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Protein

Uncharacterized protein KIAA1211

Gene

KIAA1211

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA1211
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:29219. KIAA1211.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164721869.

Polymorphism and mutation databases

BioMutaiKIAA1211.
DMDMi296439324.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12331233Uncharacterized protein KIAA1211PRO_0000342475Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphoserineBy similarity
Modified residuei28 – 281PhosphoserineBy similarity
Modified residuei132 – 1321PhosphoserineBy similarity
Modified residuei420 – 4201PhosphoserineCombined sources
Modified residuei556 – 5561PhosphoserineCombined sources
Modified residuei559 – 5591PhosphothreonineCombined sources
Modified residuei971 – 9711PhosphothreonineCombined sources
Modified residuei975 – 9751PhosphoserineCombined sources
Modified residuei1017 – 10171PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZU35.
MaxQBiQ6ZU35.
PaxDbiQ6ZU35.
PeptideAtlasiQ6ZU35.
PRIDEiQ6ZU35.

PTM databases

iPTMnetiQ6ZU35.
PhosphoSiteiQ6ZU35.

Expressioni

Gene expression databases

BgeeiQ6ZU35.
ExpressionAtlasiQ6ZU35. baseline and differential.
GenevisibleiQ6ZU35. HS.

Organism-specific databases

HPAiHPA043249.
HPA048148.

Interactioni

Protein-protein interaction databases

BioGridi121552. 11 interactions.
IntActiQ6ZU35. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6ZU35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi209 – 529321Glu-richAdd
BLAST
Compositional biasi867 – 8704Poly-Lys
Compositional biasi930 – 102192Pro-richAdd
BLAST
Compositional biasi1031 – 10344Poly-Glu

Phylogenomic databases

eggNOGiENOG410IIMH. Eukaryota.
ENOG41101DD. LUCA.
GeneTreeiENSGT00740000115532.
HOGENOMiHOG000113159.
HOVERGENiHBG108030.
InParanoidiQ6ZU35.
OMAiGSEMEEK.
OrthoDBiEOG7BGHK7.
PhylomeDBiQ6ZU35.
TreeFamiTF335584.

Family and domain databases

InterProiIPR028030. DUF4592.
[Graphical view]
PfamiPF15262. DUF4592. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZU35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTRAFSHDS IFIPDGGAES EQTVQAMSQD NILGKVKTLQ QQLGKNIKFG
60 70 80 90 100
QRSPNAIPMN KANSGEASLE EDLFLTSPME IVTQQDIVLS DAENKSSDTP
110 120 130 140 150
SSLSPLNLPG AGSEMEEKVA PVKPSRPKRH FSSAGTIESV NLDAIPLAIA
160 170 180 190 200
RLDNSAAKHK LAVKPKKQRV SKKHRRLAQD PQHEQGGLES RPCLDQNGHP
210 220 230 240 250
GEDKPTWHEE EPNPLDSEEE RRRQEDYWRE LEAKCKRQKA EAAEKRRLEE
260 270 280 290 300
QRLQALERRL WEENRRQELL EEEGEGQEPP LEAERAPREE QQRSLEAPGW
310 320 330 340 350
EDAERREREE RERLEAEEER RRLQAQAQAE ERRRLEEDAR LEERRRQEEE
360 370 380 390 400
EGRCAEELKR QEEEEAEGWE ELEQQEAEVQ GPPEALEETG EGRRGAEEED
410 420 430 440 450
LGEEEEEGQA HLEDWRGQLS ELLNDFEERL EDQERLKPEG QREHSEEPGI
460 470 480 490 500
CEEQNPEAER RREQQGRSGD FQGADRPGPE EKREEGDTEP LLKQEGPVEA
510 520 530 540 550
AQPPVERKEA AALEQGRKVE ELRWQEVDER QTMPRPYTFQ VSSGGKQILF
560 570 580 590 600
PKVNLSPVTP AKDTGLTAAP QEPKAPKASP VQHALPSSLS VPHTAILVTG
610 620 630 640 650
AQLCGPAVNL SQIKDTACKS LLGLEEKKHA EAPAGENPPR GPGDARAGSG
660 670 680 690 700
KAKPRQESPS SASALAEWAS IRSRILKNAE SDPRSSERDQ LRPGDESTPR
710 720 730 740 750
GRCDSRGNQR KTPPVNAKFS IMPAWQKFSD GGTETSKQST EAESIRKRPM
760 770 780 790 800
LGPSEETAPQ PPPAGVRELG KGPEKSEMHR EPADTTEGCK FAKDLPSFLV
810 820 830 840 850
PSLPYPPQKV VAHTEFTTSS DSETANGIAK PDPVMPGGEE KASPFGIKLR
860 870 880 890 900
RTNYSLRFNC DQQAEQKKKK RHSSTGDSAD AGPPAAGSAR GEKEMEGVAL
910 920 930 940 950
KHGPSLPQER KQAPSTRRDS AEPSSSRSVP VAHPGPPPAS SQTPAPEHDK
960 970 980 990 1000
AANKMPLAQK PALAPKPTSQ TPPASPLSKL SRPYLVELLS RRAGRPDPEP
1010 1020 1030 1040 1050
SEPSKEDQES SDRRPPSPPG PEERKGQKRD EEEEATERKP ASPPLPATQQ
1060 1070 1080 1090 1100
EKPSQTPEAG RKEKPMLQSR HSLDGSKLTE KVETAQPLWI TLALQKQKGF
1110 1120 1130 1140 1150
REQQATREER KQAREAKQAE KLSKENVSVS VQPGSSSVSR AGSLHKSTAL
1160 1170 1180 1190 1200
PEEKRPETAV SRLERREQLK KANTLPTSVT VEISDSAPPA PLVKEVTKRF
1210 1220 1230
STPDAAPVST EPAWLALAKR KAKAWSDCPQ IIK
Length:1,233
Mass (Da):136,760
Last modified:May 18, 2010 - v3
Checksum:i277958DCD15528C4
GO

