Q6ZUM4 (RHG27_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho GTPase-activating protein 27

Alternative name(s):
CIN85-associated multi-domain-containing Rho GTPase-activating protein 1
Rho-type GTPase-activating protein 27
SH3 domain-containing protein 20

Gene names

Name:	ARHGAP27
Synonyms:	CAMGAP1, SH3D20
ORF Names:	PP905

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	889 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 By similarity.
Subunit structure	Interacts with SH3KBP1/CIN85 By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.
Tissue specificity	Expressed in germinal center B-cell, spleen, chronic lymphocytic leukemia, pancreatic cancer and lung cancer. Ref.5
Sequence similarities	Contains 1 PH domain. Contains 1 Rho-GAP domain. Contains 1 SH3 domain. Contains 3 WW domains.
Caution	According to HGNC, ARHGAP27 and SH3D20 are 2 separate genes, corresponding to isoform 2 and isoform 4, respectively. However, a rat transcript and paralog proteins with a similar domain structure suggest the existence of a single gene encoding for a protein of 889 residues as displayed here.
Sequence caution	The sequence AAI01389.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAI01390.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAI01391.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat SH3 domain
Molecular function	GTPase activation
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of Cdc42 GTPase activity Inferred from sequence or structural similarity. Source: HGNC receptor-mediated endocytosis Inferred from sequence or structural similarity. Source: HGNC signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell intracellular Inferred from sequence or structural similarity. Source: HGNC membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	Rac GTPase activator activity Inferred from sequence or structural similarity. Source: HGNC SH3 domain binding Inferred from sequence or structural similarity. Source: HGNC phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZUM4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZUM4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-341: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q6ZUM4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     416-442: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q6ZUM4-4)

Also known as: SH3D20;

The sequence of this isoform differs from the canonical sequence as follows:
     221-263: DDPPEPVYAN...THTDAGTGRP → PPRALGRGGG...RRPPLSEDFG
     264-889: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 889

889

Rho GTPase-activating protein 27

PRO_0000317578

Regions

Domain

8 – 69

62

SH3

Domain

246 – 280

35

WW 1

Domain

299 – 333

35

WW 2

Domain

411 – 444

34

WW 3

Domain

496 – 612

117

PH

Domain

697 – 886

190

Rho-GAP

Amino acid modifications

Modified residue

156

1

Phosphoserine By similarity

Modified residue

216

1

Phosphoserine By similarity

Modified residue

228

1

Phosphotyrosine By similarity

Modified residue

638

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 341

341

Missing in isoform 2.

VSP_031053

Alternative sequence

221 – 263

43

DDPPE…GTGRP → PPRALGRGGGWRARDRARTE PGRKETRSAQRRARRPPLSE DFG in isoform 4.

VSP_031054

Alternative sequence

264 – 889

626

Missing in isoform 4.

VSP_031055

Alternative sequence

416 – 442

27

Missing in isoform 3.

VSP_031056

Natural variant

889

1

H → Q. Ref.4
Corresponds to variant rs34793644 [ dbSNP | Ensembl ].

VAR_038551

Experimental info

Sequence conflict

41

1

S → N in AAG23796. Ref.1

Sequence conflict

162

1

C → R in BAF83339. Ref.2

Sequence conflict

213

1

P → R in AAH67345. Ref.4

Secondary structure

1

.

.

.

.

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.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

889

Helix Strand Turn

Details...

