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Q6ZUJ8

- BCAP_HUMAN

UniProt

Q6ZUJ8 - BCAP_HUMAN

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Protein
Phosphoinositide 3-kinase adapter protein 1
Gene
PIK3AP1, BCAP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.1 Publication

GO - Molecular functioni

  1. phosphatidylinositol 3-kinase regulatory subunit binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of toll-like receptor signaling pathway Source: Ensembl
  2. positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  3. positive regulation of toll-like receptor signaling pathway Source: Ensembl
  4. regulation of inflammatory response Source: UniProtKB
  5. toll-like receptor 2 signaling pathway Source: UniProtKB
  6. toll-like receptor 4 signaling pathway Source: UniProtKB
  7. toll-like receptor 7 signaling pathway Source: UniProtKB
  8. toll-like receptor 9 signaling pathway Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide 3-kinase adapter protein 1
Alternative name(s):
B-cell adapter for phosphoinositide 3-kinase
B-cell phosphoinositide 3-kinase adapter protein 1
Gene namesi
Name:PIK3AP1
Synonyms:BCAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:30034. PIK3AP1.

Subcellular locationi

Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. membrane Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134979629.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Phosphoinositide 3-kinase adapter protein 1
PRO_0000341273Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei263 – 2631Phosphotyrosine By similarity
Modified residuei419 – 4191Phosphotyrosine; by SYK By similarity
Modified residuei444 – 4441Phosphotyrosine; by SYK By similarity
Modified residuei459 – 4591Phosphotyrosine; by SYK By similarity
Modified residuei513 – 5131Phosphotyrosine; by ABL11 Publication
Modified residuei553 – 5531Phosphotyrosine; by ABL11 Publication
Modified residuei570 – 5701Phosphotyrosine; by ABL11 Publication
Modified residuei594 – 5941Phosphotyrosine; by ABL11 Publication
Modified residuei694 – 6941Phosphotyrosine; by ABL11 Publication

Post-translational modificationi

Constitutively phosphorylated. Phosphorylated on tyrosine residues in C-terminal region by ABL1. Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK By similarity. Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation By similarity. Toll-like receptor activation induces appearance of a phosphorylated form associated with membranes By similarity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6ZUJ8.
PaxDbiQ6ZUJ8.
PRIDEiQ6ZUJ8.

PTM databases

PhosphoSiteiQ6ZUJ8.

Expressioni

Tissue specificityi

Expressed in natural killer (NK) cells.1 Publication

Gene expression databases

BgeeiQ6ZUJ8.
CleanExiHS_PIK3AP1.
GenevestigatoriQ6ZUJ8.

Organism-specific databases

HPAiCAB026136.

Interactioni

Subunit structurei

Homooligomer By similarity. Interacts (phosphorylated on tyrosine residues within YXXM motifs) with PIK3R1 (via SH2 domain); required for BCR- and TLR-mediated activation of phosphoinositide 3-kinase. Interacts (via polyproline C-terminal region) with ABI1 (via SH3 domain); the interaction promotes phosphorylation of PIK3AP1 by ABL1. May interact with MYD88 and TIRAP By similarity.2 Publications

Protein-protein interaction databases

BioGridi125621. 5 interactions.
IntActiQ6ZUJ8. 5 interactions.
MINTiMINT-7009152.
STRINGi9606.ENSP00000339826.

Structurei

3D structure databases

ProteinModelPortaliQ6ZUJ8.
SMRiQ6ZUJ8. Positions 338-393.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini181 – 317137DBB
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 144135Necessary and sufficent to mediate inhibition of NF-kappa-B downstream of activated TLRs; may mediate interaction with MYD88 and TIRAP By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili645 – 66723 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi760 – 80243Pro-rich
Add
BLAST

Domaini

The DBB domain is required for dimerization By similarity.

Sequence similaritiesi

Contains 1 DBB domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG70048.
HOGENOMiHOG000095183.
HOVERGENiHBG104426.
InParanoidiQ6ZUJ8.
KOiK12230.
OMAiPGKVEFG.
OrthoDBiEOG77DJ53.
PhylomeDBiQ6ZUJ8.
TreeFamiTF328570.

