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Protein

Coiled-coil domain-containing protein 121

Gene

CCDC121

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 121
Gene namesi
Name:CCDC121
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25833. CCDC121.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147358222.

Polymorphism and mutation databases

BioMutaiCCDC121.
DMDMi74738330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Coiled-coil domain-containing protein 121PRO_0000286559Add
BLAST

Proteomic databases

PaxDbiQ6ZUS5.
PeptideAtlasiQ6ZUS5.
PRIDEiQ6ZUS5.

PTM databases

iPTMnetiQ6ZUS5.
PhosphoSiteiQ6ZUS5.

Expressioni

Gene expression databases

BgeeiQ6ZUS5.
CleanExiHS_CCDC121.
ExpressionAtlasiQ6ZUS5. baseline and differential.
GenevisibleiQ6ZUS5. HS.

Organism-specific databases

HPAiHPA051791.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NUP62P371984EBI-2836982,EBI-347978
RINT1Q6NUQ13EBI-2836982,EBI-726876
TFIP11Q9UBB93EBI-2836982,EBI-1105213
USHBP1Q8N6Y03EBI-2836982,EBI-739895

Protein-protein interaction databases

BioGridi122765. 12 interactions.
IntActiQ6ZUS5. 7 interactions.
MINTiMINT-8417641.

Structurei

3D structure databases

ProteinModelPortaliQ6ZUS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 3030Sequence analysisAdd
BLAST
Coiled coili105 – 243139Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IUNP. Eukaryota.
ENOG41119U4. LUCA.
GeneTreeiENSGT00510000049520.
HOGENOMiHOG000065769.
InParanoidiQ6ZUS5.
OMAiEQWYLES.
OrthoDBiEOG7J9VQ8.
PhylomeDBiQ6ZUS5.
TreeFamiTF350484.

Family and domain databases

InterProiIPR032777. DUF4515.
[Graphical view]
PfamiPF14988. DUF4515. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZUS5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDLNKHIKQ AQTQRKQLLE ESRELHREKL LVQAENRFFL EYLTNKTEEY
60 70 80 90 100
TEQPEKVWNS YLQKSGEIER RRQESASRYA EQISVLKTAL LQKENIQSSL
110 120 130 140 150
KRKLQAMRDI AILKEKQEKE IQTLQEETKK VQAETASKTR EVQAQLLQEK
160 170 180 190 200
RLLEKQLSEP DRRLLGKRKR RELNMKAQAL KLAAKRFIFE YSCGINRENQ
210 220 230 240 250
QFKKELLQLI EQAQKLTATQ SHLENRKQQL QQEQWYLESL IQARQRLQGS
260 270
HNQCLNRQDV PKTTPSLPQG TKSRINPK
Length:278
Mass (Da):33,061
Last modified:July 5, 2004 - v1
Checksum:iDA5E08E7C80198C8
GO
Isoform 2 (identifier: Q6ZUS5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGSRGQGSHS...RLKEKIVAEM

Show »
Length:440
Mass (Da):50,589
Checksum:iE125216EFECD7E12
GO

Sequence cautioni

The sequence AAX93200.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB14651.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MGSRGQGSHSKKTRSMPVIL SPQRTGSGATGGPAARAYSV AEAVKQFRAGPAGTGAGCSL QGCWAAPRPFEHRTNKLREL STLAHCSRELQTQVPDASAH SLAVTLSELHSCRDLQDECL DSRFAEGPRRLLPPYHSLIN NFVKPEKLTKVETRLKEKIV AEM in isoform 2. CuratedVSP_046649

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023708 mRNA. Translation: BAB14651.1. Different initiation.
AK124337 mRNA. Translation: BAG54028.1.
AK125354 mRNA. Translation: BAC86143.1.
AC074091 Genomic DNA. Translation: AAX93200.1. Different initiation.
CH471053 Genomic DNA. Translation: EAX00560.1.
CH471053 Genomic DNA. Translation: EAX00561.1.
BC066936 mRNA. Translation: AAH66936.1.
BC066969 mRNA. Translation: AAH66969.1.
CCDSiCCDS1759.1. [Q6ZUS5-1]
CCDS46247.1. [Q6ZUS5-2]
RefSeqiNP_001136155.1. NM_001142683.2. [Q6ZUS5-2]
NP_078860.2. NM_024584.4. [Q6ZUS5-1]
UniGeneiHs.21081.

Genome annotation databases

EnsembliENST00000324364; ENSP00000339087; ENSG00000176714. [Q6ZUS5-1]
ENST00000394775; ENSP00000412150; ENSG00000176714. [Q6ZUS5-2]
GeneIDi79635.
KEGGihsa:79635.
UCSCiuc002rld.4. human. [Q6ZUS5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023708 mRNA. Translation: BAB14651.1. Different initiation.
AK124337 mRNA. Translation: BAG54028.1.
AK125354 mRNA. Translation: BAC86143.1.
AC074091 Genomic DNA. Translation: AAX93200.1. Different initiation.
CH471053 Genomic DNA. Translation: EAX00560.1.
CH471053 Genomic DNA. Translation: EAX00561.1.
BC066936 mRNA. Translation: AAH66936.1.
BC066969 mRNA. Translation: AAH66969.1.
CCDSiCCDS1759.1. [Q6ZUS5-1]
CCDS46247.1. [Q6ZUS5-2]
RefSeqiNP_001136155.1. NM_001142683.2. [Q6ZUS5-2]
NP_078860.2. NM_024584.4. [Q6ZUS5-1]
UniGeneiHs.21081.

3D structure databases

ProteinModelPortaliQ6ZUS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122765. 12 interactions.
IntActiQ6ZUS5. 7 interactions.
MINTiMINT-8417641.

PTM databases

iPTMnetiQ6ZUS5.
PhosphoSiteiQ6ZUS5.

Polymorphism and mutation databases

BioMutaiCCDC121.
DMDMi74738330.

Proteomic databases

PaxDbiQ6ZUS5.
PeptideAtlasiQ6ZUS5.
PRIDEiQ6ZUS5.

Protocols and materials databases

DNASUi79635.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324364; ENSP00000339087; ENSG00000176714. [Q6ZUS5-1]
ENST00000394775; ENSP00000412150; ENSG00000176714. [Q6ZUS5-2]
GeneIDi79635.
KEGGihsa:79635.
UCSCiuc002rld.4. human. [Q6ZUS5-1]

Organism-specific databases

CTDi79635.
GeneCardsiCCDC121.
HGNCiHGNC:25833. CCDC121.
HPAiHPA051791.
neXtProtiNX_Q6ZUS5.
PharmGKBiPA147358222.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUNP. Eukaryota.
ENOG41119U4. LUCA.
GeneTreeiENSGT00510000049520.
HOGENOMiHOG000065769.
InParanoidiQ6ZUS5.
OMAiEQWYLES.
OrthoDBiEOG7J9VQ8.
PhylomeDBiQ6ZUS5.
TreeFamiTF350484.

Miscellaneous databases

GenomeRNAii79635.
PROiQ6ZUS5.

Gene expression databases

BgeeiQ6ZUS5.
CleanExiHS_CCDC121.
ExpressionAtlasiQ6ZUS5. baseline and differential.
GenevisibleiQ6ZUS5. HS.

Family and domain databases

InterProiIPR032777. DUF4515.
[Graphical view]
PfamiPF14988. DUF4515. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta and Uterus.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Testis.

Entry informationi

Entry nameiCC121_HUMAN
AccessioniPrimary (citable) accession number: Q6ZUS5
Secondary accession number(s): B3KW66, J3KQZ8, Q9H8G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.