Q6ZTQ4 (CDHR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 64.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Cadherin-related family member 3 Alternative name(s): Cadherin-like protein 28 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 885 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. |
| Subcellular location | Cell membrane; Single-pass type I membrane protein By similarity. |
| Sequence similarities | Contains 6 cadherin domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell adhesion |
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Repeat Signal Transmembrane Transmembrane helix |
| Ligand | Calcium |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | homophilic cell adhesion Inferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q6ZTQ4-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q6ZTQ4-2) The sequence of this isoform differs from the canonical sequence as follows: 1-283: Missing. 477-560: RTRVGQVRAT...TVTVNILEEN → QGHLSGPEEK...GGNYPDEHYL 561-885: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | Potential | ||||||
| Chain | 20 – 885 | 866 | Cadherin-related family member 3 | PRO_0000305903 | |||||
Regions | |||||||||
| Topological domain | 20 – 713 | 694 | Extracellular Potential | ||||||
| Transmembrane | 714 – 734 | 21 | Helical; Potential | ||||||
| Topological domain | 735 – 885 | 151 | Cytoplasmic Potential | ||||||
| Domain | 23 – 132 | 110 | Cadherin 1 | ||||||
| Domain | 136 – 236 | 101 | Cadherin 2 | ||||||
| Domain | 237 – 344 | 108 | Cadherin 3 | ||||||
| Domain | 346 – 466 | 121 | Cadherin 4 | ||||||
| Domain | 462 – 566 | 105 | Cadherin 5 | ||||||
| Domain | 567 – 695 | 129 | Cadherin 6 | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 186 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 257 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 624 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 283 | 283 | Missing in isoform 2. | VSP_028352 | |||||
| Alternative sequence | 477 – 560 | 84 | RTRVG…ILEEN → QGHLSGPEEKRLLSICMVRA VCHHFGLHIASGSPRVPGRP IGQSRPQTLPLQDWEEQGTS DKERRNEDCRERRRGGNYPD EHYL in isoform 2. | VSP_028353 | |||||
| Alternative sequence | 561 – 885 | 325 | Missing in isoform 2. | VSP_028354 | |||||
| Natural variant | 55 | 1 | V → M. Corresponds to variant rs35008315 [ dbSNP | Ensembl ]. | VAR_035228 | |||||
| Natural variant | 61 | 1 | Q → H. Corresponds to variant rs34426483 [ dbSNP | Ensembl ]. | VAR_035229 | |||||
| Natural variant | 529 | 1 | C → Y. Corresponds to variant rs6967330 [ dbSNP | Ensembl ]. | VAR_035230 | |||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AK074414 mRNA. Translation: BAB85073.1. AK126338 mRNA. Translation: BAC86529.1. CH236947 Genomic DNA. Translation: EAL24403.1. BC111696 mRNA. Translation: AAI11697.1. BC111738 mRNA. Translation: AAI11739.1. |
| IPI | IPI00291088. IPI00411702. |
| RefSeq | NP_689963.2. NM_152750.4. |
| UniGene | Hs.150120. Hs.729434. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1NCJ based on UniProtKB P15116. |
| ProteinModelPortal | Q6ZTQ4. |
| SMR | Q6ZTQ4. Positions 27-134, 142-686. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q6ZTQ4. |
Polymorphism databases | |
| DMDM | 74758833. |
Proteomic databases | |
| PRIDE | Q6ZTQ4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000317716; ENSP00000325954; ENSG00000128536. |
| GeneID | 222256. |
| KEGG | hsa:222256. |
| UCSC | uc003vdk.1. human. uc003vdl.2. human. |
Organism-specific databases | |
| CTD | 222256. |
| GeneCards | GC07P105517. |
| HGNC | HGNC:26308. CDHR3. |
| HPA | HPA011218. |
| neXtProt | NX_Q6ZTQ4. |
| PharmGKB | PA165617747. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG11146. |
| GeneTree | ENSGT00580000081266. |
| HOGENOM | HBG283878. |
| HOVERGEN | HBG106392. |
| InParanoid | Q6ZTQ4. |
| OMA | SFRYSIG. |
| OrthoDB | EOG4Z8XVS. |
| PhylomeDB | Q6ZTQ4. |
Gene expression databases | |
| ArrayExpress | Q6ZTQ4. |
| Bgee | Q6ZTQ4. |
| Genevestigator | Q6ZTQ4. |
Family and domain databases | |
| InterPro | IPR002126. Cadherin. IPR015919. Cadherin-like. [Graphical view] |
| Gene3D | G3DSA:2.60.40.60. Cadherin. 5 hits. |
| Pfam | PF00028. Cadherin. 3 hits. [Graphical view] |
| PRINTS | PR00205. CADHERIN. |
| SMART | SM00112. CA. 5 hits. [Graphical view] |
| SUPFAM | SSF49313. Cadherin. 5 hits. |
| PROSITE | PS00232. CADHERIN_1. False negative. PS50268. CADHERIN_2. 6 hits. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 91592. |
Entry information
| Entry name | CDHR3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q6ZTQ4 Secondary accession number(s): Q8TCI7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with