Family and domain databases

InterProiIPR017893. DBB_domain.
[Graphical view]
PfamiPF14545. DBB. 1 hit.
[Graphical view]
PROSITEiPS51376. DBB. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZUJ8-1) [UniParc]FASTAAdd to Basket

Also known as: BCAP-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAASGVPRGC DILIVYSPDA EEWCQYLQTL FLSSRQVRSQ KILTHRLGPE    50
ASFSAEDLSL FLSTRCVVVL LSAELVQHFH KPALLPLLQR AFHPPHRVVR 100
LLCGVRDSEE FLDFFPDWAH WQELTCDDEP ETYVAAVKKA ISEDSGCDSV 150
TDTEPEDEKV VSYSKQQNLP TVTSPGNLMV VQPDRIRCGA ETTVYVIVRC 200
KLDDRVATEA EFSPEDSPSV RMEAKVENEY TISVKAPNLS SGNVSLKIYS 250
GDLVVCETVI SYYTDMEEIG NLLSNAANPV EFMCQAFKIV PYNTETLDKL 300
LTESLKNNIP ASGLHLFGIN QLEEEDMMTN QRDEELPTLL HFAAKYGLKN 350
LTALLLTCPG ALQAYSVANK HGHYPNTIAE KHGFRDLRQF IDEYVETVDM 400
LKSHIKEELM HGEEADAVYE SMAHLSTDLL MKCSLNPGCD EDLYESMAAF 450
VPAATEDLYV EMLQASTSNP IPGDGFSRAT KDSMIRKFLE GNSMGMTNLE 500
RDQCHLGQEE DVYHTVDDDE AFSVDLASRP PVPVPRPETT APGAHQLPDN 550
EPYIFKVFAE KSQERPGNFY VSSESIRKGP PVRPWRDRPQ SSIYDPFAGM 600
KTPGQRQLIT LQEQVKLGIV NVDEAVLHFK EWQLNQKKRS ESFRFQQENL 650
KRLRDSITRR QREKQKSGKQ TDLEITVPIR HSQHLPAKVE FGVYESGPRK 700
SVIPPRTELR RGDWKTDSTS STASSTSNRS STRSLLSVSS GMEGDNEDNE 750
VPEVTRSRSP GPPQVDGTPT MSLERPPRVP PRAASQRPPT RETFHPPPPV 800
PPRGR 805
Length:805
Mass (Da):90,398
Last modified:July 22, 2008 - v2
Checksum:iDF1025A37905AEA7
GO
Isoform 2 (identifier: Q6ZUJ8-2) [UniParc]FASTAAdd to Basket

Also known as: BCAP-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.

Show »
Length:627
Mass (Da):70,412
Checksum:iA2D7C2496537C129
GO
Isoform 3 (identifier: Q6ZUJ8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: MAASGVPRGC...GPEASFSAED → MRFFTSVACY...TGAKHVPGSS
     58-458: Missing.

Show »
Length:404
Mass (Da):45,484
Checksum:iEDBB28E0023875E9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211E → K.1 Publication
Corresponds to variant rs17112076 [ dbSNP | Ensembl ].
VAR_044035
Natural varianti83 – 831A → S.1 Publication
Corresponds to variant rs3748229 [ dbSNP | Ensembl ].
VAR_044036
Natural varianti551 – 5511E → K.
Corresponds to variant rs3748233 [ dbSNP | Ensembl ].
VAR_044037
Natural varianti638 – 6381K → R.
Corresponds to variant rs12784975 [ dbSNP | Ensembl ].
VAR_044038

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 178178Missing in isoform 2.
VSP_034238Add
BLAST
Alternative sequencei1 – 5757MAASG…FSAED → MRFFTSVACYGSCLFASELL IRCKDWLKGRPALFTALLAC VLYLCEWTGAKHVPGSS in isoform 3.
VSP_034239Add
BLAST
Alternative sequencei58 – 458401Missing in isoform 3.
VSP_034240Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti726 – 7261T → P in BAC03996. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK092883 mRNA. Translation: BAC03996.1.
AK125635 mRNA. Translation: BAC86227.1.
BX648550 mRNA. No translation available.
AL358235, AL138765, AL591364 Genomic DNA. Translation: CAH71154.2.
AL591364, AL358235, AL138765 Genomic DNA. Translation: CAH73440.2.
AL591364, AL358235, AL138765 Genomic DNA. Translation: CAH73441.2.
AL138765, AL591364 Genomic DNA. Translation: CAI13579.2.
AL138765, AL358235, AL591364 Genomic DNA. Translation: CAI13581.2.
AL138765 Genomic DNA. Translation: CAI13586.1.
BC029917 mRNA. Translation: AAH29917.1.
CCDSiCCDS31259.1. [Q6ZUJ8-1]
RefSeqiNP_689522.2. NM_152309.2. [Q6ZUJ8-1]
XP_005269555.1. XM_005269498.1. [Q6ZUJ8-2]
XP_005269556.1. XM_005269499.1. [Q6ZUJ8-2]
UniGeneiHs.310456.

