Q6ZU52 (K0408_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein KIAA0408

Gene names

Name:

KIAA0408

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	694 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence caution

The sequence BAA23704.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NR3C1	P04150	2	EBI-739493,EBI-493507

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZU52-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZU52-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 694	694	Uncharacterized protein KIAA0408		PRO_0000247177
Regions
	Coiled coil	15 – 51	37	Potential
Natural variations
	Alternative sequence	1 – 117	117	Missing in isoform 2.		VSP_019942
	Natural variant	61	1	S → R. Ref.2 Ref.4 Ref.5 Corresponds to variant rs3734447 [ dbSNP | Ensembl ].		VAR_027082
	Natural variant	331	1	S → L. Corresponds to variant rs2236026 [ dbSNP | Ensembl ].		VAR_049510

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 2938DEA5B7B1B693	FASTA	694	79,163
	10 20 30 40 50 60 MDLHKQWENT ETNWHKEKME LLDQFDNERK EWESQWKIMQ KKIEELCREV KLWRKININE 70 80 90 100 110 120 SAKIIDLYHE KTIPEKVIES SPNYPDLGQS EFIRTNHKDG LRKENKREQS LVSGGNQMCK 130 140 150 160 170 180 EQKATKKSKV GFLDPLATDN QKECEAWPDL RTSEEDSKSC SGALSTALEE LAKVSEELCS 190 200 210 220 230 240 FQEEIRKRSN HRRMKSDSFL QEMPNVTNIP HGDPMINNDQ CILPISLEKE KQKNRKNLSC 250 260 270 280 290 300 TNVLQSNSTK KCGIDTIDLK RNETPPVPPP RSTSRNFPSS DSEQAYERWK ERLDHNSWVP 310 320 330 340 350 360 HEGRSKRNYN PHFPLRQQEM SMLYPNEGKT SKDGIIFSSL VPEVKIDSKP PSNEDVGLSM 370 380 390 400 410 420 WSCDIGIGAK RSPSTSWFQK TCSTPSNPKY EMVIPDHPAK SHPDLHVSND CSSSVAESSS 430 440 450 460 470 480 PLRNFSCGFE RTTRNEKLAA KTDEFNRTVF RTDRNCQAIQ QNHSCSKSSE DLKPCDTSST 490 500 510 520 530 540 HTGSISQSND VSGIWKTNAH MPVPMENVPD NPTKKSTTGL VRQMQGHLSP RSYRNMLHEH 550 560 570 580 590 600 DWRPSNLSGR PRSADPRSNY GVVEKLLKTY ETATESALQN SKCFQDNWTK CNSDVSGGAT 610 620 630 640 650 660 LSQHLEMLQM EQQFQQKTAV WGGQEVKQGI DPKKITEESM SVNASHGKGF SRPARPANRR 670 680 690 LPSRWASRSP SAPPALRRTT HNYTISLRSE ALMV
	Isoform 2 [UniParc]. Checksum: 203C85612EAF45D9	FASTA	577	64,958
	10 20 30 40 50 60 MCKEQKATKK SKVGFLDPLA TDNQKECEAW PDLRTSEEDS KSCSGALSTA LEELAKVSEE 70 80 90 100 110 120 LCSFQEEIRK RSNHRRMKSD SFLQEMPNVT NIPHGDPMIN NDQCILPISL EKEKQKNRKN 130 140 150 160 170 180 LSCTNVLQSN STKKCGIDTI DLKRNETPPV PPPRSTSRNF PSSDSEQAYE RWKERLDHNS 190 200 210 220 230 240 WVPHEGRSKR NYNPHFPLRQ QEMSMLYPNE GKTSKDGIIF SSLVPEVKID SKPPSNEDVG 250 260 270 280 290 300 LSMWSCDIGI GAKRSPSTSW FQKTCSTPSN PKYEMVIPDH PAKSHPDLHV SNDCSSSVAE 310 320 330 340 350 360 SSSPLRNFSC GFERTTRNEK LAAKTDEFNR TVFRTDRNCQ AIQQNHSCSK SSEDLKPCDT 370 380 390 400 410 420 SSTHTGSISQ SNDVSGIWKT NAHMPVPMEN VPDNPTKKST TGLVRQMQGH LSPRSYRNML 430 440 450 460 470 480 HEHDWRPSNL SGRPRSADPR SNYGVVEKLL KTYETATESA LQNSKCFQDN WTKCNSDVSG 490 500 510 520 530 540 GATLSQHLEM LQMEQQFQQK TAVWGGQEVK QGIDPKKITE ESMSVNASHG KGFSRPARPA 550 560 570 NRRLPSRWAS RSPSAPPALR RTTHNYTISL RSEALMV

References

[1]	"Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro." Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-61. Tissue: Brain and Testis.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-61.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-61. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB007868 mRNA. Translation: BAA23704.2. Different initiation. AK091424 mRNA. Translation: BAG52357.1. AK125983 mRNA. Translation: BAC86375.1. AL096711 Genomic DNA. Translation: CAB65988.1. CH471051 Genomic DNA. Translation: EAW48095.1. CH471051 Genomic DNA. Translation: EAW48096.1. CH471051 Genomic DNA. Translation: EAW48098.1. BC018396 mRNA. Translation: AAH18396.2.
IPI	IPI00006011. IPI00553104.
RefSeq	NP_055517.3. NM_014702.4.
UniGene	Hs.319247.
3D structure databases
ProteinModelPortal	Q6ZU52.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6ZU52. 22 interactions.
MINT	MINT-1441077.
STRING	9606.ENSP00000009606.
PTM databases
PhosphoSite	Q6ZU52.
Polymorphism databases
DMDM	74749666.
Proteomic databases
PaxDb	Q6ZU52.
PRIDE	Q6ZU52.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000483725; ENSP00000435150; ENSG00000189367.
GeneID	9729.
KEGG	hsa:9729.
UCSC	uc003qbb.3. human.
Organism-specific databases
CTD	9729.
GeneCards	GC06M127803.
HGNC	HGNC:21636. KIAA0408.
HPA	HPA044035.
neXtProt	NX_Q6ZU52.
PharmGKB	PA134883396.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG73425.
HOGENOM	HOG000113146.
HOVERGEN	HBG081821.
InParanoid	Q6ZU52.
OMA	KTYETST.
Gene expression databases
ArrayExpress	Q6ZU52.
Genevestigator	Q6ZU52.
GermOnline	ENSG00000189367. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	9729.
NextBio	36600.

Entry information

Entry name

K0408_HUMAN

Accession

Primary (citable) accession number: Q6ZU52
Secondary accession number(s): B3KRE5 , E1P573, O43158, Q5TF20, Q7L2M2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.