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Q6ZU52

- K0408_HUMAN

UniProt

Q6ZU52 - K0408_HUMAN

Protein

Uncharacterized protein KIAA0408

Gene

KIAA0408

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein KIAA0408
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21636. KIAA0408.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134883396.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 694694Uncharacterized protein KIAA0408PRO_0000247177Add
    BLAST

    Proteomic databases

    MaxQBiQ6ZU52.
    PaxDbiQ6ZU52.
    PRIDEiQ6ZU52.

    PTM databases

    PhosphoSiteiQ6ZU52.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6ZU52.

    Organism-specific databases

    HPAiHPA044035.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NR3C1P041502EBI-739493,EBI-493507

    Protein-protein interaction databases

    BioGridi115078. 26 interactions.
    IntActiQ6ZU52. 29 interactions.
    MINTiMINT-1441077.
    STRINGi9606.ENSP00000009606.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZU52.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili15 – 5137Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG73425.
    HOGENOMiHOG000113146.
    HOVERGENiHBG081821.
    InParanoidiQ6ZU52.
    OMAiQQNQSYS.
    OrthoDBiEOG7HXCQJ.
    PhylomeDBiQ6ZU52.
    TreeFamiTF336502.

    Family and domain databases

    InterProiIPR027882. DUF4482.
    [Graphical view]
    PfamiPF14818. DUF4482. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZU52-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLHKQWENT ETNWHKEKME LLDQFDNERK EWESQWKIMQ KKIEELCREV    50
    KLWRKININE SAKIIDLYHE KTIPEKVIES SPNYPDLGQS EFIRTNHKDG 100
    LRKENKREQS LVSGGNQMCK EQKATKKSKV GFLDPLATDN QKECEAWPDL 150
    RTSEEDSKSC SGALSTALEE LAKVSEELCS FQEEIRKRSN HRRMKSDSFL 200
    QEMPNVTNIP HGDPMINNDQ CILPISLEKE KQKNRKNLSC TNVLQSNSTK 250
    KCGIDTIDLK RNETPPVPPP RSTSRNFPSS DSEQAYERWK ERLDHNSWVP 300
    HEGRSKRNYN PHFPLRQQEM SMLYPNEGKT SKDGIIFSSL VPEVKIDSKP 350
    PSNEDVGLSM WSCDIGIGAK RSPSTSWFQK TCSTPSNPKY EMVIPDHPAK 400
    SHPDLHVSND CSSSVAESSS PLRNFSCGFE RTTRNEKLAA KTDEFNRTVF 450
    RTDRNCQAIQ QNHSCSKSSE DLKPCDTSST HTGSISQSND VSGIWKTNAH 500
    MPVPMENVPD NPTKKSTTGL VRQMQGHLSP RSYRNMLHEH DWRPSNLSGR 550
    PRSADPRSNY GVVEKLLKTY ETATESALQN SKCFQDNWTK CNSDVSGGAT 600
    LSQHLEMLQM EQQFQQKTAV WGGQEVKQGI DPKKITEESM SVNASHGKGF 650
    SRPARPANRR LPSRWASRSP SAPPALRRTT HNYTISLRSE ALMV 694
    Length:694
    Mass (Da):79,163
    Last modified:July 5, 2004 - v1
    Checksum:i2938DEA5B7B1B693
    GO
    Isoform 2 (identifier: Q6ZU52-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-117: Missing.

    Show »
    Length:577
    Mass (Da):64,958
    Checksum:i203C85612EAF45D9
    GO

    Sequence cautioni

    The sequence BAA23704.2 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti61 – 611S → R.3 Publications
    Corresponds to variant rs3734447 [ dbSNP | Ensembl ].
    VAR_027082
    Natural varianti331 – 3311S → L.
    Corresponds to variant rs2236026 [ dbSNP | Ensembl ].
    VAR_049510

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 117117Missing in isoform 2. 1 PublicationVSP_019942Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB007868 mRNA. Translation: BAA23704.2. Different initiation.
    AK091424 mRNA. Translation: BAG52357.1.
    AK125983 mRNA. Translation: BAC86375.1.
    AL096711 Genomic DNA. Translation: CAB65988.1.
    CH471051 Genomic DNA. Translation: EAW48095.1.
    CH471051 Genomic DNA. Translation: EAW48096.1.
    CH471051 Genomic DNA. Translation: EAW48098.1.
    BC018396 mRNA. Translation: AAH18396.2.
    CCDSiCCDS34531.1. [Q6ZU52-1]
    RefSeqiNP_055517.3. NM_014702.4. [Q6ZU52-1]
    UniGeneiHs.319247.

    Genome annotation databases

    EnsembliENST00000483725; ENSP00000435150; ENSG00000189367. [Q6ZU52-1]
    GeneIDi9729.
    KEGGihsa:9729.
    UCSCiuc003qbb.3. human. [Q6ZU52-1]

    Polymorphism databases

    DMDMi74749666.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB007868 mRNA. Translation: BAA23704.2 . Different initiation.
    AK091424 mRNA. Translation: BAG52357.1 .
    AK125983 mRNA. Translation: BAC86375.1 .
    AL096711 Genomic DNA. Translation: CAB65988.1 .
    CH471051 Genomic DNA. Translation: EAW48095.1 .
    CH471051 Genomic DNA. Translation: EAW48096.1 .
    CH471051 Genomic DNA. Translation: EAW48098.1 .
    BC018396 mRNA. Translation: AAH18396.2 .
    CCDSi CCDS34531.1. [Q6ZU52-1 ]
    RefSeqi NP_055517.3. NM_014702.4. [Q6ZU52-1 ]
    UniGenei Hs.319247.

    3D structure databases

    ProteinModelPortali Q6ZU52.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115078. 26 interactions.
    IntActi Q6ZU52. 29 interactions.
    MINTi MINT-1441077.
    STRINGi 9606.ENSP00000009606.

    PTM databases

    PhosphoSitei Q6ZU52.

    Polymorphism databases

    DMDMi 74749666.

    Proteomic databases

    MaxQBi Q6ZU52.
    PaxDbi Q6ZU52.
    PRIDEi Q6ZU52.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000483725 ; ENSP00000435150 ; ENSG00000189367 . [Q6ZU52-1 ]
    GeneIDi 9729.
    KEGGi hsa:9729.
    UCSCi uc003qbb.3. human. [Q6ZU52-1 ]

    Organism-specific databases

    CTDi 9729.
    GeneCardsi GC06M127803.
    HGNCi HGNC:21636. KIAA0408.
    HPAi HPA044035.
    neXtProti NX_Q6ZU52.
    PharmGKBi PA134883396.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG73425.
    HOGENOMi HOG000113146.
    HOVERGENi HBG081821.
    InParanoidi Q6ZU52.
    OMAi QQNQSYS.
    OrthoDBi EOG7HXCQJ.
    PhylomeDBi Q6ZU52.
    TreeFami TF336502.

    Miscellaneous databases

    GenomeRNAii 9729.
    NextBioi 36600.

    Gene expression databases

    Genevestigatori Q6ZU52.

    Family and domain databases

    InterProi IPR027882. DUF4482.
    [Graphical view ]
    Pfami PF14818. DUF4482. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
      Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-61.
      Tissue: Brain and Testis.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-61.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-61.
      Tissue: Brain.

    Entry informationi

    Entry nameiK0408_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZU52
    Secondary accession number(s): B3KRE5
    , E1P573, O43158, Q5TF20, Q7L2M2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3