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Q6ZUJ8

- BCAP_HUMAN

UniProt

Q6ZUJ8 - BCAP_HUMAN

Protein

Phosphoinositide 3-kinase adapter protein 1

Gene

PIK3AP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.1 Publication

    GO - Molecular functioni

    1. phosphatidylinositol 3-kinase regulatory subunit binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of toll-like receptor signaling pathway Source: Ensembl
    2. positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
    3. positive regulation of toll-like receptor signaling pathway Source: Ensembl
    4. regulation of inflammatory response Source: UniProtKB
    5. toll-like receptor 2 signaling pathway Source: UniProtKB
    6. toll-like receptor 4 signaling pathway Source: UniProtKB
    7. toll-like receptor 7 signaling pathway Source: UniProtKB
    8. toll-like receptor 9 signaling pathway Source: UniProtKB

    Enzyme and pathway databases

    ReactomeiREACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoinositide 3-kinase adapter protein 1
    Alternative name(s):
    B-cell adapter for phosphoinositide 3-kinase
    B-cell phosphoinositide 3-kinase adapter protein 1
    Gene namesi
    Name:PIK3AP1
    Synonyms:BCAP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:30034. PIK3AP1.

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134979629.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 805805Phosphoinositide 3-kinase adapter protein 1PRO_0000341273Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei263 – 2631PhosphotyrosineBy similarity
    Modified residuei419 – 4191Phosphotyrosine; by SYKBy similarity
    Modified residuei444 – 4441Phosphotyrosine; by SYKBy similarity
    Modified residuei459 – 4591Phosphotyrosine; by SYKBy similarity
    Modified residuei513 – 5131Phosphotyrosine; by ABL11 Publication
    Modified residuei553 – 5531Phosphotyrosine; by ABL11 Publication
    Modified residuei570 – 5701Phosphotyrosine; by ABL11 Publication
    Modified residuei594 – 5941Phosphotyrosine; by ABL11 Publication
    Modified residuei694 – 6941Phosphotyrosine; by ABL11 Publication

    Post-translational modificationi

    Constitutively phosphorylated. Phosphorylated on tyrosine residues in C-terminal region by ABL1. Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK By similarity. Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation By similarity. Toll-like receptor activation induces appearance of a phosphorylated form associated with membranes By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6ZUJ8.
    PaxDbiQ6ZUJ8.
    PRIDEiQ6ZUJ8.

    PTM databases

    PhosphoSiteiQ6ZUJ8.

    Expressioni

    Tissue specificityi

    Expressed in natural killer (NK) cells.1 Publication

    Gene expression databases

    BgeeiQ6ZUJ8.
    CleanExiHS_PIK3AP1.
    GenevestigatoriQ6ZUJ8.

    Organism-specific databases

    HPAiCAB026136.

    Interactioni

    Subunit structurei

    Homooligomer By similarity. Interacts (phosphorylated on tyrosine residues within YXXM motifs) with PIK3R1 (via SH2 domain); required for BCR- and TLR-mediated activation of phosphoinositide 3-kinase. Interacts (via polyproline C-terminal region) with ABI1 (via SH3 domain); the interaction promotes phosphorylation of PIK3AP1 by ABL1. May interact with MYD88 and TIRAP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi125621. 5 interactions.
    IntActiQ6ZUJ8. 5 interactions.
    MINTiMINT-7009152.
    STRINGi9606.ENSP00000339826.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZUJ8.
    SMRiQ6ZUJ8. Positions 338-393.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini181 – 317137DBBPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni10 – 144135Necessary and sufficent to mediate inhibition of NF-kappa-B downstream of activated TLRs; may mediate interaction with MYD88 and TIRAPBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili645 – 66723Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi760 – 80243Pro-richAdd
    BLAST

    Domaini

    The DBB domain is required for dimerization.By similarity

    Sequence similaritiesi

    Contains 1 DBB domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG70048.
    HOGENOMiHOG000095183.
    HOVERGENiHBG104426.
    InParanoidiQ6ZUJ8.
    KOiK12230.
    OMAiPGKVEFG.
    OrthoDBiEOG77DJ53.
    PhylomeDBiQ6ZUJ8.
    TreeFamiTF328570.

