Reviewed, UniProtKB/Swiss-Prot Q6ZTQ4 (CAD28_HUMAN)

Names and origin

Protein names

Recommended name:
    Cadherin-like protein 28

Gene names

Name:

CDH28

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	885 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Contains 6 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane
Ligand	Calcium
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleolus Inferred from direct assay. Source: HPA plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZTQ4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZTQ4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-283: Missing.
     477-560: RTRVGQVRAT...TVTVNILEEN → QGHLSGPEEK...GGNYPDEHYL
     561-885: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 885	866	Cadherin-like protein 28		PRO_0000305903
Regions
	Topological domain	20 – 713	694	Extracellular Potential
	Transmembrane	714 – 734	21	Potential
	Topological domain	735 – 885	151	Cytoplasmic Potential
	Domain	23 – 132	110	Cadherin 1
	Domain	136 – 236	101	Cadherin 2
	Domain	237 – 344	108	Cadherin 3
	Domain	346 – 466	121	Cadherin 4
	Domain	462 – 566	105	Cadherin 5
	Domain	567 – 695	129	Cadherin 6
Amino acid modifications
	Glycosylation	186	1	N-linked (GlcNAc...) Potential
	Glycosylation	257	1	N-linked (GlcNAc...) Potential
	Glycosylation	624	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 283	283	Missing in isoform 2.		VSP_028352
	Alternative sequence	477 – 560	84	RTRVG…ILEEN → QGHLSGPEEKRLLSICMVRA VCHHFGLHIASGSPRVPGRP IGQSRPQTLPLQDWEEQGTS DKERRNEDCRERRRGGNYPD EHYL in isoform 2.		VSP_028353
	Alternative sequence	561 – 885	325	Missing in isoform 2.		VSP_028354
	Natural variant	55	1	V → M: dbSNP rs35008315.		VAR_035228
	Natural variant	61	1	Q → H: dbSNP rs34426483.		VAR_035229
	Natural variant	529	1	C → Y: dbSNP rs6967330.		VAR_035230

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: CDF0EEAFA904E9BE	FASTA	885	97,977
	10 20 30 40 50 60 MQEAIILLAL LGAMSGGEAL HLILLPATGN VAENSPPGTS VHKFSVKLSA SLSPVIPGFP 70 80 90 100 110 120 QIVNSNPLTE AFRVNWLSGT YFEVVTTGME QLDFETGPNI FDLQIYVKDE VGVTDLQVLT 130 140 150 160 170 180 VQVTDVNEPP QFQGNLAEGL HLYIVERANP GFIYQVEAFD PEDTSRNIPL SYFLISPPKS 190 200 210 220 230 240 FRMSANGTLF STTELDFEAG HRSFHLIVEV RDSGGLKAST ELQVNIVNLN DEVPRFTSPT 250 260 270 280 290 300 RVYTVLEELS PGTIVANITA EDPDDEGFPS HLLYSITTVS KYFMINQLTG TIQVAQRIDR 310 320 330 340 350 360 DAGELRQNPT ISLEVLVKDR PYGGQENRIQ ITFIVEDVND NPATCQKFTF SIMVPERTAK 370 380 390 400 410 420 GTLLLDLNKF CFDDDSEAPN NRFNFTMPSG VGSGSRFLQD PAGSGKIVLI GDLDYENPSN 430 440 450 460 470 480 LAAGNKYTVI IQVQDVAPPY YKNNVYVYIL TSPENEFPLI FDRPSYVFDV SERRPARTRV 490 500 510 520 530 540 GQVRATDKDL PQSSLLYSIS TGGASLQYPN VFWINPKTGE LQLVTKVDCE TTPIYILRIQ 550 560 570 580 590 600 ATNNEDTSSV TVTVNILEEN DEKPICTPNS YFLALPVDLK VGTNIQNFKL TCTDLDSSPR 610 620 630 640 650 660 SFRYSIGPGN VNNHFTFSPN AGSNVTRLLL TSRFDYAGGF DKIWDYKLLV YVTDDNLMSD 670 680 690 700 710 720 RKKAEALVET GTVTLSIKVI PHPTTIITTT PRPRVTYQVL RKNVYSPSAW YVPFVITLGS 730 740 750 760 770 780 ILLLGLLVYL VVLLAKAIHR HCPCKTGKNK EPLTKKGETK TAERDVVVET IQMNTIFDGE 790 800 810 820 830 840 AIDPVTGETY EFNSKTGARK WKDPLTQMPK WKESSHQGAA PRRVTAGEGM GSLRSANWEE 850 860 870 880 DELSGKAWAE DAGLGSRNEG GKLGNPKNRN PAFMNRAYPK PHPGK
	Isoform 2. Checksum: 5B89A2395D907721	FASTA	277	31,260
	10 20 30 40 50 60 MINQLTGTIQ VAQRIDRDAG ELRQNPTISL EVLVKDRPYG GQENRIQITF IVEDVNDNPA 70 80 90 100 110 120 TCQKFTFSIM VPERTAKGTL LLDLNKFCFD DDSEAPNNRF NFTMPSGVGS GSRFLQDPAG 130 140 150 160 170 180 SGKIVLIGDL DYENPSNLAA GNKYTVIIQV QDVAPPYYKN NVYVYILTSP ENEFPLIFDR 190 200 210 220 230 240 PSYVFDVSER RPAQGHLSGP EEKRLLSICM VRAVCHHFGL HIASGSPRVP GRPIGQSRPQ 250 260 270 TLPLQDWEEQ GTSDKERRNE DCRERRRGGN YPDEHYL

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Ileal mucosa and Trachea.
[2]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed: 12690205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK074414 mRNA. Translation: BAB85073.1. AK126338 mRNA. Translation: BAC86529.1. CH236947 Genomic DNA. Translation: EAL24403.1. BC111696 mRNA. Translation: AAI11697.1. BC111738 mRNA. Translation: AAI11739.1.
IPI	IPI00291088. IPI00411702.
RefSeq	NP_689963.2.
UniGene	Hs.150120
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000128536. Homo sapiens. [Contig view]
GeneID	222256.
KEGG	hsa:222256.
Organism-specific databases
GeneCards	GC07P105390.
HPA	HPA011218.
Phylogenomic databases
HOGENOM	Q6ZTQ4.
HOVERGEN	Q6ZTQ4.
Gene expression databases
ArrayExpress	Q6ZTQ4.
Bgee	Q6ZTQ4.
Family and domain databases
InterPro	IPR002126. Cadherin. [Graphical view]
Gene3D	G3DSA:2.60.40.60. Cadherin. 4 hits.
Pfam	PF00028. Cadherin. 5 hits. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
PROSITE	PS00232. CADHERIN_1. False negative. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	91592.

Entry information

Entry name

CAD28_HUMAN

Accession

Primary (citable) accession number: Q6ZTQ4
Secondary accession number(s): Q8TCI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)