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Protein

Uncharacterized protein KIAA0408

Gene

KIAA0408

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA0408
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21636. KIAA0408.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134883396.

Polymorphism and mutation databases

BioMutaiKIAA0408.
DMDMi74749666.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694Uncharacterized protein KIAA0408PRO_0000247177Add
BLAST

Proteomic databases

MaxQBiQ6ZU52.
PaxDbiQ6ZU52.
PRIDEiQ6ZU52.

PTM databases

PhosphoSiteiQ6ZU52.

Expressioni

Gene expression databases

ExpressionAtlasiQ6ZU52. baseline.
GenevisibleiQ6ZU52. HS.

Organism-specific databases

HPAiHPA044035.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NR3C1P041502EBI-739493,EBI-493507
SORBS3O605044EBI-739493,EBI-741237

Protein-protein interaction databases

BioGridi115078. 26 interactions.
IntActiQ6ZU52. 30 interactions.
MINTiMINT-1441077.
STRINGi9606.ENSP00000435150.

Structurei

3D structure databases

ProteinModelPortaliQ6ZU52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili15 – 5137Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG73425.
GeneTreeiENSGT00390000001962.
HOGENOMiHOG000113146.
HOVERGENiHBG081821.
InParanoidiQ6ZU52.
OMAiRTDRNCH.
OrthoDBiEOG7HXCQJ.
PhylomeDBiQ6ZU52.
TreeFamiTF336502.

Family and domain databases

InterProiIPR027882. DUF4482.
[Graphical view]
PfamiPF14818. DUF4482. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZU52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLHKQWENT ETNWHKEKME LLDQFDNERK EWESQWKIMQ KKIEELCREV
60 70 80 90 100
KLWRKININE SAKIIDLYHE KTIPEKVIES SPNYPDLGQS EFIRTNHKDG
110 120 130 140 150
LRKENKREQS LVSGGNQMCK EQKATKKSKV GFLDPLATDN QKECEAWPDL
160 170 180 190 200
RTSEEDSKSC SGALSTALEE LAKVSEELCS FQEEIRKRSN HRRMKSDSFL
210 220 230 240 250
QEMPNVTNIP HGDPMINNDQ CILPISLEKE KQKNRKNLSC TNVLQSNSTK
260 270 280 290 300
KCGIDTIDLK RNETPPVPPP RSTSRNFPSS DSEQAYERWK ERLDHNSWVP
310 320 330 340 350
HEGRSKRNYN PHFPLRQQEM SMLYPNEGKT SKDGIIFSSL VPEVKIDSKP
360 370 380 390 400
PSNEDVGLSM WSCDIGIGAK RSPSTSWFQK TCSTPSNPKY EMVIPDHPAK
410 420 430 440 450
SHPDLHVSND CSSSVAESSS PLRNFSCGFE RTTRNEKLAA KTDEFNRTVF
460 470 480 490 500
RTDRNCQAIQ QNHSCSKSSE DLKPCDTSST HTGSISQSND VSGIWKTNAH
510 520 530 540 550
MPVPMENVPD NPTKKSTTGL VRQMQGHLSP RSYRNMLHEH DWRPSNLSGR
560 570 580 590 600
PRSADPRSNY GVVEKLLKTY ETATESALQN SKCFQDNWTK CNSDVSGGAT
610 620 630 640 650
LSQHLEMLQM EQQFQQKTAV WGGQEVKQGI DPKKITEESM SVNASHGKGF
660 670 680 690
SRPARPANRR LPSRWASRSP SAPPALRRTT HNYTISLRSE ALMV
Length:694
Mass (Da):79,163
Last modified:July 5, 2004 - v1
Checksum:i2938DEA5B7B1B693
GO
Isoform 2 (identifier: Q6ZU52-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.

