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Q6ZUT1 (CK057_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C11orf57
Gene names
Name:C11orf57
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZUT1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZUT1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     124-124: D → DS
Note: Contains a phosphothreonine at position 123. Contains a phosphoserine at position 125. Contains a phosphoserine at position 126.
Isoform 3 (identifier: Q6ZUT1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     124-124: D → DS
Note: Contains a phosphothreonine at position 94. Contains a phosphoserine at position 96. Contains a phosphoserine at position 97.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Uncharacterized protein C11orf57
PRO_0000274244

Regions

Compositional bias134 – 257124Lys-rich

Natural variations

Alternative sequence1 – 2929Missing in isoform 3.
VSP_022685
Alternative sequence1241D → DS in isoform 2 and isoform 3.
VSP_022686

Experimental info

Sequence conflict321K → E in AAH48133. Ref.3
Sequence conflict961K → R in CAD98020. Ref.2
Sequence conflict1241D → N in BAC86137. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 6, 2007. Version 2.
Checksum: 34053EE777795A10

FASTA29234,110
        10         20         30         40         50         60 
MSRIPLGKVL LRNVIRHTDA HNKIQEESDM WKIRELEKQM EDAYRGTKRK MLPSSSSRMR 

        70         80         90        100        110        120 
SDGFDEESQR YYWRPKNEIS GTLEDDFLKA KSWNKKFYDY EANMPDRWGH SGYKELYPEE 

       130        140        150        160        170        180 
FETDSDQQDI TNGKKTSPQV KSSTHESRKH KKSKKSHKKK QKKRSHKKQK KSKKEATDIT 

       190        200        210        220        230        240 
ADSSSEFSEE TGASGTRKGK QPHKRKKKSR KKSLKKPALF LEAESNTSHS DDSASSSSEE 

       250        260        270        280        290 
SEERDTKKTK RKKREKKAHT SVANNEIQER TNKRTNWKVA TDERSAESSE DD 

« Hide

Isoform 2 [UniParc].

Checksum: 9A90B24DCDA16DA2
Show »

FASTA29334,197
Isoform 3 [UniParc].

Checksum: A32FBFEF353A069F
Show »

FASTA26430,844

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Teratocarcinoma.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Colon endothelium.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain, Cervix and PNS.
[4]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-123; SER-125 AND SER-126 (ISOFORM 2), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-94; SER-96 AND SER-97 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK125340 mRNA. Translation: BAC86137.1.
BX538107 mRNA. Translation: CAD98020.1.
BC005403 mRNA. Translation: AAH05403.3.
BC030546 mRNA. Translation: AAH30546.3.
BC048133 mRNA. Translation: AAH48133.2.
BC072455 mRNA. Translation: AAH72455.2.
RefSeqNP_001076438.1. NM_001082969.1.
NP_001076439.1. NM_001082970.1.
NP_060665.3. NM_018195.3.
UniGeneHs.195060.

3D structure databases

ProteinModelPortalQ6ZUT1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120512. 4 interactions.
IntActQ6ZUT1. 4 interactions.
STRING9606.ENSP00000376767.

PTM databases

PhosphoSiteQ6ZUT1.

Polymorphism databases

DMDM125863638.

Proteomic databases

PaxDbQ6ZUT1.
PRIDEQ6ZUT1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000280352; ENSP00000339076; ENSG00000150776. [Q6ZUT1-1]
ENST00000393047; ENSP00000376767; ENSG00000150776. [Q6ZUT1-2]
ENST00000420986; ENSP00000402208; ENSG00000150776. [Q6ZUT1-1]
ENST00000532163; ENSP00000432188; ENSG00000150776. [Q6ZUT1-3]
ENST00000570669; ENSP00000461093; ENSG00000262506. [Q6ZUT1-2]
ENST00000574413; ENSP00000460336; ENSG00000262506. [Q6ZUT1-1]
ENST00000575508; ENSP00000460769; ENSG00000262506. [Q6ZUT1-3]
ENST00000577170; ENSP00000459320; ENSG00000262506. [Q6ZUT1-1]
GeneID55216.
KEGGhsa:55216.
UCSCuc001pmr.4. human. [Q6ZUT1-1]
uc001pms.4. human. [Q6ZUT1-3]
uc001pmt.4. human. [Q6ZUT1-2]

Organism-specific databases

CTD55216.
GeneCardsGC11P111944.
H-InvDBHIX0010120.
HGNCHGNC:25569. C11orf57.
HPAHPA039493.
HPA039892.
neXtProtNX_Q6ZUT1.
PharmGKBPA143485352.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG80585.
HOGENOMHOG000264248.
HOVERGENHBG057829.
OMASSTHESH.
PhylomeDBQ6ZUT1.
TreeFamTF332101.

Gene expression databases

ArrayExpressQ6ZUT1.
BgeeQ6ZUT1.
CleanExHS_C11orf57.
GenevestigatorQ6ZUT1.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi55216.
NextBio59176.

Entry information

Entry nameCK057_HUMAN
AccessionPrimary (citable) accession number: Q6ZUT1
Secondary accession number(s): Q5RL41 expand/collapse secondary AC list , Q6IN53, Q7Z357, Q8N2T3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

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Human chromosome 11: entries, gene names and cross-references to MIM