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Q6ZUM4

- RHG27_HUMAN

UniProt

Q6ZUM4 - RHG27_HUMAN

Protein

Rho GTPase-activating protein 27

Gene

ARHGAP27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 By similarity.By similarity

    GO - Molecular functioni

    1. Rac GTPase activator activity Source: HGNC
    2. SH3 domain binding Source: HGNC

    GO - Biological processi

    1. positive regulation of Cdc42 GTPase activity Source: HGNC
    2. positive regulation of Rac GTPase activity Source: GOC
    3. receptor-mediated endocytosis Source: HGNC
    4. signal transduction Source: InterPro

    Keywords - Molecular functioni

    GTPase activation

    Keywords - Biological processi

    Endocytosis

    Enzyme and pathway databases

    SignaLinkiQ6ZUM4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho GTPase-activating protein 27
    Alternative name(s):
    CIN85-associated multi-domain-containing Rho GTPase-activating protein 1
    Rho-type GTPase-activating protein 27
    SH3 domain-containing protein 20
    Gene namesi
    Name:ARHGAP27
    Synonyms:CAMGAP1, SH3D20
    ORF Names:PP905
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:31813. ARHGAP27.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. intracellular Source: HGNC
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134873327.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 889889Rho GTPase-activating protein 27PRO_0000317578Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei216 – 2161PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6ZUM4.
    PaxDbiQ6ZUM4.
    PRIDEiQ6ZUM4.

    PTM databases

    PhosphoSiteiQ6ZUM4.

    Expressioni

    Tissue specificityi

    Expressed in germinal center B-cell, spleen, chronic lymphocytic leukemia, pancreatic cancer and lung cancer.1 Publication

    Gene expression databases

    ArrayExpressiQ6ZUM4.
    BgeeiQ6ZUM4.
    CleanExiHS_ARHGAP27.
    GenevestigatoriQ6ZUM4.

    Organism-specific databases

    HPAiHPA023919.

    Interactioni

    Subunit structurei

    Interacts with SH3KBP1/CIN85.By similarity

    Protein-protein interaction databases

    BioGridi128369. 4 interactions.
    IntActiQ6ZUM4. 1 interaction.
    MINTiMINT-5006179.
    STRINGi9606.ENSP00000366121.

    Structurei

    Secondary structure

    1
    889
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi499 – 51012
    Beta strandi521 – 5288
    Beta strandi531 – 5366
    Helixi549 – 5524
    Beta strandi554 – 5607
    Beta strandi565 – 5684
    Helixi571 – 5733
    Beta strandi575 – 5839
    Beta strandi589 – 5935
    Helixi597 – 61115

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3PP2X-ray1.42A/B491-613[»]
    ProteinModelPortaliQ6ZUM4.
    SMRiQ6ZUM4. Positions 10-67, 498-612, 678-886.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 6962SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini246 – 28035WW 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini299 – 33335WW 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini411 – 44434WW 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini496 – 612117PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini697 – 886190Rho-GAPPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation
    Contains 3 WW domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG279563.
    HOVERGENiHBG005328.
    OMAiTPEYTVD.
    PhylomeDBiQ6ZUM4.
    TreeFamiTF329345.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR011047. Quinonprotein_ADH-like_supfam.
    IPR015767. Rho_GTPase_act.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001452. SH3_domain.
    IPR001202. WW_dom.
    [Graphical view]
    PANTHERiPTHR23181. PTHR23181. 1 hit.
    PfamiPF00169. PH. 1 hit.
    PF00620. RhoGAP. 1 hit.
    PF00397. WW. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00324. RhoGAP. 1 hit.
    SM00326. SH3. 1 hit.
    SM00456. WW. 3 hits.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF50998. SSF50998. 1 hit.
    SSF51045. SSF51045. 2 hits.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS50238. RHOGAP. 1 hit.
    PS50002. SH3. 1 hit.
    PS50020. WW_DOMAIN_2. 3 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZUM4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAADVVGDVY VLVEHPFEYT GKDGRRVAIR PNERYRLLRR STEHWWHVRR    50
    EPGGRPFYLP AQYVRELPAL GNPAAAAPPG PHPSPAAPEP LAYDYRFVSA 100
    AATAGPDGAP EESGGRASSL CGPAQRGAAT QRSSLAPGLP ACLYLRPAAP 150
    VRPAQSLNDL ACAAVSPPAG LLGSSGSFKA CSVAGSWVCP RPLARSDSEN 200
    VYEVIQDLHV PPPEESAEQV DDPPEPVYAN IERQPRATSP GAAAAPLPSP 250
    VWETHTDAGT GRPYYYNPDT GVTTWESPFE AAEGAASPAT SPASVDSHVS 300
    LETEWGQYWD EESRRVFFYN PLTGETAWED EAENEPEEEL EMQPGLSPGS 350
    PGDPRPPTPE TDYPESLTSY PEEDYSPVGS FGEPGPTSPL TTPPGWSCHV 400
    SQDKQMLYTN HFTQEQWVRL EDPHGKPYFY NPEDSSVRWE LPQVPVPAPR 450
    SIHKSSQDGD TPAQASPPEE KVPAELDEVG SWEEVSPATA AVRTKTLDKA 500
    GVLHRTKTAD KGKRLRKKHW SASWTVLEGG VLTFFKDSKT SAAGGLRQPS 550
    KFSTPEYTVE LRGATLSWAP KDKSSRKNVL ELRSRDGSEY LIQHDSEAII 600
    STWHKAIAQG IQELSAELPP EESESSRVDF GSSERLGSWQ EKEEDARPNA 650
    AAPALGPVGL ESDLSKVRHK LRKFLQRRPT LQSLREKGYI KDQVFGCALA 700
    ALCERERSRV PRFVQQCIRA VEARGLDIDG LYRISGNLAT IQKLRYKVDH 750
    DERLDLDDGR WEDVHVITGA LKLFFRELPE PLFPFSHFRQ FIAAIKLQDQ 800
    ARRSRCVRDL VRSLPAPNHD TLRMLFQHLC RVIEHGEQNR MSVQSVAIVF 850
    GPTLLRPEVE ETSMPMTMVF QNQVVELILQ QCADIFPPH 889
    Length:889
    Mass (Da):98,396
    Last modified:July 13, 2010 - v3
    Checksum:iE341CCC4D012DA4C
    GO
    Isoform 2 (identifier: Q6ZUM4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-341: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:548
    Mass (Da):61,733
    Checksum:i4E0EE2190C9F20E8
    GO
    Isoform 3 (identifier: Q6ZUM4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         416-442: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:862
    Mass (Da):95,068
    Checksum:iF207CD53BDAE7EAD
    GO
    Isoform 4 (identifier: Q6ZUM4-4) [UniParc]FASTAAdd to Basket