Beta strand

499 – 510

12

Beta strand

521 – 528

8

Beta strand

531 – 536

6

Helix

549 – 552

4

Beta strand

554 – 560

7

Beta strand

565 – 568

4

Helix

571 – 573

3

Beta strand

575 – 583

9

Beta strand

589 – 593

5

Helix

597 – 611

15

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 13, 2010. Version 3. Checksum: E341CCC4D012DA4C	FASTA	889	98,396
	10 20 30 40 50 60 MAADVVGDVY VLVEHPFEYT GKDGRRVAIR PNERYRLLRR STEHWWHVRR EPGGRPFYLP 70 80 90 100 110 120 AQYVRELPAL GNPAAAAPPG PHPSPAAPEP LAYDYRFVSA AATAGPDGAP EESGGRASSL 130 140 150 160 170 180 CGPAQRGAAT QRSSLAPGLP ACLYLRPAAP VRPAQSLNDL ACAAVSPPAG LLGSSGSFKA 190 200 210 220 230 240 CSVAGSWVCP RPLARSDSEN VYEVIQDLHV PPPEESAEQV DDPPEPVYAN IERQPRATSP 250 260 270 280 290 300 GAAAAPLPSP VWETHTDAGT GRPYYYNPDT GVTTWESPFE AAEGAASPAT SPASVDSHVS 310 320 330 340 350 360 LETEWGQYWD EESRRVFFYN PLTGETAWED EAENEPEEEL EMQPGLSPGS PGDPRPPTPE 370 380 390 400 410 420 TDYPESLTSY PEEDYSPVGS FGEPGPTSPL TTPPGWSCHV SQDKQMLYTN HFTQEQWVRL 430 440 450 460 470 480 EDPHGKPYFY NPEDSSVRWE LPQVPVPAPR SIHKSSQDGD TPAQASPPEE KVPAELDEVG 490 500 510 520 530 540 SWEEVSPATA AVRTKTLDKA GVLHRTKTAD KGKRLRKKHW SASWTVLEGG VLTFFKDSKT 550 560 570 580 590 600 SAAGGLRQPS KFSTPEYTVE LRGATLSWAP KDKSSRKNVL ELRSRDGSEY LIQHDSEAII 610 620 630 640 650 660 STWHKAIAQG IQELSAELPP EESESSRVDF GSSERLGSWQ EKEEDARPNA AAPALGPVGL 670 680 690 700 710 720 ESDLSKVRHK LRKFLQRRPT LQSLREKGYI KDQVFGCALA ALCERERSRV PRFVQQCIRA 730 740 750 760 770 780 VEARGLDIDG LYRISGNLAT IQKLRYKVDH DERLDLDDGR WEDVHVITGA LKLFFRELPE 790 800 810 820 830 840 PLFPFSHFRQ FIAAIKLQDQ ARRSRCVRDL VRSLPAPNHD TLRMLFQHLC RVIEHGEQNR 850 860 870 880 MSVQSVAIVF GPTLLRPEVE ETSMPMTMVF QNQVVELILQ QCADIFPPH
	Isoform 2 [UniParc]. Checksum: 4E0EE2190C9F20E8	FASTA	548	61,733
	10 20 30 40 50 60 MQPGLSPGSP GDPRPPTPET DYPESLTSYP EEDYSPVGSF GEPGPTSPLT TPPGWSCHVS 70 80 90 100 110 120 QDKQMLYTNH FTQEQWVRLE DPHGKPYFYN PEDSSVRWEL PQVPVPAPRS IHKSSQDGDT 130 140 150 160 170 180 PAQASPPEEK VPAELDEVGS WEEVSPATAA VRTKTLDKAG VLHRTKTADK GKRLRKKHWS 190 200 210 220 230 240 ASWTVLEGGV LTFFKDSKTS AAGGLRQPSK FSTPEYTVEL RGATLSWAPK DKSSRKNVLE 250 260 270 280 290 300 LRSRDGSEYL IQHDSEAIIS TWHKAIAQGI QELSAELPPE ESESSRVDFG SSERLGSWQE 310 320 330 340 350 360 KEEDARPNAA APALGPVGLE SDLSKVRHKL RKFLQRRPTL QSLREKGYIK DQVFGCALAA 370 380 390 400 410 420 LCERERSRVP RFVQQCIRAV EARGLDIDGL YRISGNLATI QKLRYKVDHD ERLDLDDGRW 430 440 450 460 470 480 EDVHVITGAL KLFFRELPEP LFPFSHFRQF IAAIKLQDQA RRSRCVRDLV RSLPAPNHDT 490 500 510 520 530 540 LRMLFQHLCR VIEHGEQNRM SVQSVAIVFG PTLLRPEVEE TSMPMTMVFQ NQVVELILQQ CADIFPPH
	Isoform 3 [UniParc]. Checksum: F207CD53BDAE7EAD	FASTA	862	95,068
