ID K0408_HUMAN Reviewed; 694 AA. AC Q6ZU52; B3KRE5; E1P573; O43158; Q5TF20; Q7L2M2; DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 24-JAN-2024, entry version 131. DE RecName: Full=Uncharacterized protein KIAA0408; GN Name=KIAA0408; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Brain; RX PubMed=9455477; DOI=10.1093/dnares/4.5.307; RA Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., RA Tanaka A., Kotani H., Nomura N., Ohara O.; RT "Prediction of the coding sequences of unidentified human genes. VIII. 78 RT new cDNA clones from brain which code for large proteins in vitro."; RL DNA Res. 4:307-313(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-61. RC TISSUE=Brain, and Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-61. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-61. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- INTERACTION: CC Q6ZU52; Q9P2A4: ABI3; NbExp=4; IntAct=EBI-739493, EBI-742038; CC Q6ZU52; Q8NA61-2: CBY2; NbExp=5; IntAct=EBI-739493, EBI-11524851; CC Q6ZU52; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-739493, EBI-10961624; CC Q6ZU52; O43559: FRS3; NbExp=3; IntAct=EBI-739493, EBI-725515; CC Q6ZU52; P14136: GFAP; NbExp=5; IntAct=EBI-739493, EBI-744302; CC Q6ZU52; P62993: GRB2; NbExp=3; IntAct=EBI-739493, EBI-401755; CC Q6ZU52; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-739493, EBI-14103818; CC Q6ZU52; O75031: HSF2BP; NbExp=5; IntAct=EBI-739493, EBI-7116203; CC Q6ZU52; P04792: HSPB1; NbExp=3; IntAct=EBI-739493, EBI-352682; CC Q6ZU52; P42858: HTT; NbExp=6; IntAct=EBI-739493, EBI-466029; CC Q6ZU52; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-739493, EBI-1055254; CC Q6ZU52; O60333-2: KIF1B; NbExp=3; IntAct=EBI-739493, EBI-10975473; CC Q6ZU52; O14901: KLF11; NbExp=3; IntAct=EBI-739493, EBI-948266; CC Q6ZU52; O43639: NCK2; NbExp=7; IntAct=EBI-739493, EBI-713635; CC Q6ZU52; Q9UHB4: NDOR1; NbExp=3; IntAct=EBI-739493, EBI-10249760; CC Q6ZU52; P28331-2: NDUFS1; NbExp=3; IntAct=EBI-739493, EBI-6190702; CC Q6ZU52; P07196: NEFL; NbExp=3; IntAct=EBI-739493, EBI-475646; CC Q6ZU52; P04150: NR3C1; NbExp=2; IntAct=EBI-739493, EBI-493507; CC Q6ZU52; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-739493, EBI-2811583; CC Q6ZU52; P16284: PECAM1; NbExp=3; IntAct=EBI-739493, EBI-716404; CC Q6ZU52; O43189: PHF1; NbExp=4; IntAct=EBI-739493, EBI-530034; CC Q6ZU52; Q92569: PIK3R3; NbExp=3; IntAct=EBI-739493, EBI-79893; CC Q6ZU52; Q9BUI4: POLR3C; NbExp=4; IntAct=EBI-739493, EBI-5452779; CC Q6ZU52; P41219: PRPH; NbExp=3; IntAct=EBI-739493, EBI-752074; CC Q6ZU52; P60891: PRPS1; NbExp=3; IntAct=EBI-739493, EBI-749195; CC Q6ZU52; Q06455-2: RUNX1T1; NbExp=5; IntAct=EBI-739493, EBI-11984663; CC Q6ZU52; O60504: SORBS3; NbExp=4; IntAct=EBI-739493, EBI-741237; CC Q6ZU52; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-739493, EBI-7353612; CC Q6ZU52; P08670: VIM; NbExp=4; IntAct=EBI-739493, EBI-353844; CC Q6ZU52; O76024: WFS1; NbExp=3; IntAct=EBI-739493, EBI-720609; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q6ZU52-1; Sequence=Displayed; CC Name=2; CC IsoId=Q6ZU52-2; Sequence=VSP_019942; CC -!