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Q6ZU52

- K0408_HUMAN

UniProt

Q6ZU52 - K0408_HUMAN

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Protein
Uncharacterized protein KIAA0408
Gene
KIAA0408
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA0408
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21636. KIAA0408.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134883396.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694Uncharacterized protein KIAA0408
PRO_0000247177Add
BLAST

Proteomic databases

MaxQBiQ6ZU52.
PaxDbiQ6ZU52.
PRIDEiQ6ZU52.

PTM databases

PhosphoSiteiQ6ZU52.

Expressioni

Gene expression databases

GenevestigatoriQ6ZU52.

Organism-specific databases

HPAiHPA044035.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NR3C1P041502EBI-739493,EBI-493507

Protein-protein interaction databases

BioGridi115078. 26 interactions.
IntActiQ6ZU52. 29 interactions.
MINTiMINT-1441077.
STRINGi9606.ENSP00000009606.

Structurei

3D structure databases

ProteinModelPortaliQ6ZU52.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili15 – 5137 Reviewed prediction
Add
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG73425.
HOGENOMiHOG000113146.
HOVERGENiHBG081821.
InParanoidiQ6ZU52.
OMAiQQNQSYS.
OrthoDBiEOG7HXCQJ.
PhylomeDBiQ6ZU52.
TreeFamiTF336502.

Family and domain databases

InterProiIPR027882. DUF4482.
[Graphical view]
PfamiPF14818. DUF4482. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZU52-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDLHKQWENT ETNWHKEKME LLDQFDNERK EWESQWKIMQ KKIEELCREV    50
KLWRKININE SAKIIDLYHE KTIPEKVIES SPNYPDLGQS EFIRTNHKDG 100
LRKENKREQS LVSGGNQMCK EQKATKKSKV GFLDPLATDN QKECEAWPDL 150
RTSEEDSKSC SGALSTALEE LAKVSEELCS FQEEIRKRSN HRRMKSDSFL 200
QEMPNVTNIP HGDPMINNDQ CILPISLEKE KQKNRKNLSC TNVLQSNSTK 250
KCGIDTIDLK RNETPPVPPP RSTSRNFPSS DSEQAYERWK ERLDHNSWVP 300
HEGRSKRNYN PHFPLRQQEM SMLYPNEGKT SKDGIIFSSL VPEVKIDSKP 350
PSNEDVGLSM WSCDIGIGAK RSPSTSWFQK TCSTPSNPKY EMVIPDHPAK 400
SHPDLHVSND CSSSVAESSS PLRNFSCGFE RTTRNEKLAA KTDEFNRTVF 450
RTDRNCQAIQ QNHSCSKSSE DLKPCDTSST HTGSISQSND VSGIWKTNAH 500
MPVPMENVPD NPTKKSTTGL VRQMQGHLSP RSYRNMLHEH DWRPSNLSGR 550
PRSADPRSNY GVVEKLLKTY ETATESALQN SKCFQDNWTK CNSDVSGGAT 600
LSQHLEMLQM EQQFQQKTAV WGGQEVKQGI DPKKITEESM SVNASHGKGF 650
SRPARPANRR LPSRWASRSP SAPPALRRTT HNYTISLRSE ALMV 694
Length:694
Mass (Da):79,163
Last modified:July 5, 2004 - v1
Checksum:i2938DEA5B7B1B693
GO
Isoform 2 (identifier: Q6ZU52-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.

Show »
Length:577
Mass (Da):64,958
Checksum:i203C85612EAF45D9
GO

Sequence cautioni

The sequence BAA23704.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611S → R.3 Publications
Corresponds to variant rs3734447 [ dbSNP | Ensembl ].
VAR_027082
Natural varianti331 – 3311S → L.
Corresponds to variant rs2236026 [ dbSNP | Ensembl ].
VAR_049510

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 117117Missing in isoform 2.
VSP_019942Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB007868 mRNA. Translation: BAA23704.2. Different initiation.
AK091424 mRNA. Translation: BAG52357.1.
AK125983 mRNA. Translation: BAC86375.1.
AL096711 Genomic DNA. Translation: CAB65988.1.
CH471051 Genomic DNA. Translation: EAW48095.1.
CH471051 Genomic DNA. Translation: EAW48096.1.
CH471051 Genomic DNA. Translation: EAW48098.1.
BC018396 mRNA. Translation: AAH18396.2.
CCDSiCCDS34531.1. [Q6ZU52-1]
RefSeqiNP_055517.3. NM_014702.4. [Q6ZU52-1]
UniGeneiHs.319247.

Genome annotation databases

EnsembliENST00000483725; ENSP00000435150; ENSG00000189367. [Q6ZU52-1]
GeneIDi9729.
KEGGihsa:9729.
UCSCiuc003qbb.3. human. [Q6ZU52-1]

Polymorphism databases

DMDMi74749666.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB007868 mRNA. Translation: BAA23704.2 . Different initiation.
AK091424 mRNA. Translation: BAG52357.1 .
AK125983 mRNA. Translation: BAC86375.1 .
AL096711 Genomic DNA. Translation: CAB65988.1 .
CH471051 Genomic DNA. Translation: EAW48095.1 .
CH471051 Genomic DNA. Translation: EAW48096.1 .
CH471051 Genomic DNA. Translation: EAW48098.1 .
BC018396 mRNA. Translation: AAH18396.2 .
CCDSi CCDS34531.1. [Q6ZU52-1 ]
RefSeqi NP_055517.3. NM_014702.4. [Q6ZU52-1 ]
UniGenei Hs.319247.

3D structure databases

ProteinModelPortali Q6ZU52.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115078. 26 interactions.
IntActi Q6ZU52. 29 interactions.
MINTi MINT-1441077.
STRINGi 9606.ENSP00000009606.

PTM databases

PhosphoSitei Q6ZU52.

Polymorphism databases

DMDMi 74749666.

Proteomic databases

MaxQBi Q6ZU52.
PaxDbi Q6ZU52.
PRIDEi Q6ZU52.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000483725 ; ENSP00000435150 ; ENSG00000189367 . [Q6ZU52-1 ]
GeneIDi 9729.
KEGGi hsa:9729.
UCSCi uc003qbb.3. human. [Q6ZU52-1 ]

Organism-specific databases

CTDi 9729.
GeneCardsi GC06M127803.
HGNCi HGNC:21636. KIAA0408.
HPAi HPA044035.
neXtProti NX_Q6ZU52.
PharmGKBi PA134883396.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG73425.
HOGENOMi HOG000113146.
HOVERGENi HBG081821.
InParanoidi Q6ZU52.
OMAi QQNQSYS.
OrthoDBi EOG7HXCQJ.
PhylomeDBi Q6ZU52.
TreeFami TF336502.

Miscellaneous databases

GenomeRNAii 9729.
NextBioi 36600.

Gene expression databases

Genevestigatori Q6ZU52.

Family and domain databases

InterProi IPR027882. DUF4482.
[Graphical view ]
Pfami PF14818. DUF4482. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
    Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-61.
    Tissue: Brain and Testis.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-61.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-61.
    Tissue: Brain.

Entry informationi

Entry nameiK0408_HUMAN
AccessioniPrimary (citable) accession number: Q6ZU52
Secondary accession number(s): B3KRE5
, E1P573, O43158, Q5TF20, Q7L2M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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