	10 20 30 40 50 60 MAADVVGDVY VLVEHPFEYT GKDGRRVAIR PNERYRLLRR STEHWWHVRR EPGGRPFYLP 70 80 90 100 110 120 AQYVRELPAL GNPAAAAPPG PHPSPAAPEP LAYDYRFVSA AATAGPDGAP EESGGRASSL 130 140 150 160 170 180 CGPAQRGAAT QRSSLAPGLP ACLYLRPAAP VRPAQSLNDL ACAAVSPPAG LLGSSGSFKA 190 200 210 220 230 240 CSVAGSWVCP RPLARSDSEN VYEVIQDLHV PPPEESAEQV DDPPEPVYAN IERQPRATSP 250 260 270 280 290 300 GAAAAPLPSP VWETHTDAGT GRPYYYNPDT GVTTWESPFE AAEGAASPAT SPASVDSHVS 310 320 330 340 350 360 LETEWGQYWD EESRRVFFYN PLTGETAWED EAENEPEEEL EMQPGLSPGS PGDPRPPTPE 370 380 390 400 410 420 TDYPESLTSY PEEDYSPVGS FGEPGPTSPL TTPPGWSCHV SQDKQMLYTN HFTQEQVPVP 430 440 450 460 470 480 APRSIHKSSQ DGDTPAQASP PEEKVPAELD EVGSWEEVSP ATAAVRTKTL DKAGVLHRTK 490 500 510 520 530 540 TADKGKRLRK KHWSASWTVL EGGVLTFFKD SKTSAAGGLR QPSKFSTPEY TVELRGATLS 550 560 570 580 590 600 WAPKDKSSRK NVLELRSRDG SEYLIQHDSE AIISTWHKAI AQGIQELSAE LPPEESESSR 610 620 630 640 650 660 VDFGSSERLG SWQEKEEDAR PNAAAPALGP VGLESDLSKV RHKLRKFLQR RPTLQSLREK 670 680 690 700 710 720 GYIKDQVFGC ALAALCERER SRVPRFVQQC IRAVEARGLD IDGLYRISGN LATIQKLRYK 730 740 750 760 770 780 VDHDERLDLD DGRWEDVHVI TGALKLFFRE LPEPLFPFSH FRQFIAAIKL QDQARRSRCV 790 800 810 820 830 840 RDLVRSLPAP NHDTLRMLFQ HLCRVIEHGE QNRMSVQSVA IVFGPTLLRP EVEETSMPMT 850 860 MVFQNQVVEL ILQQCADIFP PH
	Isoform 4 (SH3D20) [UniParc]. Checksum: 5731E04A9F89B4D4	FASTA	263	28,192
	10 20 30 40 50 60 MAADVVGDVY VLVEHPFEYT GKDGRRVAIR PNERYRLLRR STEHWWHVRR EPGGRPFYLP 70 80 90 100 110 120 AQYVRELPAL GNPAAAAPPG PHPSPAAPEP LAYDYRFVSA AATAGPDGAP EESGGRASSL 130 140 150 160 170 180 CGPAQRGAAT QRSSLAPGLP ACLYLRPAAP VRPAQSLNDL ACAAVSPPAG LLGSSGSFKA 190 200 210 220 230 240 CSVAGSWVCP RPLARSDSEN VYEVIQDLHV PPPEESAEQV PPRALGRGGG WRARDRARTE 250 260 PGRKETRSAQ RRARRPPLSE DFG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Embryo and Prostate.
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 270-889 (ISOFORMS 1 AND 3), VARIANT GLN-889. Tissue: Pancreas.
[5]	"Identification and characterization of ARHGAP27 gene in silico." Katoh Y., Katoh M. Int. J. Mol. Med. 14:943-947(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF258593 mRNA. Translation: AAG23796.1.
AK125535 mRNA. Translation: BAC86196.1.
AK290650 mRNA. Translation: BAF83339.1.
AC003070 Genomic DNA. No translation available.
AC091132 Genomic DNA. No translation available.
BC067345 mRNA. Translation: AAH67345.1.
BC101388 mRNA. Translation: AAI01389.1. Different initiation.
BC101389 mRNA. Translation: AAI01390.1. Different initiation.
BC101390 mRNA. Translation: AAI01391.1. Different initiation.
BC101391 mRNA. Translation: AAI01392.3.