Genome annotation databases

EnsembliENST00000339364; ENSP00000339826; ENSG00000155629. [Q6ZUJ8-1]
ENST00000371109; ENSP00000360150; ENSG00000155629. [Q6ZUJ8-3]
ENST00000371110; ENSP00000360151; ENSG00000155629. [Q6ZUJ8-2]
GeneIDi118788.
KEGGihsa:118788.
UCSCiuc001kmo.3. human. [Q6ZUJ8-3]
uc001kmp.3. human. [Q6ZUJ8-1]

Polymorphism databases

DMDMi205830907.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK092883 mRNA. Translation: BAC03996.1 .
AK125635 mRNA. Translation: BAC86227.1 .
BX648550 mRNA. No translation available.
AL358235 , AL138765 , AL591364 Genomic DNA. Translation: CAH71154.2 .
AL591364 , AL358235 , AL138765 Genomic DNA. Translation: CAH73440.2 .
AL591364 , AL358235 , AL138765 Genomic DNA. Translation: CAH73441.2 .
AL138765 , AL591364 Genomic DNA. Translation: CAI13579.2 .
AL138765 , AL358235 , AL591364 Genomic DNA. Translation: CAI13581.2 .
AL138765 Genomic DNA. Translation: CAI13586.1 .
BC029917 mRNA. Translation: AAH29917.1 .
CCDSi CCDS31259.1. [Q6ZUJ8-1 ]
RefSeqi NP_689522.2. NM_152309.2. [Q6ZUJ8-1 ]
XP_005269555.1. XM_005269498.1. [Q6ZUJ8-2 ]
XP_005269556.1. XM_005269499.1. [Q6ZUJ8-2 ]
UniGenei Hs.310456.

3D structure databases

ProteinModelPortali Q6ZUJ8.
SMRi Q6ZUJ8. Positions 338-393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125621. 5 interactions.
IntActi Q6ZUJ8. 5 interactions.
MINTi MINT-7009152.
STRINGi 9606.ENSP00000339826.

PTM databases

PhosphoSitei Q6ZUJ8.

Polymorphism databases

DMDMi 205830907.

Proteomic databases

MaxQBi Q6ZUJ8.
PaxDbi Q6ZUJ8.
PRIDEi Q6ZUJ8.

Protocols and materials databases

DNASUi 118788.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339364 ; ENSP00000339826 ; ENSG00000155629 . [Q6ZUJ8-1 ]
ENST00000371109 ; ENSP00000360150 ; ENSG00000155629 . [Q6ZUJ8-3 ]
ENST00000371110 ; ENSP00000360151 ; ENSG00000155629 . [Q6ZUJ8-2 ]
GeneIDi 118788.
KEGGi hsa:118788.
UCSCi uc001kmo.3. human. [Q6ZUJ8-3 ]
uc001kmp.3. human. [Q6ZUJ8-1 ]

Organism-specific databases

CTDi 118788.
GeneCardsi GC10M098343.
H-InvDB HIX0201490.
HGNCi HGNC:30034. PIK3AP1.
HPAi CAB026136.
MIMi 607942. gene.
neXtProti NX_Q6ZUJ8.
PharmGKBi PA134979629.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG70048.
HOGENOMi HOG000095183.
HOVERGENi HBG104426.
InParanoidi Q6ZUJ8.
KOi K12230.
OMAi PGKVEFG.
OrthoDBi EOG77DJ53.
PhylomeDBi Q6ZUJ8.
TreeFami TF328570.

Enzyme and pathway databases

Reactomei REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Miscellaneous databases

GeneWikii PIK3AP1.
GenomeRNAii 118788.
NextBioi 80340.
PROi Q6ZUJ8.
SOURCEi Search...

Gene expression databases

Bgeei Q6ZUJ8.
CleanExi HS_PIK3AP1.
Genevestigatori Q6ZUJ8.

Family and domain databases

InterProi IPR017893. DBB_domain.
[Graphical view ]
Pfami PF14545. DBB. 1 hit.
[Graphical view ]
PROSITEi PS51376. DBB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LYS-21.
    Tissue: Spleen and Synovium.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-83.
    Tissue: Fetal liver.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  5. "Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases."
    Maruoka M., Suzuki J., Kawata S., Yoshida K., Hirao N., Sato S., Goff S.P., Takeya T., Tani K., Shishido T.
    FEBS Lett. 579:2986-2990(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ABI1, PHOSPHORYLATION AT TYR-513; TYR-553; TYR-570; TYR-594 AND TYR-694.
  6. "Enhanced NK cell development and function in BCAP-deficient mice."
    Macfarlane A.W. IV, Yamazaki T., Fang M., Sigal L.J., Kurosaki T., Campbell K.S.
    Blood 112:131-140(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PIK3R1, TISSUE SPECIFICITY.

Entry informationi

Entry nameiBCAP_HUMAN
AccessioniPrimary (citable) accession number: Q6ZUJ8
Secondary accession number(s): Q5TB56
, Q5VXJ9, Q8N6J6, Q8NAC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 3, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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