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK125340 mRNA. Translation: BAC86137.1.
BX538107 mRNA. Translation: CAD98020.1.
BC005403 mRNA. Translation: AAH05403.3.
BC030546 mRNA. Translation: AAH30546.3.
BC048133 mRNA. Translation: AAH48133.2.
BC072455 mRNA. Translation: AAH72455.2.
CCDSiCCDS41715.1. [Q6ZUT1-1]
CCDS73383.1. [Q6ZUT1-3]
CCDS8356.2. [Q6ZUT1-2]
RefSeqiNP_001076439.1. NM_001082970.1. [Q6ZUT1-1]
UniGeneiHs.195060.

Genome annotation databases

EnsembliENST00000280352; ENSP00000339076; ENSG00000150776. [Q6ZUT1-1]
ENST00000393047; ENSP00000376767; ENSG00000150776. [Q6ZUT1-2]
ENST00000420986; ENSP00000402208; ENSG00000150776. [Q6ZUT1-1]
ENST00000532163; ENSP00000432188; ENSG00000150776. [Q6ZUT1-3]
GeneIDi55216.
KEGGihsa:55216.
UCSCiuc001pmr.4. human. [Q6ZUT1-1]
uc001pms.4. human. [Q6ZUT1-3]
uc001pmt.4. human. [Q6ZUT1-2]

Polymorphism databases

DMDMi125863638.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK125340 mRNA. Translation: BAC86137.1 .
BX538107 mRNA. Translation: CAD98020.1 .
BC005403 mRNA. Translation: AAH05403.3 .
BC030546 mRNA. Translation: AAH30546.3 .
BC048133 mRNA. Translation: AAH48133.2 .
BC072455 mRNA. Translation: AAH72455.2 .
CCDSi CCDS41715.1. [Q6ZUT1-1 ]
CCDS73383.1. [Q6ZUT1-3 ]
CCDS8356.2. [Q6ZUT1-2 ]
RefSeqi NP_001076439.1. NM_001082970.1. [Q6ZUT1-1 ]
UniGenei Hs.195060.

3D structure databases

ProteinModelPortali Q6ZUT1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120512. 9 interactions.
IntActi Q6ZUT1. 5 interactions.
STRINGi 9606.ENSP00000376767.

PTM databases

PhosphoSitei Q6ZUT1.

Polymorphism databases

DMDMi 125863638.

Proteomic databases

MaxQBi Q6ZUT1.
PaxDbi Q6ZUT1.
PRIDEi Q6ZUT1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000280352 ; ENSP00000339076 ; ENSG00000150776 . [Q6ZUT1-1 ]
ENST00000393047 ; ENSP00000376767 ; ENSG00000150776 . [Q6ZUT1-2 ]
ENST00000420986 ; ENSP00000402208 ; ENSG00000150776 . [Q6ZUT1-1 ]
ENST00000532163 ; ENSP00000432188 ; ENSG00000150776 . [Q6ZUT1-3 ]
GeneIDi 55216.
KEGGi hsa:55216.
UCSCi uc001pmr.4. human. [Q6ZUT1-1 ]
uc001pms.4. human. [Q6ZUT1-3 ]
uc001pmt.4. human. [Q6ZUT1-2 ]

Organism-specific databases

CTDi 55216.
GeneCardsi GC11P111944.
H-InvDB HIX0010120.
HGNCi HGNC:25569. C11orf57.
HPAi HPA039493.
HPA039892.
neXtProti NX_Q6ZUT1.
PharmGKBi PA143485352.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG80585.
GeneTreei ENSGT00510000048628.
HOGENOMi HOG000264248.
HOVERGENi HBG057829.
InParanoidi Q6ZUT1.
OMAi SSTHESH.
PhylomeDBi Q6ZUT1.
TreeFami TF332101.

Miscellaneous databases

GenomeRNAii 55216.
NextBioi 59176.

Gene expression databases

Bgeei Q6ZUT1.
CleanExi HS_C11orf57.
ExpressionAtlasi Q6ZUT1. baseline and differential.
Genevestigatori Q6ZUT1.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Colon endothelium.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Cervix and PNS.
  4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-123; SER-125 AND SER-126 (ISOFORM 2), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-94; SER-96 AND SER-97 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCK057_HUMAN
AccessioniPrimary (citable) accession number: Q6ZUT1
Secondary accession number(s): Q5RL41
, Q6IN53, Q7Z357, Q8N2T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM

External Data

Dasty 3