    Also known as: SH3D20

    The sequence of this isoform differs from the canonical sequence as follows:
         221-263: DDPPEPVYAN...THTDAGTGRP → PPRALGRGGG...RRPPLSEDFG
         264-889: Missing.

    Show »
    Length:263
    Mass (Da):28,192
    Checksum:i5731E04A9F89B4D4
    GO

    Sequence cautioni

    The sequence AAI01389.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAI01390.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAI01391.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti41 – 411S → N in AAG23796. (PubMed:15498874)Curated
    Sequence conflicti162 – 1621C → R in BAF83339. (PubMed:14702039)Curated
    Sequence conflicti213 – 2131P → R in AAH67345. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti889 – 8891H → Q.1 Publication
    Corresponds to variant rs34793644 [ dbSNP | Ensembl ].
    VAR_038551

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 341341Missing in isoform 2. 1 PublicationVSP_031053Add
    BLAST
    Alternative sequencei221 – 26343DDPPE…GTGRP → PPRALGRGGGWRARDRARTE PGRKETRSAQRRARRPPLSE DFG in isoform 4. 2 PublicationsVSP_031054Add
    BLAST
    Alternative sequencei264 – 889626Missing in isoform 4. 2 PublicationsVSP_031055Add
    BLAST
    Alternative sequencei416 – 44227Missing in isoform 3. 1 PublicationVSP_031056Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF258593 mRNA. Translation: AAG23796.1.
    AK125535 mRNA. Translation: BAC86196.1.
    AK290650 mRNA. Translation: BAF83339.1.
    AC003070 Genomic DNA. No translation available.
    AC091132 Genomic DNA. No translation available.
    BC067345 mRNA. Translation: AAH67345.1.
    BC101388 mRNA. Translation: AAI01389.1. Different initiation.
    BC101389 mRNA. Translation: AAI01390.1. Different initiation.
    BC101390 mRNA. Translation: AAI01391.1. Different initiation.
    BC101391 mRNA. Translation: AAI01392.3.
    CCDSiCCDS11498.1. [Q6ZUM4-2]
    CCDS32670.1. [Q6ZUM4-4]
    RefSeqiNP_001269219.1. NM_001282290.1. [Q6ZUM4-1]
    NP_777579.2. NM_174919.3. [Q6ZUM4-4]
    NP_954976.1. NM_199282.2. [Q6ZUM4-2]
    XP_006721808.1. XM_006721745.1. [Q6ZUM4-1]
    XP_006721809.1. XM_006721746.1. [Q6ZUM4-1]
    XP_006725671.1. XM_006725608.1. [Q6ZUM4-1]
    XP_006725672.1. XM_006725609.1. [Q6ZUM4-1]
    UniGeneiHs.205326.

