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Protein

Cadherin-related family member 3

Gene

CDHR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
(Microbial infection) Acts as a receptor for rhinovirus C.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Cell adhesion, Host-virus interaction

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-related family member 3
Alternative name(s):
Cadherin-like protein 28
Gene namesi
Name:CDHR3
Synonyms:CDH28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:26308. CDHR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 713694ExtracellularSequence analysisAdd
BLAST
Transmembranei714 – 73421HelicalSequence analysisAdd
BLAST
Topological domaini735 – 885151CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Asthma susceptibility may be associated with variations affecting the gene represented in this entry in early childhood asthma with severe exacerbations occurring between 2 and 6 years of age.

Keywords - Diseasei

Asthma

Organism-specific databases

PharmGKBiPA165617747.

Polymorphism and mutation databases

BioMutaiCDHR3.
DMDMi74758833.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 885866Cadherin-related family member 3PRO_0000305903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence analysis
Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence analysis
Glycosylationi624 – 6241N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6ZTQ4.
PRIDEiQ6ZTQ4.

PTM databases

iPTMnetiQ6ZTQ4.
PhosphoSiteiQ6ZTQ4.

Expressioni

Tissue specificityi

Expressed in bronchial epithelium from adults and in fetal lung tissue.1 Publication

Gene expression databases

BgeeiQ6ZTQ4.
ExpressionAtlasiQ6ZTQ4. baseline and differential.
GenevisibleiQ6ZTQ4. HS.

Organism-specific databases

HPAiHPA011218.

Interactioni

Subunit structurei

(Microbial infection) Interacts with rhinovirus C capsid proteins.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000325954.

Structurei

3D structure databases

ProteinModelPortaliQ6ZTQ4.
SMRiQ6ZTQ4. Positions 169-596.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 132110Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini136 – 236101Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini237 – 344108Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini346 – 466121Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini462 – 566105Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini567 – 695129Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00650000093370.
HOGENOMiHOG000060182.
HOVERGENiHBG106392.
InParanoidiQ6ZTQ4.
KOiK16503.
OMAiIYQVEAF.
OrthoDBiEOG7WMCHT.
PhylomeDBiQ6ZTQ4.
TreeFamiTF336601.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
[Graphical view]
PfamiPF00028. Cadherin. 3 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZTQ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQEAIILLAL LGAMSGGEAL HLILLPATGN VAENSPPGTS VHKFSVKLSA
60 70 80 90 100
SLSPVIPGFP QIVNSNPLTE AFRVNWLSGT YFEVVTTGME QLDFETGPNI
110 120 130 140 150
FDLQIYVKDE VGVTDLQVLT VQVTDVNEPP QFQGNLAEGL HLYIVERANP
160 170 180 190 200
GFIYQVEAFD PEDTSRNIPL SYFLISPPKS FRMSANGTLF STTELDFEAG
210 220 230 240 250
HRSFHLIVEV RDSGGLKAST ELQVNIVNLN DEVPRFTSPT RVYTVLEELS
260 270 280 290 300
PGTIVANITA EDPDDEGFPS HLLYSITTVS KYFMINQLTG TIQVAQRIDR
310 320 330 340 350
DAGELRQNPT ISLEVLVKDR PYGGQENRIQ ITFIVEDVND NPATCQKFTF
360 370 380 390 400
SIMVPERTAK GTLLLDLNKF CFDDDSEAPN NRFNFTMPSG VGSGSRFLQD
410 420 430 440 450
PAGSGKIVLI GDLDYENPSN LAAGNKYTVI IQVQDVAPPY YKNNVYVYIL
460 470 480 490 500
TSPENEFPLI FDRPSYVFDV SERRPARTRV GQVRATDKDL PQSSLLYSIS
510 520 530 540 550
TGGASLQYPN VFWINPKTGE LQLVTKVDCE TTPIYILRIQ ATNNEDTSSV
560 570 580 590 600
TVTVNILEEN DEKPICTPNS YFLALPVDLK VGTNIQNFKL TCTDLDSSPR
610 620 630 640 650
SFRYSIGPGN VNNHFTFSPN AGSNVTRLLL TSRFDYAGGF DKIWDYKLLV
660 670 680 690 700
YVTDDNLMSD RKKAEALVET GTVTLSIKVI PHPTTIITTT PRPRVTYQVL
710 720 730 740 750
RKNVYSPSAW YVPFVITLGS ILLLGLLVYL VVLLAKAIHR HCPCKTGKNK
760 770 780 790 800
EPLTKKGETK TAERDVVVET IQMNTIFDGE AIDPVTGETY EFNSKTGARK
810 820 830 840 850
WKDPLTQMPK WKESSHQGAA PRRVTAGEGM GSLRSANWEE DELSGKAWAE
860 870 880
DAGLGSRNEG GKLGNPKNRN PAFMNRAYPK PHPGK
Length:885
Mass (Da):97,977
Last modified:July 5, 2004 - v1
Checksum:iCDF0EEAFA904E9BE
GO
Isoform 2 (identifier: Q6ZTQ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-283: Missing.
     477-560: RTRVGQVRAT...TVTVNILEEN → QGHLSGPEEK...GGNYPDEHYL
     561-885: Missing.