Sequence cautioni

The sequence BAA86525.1 differs from that shown.Unlikely isoform. Aberrant splice sites.Curated
The sequence CAB61360.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti299 – 2991G → R in BAC86392 (PubMed:14702039).Curated
Sequence conflicti654 – 6541P → L in BAC86392 (PubMed:14702039).Curated
Sequence conflicti777 – 7771E → G in BAC86392 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti269 – 2691L → I.
Corresponds to variant rs6823339 [ dbSNP | Ensembl ].
VAR_044205
Natural varianti655 – 6551R → P.5 Publications
Corresponds to variant rs7672073 [ dbSNP | Ensembl ].
VAR_044206
Natural varianti710 – 7101R → Q.
Corresponds to variant rs3796546 [ dbSNP | Ensembl ].
VAR_044207
Natural varianti776 – 7761S → L.1 Publication
Corresponds to variant rs3796547 [ dbSNP | Ensembl ].
VAR_044208

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033037 mRNA. Translation: BAA86525.1. Sequence problems.
AK126014 mRNA. Translation: BAC86392.1.
AC068620 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05481.1.
AL133028 mRNA. Translation: CAB61360.2. Different initiation.
AL137336 mRNA. Translation: CAB70699.1.
CCDSiCCDS43230.1.
PIRiT42702.
RefSeqiNP_065773.1. NM_020722.1.
XP_005265809.1. XM_005265752.2.
XP_011532699.1. XM_011534397.1.
UniGeneiHs.596667.

Genome annotation databases

EnsembliENST00000264229; ENSP00000264229; ENSG00000109265.
ENST00000504228; ENSP00000423366; ENSG00000109265.
GeneIDi57482.
KEGGihsa:57482.
UCSCiuc003hbk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033037 mRNA. Translation: BAA86525.1. Sequence problems.
AK126014 mRNA. Translation: BAC86392.1.
AC068620 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05481.1.
AL133028 mRNA. Translation: CAB61360.2. Different initiation.
AL137336 mRNA. Translation: CAB70699.1.
CCDSiCCDS43230.1.
PIRiT42702.
RefSeqiNP_065773.1. NM_020722.1.
XP_005265809.1. XM_005265752.2.
XP_011532699.1. XM_011534397.1.
UniGeneiHs.596667.

3D structure databases

ProteinModelPortaliQ6ZU35.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121552. 11 interactions.
IntActiQ6ZU35. 1 interaction.

PTM databases

iPTMnetiQ6ZU35.
PhosphoSiteiQ6ZU35.

Polymorphism and mutation databases

BioMutaiKIAA1211.
DMDMi296439324.

Proteomic databases

EPDiQ6ZU35.
MaxQBiQ6ZU35.
PaxDbiQ6ZU35.
PeptideAtlasiQ6ZU35.
PRIDEiQ6ZU35.

Protocols and materials databases

DNASUi57482.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264229; ENSP00000264229; ENSG00000109265.
ENST00000504228; ENSP00000423366; ENSG00000109265.
GeneIDi57482.
KEGGihsa:57482.
UCSCiuc003hbk.3. human.

Organism-specific databases

CTDi57482.
GeneCardsiKIAA1211.
HGNCiHGNC:29219. KIAA1211.
HPAiHPA043249.
HPA048148.
neXtProtiNX_Q6ZU35.
PharmGKBiPA164721869.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIMH. Eukaryota.
ENOG41101DD. LUCA.
GeneTreeiENSGT00740000115532.
HOGENOMiHOG000113159.
HOVERGENiHBG108030.
InParanoidiQ6ZU35.
OMAiGSEMEEK.
OrthoDBiEOG7BGHK7.
PhylomeDBiQ6ZU35.
TreeFamiTF335584.

Miscellaneous databases

ChiTaRSiKIAA1211. human.
GenomeRNAii57482.
PROiQ6ZU35.

Gene expression databases

BgeeiQ6ZU35.
ExpressionAtlasiQ6ZU35. baseline and differential.
GenevisibleiQ6ZU35. HS.

Family and domain databases

InterProiIPR028030. DUF4592.
[Graphical view]
PfamiPF15262. DUF4592. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-655.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-655 AND LEU-776.
    Tissue: Testis.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-655.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 400-1233, VARIANT PRO-655.
    Tissue: Testis.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 612-1233, VARIANT PRO-655.
    Tissue: Testis.
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-556 AND THR-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-971 AND SER-975, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-556 AND SER-1017, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiK1211_HUMAN
AccessioniPrimary (citable) accession number: Q6ZU35
Secondary accession number(s): Q9NTE2, Q9NTP8, Q9ULK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.