    Genome annotation databases

    EnsembliENST00000290470; ENSP00000290470; ENSG00000159314. [Q6ZUM4-4]
    ENST00000376922; ENSP00000366121; ENSG00000159314. [Q6ZUM4-2]
    ENST00000428638; ENSP00000403323; ENSG00000159314. [Q6ZUM4-1]
    ENST00000528273; ENSP00000436137; ENSG00000159314. [Q6ZUM4-4]
    ENST00000528384; ENSP00000431591; ENSG00000159314.
    GeneIDi201176.
    KEGGihsa:201176.
    UCSCiuc002iix.3. human. [Q6ZUM4-1]
    uc010dal.3. human. [Q6ZUM4-4]

    Polymorphism databases

    DMDMi300669680.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF258593 mRNA. Translation: AAG23796.1 .
    AK125535 mRNA. Translation: BAC86196.1 .
    AK290650 mRNA. Translation: BAF83339.1 .
    AC003070 Genomic DNA. No translation available.
    AC091132 Genomic DNA. No translation available.
    BC067345 mRNA. Translation: AAH67345.1 .
    BC101388 mRNA. Translation: AAI01389.1 . Different initiation.
    BC101389 mRNA. Translation: AAI01390.1 . Different initiation.
    BC101390 mRNA. Translation: AAI01391.1 . Different initiation.
    BC101391 mRNA. Translation: AAI01392.3 .
    CCDSi CCDS11498.1. [Q6ZUM4-2 ]
    CCDS32670.1. [Q6ZUM4-4 ]
    RefSeqi NP_001269219.1. NM_001282290.1. [Q6ZUM4-1 ]
    NP_777579.2. NM_174919.3. [Q6ZUM4-4 ]
    NP_954976.1. NM_199282.2. [Q6ZUM4-2 ]
    XP_006721808.1. XM_006721745.1. [Q6ZUM4-1 ]
    XP_006721809.1. XM_006721746.1. [Q6ZUM4-1 ]
    XP_006725671.1. XM_006725608.1. [Q6ZUM4-1 ]
    XP_006725672.1. XM_006725609.1. [Q6ZUM4-1 ]
    UniGenei Hs.205326.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3PP2 X-ray 1.42 A/B 491-613 [» ]
    ProteinModelPortali Q6ZUM4.
    SMRi Q6ZUM4. Positions 10-67, 498-612, 678-886.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128369. 4 interactions.
    IntActi Q6ZUM4. 1 interaction.
    MINTi MINT-5006179.
    STRINGi 9606.ENSP00000366121.

    PTM databases

    PhosphoSitei Q6ZUM4.

    Polymorphism databases

    DMDMi 300669680.

    Proteomic databases

    MaxQBi Q6ZUM4.
    PaxDbi Q6ZUM4.
    PRIDEi Q6ZUM4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000290470 ; ENSP00000290470 ; ENSG00000159314 . [Q6ZUM4-4 ]
    ENST00000376922 ; ENSP00000366121 ; ENSG00000159314 . [Q6ZUM4-2 ]
    ENST00000428638 ; ENSP00000403323 ; ENSG00000159314 . [Q6ZUM4-1 ]
    ENST00000528273 ; ENSP00000436137 ; ENSG00000159314 . [Q6ZUM4-4 ]
    ENST00000528384 ; ENSP00000431591 ; ENSG00000159314 .
    GeneIDi 201176.
    KEGGi hsa:201176.
    UCSCi uc002iix.3. human. [Q6ZUM4-1 ]
    uc010dal.3. human. [Q6ZUM4-4 ]

    Organism-specific databases

    CTDi 201176.
    GeneCardsi GC17M043488.
    HGNCi HGNC:31813. ARHGAP27.
    HPAi HPA023919.
    MIMi 610591. gene.
    neXtProti NX_Q6ZUM4.
    PharmGKBi PA134873327.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279563.
    HOVERGENi HBG005328.
    OMAi TPEYTVD.
    PhylomeDBi Q6ZUM4.
    TreeFami TF329345.

    Enzyme and pathway databases

    SignaLinki Q6ZUM4.

    Miscellaneous databases

    GenomeRNAii 201176.
    NextBioi 90073.
    PROi Q6ZUM4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6ZUM4.
    Bgeei Q6ZUM4.
    CleanExi HS_ARHGAP27.
    Genevestigatori Q6ZUM4.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR011047. Quinonprotein_ADH-like_supfam.
    IPR015767. Rho_GTPase_act.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001452. SH3_domain.
    IPR001202. WW_dom.
    [Graphical view ]
    PANTHERi PTHR23181. PTHR23181. 1 hit.
    Pfami PF00169. PH. 1 hit.
    PF00620. RhoGAP. 1 hit.
    PF00397. WW. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00324. RhoGAP. 1 hit.
    SM00326. SH3. 1 hit.
    SM00456. WW. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF50998. SSF50998. 1 hit.
    SSF51045. SSF51045. 2 hits.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS50238. RHOGAP. 1 hit.
    PS50002. SH3. 1 hit.
    PS50020. WW_DOMAIN_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Embryo and Prostate.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 270-889 (ISOFORMS 1 AND 3), VARIANT GLN-889.
      Tissue: Pancreas.
    5. "Identification and characterization of ARHGAP27 gene in silico."
      Katoh Y., Katoh M.
      Int. J. Mol. Med. 14:943-947(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiRHG27_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZUM4
    Secondary accession number(s): A4FU35
    , A8K3N5, C9JTF3, Q494U0, Q6NWZ8, Q8WY58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3