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Protein

Ubinuclein-2

Gene

UBN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ubinuclein-2
Gene namesi
Name:UBN2
Synonyms:KIAA2030
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21931. UBN2.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164727415.

Polymorphism and mutation databases

BioMutaiUBN2.
DMDMi156630841.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13471347Ubinuclein-2PRO_0000295725Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineCombined sources
Modified residuei243 – 2431PhosphothreonineCombined sources
Modified residuei250 – 2501PhosphoserineCombined sources
Modified residuei252 – 2521PhosphothreonineCombined sources
Modified residuei311 – 3111PhosphoserineCombined sources
Modified residuei416 – 4161PhosphoserineBy similarity
Modified residuei419 – 4191PhosphoserineBy similarity
Modified residuei422 – 4221PhosphoserineBy similarity
Modified residuei584 – 5841PhosphoserineCombined sources
Modified residuei1068 – 10681N6-acetyllysineBy similarity
Modified residuei1123 – 11231PhosphoserineCombined sources
Modified residuei1148 – 11481N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6ZU65.
MaxQBiQ6ZU65.
PaxDbiQ6ZU65.
PeptideAtlasiQ6ZU65.
PRIDEiQ6ZU65.

PTM databases

iPTMnetiQ6ZU65.
PhosphoSiteiQ6ZU65.

Expressioni

Tissue specificityi

Expressed in several cell lines tested, including primary and transformed cell lines.1 Publication

Gene expression databases

BgeeiENSG00000157741.
ExpressionAtlasiQ6ZU65. baseline and differential.
GenevisibleiQ6ZU65. HS.

Organism-specific databases

HPAiHPA019743.
HPA020122.
HPA020124.

Interactioni

Protein-protein interaction databases

BioGridi129009. 11 interactions.
DIPiDIP-47312N.
IntActiQ6ZU65. 5 interactions.
STRINGi9606.ENSP00000418648.

Structurei

3D structure databases

ProteinModelPortaliQ6ZU65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi23 – 123101Pro-richAdd
BLAST
Compositional biasi262 – 34584Lys-richAdd
BLAST
Compositional biasi884 – 1224341Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the ubinuclein family.Curated

Phylogenomic databases

eggNOGiKOG4786. Eukaryota.
ENOG4110DA0. LUCA.
GeneTreeiENSGT00530000063595.
HOGENOMiHOG000154754.
InParanoidiQ6ZU65.
KOiK17492.
OMAiNKGPPVG.
OrthoDBiEOG091G0F5T.
PhylomeDBiQ6ZU65.
TreeFamiTF326088.

Family and domain databases

InterProiIPR014840. HRD.
IPR026943. Ubinuclein-2.
IPR026947. UBN_middle_dom.
[Graphical view]
PANTHERiPTHR21669:SF10. PTHR21669:SF10. 3 hits.
PfamiPF08729. HUN. 1 hit.
PF14075. UBN_AB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZU65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEPRRVAFI SLSPVRRREA EYPGPEREPE YPREPPRLEP QPYREPARAE
60 70 80 90 100
PPAPREPAPR SDAQPPSREK PLPQREVSRA EPPMSLQREP PRPEPPPPFP
110 120 130 140 150
PLPLQPPPPR ESASRAEQPP RPPRETVRLE LVLKDPTDES CVEFSYPELL
160 170 180 190 200
LCGEQRKKLI HTEDPFNDEH QERQEVEMLA KKFEMKYGGK PRKHRKDRLQ
210 220 230 240 250
DLIDIGFGYD ETDPFIDNSE AYDELVPASL TTKYGGFYIN TGTLQFRQAS
260 270 280 290 300
DTEEDDITDN QKHKPPKVPK IKEDDIEMKK RKRKEEGEKE KKPRKKVPKQ
310 320 330 340 350
LGVVALNSHK SEKKKKRYKD SLSLAAMIRK FQKEKDALKK ESNPKVPVTL
360 370 380 390 400
STPSLNKPPC AAAALGNDVP DLNLSSGDPD LPIFVSTNEH ELFQEAENAL
410 420 430 440 450
EMLDDFDFDR LLDAASDGSP LSESGGENGT TTQPTYTSQV MPKVVPTLPE
460 470 480 490 500
GLPVLLEKRI EDLRVAAKLF DEEGRKKFFT QDMNNILLDI ELQLQELGPV
510 520 530 540 550
IRSGVYSHLE AFVPCNKETL VKRLKKLHLN VQDDRLREPL QKLKLAVSNV
560 570 580 590 600
MPEQLFKYQE DCQARSQAKC AKLQTDEERE KNGSEEDDDE KPGKRVIGPR
610 620 630 640 650
KKFHWDDTIR TLLCNLVEIK LGCYELEPNK SQSAEDYLKS FMETEVKPLW
660 670 680 690 700
PKGWMQARML FKESRSVHNH LTSAPAKKKV IPAPKPKVKE VMVKTLPLHS
710 720 730 740 750
FPTMLKECSP KKDQKTPTSL VASVSGPPTS SSTAAIAAAS SSSAPAQETI
760 770 780 790 800
CLDDSLDEDL SFHSPSLDLV SEALAVINNG NKGPPVGSRI SMPTTKPRPG
810 820 830 840 850
LREEKLASIM SKLPLATPKK LDSTQTTHSS SLIAGHTGPV PKKPQDLAHT
860 870 880 890 900
GISSGLIAGS SIQNPKVSLE PLPARLLQQG LQRSSQIHTS SSSQTHVSSS
910 920 930 940 950
SQAQIAASSH ALGTSEAQDA SSLTQVTKVH QHSAVQQNYV SPLQATISKS
960 970 980 990 1000
QTNPVVKLSN NPQLSCSSSL IKTSDKPLMY RLPLSTPSPG NGSQGSHPLV
1010 1020 1030 1040 1050
SRTVPSTTTS SNYLAKAMVS QISTQGFKSP FSMAASPKLA ASPKPATSPK
1060 1070 1080 1090 1100
PLPSPKPSAS PKPSLSAKPS VSTKLISKSN PTPKPTVSPS SSSPNALVAQ
1110 1120 1130 1140 1150
GSHSSTNSPV HKQPSGMNIS RQSPTLNLLP SSRTSGLPPT KNLQAPSKLT
1160 1170 1180 1190 1200
NSSSTGTVGK NSLSGIAMNV PASRGSNLNS SGANRTSLSG GTGSGTQGAT
1210 1220 1230 1240 1250
KPLSTPHRPS TASGSSVVTA SVQSTAGASL LANASPLTLM TSPLSVTNQN
1260 1270 1280 1290 1300
VTPFGMLGGL VPVTMPFQFP LEIFGFGTDT AGVTTTSGST SAAFHHSLTQ
1310 1320 1330 1340
NLLKGLQPGG AQHAATLSHS PLPAHLQQAF HDGGQSKGDT KLPRKSQ
Length:1,347
Mass (Da):146,089
Last modified:July 24, 2007 - v2
Checksum:i6B52672B860B18B5
GO
Isoform 2 (identifier: Q6ZU65-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     958-970: LSNNPQLSCSSSL → GPCLRDVSEQFGP
     971-1347: Missing.