- SEQUENCE CAUTION: CC Sequence=BAA23704.2; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB007868; BAA23704.2; ALT_INIT; mRNA. DR EMBL; AK091424; BAG52357.1; -; mRNA. DR EMBL; AK125983; BAC86375.1; -; mRNA. DR EMBL; AL096711; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471051; EAW48095.1; -; Genomic_DNA. DR EMBL; CH471051; EAW48096.1; -; Genomic_DNA. DR EMBL; CH471051; EAW48098.1; -; Genomic_DNA. DR EMBL; BC018396; AAH18396.2; -; mRNA. DR CCDS; CCDS34531.1; -. [Q6ZU52-1] DR RefSeq; NP_055517.3; NM_014702.4. [Q6ZU52-1] DR AlphaFoldDB; Q6ZU52; -. DR SMR; Q6ZU52; -. DR BioGRID; 115078; 60. DR IntAct; Q6ZU52; 57. DR MINT; Q6ZU52; -. DR STRING; 9606.ENSP00000435150; -. DR GlyGen; Q6ZU52; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q6ZU52; -. DR PhosphoSitePlus; Q6ZU52; -. DR BioMuta; KIAA0408; -. DR DMDM; 74749666; -. DR jPOST; Q6ZU52; -. DR MassIVE; Q6ZU52; -. DR MaxQB; Q6ZU52; -. DR PaxDb; 9606-ENSP00000435150; -. DR PeptideAtlas; Q6ZU52; -. DR ProteomicsDB; 68310; -. [Q6ZU52-1] DR ProteomicsDB; 68311; -. [Q6ZU52-2] DR Antibodypedia; 32770; 15 antibodies from 7 providers. DR DNASU; 9729; -. DR Ensembl; ENST00000483725.8; ENSP00000435150.2; ENSG00000189367.15. [Q6ZU52-1] DR GeneID; 9729; -. DR KEGG; hsa:9729; -. DR MANE-Select; ENST00000483725.8; ENSP00000435150.2; NM_014702.5; NP_055517.3. DR UCSC; uc011ebs.3; human. [Q6ZU52-1] DR AGR; HGNC:21636; -. DR CTD; 9729; -. DR DisGeNET; 9729; -. DR GeneCards; KIAA0408; -. DR HGNC; HGNC:21636; KIAA0408. DR HPA; ENSG00000189367; Tissue enhanced (brain, skeletal muscle). DR MIM; 619236; gene. DR neXtProt; NX_Q6ZU52; -. DR OpenTargets; ENSG00000189367; -. DR PharmGKB; PA134883396; -. DR VEuPathDB; HostDB:ENSG00000189367; -. DR eggNOG; ENOG502RJ9I; Eukaryota. DR GeneTree; ENSGT00390000001962; -. DR HOGENOM; CLU_024871_0_0_1; -. DR InParanoid; Q6ZU52; -. DR OMA; CGAQQVK; -. DR OrthoDB; 4205198at2759; -. DR PhylomeDB; Q6ZU52; -. DR TreeFam; TF336502; -. DR PathwayCommons; Q6ZU52; -. DR SignaLink; Q6ZU52; -. DR BioGRID-ORCS; 9729; 7 hits in 1146 CRISPR screens. DR GenomeRNAi; 9729; -. DR Pharos; Q6ZU52; Tdark. DR PRO; PR:Q6ZU52; -. DR Proteomes; UP000005640; Chromosome 6. DR RNAct; Q6ZU52; Protein. DR Bgee; ENSG00000189367; Expressed in cortical plate and 103 other cell types or tissues. DR ExpressionAtlas; Q6ZU52; baseline and differential. DR InterPro; IPR027882; DUF4482. DR PANTHER; PTHR15705; MCG7194, ISOFORM CRA_A; 1. DR PANTHER; PTHR15705:SF1; RIKEN CDNA 9330159F19 GENE; 1. DR Pfam; PF14818; DUF4482; 1. PE 1: Evidence at protein level; KW Alternative splicing; Coiled coil; Reference proteome. FT CHAIN 1..694 FT /note="Uncharacterized protein KIAA0408" FT /id="PRO_0000247177" FT REGION 259..286 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 461..490 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 643..680 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 15..51 FT /evidence="ECO:0000255" FT VAR_SEQ 1..117 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:9455477" FT /id="VSP_019942" FT VARIANT 61 FT /note="S -> R (in dbSNP:rs3734447)" FT /evidence="ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4" FT /id="VAR_027082" FT VARIANT 331 FT /note="S -> L (in dbSNP:rs2236026)" FT /id="VAR_049510" SQ SEQUENCE 694 AA; 79163 MW; 2938DEA5B7B1B693 CRC64; MDLHKQWENT ETNWHKEKME LLDQFDNERK EWESQWKIMQ KKIEELCREV KLWRKININE SAKIIDLYHE KTIPEKVIES SPNYPDLGQS EFIRTNHKDG LRKENKREQS LVSGGNQMCK EQKATKKSKV GFLDPLATDN QKECEAWPDL RTSEEDSKSC SGALSTALEE LAKVSEELCS FQEEIRKRSN HRRMKSDSFL QEMPNVTNIP HGDPMINNDQ CILPISLEKE KQKNRKNLSC TNVLQSNSTK KCGIDTIDLK RNETPPVPPP RSTSRNFPSS DSEQAYERWK ERLDHNSWVP HEGRSKRNYN PHFPLRQQEM SMLYPNEGKT SKDGIIFSSL VPEVKIDSKP PSNEDVGLSM WSCDIGIGAK RSPSTSWFQK TCSTPSNPKY EMVIPDHPAK SHPDLHVSND CSSSVAESSS PLRNFSCGFE RTTRNEKLAA KTDEFNRTVF RTDRNCQAIQ QNHSCSKSSE DLKPCDTSST HTGSISQSND VSGIWKTNAH MPVPMENVPD NPTKKSTTGL VRQMQGHLSP RSYRNMLHEH DWRPSNLSGR PRSADPRSNY GVVEKLLKTY ETATESALQN SKCFQDNWTK CNSDVSGGAT LSQHLEMLQM EQQFQQKTAV WGGQEVKQGI DPKKITEESM SVNASHGKGF SRPARPANRR LPSRWASRSP SAPPALRRTT HNYTISLRSE ALMV //