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Protein

Protein FAM92B

Gene

FAM92B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616).By similarity1 Publication

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM92B
Gene namesi
Name:FAM92B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000153789.12.
HGNCiHGNC:24781. FAM92B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi105K → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-108; E-112; E-130; E-132 and E-134. 1 Publication1
Mutagenesisi108R → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-105; E-112; E-130; E-132 and E-134. 1 Publication1
Mutagenesisi112K → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-105; E-108; E-130; E-132 and E-134. 1 Publication1
Mutagenesisi130K → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-105; E-108; E-112; E-132 and E-134. 1 Publication1
Mutagenesisi132R → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-105; E-108; E-112; E-130 and E-134. 1 Publication1
Mutagenesisi134K → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-105; E-108; E-1112; E-130 and E-132. 1 Publication1

Organism-specific databases

DisGeNETi339145.
OpenTargetsiENSG00000153789.
PharmGKBiPA142671826.

Polymorphism and mutation databases

BioMutaiFAM92B.
DMDMi74738328.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003330041 – 304Protein FAM92BAdd BLAST304

Proteomic databases

PaxDbiQ6ZTR7.
PeptideAtlasiQ6ZTR7.
PRIDEiQ6ZTR7.

PTM databases

iPTMnetiQ6ZTR7.
PhosphoSitePlusiQ6ZTR7.

Expressioni

Tissue specificityi

Restricted to certain tissues, most prominently expressed in multicilaited tissues.1 Publication

Gene expression databases

BgeeiENSG00000153789.
CleanExiHS_FAM92B.
ExpressionAtlasiQ6ZTR7. baseline and differential.

Organism-specific databases

HPAiHPA041022.

Interactioni

Subunit structurei

Homodimer (via BAR-like domain) (PubMed:27528616). Heterodimer (via BAR-like domain) with FAM92B (PubMed:27528616). Interacts with CBY1; this interaction is required for targeting FAM92B to centriole (PubMed:27528616).1 Publication

Protein-protein interaction databases

BioGridi130832. 1 interactor.
IntActiQ6ZTR7. 1 interactor.
STRINGi9606.ENSP00000443411.

Structurei

3D structure databases

ProteinModelPortaliQ6ZTR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni6 – 217BAR-likeBy similarityAdd BLAST212

Domaini

The BAR-like domain displays limited similarity to other BAR domains.By similarity

Sequence similaritiesi

Belongs to the FAM92 family.Curated

Phylogenomic databases

eggNOGiENOG410IFRR. Eukaryota.
ENOG410YE7H. LUCA.
GeneTreeiENSGT00390000010285.
HOGENOMiHOG000060253.
HOVERGENiHBG107895.
InParanoidiQ6ZTR7.
OMAiANTENPE.
OrthoDBiEOG091G0T7H.
PhylomeDBiQ6ZTR7.
TreeFamiTF324316.

Family and domain databases

CDDicd07598. BAR_FAM92. 1 hit.
Gene3Di1.20.1270.60. 1 hit.
InterProiView protein in InterPro
IPR027267. AH/BAR-dom.
IPR035590. BAR_FAM92.
IPR009602. FAM92.
PANTHERiPTHR21223. PTHR21223. 1 hit.
PfamiView protein in Pfam
PF06730. FAM92. 1 hit.
SUPFAMiSSF103657. SSF103657. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ZTR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIVFSRDSQ VRVMENTVAN TEKYFGQFCS LLAAYTRKTA RLRDKADQLV
60 70 80 90 100
KQLIDFANSE NPELRATMRG FAEDLAKVQD YRQAQVERLE TKVVNPLKLY
110 120 130 140 150
GAQIKQTRAE IKKFKHVQNH EIKQLEKLEK LRQKSPSDQQ MIGQAETRVQ
160 170 180 190 200
RAAVDSSRTT LQLEETVDGF QRQKLKDLQK FFCDFVTIEM VFHAKAVEVY
210 220 230 240 250
SSAFQTLEKY DLERDLLDFR AKMQGVYGHY DTRLLANTSP PPSVLQSLAS
260 270 280 290 300
QGTLQVQLSR ANEDPEHPHA NHGRFSLCEW VVKGQPAHCV CGQGGHLMLP

GHSL
Length:304
Mass (Da):34,755
Last modified:May 10, 2017 - v2
Checksum:i8126DCC535375296
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143G → S in BAC86515 (PubMed:14702039).1
Sequence conflicti143G → S in AAH93665 (PubMed:15489334).1
Sequence conflicti143G → S in AAI11945 (PubMed:15489334).1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04303522E → K. Corresponds to variant dbSNP:rs9934891Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126284 mRNA. Translation: BAC86515.1.
AC026469 Genomic DNA. No translation available.
BC093665 mRNA. Translation: AAH93665.1.
BC111944 mRNA. Translation: AAI11945.1.
CCDSiCCDS32500.1.
RefSeqiNP_940893.1. NM_198491.2.
XP_011521365.1. XM_011523063.1.
UniGeneiHs.125713.

Genome annotation databases

EnsembliENST00000629253; ENSP00000487117; ENSG00000153789.
GeneIDi339145.
KEGGihsa:339145.
UCSCiuc059xyr.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFA92B_HUMAN
AccessioniPrimary (citable) accession number: Q6ZTR7
Secondary accession number(s): A0A0D9SG36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 10, 2017
Last modified: October 25, 2017
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families