Q6ZU15 (SEP14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Septin-14

Gene names

Name:

SEPT14

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Filament-forming cytoskeletal GTPase By similarity. May play a role in cytokinesis Potential.
Subunit structure	Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation By similarity. Interacts with SEPT9. Ref.3
Subcellular location	Cytoplasm. Cytoplasm › cytoskeleton. Note: Colocalizes with actin stress fibers. Ref.3
Tissue specificity	Testis-specific. Ref.3
Sequence similarities	Belongs to the septin family.
Sequence caution	The sequence BAC86412.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cytoplasm Cytoskeleton
Domain	Coiled coil
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	septin complex Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction Ref.3. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SEPT9	Q9UHD8-1	3	EBI-2009297,EBI-851558
SEPT9	Q9UHD8-3	3	EBI-2009297,EBI-851569

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 432	432	Septin-14		PRO_0000294425
Regions
	Nucleotide binding	59 – 66	8	GTP By similarity
	Nucleotide binding	195 – 203	9	GTP By similarity
	Coiled coil	332 – 412	81	Potential
Sites
	Binding site	114	1	GTP; via amide nitrogen By similarity
	Binding site	249	1	GTP; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	264	1	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6ZU15 [UniParc]. Last modified July 10, 2007. Version 2. Checksum: AFFF9A953F1FC637	FASTA	432	50,025
	10 20 30 40 50 60 MAERTMAMPT QIPADGDTQK ENNIRCLTTI GHFGFECLPN QLVSRSIRQG FTFNILCVGE 70 80 90 100 110 120 TGIGKSTLID TLFNTNLKDN KSSHFYSNVG LQIQTYELQE SNVQLKLTVV ETVGYGDQID 130 140 150 160 170 180 KEASYQPIVD YIDAQFEAYL QEELKIKRSL FEYHDSRVHV CLYFISPTGH SLKSLDLLTM 190 200 210 220 230 240 KNLDSKVNII PLIAKADTIS KNDLQTFKNK IMSELISNGI QIYQLPTDEE TAAQANSSVS 250 260 270 280 290 300 GLLPFAVVGS TDEVKVGKRM VRGRHYPWGV LQVENENHCD FVKLRDMLLC TNMENLKEKT 310 320 330 340 350 360 HTQHYECYRY QKLQKMGFTD VGPNNQPVSF QEIFEAKRQE FYDQCQREEE ELKQRFMQRV 370 380 390 400 410 420 KEKEATFKEA EKELQDKFEH LKMIQQEEIR KLEEEKKQLE GEIIDFYKMK AASEALQTQL 430 STDTKKDKHR KK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin." Peterson E.A., Kalikin L.M., Steels J.D., Estey M.P., Trimble W.S., Petty E.M. Mamm. Genome 18:796-807(2007) [PubMed: 17922164] [Abstract] Cited for: INTERACTION WITH SEPT9, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK126048 mRNA. Translation: BAC86412.1. Different initiation. AK301928 mRNA. Translation: BAG63348.1. AC092647 Genomic DNA. No translation available.
IPI	IPI00248126.
RefSeq	NP_997249.2. NM_207366.2.
UniGene	Hs.453629.
3D structure databases
ProteinModelPortal	Q6ZU15.
SMR	Q6ZU15. Positions 27-317.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6ZU15. 10 interactions.
STRING	Q6ZU15.
Polymorphism databases
DMDM	152112291.
Proteomic databases
PRIDE	Q6ZU15.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000388975; ENSP00000373627; ENSG00000154997.
GeneID	346288.
KEGG	hsa:346288.
UCSC	uc003tqz.2. human.
Organism-specific databases
CTD	346288.
GeneCards	GC07M055829.
HGNC	HGNC:33280. SEPT14.
MIM	612140. gene.
neXtProt	NX_Q6ZU15.
PharmGKB	PA162402917.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG19050.
GeneTree	ENSGT00590000082767.
HOGENOM	HBG715249.
HOVERGEN	HBG065093.
InParanoid	Q6ZU15.
OMA	KEASYQP.
OrthoDB	EOG4QFWDB.
PhylomeDB	Q6ZU15.
Gene expression databases
ArrayExpress	Q6ZU15.
Bgee	Q6ZU15.
CleanEx	HS_SEPT14.
Genevestigator	Q6ZU15.
Family and domain databases
InterPro	IPR000038. Cell_div_GTP-bd. IPR016491. Septin. [Graphical view]
PANTHER	PTHR18884. Cell_Div_GTP_bd. 1 hit.
Pfam	PF00735. Septin. 1 hit. [Graphical view]
PIRSF	PIRSF006698. Septin. 1 hit.
ProtoNet	Search...
Other
NextBio	98947.
SOURCE	Search...

Entry information

Entry name

SEP14_HUMAN

Accession

Primary (citable) accession number: Q6ZU15
Secondary accession number(s): A6NCC2, B4DXD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	January 25, 2012
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.