    Family and domain databases

    InterProiIPR017893. DBB_domain.
    [Graphical view]
    PfamiPF14545. DBB. 1 hit.
    [Graphical view]
    PROSITEiPS51376. DBB. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZUJ8-1) [UniParc]FASTAAdd to Basket

    Also known as: BCAP-L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAASGVPRGC DILIVYSPDA EEWCQYLQTL FLSSRQVRSQ KILTHRLGPE    50
    ASFSAEDLSL FLSTRCVVVL LSAELVQHFH KPALLPLLQR AFHPPHRVVR 100
    LLCGVRDSEE FLDFFPDWAH WQELTCDDEP ETYVAAVKKA ISEDSGCDSV 150
    TDTEPEDEKV VSYSKQQNLP TVTSPGNLMV VQPDRIRCGA ETTVYVIVRC 200
    KLDDRVATEA EFSPEDSPSV RMEAKVENEY TISVKAPNLS SGNVSLKIYS 250
    GDLVVCETVI SYYTDMEEIG NLLSNAANPV EFMCQAFKIV PYNTETLDKL 300
    LTESLKNNIP ASGLHLFGIN QLEEEDMMTN QRDEELPTLL HFAAKYGLKN 350
    LTALLLTCPG ALQAYSVANK HGHYPNTIAE KHGFRDLRQF IDEYVETVDM 400
    LKSHIKEELM HGEEADAVYE SMAHLSTDLL MKCSLNPGCD EDLYESMAAF 450
    VPAATEDLYV EMLQASTSNP IPGDGFSRAT KDSMIRKFLE GNSMGMTNLE 500
    RDQCHLGQEE DVYHTVDDDE AFSVDLASRP PVPVPRPETT APGAHQLPDN 550
    EPYIFKVFAE KSQERPGNFY VSSESIRKGP PVRPWRDRPQ SSIYDPFAGM 600
    KTPGQRQLIT LQEQVKLGIV NVDEAVLHFK EWQLNQKKRS ESFRFQQENL 650
    KRLRDSITRR QREKQKSGKQ TDLEITVPIR HSQHLPAKVE FGVYESGPRK 700
    SVIPPRTELR RGDWKTDSTS STASSTSNRS STRSLLSVSS GMEGDNEDNE 750
    VPEVTRSRSP GPPQVDGTPT MSLERPPRVP PRAASQRPPT RETFHPPPPV 800
    PPRGR 805
    Length:805
    Mass (Da):90,398
    Last modified:July 22, 2008 - v2
    Checksum:iDF1025A37905AEA7
    GO
    Isoform 2 (identifier: Q6ZUJ8-2) [UniParc]FASTAAdd to Basket

    Also known as: BCAP-S

    The sequence of this isoform differs from the canonical sequence as follows:
         1-178: Missing.

    Show »
    Length:627
    Mass (Da):70,412
    Checksum:iA2D7C2496537C129
    GO
    Isoform 3 (identifier: Q6ZUJ8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-57: MAASGVPRGC...GPEASFSAED → MRFFTSVACY...TGAKHVPGSS
         58-458: Missing.

    Show »
    Length:404
    Mass (Da):45,484
    Checksum:iEDBB28E0023875E9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti726 – 7261T → P in BAC03996. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211E → K.1 Publication
    Corresponds to variant rs17112076 [ dbSNP | Ensembl ].
    VAR_044035
    Natural varianti83 – 831A → S.1 Publication
    Corresponds to variant rs3748229 [ dbSNP | Ensembl ].
    VAR_044036
    Natural varianti551 – 5511E → K.
    Corresponds to variant rs3748233 [ dbSNP | Ensembl ].
    VAR_044037
    Natural varianti638 – 6381K → R.
    Corresponds to variant rs12784975 [ dbSNP | Ensembl ].
    VAR_044038

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 178178Missing in isoform 2. 1 PublicationVSP_034238Add
    BLAST
    Alternative sequencei1 – 5757MAASG…FSAED → MRFFTSVACYGSCLFASELL IRCKDWLKGRPALFTALLAC VLYLCEWTGAKHVPGSS in isoform 3. 1 PublicationVSP_034239Add
    BLAST
    Alternative sequencei58 – 458401Missing in isoform 3. 1 PublicationVSP_034240Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK092883 mRNA. Translation: BAC03996.1.
    AK125635 mRNA. Translation: BAC86227.1.
    BX648550 mRNA. No translation available.
    AL358235, AL138765, AL591364 Genomic DNA. Translation: CAH71154.2.
    AL591364, AL358235, AL138765 Genomic DNA. Translation: CAH73440.2.
    AL591364, AL358235, AL138765 Genomic DNA. Translation: CAH73441.2.
    AL138765, AL591364 Genomic DNA. Translation: CAI13579.2.
    AL138765, AL358235, AL591364 Genomic DNA. Translation: CAI13581.2.
    AL138765 Genomic DNA. Translation: CAI13586.1.
    BC029917 mRNA. Translation: AAH29917.1.
    CCDSiCCDS31259.1. [Q6ZUJ8-1]
    RefSeqiNP_689522.2. NM_152309.2. [Q6ZUJ8-1]
    XP_005269555.1. XM_005269498.1. [Q6ZUJ8-2]
    XP_005269556.1. XM_005269499.1. [Q6ZUJ8-2]
    UniGeneiHs.310456.

