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Protein

Septin-14

Gene

SEPT14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei114 – 1141GTP; via amide nitrogenBy similarity
Binding sitei249 – 2491GTP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei264 – 2641GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi59 – 668GTPBy similarity
Nucleotide bindingi195 – 2039GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-14
Gene namesi
Name:SEPT14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:33280. SEPT14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

MalaCardsiSEPT14.
Orphaneti251579. Giant cell glioblastoma.
251576. Gliosarcoma.
PharmGKBiPA162402917.

Polymorphism and mutation databases

BioMutaiSEPT14.
DMDMi152112291.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Septin-14PRO_0000294425Add
BLAST

Proteomic databases

EPDiQ6ZU15.
MaxQBiQ6ZU15.
PaxDbiQ6ZU15.
PRIDEiQ6ZU15.

PTM databases

PhosphoSiteiQ6ZU15.

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Gene expression databases

BgeeiQ6ZU15.
CleanExiHS_SEPT14.

Organism-specific databases

HPAiHPA058456.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with SEPT9.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SEPT9Q9UHD8-13EBI-2009297,EBI-851558
SEPT9Q9UHD8-33EBI-2009297,EBI-851569

Protein-protein interaction databases

BioGridi131376. 5 interactions.
IntActiQ6ZU15. 8 interactions.
STRINGi9606.ENSP00000373627.

Structurei

3D structure databases

ProteinModelPortaliQ6ZU15.
SMRiQ6ZU15. Positions 51-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 315267Septin-type GAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili332 – 41281Sequence analysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00760000118899.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ6ZU15.
KOiK16941.
OMAiNIRCLTT.
OrthoDBiEOG7J9VQK.
PhylomeDBiQ6ZU15.
TreeFamiTF101080.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZU15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERTMAMPT QIPADGDTQK ENNIRCLTTI GHFGFECLPN QLVSRSIRQG
60 70 80 90 100
FTFNILCVGE TGIGKSTLID TLFNTNLKDN KSSHFYSNVG LQIQTYELQE
110 120 130 140 150
SNVQLKLTVV ETVGYGDQID KEASYQPIVD YIDAQFEAYL QEELKIKRSL
160 170 180 190 200
FEYHDSRVHV CLYFISPTGH SLKSLDLLTM KNLDSKVNII PLIAKADTIS
210 220 230 240 250
KNDLQTFKNK IMSELISNGI QIYQLPTDEE TAAQANSSVS GLLPFAVVGS
260 270 280 290 300
TDEVKVGKRM VRGRHYPWGV LQVENENHCD FVKLRDMLLC TNMENLKEKT
310 320 330 340 350
HTQHYECYRY QKLQKMGFTD VGPNNQPVSF QEIFEAKRQE FYDQCQREEE
360 370 380 390 400
ELKQRFMQRV KEKEATFKEA EKELQDKFEH LKMIQQEEIR KLEEEKKQLE
410 420 430
GEIIDFYKMK AASEALQTQL STDTKKDKHR KK
Length:432
Mass (Da):50,025
Last modified:July 10, 2007 - v2
Checksum:iAFFF9A953F1FC637
GO

Sequence cautioni

The sequence BAC86412.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126048 mRNA. Translation: BAC86412.1. Different initiation.
AK301928 mRNA. Translation: BAG63348.1.
AC092647 Genomic DNA. No translation available.
CCDSiCCDS5519.2.
RefSeqiNP_997249.2. NM_207366.2.
XP_011513675.1. XM_011515373.1.
UniGeneiHs.453629.

Genome annotation databases

EnsembliENST00000388975; ENSP00000373627; ENSG00000154997.
GeneIDi346288.
KEGGihsa:346288.
UCSCiuc003tqz.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126048 mRNA. Translation: BAC86412.1. Different initiation.
AK301928 mRNA. Translation: BAG63348.1.
AC092647 Genomic DNA. No translation available.
CCDSiCCDS5519.2.
RefSeqiNP_997249.2. NM_207366.2.
XP_011513675.1. XM_011515373.1.
UniGeneiHs.453629.

3D structure databases

ProteinModelPortaliQ6ZU15.
SMRiQ6ZU15. Positions 51-317.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131376. 5 interactions.
IntActiQ6ZU15. 8 interactions.
STRINGi9606.ENSP00000373627.

PTM databases

PhosphoSiteiQ6ZU15.

Polymorphism and mutation databases

BioMutaiSEPT14.
DMDMi152112291.

Proteomic databases

EPDiQ6ZU15.
MaxQBiQ6ZU15.
PaxDbiQ6ZU15.
PRIDEiQ6ZU15.

Protocols and materials databases

DNASUi346288.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000388975; ENSP00000373627; ENSG00000154997.
GeneIDi346288.
KEGGihsa:346288.
UCSCiuc003tqz.2. human.

Organism-specific databases

CTDi346288.
GeneCardsiSEPT14.
H-InvDBHIX0025388.
HGNCiHGNC:33280. SEPT14.
HPAiHPA058456.
MalaCardsiSEPT14.
MIMi612140. gene.
neXtProtiNX_Q6ZU15.
Orphaneti251579. Giant cell glioblastoma.
251576. Gliosarcoma.
PharmGKBiPA162402917.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00760000118899.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ6ZU15.
KOiK16941.
OMAiNIRCLTT.
OrthoDBiEOG7J9VQK.
PhylomeDBiQ6ZU15.
TreeFamiTF101080.

Miscellaneous databases

GenomeRNAii346288.
NextBioi98947.
PROiQ6ZU15.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZU15.
CleanExiHS_SEPT14.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin."
    Peterson E.A., Kalikin L.M., Steels J.D., Estey M.P., Trimble W.S., Petty E.M.
    Mamm. Genome 18:796-807(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SEPT9, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSEP14_HUMAN
AccessioniPrimary (citable) accession number: Q6ZU15
Secondary accession number(s): A6NCC2, B4DXD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: March 16, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.