Show »
Length:577
Mass (Da):64,958
Checksum:i203C85612EAF45D9
GO

Sequence cautioni

The sequence BAA23704.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611S → R.3 Publications
Corresponds to variant rs3734447 [ dbSNP | Ensembl ].
VAR_027082
Natural varianti331 – 3311S → L.
Corresponds to variant rs2236026 [ dbSNP | Ensembl ].
VAR_049510

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 117117Missing in isoform 2. 1 PublicationVSP_019942Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007868 mRNA. Translation: BAA23704.2. Different initiation.
AK091424 mRNA. Translation: BAG52357.1.
AK125983 mRNA. Translation: BAC86375.1.
AL096711 Genomic DNA. Translation: CAB65988.1.
CH471051 Genomic DNA. Translation: EAW48095.1.
CH471051 Genomic DNA. Translation: EAW48096.1.
CH471051 Genomic DNA. Translation: EAW48098.1.
BC018396 mRNA. Translation: AAH18396.2.
CCDSiCCDS34531.1. [Q6ZU52-1]
RefSeqiNP_055517.3. NM_014702.4. [Q6ZU52-1]
UniGeneiHs.319247.

Genome annotation databases

EnsembliENST00000483725; ENSP00000435150; ENSG00000189367.
GeneIDi9729.
KEGGihsa:9729.
UCSCiuc003qbb.3. human. [Q6ZU52-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007868 mRNA. Translation: BAA23704.2. Different initiation.
AK091424 mRNA. Translation: BAG52357.1.
AK125983 mRNA. Translation: BAC86375.1.
AL096711 Genomic DNA. Translation: CAB65988.1.
CH471051 Genomic DNA. Translation: EAW48095.1.
CH471051 Genomic DNA. Translation: EAW48096.1.
CH471051 Genomic DNA. Translation: EAW48098.1.
BC018396 mRNA. Translation: AAH18396.2.
CCDSiCCDS34531.1. [Q6ZU52-1]
RefSeqiNP_055517.3. NM_014702.4. [Q6ZU52-1]
UniGeneiHs.319247.

3D structure databases

ProteinModelPortaliQ6ZU52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115078. 26 interactions.
IntActiQ6ZU52. 30 interactions.
MINTiMINT-1441077.
STRINGi9606.ENSP00000435150.

PTM databases

PhosphoSiteiQ6ZU52.

Polymorphism and mutation databases

BioMutaiKIAA0408.
DMDMi74749666.

Proteomic databases

MaxQBiQ6ZU52.
PaxDbiQ6ZU52.
PRIDEiQ6ZU52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000483725; ENSP00000435150; ENSG00000189367.
GeneIDi9729.
KEGGihsa:9729.
UCSCiuc003qbb.3. human. [Q6ZU52-1]

Organism-specific databases

CTDi9729.
GeneCardsiGC06M127761.
HGNCiHGNC:21636. KIAA0408.
HPAiHPA044035.
neXtProtiNX_Q6ZU52.
PharmGKBiPA134883396.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG73425.
GeneTreeiENSGT00390000001962.
HOGENOMiHOG000113146.
HOVERGENiHBG081821.
InParanoidiQ6ZU52.
OMAiRTDRNCH.
OrthoDBiEOG7HXCQJ.
PhylomeDBiQ6ZU52.
TreeFamiTF336502.

Miscellaneous databases

ChiTaRSiKIAA0408. human.
GenomeRNAii9729.
NextBioi36600.
PROiQ6ZU52.

Gene expression databases

ExpressionAtlasiQ6ZU52. baseline.
GenevisibleiQ6ZU52. HS.

Family and domain databases

InterProiIPR027882. DUF4482.
[Graphical view]
PfamiPF14818. DUF4482. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
    Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-61.
    Tissue: Brain and Testis.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-61.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-61.
    Tissue: Brain.

Entry informationi

Entry nameiK0408_HUMAN
AccessioniPrimary (citable) accession number: Q6ZU52
Secondary accession number(s): B3KRE5
, E1P573, O43158, Q5TF20, Q7L2M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.