    Genome annotation databases

    EnsembliENST00000339364; ENSP00000339826; ENSG00000155629. [Q6ZUJ8-1]
    ENST00000371109; ENSP00000360150; ENSG00000155629. [Q6ZUJ8-3]
    ENST00000371110; ENSP00000360151; ENSG00000155629. [Q6ZUJ8-2]
    GeneIDi118788.
    KEGGihsa:118788.
    UCSCiuc001kmo.3. human. [Q6ZUJ8-3]
    uc001kmp.3. human. [Q6ZUJ8-1]

    Polymorphism databases

    DMDMi205830907.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK092883 mRNA. Translation: BAC03996.1 .
    AK125635 mRNA. Translation: BAC86227.1 .
    BX648550 mRNA. No translation available.
    AL358235 , AL138765 , AL591364 Genomic DNA. Translation: CAH71154.2 .
    AL591364 , AL358235 , AL138765 Genomic DNA. Translation: CAH73440.2 .
    AL591364 , AL358235 , AL138765 Genomic DNA. Translation: CAH73441.2 .
    AL138765 , AL591364 Genomic DNA. Translation: CAI13579.2 .
    AL138765 , AL358235 , AL591364 Genomic DNA. Translation: CAI13581.2 .
    AL138765 Genomic DNA. Translation: CAI13586.1 .
    BC029917 mRNA. Translation: AAH29917.1 .
    CCDSi CCDS31259.1. [Q6ZUJ8-1 ]
    RefSeqi NP_689522.2. NM_152309.2. [Q6ZUJ8-1 ]
    XP_005269555.1. XM_005269498.1. [Q6ZUJ8-2 ]
    XP_005269556.1. XM_005269499.1. [Q6ZUJ8-2 ]
    UniGenei Hs.310456.

    3D structure databases

    ProteinModelPortali Q6ZUJ8.
    SMRi Q6ZUJ8. Positions 338-393.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125621. 5 interactions.
    IntActi Q6ZUJ8. 5 interactions.
    MINTi MINT-7009152.
    STRINGi 9606.ENSP00000339826.

    PTM databases

    PhosphoSitei Q6ZUJ8.

    Polymorphism databases

    DMDMi 205830907.

    Proteomic databases

    MaxQBi Q6ZUJ8.
    PaxDbi Q6ZUJ8.
    PRIDEi Q6ZUJ8.

    Protocols and materials databases

    DNASUi 118788.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339364 ; ENSP00000339826 ; ENSG00000155629 . [Q6ZUJ8-1 ]
    ENST00000371109 ; ENSP00000360150 ; ENSG00000155629 . [Q6ZUJ8-3 ]
    ENST00000371110 ; ENSP00000360151 ; ENSG00000155629 . [Q6ZUJ8-2 ]
    GeneIDi 118788.
    KEGGi hsa:118788.
    UCSCi uc001kmo.3. human. [Q6ZUJ8-3 ]
    uc001kmp.3. human. [Q6ZUJ8-1 ]

    Organism-specific databases

    CTDi 118788.
    GeneCardsi GC10M098343.
    H-InvDB HIX0201490.
    HGNCi HGNC:30034. PIK3AP1.
    HPAi CAB026136.
    MIMi 607942. gene.
    neXtProti NX_Q6ZUJ8.
    PharmGKBi PA134979629.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG70048.
    HOGENOMi HOG000095183.
    HOVERGENi HBG104426.
    InParanoidi Q6ZUJ8.
    KOi K12230.
    OMAi PGKVEFG.
    OrthoDBi EOG77DJ53.
    PhylomeDBi Q6ZUJ8.
    TreeFami TF328570.

    Enzyme and pathway databases

    Reactomei REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

    Miscellaneous databases

    GeneWikii PIK3AP1.
    GenomeRNAii 118788.
    NextBioi 80340.
    PROi Q6ZUJ8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6ZUJ8.
    CleanExi HS_PIK3AP1.
    Genevestigatori Q6ZUJ8.

    Family and domain databases

    InterProi IPR017893. DBB_domain.
    [Graphical view ]
    Pfami PF14545. DBB. 1 hit.
    [Graphical view ]
    PROSITEi PS51376. DBB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LYS-21.
      Tissue: Spleen and Synovium.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-83.
      Tissue: Fetal liver.
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    5. "Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases."
      Maruoka M., Suzuki J., Kawata S., Yoshida K., Hirao N., Sato S., Goff S.P., Takeya T., Tani K., Shishido T.
      FEBS Lett. 579:2986-2990(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ABI1, PHOSPHORYLATION AT TYR-513; TYR-553; TYR-570; TYR-594 AND TYR-694.
    6. "Enhanced NK cell development and function in BCAP-deficient mice."
      Macfarlane A.W. IV, Yamazaki T., Fang M., Sigal L.J., Kurosaki T., Campbell K.S.
      Blood 112:131-140(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PIK3R1, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiBCAP_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZUJ8
    Secondary accession number(s): Q5TB56
    , Q5VXJ9, Q8N6J6, Q8NAC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3