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Protein

Tubulin polyglutamylase complex subunit 1

Gene

TPGS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin polyglutamylase complex subunit 1
Short name:
PGs1
Gene namesi
Name:TPGS1
Synonyms:C19orf20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25058. TPGS1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: UniProtKB-SubCell
  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
  • dendrite Source: UniProtKB-SubCell
  • microtubule Source: UniProtKB-KW
  • motile cilium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134901246.

Polymorphism and mutation databases

BioMutaiTPGS1.
DMDMi114152292.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Tubulin polyglutamylase complex subunit 1PRO_0000249316Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341PhosphoserineCombined sources
Modified residuei266 – 2661PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZTW0.
MaxQBiQ6ZTW0.
PaxDbiQ6ZTW0.
PeptideAtlasiQ6ZTW0.
PRIDEiQ6ZTW0.

PTM databases

iPTMnetiQ6ZTW0.
PhosphoSiteiQ6ZTW0.

Expressioni

Gene expression databases

BgeeiENSG00000141933.
CleanExiHS_C19orf20.
GenevisibleiQ6ZTW0. HS.

Interactioni

Subunit structurei

Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.By similarity

Protein-protein interaction databases

BioGridi124900. 18 interactions.
IntActiQ6ZTW0. 11 interactions.
STRINGi9606.ENSP00000352265.

Structurei

3D structure databases

ProteinModelPortaliQ6ZTW0.
SMRiQ6ZTW0. Positions 36-74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IKJ3. Eukaryota.
ENOG4111GS0. LUCA.
GeneTreeiENSGT00500000045074.
HOGENOMiHOG000060156.
HOVERGENiHBG094083.
InParanoidiQ6ZTW0.
KOiK16581.
OMAiTDSGRQS.
OrthoDBiEOG091G0RLI.
PhylomeDBiQ6ZTW0.
TreeFamiTF329086.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZTW0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVEKRRQA VPPPAGFTDS GRQSVSRAAG AAESEEDFLR QVGVTEMLRA
60 70 80 90 100
ALLKVLEARP EEPIAFLAHY FENMGLRSPV NGGAGEPPGQ LLLQQQRLGR
110 120 130 140 150
ALWHLRLAHH SQRAAFNNNV SVAYECLSAG GRRKRPGLDG RTYSELLRRI
160 170 180 190 200
CRDGQAPEEV VAPLLRKVQC RDHEAVPLSV FRAGTLTCFV LLEFVARAGA
210 220 230 240 250
LFQLLEDSAA AVADRRVGQA VLDTLEGALQ ASDAAAPARF LEAGSRLGPD
260 270 280 290
SLALALDRAV GGRRPSAPMT REEFLERAAA LFIAKVKPVG
Length:290
Mass (Da):31,275
Last modified:September 5, 2006 - v2
Checksum:i51BB1D8875827E84
GO
Isoform 2 (identifier: Q6ZTW0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-266: Missing.

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):29,385
Checksum:i718488818CA16931
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei248 – 26619Missing in isoform 2. 1 PublicationVSP_020401Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126170 mRNA. Translation: BAC86469.1.
BC009520 mRNA. Translation: AAH09520.1.
CCDSiCCDS42454.1. [Q6ZTW0-1]
RefSeqiNP_277048.2. NM_033513.2. [Q6ZTW0-1]
UniGeneiHs.369613.

Genome annotation databases

EnsembliENST00000359315; ENSP00000352265; ENSG00000141933. [Q6ZTW0-1]
GeneIDi91978.
KEGGihsa:91978.
UCSCiuc002lou.4. human. [Q6ZTW0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126170 mRNA. Translation: BAC86469.1.
BC009520 mRNA. Translation: AAH09520.1.
CCDSiCCDS42454.1. [Q6ZTW0-1]
RefSeqiNP_277048.2. NM_033513.2. [Q6ZTW0-1]
UniGeneiHs.369613.

3D structure databases

ProteinModelPortaliQ6ZTW0.
SMRiQ6ZTW0. Positions 36-74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124900. 18 interactions.
IntActiQ6ZTW0. 11 interactions.
STRINGi9606.ENSP00000352265.

PTM databases

iPTMnetiQ6ZTW0.
PhosphoSiteiQ6ZTW0.

Polymorphism and mutation databases

BioMutaiTPGS1.
DMDMi114152292.

Proteomic databases

EPDiQ6ZTW0.
MaxQBiQ6ZTW0.
PaxDbiQ6ZTW0.
PeptideAtlasiQ6ZTW0.
PRIDEiQ6ZTW0.

Protocols and materials databases

DNASUi91978.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359315; ENSP00000352265; ENSG00000141933. [Q6ZTW0-1]
GeneIDi91978.
KEGGihsa:91978.
UCSCiuc002lou.4. human. [Q6ZTW0-1]

Organism-specific databases

CTDi91978.
GeneCardsiTPGS1.
HGNCiHGNC:25058. TPGS1.
neXtProtiNX_Q6ZTW0.
PharmGKBiPA134901246.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKJ3. Eukaryota.
ENOG4111GS0. LUCA.
GeneTreeiENSGT00500000045074.
HOGENOMiHOG000060156.
HOVERGENiHBG094083.
InParanoidiQ6ZTW0.
KOiK16581.
OMAiTDSGRQS.
OrthoDBiEOG091G0RLI.
PhylomeDBiQ6ZTW0.
TreeFamiTF329086.

Miscellaneous databases

ChiTaRSiTPGS1. human.
GenomeRNAii91978.
PROiQ6ZTW0.

Gene expression databases

BgeeiENSG00000141933.
CleanExiHS_C19orf20.
GenevisibleiQ6ZTW0. HS.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTPGS1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZTW0
Secondary accession number(s): Q96GE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.