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Protein

Coiled-coil domain-containing protein 121

Gene

CCDC121

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 121
Gene namesi
Name:CCDC121
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000176714.9.
HGNCiHGNC:25833. CCDC121.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176714.
PharmGKBiPA147358222.

Polymorphism and mutation databases

BioMutaiCCDC121.
DMDMi74738330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002865591 – 278Coiled-coil domain-containing protein 121Add BLAST278

Proteomic databases

PaxDbiQ6ZUS5.
PeptideAtlasiQ6ZUS5.
PRIDEiQ6ZUS5.

PTM databases

iPTMnetiQ6ZUS5.
PhosphoSitePlusiQ6ZUS5.

Expressioni

Gene expression databases

BgeeiENSG00000176714.
CleanExiHS_CCDC121.
ExpressionAtlasiQ6ZUS5. baseline and differential.
GenevisibleiQ6ZUS5. HS.

Organism-specific databases

HPAiHPA051791.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122765. 12 interactors.
IntActiQ6ZUS5. 7 interactors.
MINTiMINT-8417641.
STRINGi9606.ENSP00000412150.

Structurei

3D structure databases

ProteinModelPortaliQ6ZUS5.
SMRiQ6ZUS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 30Sequence analysisAdd BLAST30
Coiled coili105 – 243Sequence analysisAdd BLAST139

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IUNP. Eukaryota.
ENOG41119U4. LUCA.
GeneTreeiENSGT00510000049520.
HOGENOMiHOG000065769.
InParanoidiQ6ZUS5.
OMAiEQWYLES.
OrthoDBiEOG091G0EZ5.
PhylomeDBiQ6ZUS5.
TreeFamiTF350484.

Family and domain databases

InterProiView protein in InterPro
IPR032777. DUF4515.
PfamiView protein in Pfam
PF14988. DUF4515. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZUS5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDLNKHIKQ AQTQRKQLLE ESRELHREKL LVQAENRFFL EYLTNKTEEY
60 70 80 90 100
TEQPEKVWNS YLQKSGEIER RRQESASRYA EQISVLKTAL LQKENIQSSL
110 120 130 140 150
KRKLQAMRDI AILKEKQEKE IQTLQEETKK VQAETASKTR EVQAQLLQEK
160 170 180 190 200
RLLEKQLSEP DRRLLGKRKR RELNMKAQAL KLAAKRFIFE YSCGINRENQ
210 220 230 240 250
QFKKELLQLI EQAQKLTATQ SHLENRKQQL QQEQWYLESL IQARQRLQGS
260 270
HNQCLNRQDV PKTTPSLPQG TKSRINPK
Length:278
Mass (Da):33,061
Last modified:July 5, 2004 - v1
Checksum:iDA5E08E7C80198C8
GO
Isoform 2 (identifier: Q6ZUS5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGSRGQGSHS...RLKEKIVAEM

Show »
Length:440
Mass (Da):50,589
Checksum:iE125216EFECD7E12
GO

Sequence cautioni

Q6ZUS5: The sequence AAX93200 differs from that shown. Reason: Erroneous initiation.Curated
Q6ZUS5: The sequence BAB14651 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0466491M → MGSRGQGSHSKKTRSMPVIL SPQRTGSGATGGPAARAYSV AEAVKQFRAGPAGTGAGCSL QGCWAAPRPFEHRTNKLREL STLAHCSRELQTQVPDASAH SLAVTLSELHSCRDLQDECL DSRFAEGPRRLLPPYHSLIN NFVKPEKLTKVETRLKEKIV AEM in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023708 mRNA. Translation: BAB14651.1. Different initiation.
AK124337 mRNA. Translation: BAG54028.1.
AK125354 mRNA. Translation: BAC86143.1.
AC074091 Genomic DNA. Translation: AAX93200.1. Different initiation.
CH471053 Genomic DNA. Translation: EAX00560.1.
CH471053 Genomic DNA. Translation: EAX00561.1.
BC066936 mRNA. Translation: AAH66936.1.
BC066969 mRNA. Translation: AAH66969.1.
CCDSiCCDS1759.1. [Q6ZUS5-1]
CCDS46247.1. [Q6ZUS5-2]
RefSeqiNP_001136155.1. NM_001142683.2. [Q6ZUS5-2]
NP_078860.2. NM_024584.4. [Q6ZUS5-1]
UniGeneiHs.21081.

Genome annotation databases

EnsembliENST00000324364; ENSP00000339087; ENSG00000176714. [Q6ZUS5-1]
ENST00000394775; ENSP00000412150; ENSG00000176714. [Q6ZUS5-2]
GeneIDi79635.
KEGGihsa:79635.
UCSCiuc002rld.4. human. [Q6ZUS5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCC121_HUMAN
AccessioniPrimary (citable) accession number: Q6ZUS5
Secondary accession number(s): B3KW66, J3KQZ8, Q9H8G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM