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Protein

Transmembrane protein 26

Gene

TMEM26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-30963-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 26
Gene namesi
Name:TMEM26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:28550. TMEM26.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196932.
PharmGKBiPA134887276.

Polymorphism and mutation databases

BioMutaiTMEM26.
DMDMi74749674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002458651 – 368Transmembrane protein 26Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)1 Publication1
Glycosylationi116N-linked (GlcNAc...); atypical1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6ZUK4.
PeptideAtlasiQ6ZUK4.
PRIDEiQ6ZUK4.

PTM databases

iPTMnetiQ6ZUK4.
PhosphoSitePlusiQ6ZUK4.

Expressioni

Gene expression databases

BgeeiENSG00000196932.
CleanExiHS_TMEM26.
ExpressionAtlasiQ6ZUK4. baseline and differential.
GenevisibleiQ6ZUK4. HS.

Organism-specific databases

HPAiHPA014350.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000382237.

Structurei

3D structure databases

ProteinModelPortaliQ6ZUK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4610. Eukaryota.
ENOG410XS6J. LUCA.
GeneTreeiENSGT00390000014794.
HOGENOMiHOG000047342.
HOVERGENiHBG060870.
InParanoidiQ6ZUK4.
OMAiLHHETQY.
OrthoDBiEOG091G0BYS.
PhylomeDBiQ6ZUK4.
TreeFamiTF314156.

Family and domain databases

InterProiIPR019169. Transmembrane_26.
[Graphical view]
PfamiPF09772. Tmem26. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZUK4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGLVFLNAL ATRLLFLLHS LVGVWRVTEV KKEPRYWLLA LLNLLLFLET
60 70 80 90 100
ALTLKFKRGR GYKWFSPAIF LYLISIVPSL WLLELHHETQ YCSIQAEGTS
110 120 130 140 150
QNTSRKEDFN QTLTSNEQTS RADDLIETAK VFVNNLSTVC EKVWTLGLHQ
160 170 180 190 200
TFLLMLIIGR WLLPIGGGIT RDQLSQLLLM FVGTAADILE FTSETLEEQN
210 220 230 240 250
VRNSPALVYA ILVIWTWSML QFPLDLAVQN VVCPVSVTER GFPSLFFCQY
260 270 280 290 300
SADLWNIGIS VFIQDGPFLV VRLILMTYFK VINQMLVFFA AKNFLVVVLQ
310 320 330 340 350
LYRLVVLALA VRASLRSQSE GLKGEHGCRA QTSESGPSQR DWQNESKEGL
360
AIPLRGSPVT SDDSHHTP
Length:368
Mass (Da):41,672
Last modified:July 5, 2004 - v1
Checksum:i2B1F82FEF0C1CCED
GO
Isoform 2 (identifier: Q6ZUK4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-223: NSPALVYAILVIWTWSMLQFP → LCWKNSTNRRHTNPKWQLVLF
     224-368: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:223
Mass (Da):25,784
Checksum:i7E34DC2FF33B4E3A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019806203 – 223NSPAL…MLQFP → LCWKNSTNRRHTNPKWQLVL F in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_019807224 – 368Missing in isoform 2. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125611 mRNA. Translation: BAC86218.1.
CR749606 mRNA. Translation: CAH18401.1.
AC068892 Genomic DNA. No translation available.
AL356952 Genomic DNA. No translation available.
BC042872 mRNA. Translation: AAH42872.1.
CCDSiCCDS41530.1. [Q6ZUK4-1]
RefSeqiNP_848600.2. NM_178505.7. [Q6ZUK4-1]
XP_011537753.1. XM_011539451.1. [Q6ZUK4-2]
UniGeneiHs.623955.

Genome annotation databases

EnsembliENST00000399298; ENSP00000382237; ENSG00000196932. [Q6ZUK4-1]
ENST00000488505; ENSP00000426071; ENSG00000196932. [Q6ZUK4-2]
ENST00000503886; ENSP00000425286; ENSG00000196932. [Q6ZUK4-1]
GeneIDi219623.
KEGGihsa:219623.
UCSCiuc001jlo.3. human. [Q6ZUK4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125611 mRNA. Translation: BAC86218.1.
CR749606 mRNA. Translation: CAH18401.1.
AC068892 Genomic DNA. No translation available.
AL356952 Genomic DNA. No translation available.
BC042872 mRNA. Translation: AAH42872.1.
CCDSiCCDS41530.1. [Q6ZUK4-1]
RefSeqiNP_848600.2. NM_178505.7. [Q6ZUK4-1]
XP_011537753.1. XM_011539451.1. [Q6ZUK4-2]
UniGeneiHs.623955.

3D structure databases

ProteinModelPortaliQ6ZUK4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000382237.

PTM databases

iPTMnetiQ6ZUK4.
PhosphoSitePlusiQ6ZUK4.

Polymorphism and mutation databases

BioMutaiTMEM26.
DMDMi74749674.

Proteomic databases

PaxDbiQ6ZUK4.
PeptideAtlasiQ6ZUK4.
PRIDEiQ6ZUK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399298; ENSP00000382237; ENSG00000196932. [Q6ZUK4-1]
ENST00000488505; ENSP00000426071; ENSG00000196932. [Q6ZUK4-2]
ENST00000503886; ENSP00000425286; ENSG00000196932. [Q6ZUK4-1]
GeneIDi219623.
KEGGihsa:219623.
UCSCiuc001jlo.3. human. [Q6ZUK4-1]

Organism-specific databases

CTDi219623.
GeneCardsiTMEM26.
H-InvDBHIX0025927.
HIX0035606.
HGNCiHGNC:28550. TMEM26.
HPAiHPA014350.
neXtProtiNX_Q6ZUK4.
OpenTargetsiENSG00000196932.
PharmGKBiPA134887276.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4610. Eukaryota.
ENOG410XS6J. LUCA.
GeneTreeiENSGT00390000014794.
HOGENOMiHOG000047342.
HOVERGENiHBG060870.
InParanoidiQ6ZUK4.
OMAiLHHETQY.
OrthoDBiEOG091G0BYS.
PhylomeDBiQ6ZUK4.
TreeFamiTF314156.

Enzyme and pathway databases

BioCyciZFISH:G66-30963-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM26. human.
GenomeRNAii219623.
PROiQ6ZUK4.

Gene expression databases

BgeeiENSG00000196932.
CleanExiHS_TMEM26.
ExpressionAtlasiQ6ZUK4. baseline and differential.
GenevisibleiQ6ZUK4. HS.

Family and domain databases

InterProiIPR019169. Transmembrane_26.
[Graphical view]
PfamiPF09772. Tmem26. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM26_HUMAN
AccessioniPrimary (citable) accession number: Q6ZUK4
Secondary accession number(s): Q6ZVM0, Q8IVN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.