IPI

IPI00398170.
IPI00884998.
IPI00885078.
IPI00885118.

RefSeq

NP_777579.2. NM_174919.3.
NP_954976.1. NM_199282.2.

UniGene

Hs.205326.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3PP2	X-ray	1.42	A/B	491-613	[»]

ProteinModelPortal

Q6ZUM4.

SMR

Q6ZUM4. Positions 10-67, 498-612, 678-886.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q6ZUM4. 1 interaction.

STRING

9606.ENSP00000366121.

PTM databases

PhosphoSite

Q6ZUM4.

Polymorphism databases

DMDM

300669680.

Proteomic databases

PaxDb

Q6ZUM4.

PRIDE

Q6ZUM4.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000290470; ENSP00000290470; ENSG00000159314.
ENST00000376922; ENSP00000366121; ENSG00000159314.
ENST00000428638; ENSP00000403323; ENSG00000159314.
ENST00000442348; ENSP00000409330; ENSG00000159314.
ENST00000455881; ENSP00000408235; ENSG00000159314.
ENST00000528273; ENSP00000436137; ENSG00000159314.
ENST00000528384; ENSP00000431591; ENSG00000159314.

GeneID

201176.

KEGG

hsa:201176.

UCSC

uc002iix.3. human.
uc010dal.3. human.

Organism-specific databases

CTD

201176.

GeneCards

GC17M043476.

HGNC

HGNC:31813. ARHGAP27.

HPA

HPA023919.

MIM

610591. gene.

neXtProt

NX_Q6ZUM4.

PharmGKB

PA134873327.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG279563.

HOVERGEN

HBG005328.

OMA

KGYIRDQ.

OrthoDB

EOG4X3H0P.

Gene expression databases

ArrayExpress

Q6ZUM4.

Bgee

Q6ZUM4.

CleanEx

HS_ARHGAP27.

Genevestigator

Q6ZUM4.

Family and domain databases

Gene3D

1.10.555.10. 1 hit.
2.30.29.30. 1 hit.

InterPro

IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR015767. Rho_GTPase_activating.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
IPR001202. WW_dom.
[Graphical view]

PANTHER

PTHR23181. PTHR23181. 1 hit.

Pfam

PF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]

SMART

SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
SM00456. WW. 3 hits.
[Graphical view]

SUPFAM

SSF48350. Rho_GAP. 1 hit.
SSF50044. SH3. 1 hit.
SSF51045. WW_Rsp5_WWP. 1 hit.

PROSITE

PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
PS01159. WW_DOMAIN_1. False negative.
PS50020. WW_DOMAIN_2. 3 hits.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

201176.

NextBio

90073.

SOURCE

Search...

Entry information

Entry name

RHG27_HUMAN

Accession

Primary (citable) accession number: Q6ZUM4
Secondary accession number(s): A4FU35 , A8K3N5, C9JTF3, Q494U0, Q6NWZ8, Q8WY58

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 13, 2010
Last modified:	May 1, 2013
This is version 90 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.