Note: No experimental confirmation available.
Show »
Length:277
Mass (Da):31,260
Checksum:i5B89A2395D907721
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551V → M.
Corresponds to variant rs35008315 [ dbSNP | Ensembl ].
VAR_035228
Natural varianti61 – 611Q → H.
Corresponds to variant rs34426483 [ dbSNP | Ensembl ].
VAR_035229
Natural varianti529 – 5291C → Y Common polymorphism; increases cell surface expression. 1 Publication
Corresponds to variant rs6967330 [ dbSNP | Ensembl ].
VAR_035230

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 283283Missing in isoform 2. 1 PublicationVSP_028352Add
BLAST
Alternative sequencei477 – 56084RTRVG…ILEEN → QGHLSGPEEKRLLSICMVRA VCHHFGLHIASGSPRVPGRP IGQSRPQTLPLQDWEEQGTS DKERRNEDCRERRRGGNYPD EHYL in isoform 2. 1 PublicationVSP_028353Add
BLAST
Alternative sequencei561 – 885325Missing in isoform 2. 1 PublicationVSP_028354Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074414 mRNA. Translation: BAB85073.1.
AK126338 mRNA. Translation: BAC86529.1.
CH236947 Genomic DNA. Translation: EAL24403.1.
BC111696 mRNA. Translation: AAI11697.1.
BC111738 mRNA. Translation: AAI11739.1.
CCDSiCCDS47684.1. [Q6ZTQ4-1]
RefSeqiNP_001288090.1. NM_001301161.1.
NP_689963.2. NM_152750.4. [Q6ZTQ4-1]
UniGeneiHs.150120.

Genome annotation databases

EnsembliENST00000317716; ENSP00000325954; ENSG00000128536. [Q6ZTQ4-1]
GeneIDi222256.
KEGGihsa:222256.
UCSCiuc003vdl.5. human. [Q6ZTQ4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074414 mRNA. Translation: BAB85073.1.
AK126338 mRNA. Translation: BAC86529.1.
CH236947 Genomic DNA. Translation: EAL24403.1.
BC111696 mRNA. Translation: AAI11697.1.
BC111738 mRNA. Translation: AAI11739.1.
CCDSiCCDS47684.1. [Q6ZTQ4-1]
RefSeqiNP_001288090.1. NM_001301161.1.
NP_689963.2. NM_152750.4. [Q6ZTQ4-1]
UniGeneiHs.150120.

3D structure databases

ProteinModelPortaliQ6ZTQ4.
SMRiQ6ZTQ4. Positions 169-596.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000325954.

PTM databases

iPTMnetiQ6ZTQ4.
PhosphoSiteiQ6ZTQ4.

Polymorphism and mutation databases

BioMutaiCDHR3.
DMDMi74758833.

Proteomic databases

PaxDbiQ6ZTQ4.
PRIDEiQ6ZTQ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317716; ENSP00000325954; ENSG00000128536. [Q6ZTQ4-1]
GeneIDi222256.
KEGGihsa:222256.
UCSCiuc003vdl.5. human. [Q6ZTQ4-1]

Organism-specific databases

CTDi222256.
GeneCardsiCDHR3.
HGNCiHGNC:26308. CDHR3.
HPAiHPA011218.
MIMi615610. gene.
neXtProtiNX_Q6ZTQ4.
PharmGKBiPA165617747.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00650000093370.
HOGENOMiHOG000060182.
HOVERGENiHBG106392.
InParanoidiQ6ZTQ4.
KOiK16503.
OMAiIYQVEAF.
OrthoDBiEOG7WMCHT.
PhylomeDBiQ6ZTQ4.
TreeFamiTF336601.

Miscellaneous databases

ChiTaRSiCDHR3. human.
GenomeRNAii222256.
NextBioi91592.
PROiQ6ZTQ4.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZTQ4.
ExpressionAtlasiQ6ZTQ4. baseline and differential.
GenevisibleiQ6ZTQ4. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
[Graphical view]
PfamiPF00028. Cadherin. 3 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Ileal mucosa and Trachea.
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. Cited for: TISSUE SPECIFICITY, CHARACTERIZATION OF VARIANT TYR-529, SUBCELLULAR LOCATION, INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA.
  5. "Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication."
    Bochkov Y.A., Watters K., Ashraf S., Griggs T.F., Devries M.K., Jackson D.J., Palmenberg A.C., Gern J.E.
    Proc. Natl. Acad. Sci. U.S.A. 112:5485-5490(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (MICROBIAL INFECTION).

Entry informationi

Entry nameiCDHR3_HUMAN
AccessioniPrimary (citable) accession number: Q6ZTQ4
Secondary accession number(s): Q8TCI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.