Note: No experimental confirmation available.
Show »
Length:970
Mass (Da):108,070
Checksum:i20E88FEA63650CE2
GO

Sequence cautioni

The sequence BAC05362 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAL24038 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1308 – 13081P → A.
Corresponds to variant rs17160850 [ dbSNP | Ensembl ].
VAR_033347

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei958 – 97013LSNNP…CSSSL → GPCLRDVSEQFGP in isoform 2. 1 PublicationVSP_027021Add
BLAST
Alternative sequencei971 – 1347377Missing in isoform 2. 1 PublicationVSP_027022Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009220 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24038.1. Sequence problems.
AK098644 mRNA. Translation: BAC05362.1. Different initiation.
AK125956 mRNA. Translation: BAC86361.1.
BC065034 mRNA. Translation: AAH65034.1.
BC108249 mRNA. Translation: AAI08250.1.
AB107352 mRNA. Translation: BAC67657.1.
CCDSiCCDS43655.2. [Q6ZU65-1]
RefSeqiNP_775840.3. NM_173569.3. [Q6ZU65-1]
UniGeneiHs.153458.
Hs.511486.

Genome annotation databases

EnsembliENST00000473989; ENSP00000418648; ENSG00000157741. [Q6ZU65-1]
GeneIDi254048.
KEGGihsa:254048.
UCSCiuc011kqr.2. human. [Q6ZU65-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009220 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24038.1. Sequence problems.
AK098644 mRNA. Translation: BAC05362.1. Different initiation.
AK125956 mRNA. Translation: BAC86361.1.
BC065034 mRNA. Translation: AAH65034.1.
BC108249 mRNA. Translation: AAI08250.1.
AB107352 mRNA. Translation: BAC67657.1.
CCDSiCCDS43655.2. [Q6ZU65-1]
RefSeqiNP_775840.3. NM_173569.3. [Q6ZU65-1]
UniGeneiHs.153458.
Hs.511486.

3D structure databases

ProteinModelPortaliQ6ZU65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129009. 11 interactions.
DIPiDIP-47312N.
IntActiQ6ZU65. 5 interactions.
STRINGi9606.ENSP00000418648.

PTM databases

iPTMnetiQ6ZU65.
PhosphoSiteiQ6ZU65.

Polymorphism and mutation databases

BioMutaiUBN2.
DMDMi156630841.

Proteomic databases

EPDiQ6ZU65.
MaxQBiQ6ZU65.
PaxDbiQ6ZU65.
PeptideAtlasiQ6ZU65.
PRIDEiQ6ZU65.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000473989; ENSP00000418648; ENSG00000157741. [Q6ZU65-1]
GeneIDi254048.
KEGGihsa:254048.
UCSCiuc011kqr.2. human. [Q6ZU65-1]

Organism-specific databases

CTDi254048.
GeneCardsiUBN2.
H-InvDBHIX0007131.
HIX0033992.
HGNCiHGNC:21931. UBN2.
HPAiHPA019743.
HPA020122.
HPA020124.
MIMi613841. gene.
neXtProtiNX_Q6ZU65.
PharmGKBiPA164727415.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4786. Eukaryota.
ENOG4110DA0. LUCA.
GeneTreeiENSGT00530000063595.
HOGENOMiHOG000154754.
InParanoidiQ6ZU65.
KOiK17492.
OMAiNKGPPVG.
OrthoDBiEOG091G0F5T.
PhylomeDBiQ6ZU65.
TreeFamiTF326088.

Miscellaneous databases

ChiTaRSiUBN2. human.
GenomeRNAii254048.
PROiQ6ZU65.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157741.
ExpressionAtlasiQ6ZU65. baseline and differential.
GenevisibleiQ6ZU65. HS.

Family and domain databases

InterProiIPR014840. HRD.
IPR026943. Ubinuclein-2.
IPR026947. UBN_middle_dom.
[Graphical view]
PANTHERiPTHR21669:SF10. PTHR21669:SF10. 3 hits.
PfamiPF08729. HUN. 1 hit.
PF14075. UBN_AB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBN2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZU65
Secondary accession number(s): A4D1S2
, Q2YDY4, Q6P1K0, Q86XN9, Q8N7D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: September 7, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.